Sequence Specific And Synergistic Binding Of Drugs To Dna

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Sequence Specific and Synergistic Binding of Drugs to DNA.

Author : Fu-Ming Chen
Publisher :
ISBN 13 :
Total Pages : 15 pages
Book Rating : 4.:/5 (455 download)

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Book Synopsis Sequence Specific and Synergistic Binding of Drugs to DNA. by : Fu-Ming Chen

Download or read book Sequence Specific and Synergistic Binding of Drugs to DNA. written by Fu-Ming Chen and published by . This book was released on 1997 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combination chemotherapy is one of the important strategies in cancer treatments. This is based on the observation that administering certain drugs together is more effective than giving individual drugs separately. Although the reason for such an effect is not understood, it may be related to the synergistic effect of their binding to biomacromolecules. Consequently, studies on the interplay among drugs capable of binding to different regions of DNA will be of considerable interest. Understanding the synergism of drugs at the molecular level may have important implication for designing more effective chemotherapeutic strategies in breast cancer treatments. Our proposal focuses on the sequence specific binding and synergistic effect of three drugs having distinctly different binding modes: actinomycin D (ACTD), a guanine specific intercalator; chromomycin A3 (CHR), a guanine specific minor groove binder; and distamycin A (DST), an AeT specific groove binder. In order to investigate the possible synergistic effects of drugs on DNA binding, it is essential that binding characteristics of each individual drug such as binding affinities, sequence specificities, and kinetic behaviors be thoroughly elucidated. Consistent with the Statement of Work outlined in the proposal, our laboratory has focused on the sequence specificity and binding mode studies of DST during the past year.

Sequence-specific DNA Binding Agents

Author : Michael J Waring
Publisher : Royal Society of Chemistry
ISBN 13 : 1847555306
Total Pages : 271 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Sequence-specific DNA Binding Agents by : Michael J Waring

Download or read book Sequence-specific DNA Binding Agents written by Michael J Waring and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by experts in the field, this book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment. Chapters discuss established agents like actinomycin D but also look at novel drugs with strong potential in chemotherapy such as new topoisomerase inhibitors, telomerase inhibitors, peptide nucleic acids and triple helix-forming oligonucleotides. There are also sections discussing methodological advances including computational methods, slow kinetics, melting curve analysis and approaches to medicinal chemistry. Finally there is a section on RNA structure and its potential as a drug target. The book is ideal for researchers in industry and academia who require a comprehensive source of reference to this rapidly expanding subject.

Principles of Nucleic Acid Structure

Author : Wolfram Saenger
Publisher : Springer Science & Business Media
ISBN 13 : 1461251907
Total Pages : 574 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Principles of Nucleic Acid Structure by : Wolfram Saenger

Download or read book Principles of Nucleic Acid Structure written by Wolfram Saenger and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Human Herpesviruses

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Molecular Aspects of Anticancer Drug DNA Interactions

Author : Stephen Neidle
Publisher : CRC Press
ISBN 13 : 9780849377730
Total Pages : 386 pages
Book Rating : 4.3/5 (777 download)

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Book Synopsis Molecular Aspects of Anticancer Drug DNA Interactions by : Stephen Neidle

Download or read book Molecular Aspects of Anticancer Drug DNA Interactions written by Stephen Neidle and published by CRC Press. This book was released on 1994-05-03 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 2164 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Dynamics of Proteins and Nucleic Acids

Author :
Publisher : Elsevier
ISBN 13 : 0124116272
Total Pages : 368 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Dynamics of Proteins and Nucleic Acids by :

Download or read book Dynamics of Proteins and Nucleic Acids written by and published by Elsevier. This book was released on 2013-08-14 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Pharmacology

Author : Miles Hacker
Publisher : Academic Press
ISBN 13 : 0080919227
Total Pages : 607 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Pharmacology by : Miles Hacker

Download or read book Pharmacology written by Miles Hacker and published by Academic Press. This book was released on 2009-06-19 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Chemotherapy Protocols and Infusion Sequence

Author : Iago Dillion Lima Cavalcanti
Publisher : Springer Nature
ISBN 13 : 3031108396
Total Pages : 330 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Chemotherapy Protocols and Infusion Sequence by : Iago Dillion Lima Cavalcanti

Download or read book Chemotherapy Protocols and Infusion Sequence written by Iago Dillion Lima Cavalcanti and published by Springer Nature. This book was released on 2022-10-18 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to address the infusion sequence of the main protocols used in the treatment of varied solid cancers. Since an inadequate infusion sequence can compromise the patient's treatment, this work will provide support to professionals working in the field of oncology in assessing each chemotherapy infusion sequence. The introductory chapters present the definition, indication, and the risks and benefits of polypharmacy in cancer therapy, and discuss the importance of drug combination in cancer treatment. Chapter 2 focuses on the challenges and also the toxicity of combination therapy in cancer, while chapter 3 highlights the parameters that must be evaluated before defining the infusion sequence, such as pharmacodynamic and pharmacokinetic profiles, drugs’ stability when diluted or reconstituted, toxicological profile of each drug, among others. The remaining chapters are divided by type of cancer. The content is focused on solid tumors, dividing the chapters according to breast, gastrointestinal, genitourinary, gynecological, head and neck, lung, and neurological cancers. In each chapter the epidemiological profiles, pathophysiology, therapeutic modalities, and the main chemotherapy protocols are addressed, as well as efficacy studies and data on the infusion sequence of each mentioned protocol. This work will be a valuable resource to physicians, nurses, and pharmacists, and may help to improve health service practices.

Government Reports Announcements & Index

Author :
Publisher :
ISBN 13 :
Total Pages : 650 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis Government Reports Announcements & Index by :

Download or read book Government Reports Announcements & Index written by and published by . This book was released on 1996 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology

Author : H D Kumar
Publisher : Vikas Publishing House
ISBN 13 : 9788125910138
Total Pages : 384 pages
Book Rating : 4.9/5 (11 download)

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Book Synopsis Molecular Biology by : H D Kumar

Download or read book Molecular Biology written by H D Kumar and published by Vikas Publishing House. This book was released on 2000 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a choice selection of exciting topics in molecular biology organized in a logical sequence starting with a historical and biochemical background, progressing through the structure and functions of nucleic acids, the role of nucleic acids in protein synthesis (including transcription and translation of genetic information) and culminating in a concise account of our current knowledge about genes and genomes.

Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464964114
Total Pages : 1751 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition by :

Download or read book Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1751 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Applied, Analytical, and Imaging Sciences Research. The editors have built Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Applied, Analytical, and Imaging Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1828 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Proteins Involved in DNA Replication

Author : Ulrich Huebscher
Publisher : Springer
ISBN 13 : 9781468487312
Total Pages : 584 pages
Book Rating : 4.4/5 (873 download)

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Book Synopsis Proteins Involved in DNA Replication by : Ulrich Huebscher

Download or read book Proteins Involved in DNA Replication written by Ulrich Huebscher and published by Springer. This book was released on 2014-01-15 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synergism and Antagonism in Chemotherapy

Author : Ting-Chao Chou
Publisher :
ISBN 13 :
Total Pages : 776 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Synergism and Antagonism in Chemotherapy by : Ting-Chao Chou

Download or read book Synergism and Antagonism in Chemotherapy written by Ting-Chao Chou and published by . This book was released on 1991 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical, mechanism-oriented coverage of chemotherapeutic drug interactions in the clinic and in experimental model systems. Anticancer, antimicrobial, and antiviral systems are included, as well as methodology for characterization and quantization of synergism and antagonism. Annotation copyrighted by Book News, Inc., Portland, OR