Senolytic

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Senolytics in Disease, Ageing and Longevity

Author : Daniel Muñoz-Espin
Publisher : Springer Nature
ISBN 13 : 3030449033
Total Pages : 226 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Senolytics in Disease, Ageing and Longevity by : Daniel Muñoz-Espin

Download or read book Senolytics in Disease, Ageing and Longevity written by Daniel Muñoz-Espin and published by Springer Nature. This book was released on 2020-04-27 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Redox Signaling and Biomarkers in Ageing

Author : Ufuk Çakatay
Publisher : Springer Nature
ISBN 13 : 3030849651
Total Pages : 447 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Redox Signaling and Biomarkers in Ageing by : Ufuk Çakatay

Download or read book Redox Signaling and Biomarkers in Ageing written by Ufuk Çakatay and published by Springer Nature. This book was released on 2021-12-02 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.

Senolytic

Author : Fouad Sabry
Publisher : One Billion Knowledgeable
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 (661 download)

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Book Synopsis Senolytic by : Fouad Sabry

Download or read book Senolytic written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-10-05 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is Senolytic There is a family of tiny compounds known as senolytics that are now the subject of fundamental study to establish whether or not they may selectively trigger cell death in senescent cells and enhance human health. This study aims to find or create treatments that may postpone the onset of age-related disorders, prevent them, relieve their symptoms, or even reverse their effects. The term "senostatic," which meaning to inhibit senescence, is one that is associated with this idea. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Senolytic Chapter 2: Life extension Chapter 3: Dasatinib Chapter 4: p16 Chapter 5: CGK733 fraud Chapter 6: Bcl-xL Chapter 7: Chromatin remodeling Chapter 8: Telomerase reverse transcriptase Chapter 9: ID1 Chapter 10: Cellular senescence Chapter 11: Fisetin Chapter 12: NKG2D Chapter 13: Human umbilical vein endothelial cell Chapter 14: Genetics of aging Chapter 15: Navitoclax Chapter 16: Senotherapy Chapter 17: ABT-737 Chapter 18: Senescence-associated secretory phenotype Chapter 19: Hallmarks of aging Chapter 20: Timeline of senescence research Chapter 21: Laura Niedernhofer (II) Answering the public top questions about senolytic. (III) Real world examples for the usage of senolytic in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of senolytic' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of senolytic.

Regenerative Nephrology

Author : Michael S. Goligorsky
Publisher : Academic Press
ISBN 13 : 0123809290
Total Pages : 473 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Regenerative Nephrology by : Michael S. Goligorsky

Download or read book Regenerative Nephrology written by Michael S. Goligorsky and published by Academic Press. This book was released on 2010-11-26 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

The Biology of Senescence

Author : Bernard Swynghedauw
Publisher :
ISBN 13 : 9783030151126
Total Pages : 121 pages
Book Rating : 4.1/5 (511 download)

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Book Synopsis The Biology of Senescence by : Bernard Swynghedauw

Download or read book The Biology of Senescence written by Bernard Swynghedauw and published by . This book was released on 2019 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for "treating" it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related "chronic non-transmissible diseases"), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to "treat" or "prevent" the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

Nutrition, Food and Diet in Ageing and Longevity

Author : Suresh I. S. Rattan
Publisher : Springer Nature
ISBN 13 : 3030830179
Total Pages : 643 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Nutrition, Food and Diet in Ageing and Longevity by : Suresh I. S. Rattan

Download or read book Nutrition, Food and Diet in Ageing and Longevity written by Suresh I. S. Rattan and published by Springer Nature. This book was released on 2021-10-03 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is a compilation of 30 articles discussing what constitutes food for health and longevity. The aim is to provide up-to-date information, insights, and future tendencies in the ongoing scientific research about nutritional components, food habits and dietary patterns in different cultures. The health-sustaining and health-promoting effects of food are certainly founded in its overall composition of macronutrients and micronutrients. However, the consumption of these nutrients is normally in the form of raw or prepared food from the animal and plant sources. The book is divided into four parts and a conclusion, and successfully convenes the well-established information and knowledge, along with the personal views of a diversified group of researchers and academicians on the multifaceted aspects of nutrition, food and diet. The first part reviews the scientific information about proteins, carbohydrates, fats and oils, micronutrients, pro- and pre-biotics, and hormetins, along with a discussion of the evolutionary principles and constraints about what is optimal food, if any. The second part discusses various kinds of foods and food supplements with respect to their claimed benefits for general health and prevention of some diseases. The third part brings in the cultural aspects, such as what are the principles of healthy eating according to the traditional Chinese and Indian systems, what is the importance of mealing times and daily rhythms, and how different cultures have developed different folk wisdoms for eating for health, longevity and immortality. In the part four, various approaches which are either already in practice or are still in the testing and research phases are discussed and evaluated critically, for example intermittent fasting and calorie restriction, food-based short peptides, senolytics, Ayurvedic compounds, optimal food for old people, and food for the prevention of obesity and other metabolic disorders. The overreaching aim of this book is to inform, inspire and encourage students, researchers, educators and medical health professionals thinking about food and food habits in a holistic context of our habits, cultures and patterns. Food cannot be reduced to a pill of nutritional components. Eating food is a complex human behavior culturally evolved over thousands of years. Perhaps the old adage “we are what we eat” needs to be modified to “we eat what we are”.

Stem Cells and Aging

Author : Surajit Pathak
Publisher : Academic Press
ISBN 13 : 0128204133
Total Pages : 322 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Stem Cells and Aging by : Surajit Pathak

Download or read book Stem Cells and Aging written by Surajit Pathak and published by Academic Press. This book was released on 2021-03-17 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Ageless

Author : Andrew Steele
Publisher : Anchor
ISBN 13 : 0385544936
Total Pages : 353 pages
Book Rating : 4.3/5 (855 download)

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Book Synopsis Ageless by : Andrew Steele

Download or read book Ageless written by Andrew Steele and published by Anchor. This book was released on 2021-03-23 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” —Sanjay Gupta, MD Aging—not cancer, not heart disease—is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: there are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are, a phenomenon known as “biological immortality.” In Ageless, Andrew Steelecharts the astounding progress science has made in recent years to secure the same for humans: to help us become old without getting frail, to live longer without ill health or disease.

Mechanisms and Management of Senescence

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 183969050X
Total Pages : 132 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Mechanisms and Management of Senescence by :

Download or read book Mechanisms and Management of Senescence written by and published by BoD – Books on Demand. This book was released on 2022-09-14 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Senescence represents a complex universal phenomenon that can be impacted by several factors. It is emerging as a therapeutic target for several diseases. This book presents an overview of the current mechanisms and management of senescence in humans. It also provides comparative data on senescence in animals and plants.

Nephrology and Public Health Worldwide

Author : G.B. Silva Junior
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 331806937X
Total Pages : 369 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Nephrology and Public Health Worldwide by : G.B. Silva Junior

Download or read book Nephrology and Public Health Worldwide written by G.B. Silva Junior and published by Karger Medical and Scientific Publishers. This book was released on 2021-11-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.

Cellular Senescence in Disease

Author : Manuel Serrano
Publisher : Academic Press
ISBN 13 : 0128225157
Total Pages : 474 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cellular Senescence in Disease by : Manuel Serrano

Download or read book Cellular Senescence in Disease written by Manuel Serrano and published by Academic Press. This book was released on 2021-11-27 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the 2023 PROSE award in Biomedicine and Neuroscience! Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities. 2023 PROSE Awards - Winner: Category: Biomedicine and Neuroscience: Association of American Publishers Provides a thorough introduction to Cellular Senescence Covers all major pathologies for which cellular senescence has shown evidence of involvement Focuses on possible therapeutic pathways Edited and authored by worldwide experts

The Surfaceome

Author : Kenneth R. Boheler
Publisher : Humana Press
ISBN 13 : 9781493975518
Total Pages : 348 pages
Book Rating : 4.9/5 (755 download)

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Book Synopsis The Surfaceome by : Kenneth R. Boheler

Download or read book The Surfaceome written by Kenneth R. Boheler and published by Humana Press. This book was released on 2017-12-20 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with the latest techniques and tools to assess modifications and functions of the surfaceome. The chapters in this book are divided into 4 sections: discovery-based approaches to surfaceome content; targeted approaches for surfaceome content; cell-based function analyses related to surfaceome content; and computational approaches in surfaceome studies. Section 1 focuses on discovery-based approaches for cataloging surfaceome content that analyses the surfaceome of bacteria, avian embryos, and mammalian systems. Section 2 discusses methods that over-express specific targets in Sf9 cells and generate bi-specific antibodies for targeting cancer and somatic cells. Section 3 explores voltage dependent sodium channels and high-content electrophysiological analyses. The final section looks at the new web-based platform known as targets-search. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and thorough, Surfaceome: Methods and Protocols assists in the study of cell surface protein biology and function. It is a valuable resource for all researchers interested in this field.

Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Principles of Translational Science in Medicine

Author : Martin Wehling
Publisher : Academic Press
ISBN 13 : 032399962X
Total Pages : 495 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Principles of Translational Science in Medicine by : Martin Wehling

Download or read book Principles of Translational Science in Medicine written by Martin Wehling and published by Academic Press. This book was released on 2021-07-15 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields. Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization

Joint Function Preservation

Author : Alberto Gobbi
Publisher : Springer Nature
ISBN 13 : 3030829588
Total Pages : 394 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Joint Function Preservation by : Alberto Gobbi

Download or read book Joint Function Preservation written by Alberto Gobbi and published by Springer Nature. This book was released on 2021-11-03 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This user-friendly, pragmatic book discusses the normal and pathological conditions of the appendicular skeleton, with a focus on the preservation of joint function, providing a detailed overview of strategies for both common and complex joint preservation. The first section covers basic topics, ranging from joints homeostasis and biomechanics, to genetics, bio-orthopedics, tissue engineering and 3D bioprinting. The following sections are each dedicated to a specific joint – its functional anatomy, pathologic conditions, diagnostics and treatment. This book is of interest to orthopedists and sports medicine specialists treating common and complex injuries of the joints.

Aging

Author : Michael Fossel
Publisher : Elsevier
ISBN 13 : 0443155011
Total Pages : 274 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Aging by : Michael Fossel

Download or read book Aging written by Michael Fossel and published by Elsevier. This book was released on 2024-02-29 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging: How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases explains the process of aging beyond mere entropy, exposing it as a complicated and dynamic process that undercuts maintenance and permits age-related disease. With a deeper understanding of the aging process, intervention becomes both easy to understand and clinically feasible. With a solid academic approach, this proposed book builds upon the substantial work published over the past 20 years, citing the newest data, up-to-date models based upon that data, and the implications for improved clinical intervention, including recent developments in gene and cell therapy. Coverage of age-related diseases includes neurodegenerative, cardiovascular, bone and joint, immune system, renal, pulmonary, and skin aging. Future directions of the field focus on interventions, including a summary of previous attempts to intervene in aging and age-related disease, the status of current research, and proposed biotech interventions, as well as their potential obstacles, risks, and benefits. This is the perfect reference for scientists, clinicians, and researchers interested in the translational research opportunities such as drug discovery, pharmacogenetics, and experimental therapeutics, not only summarizing where the field stands, but giving a clear and cogent view of where clinical medicine is going in the next decade. Provides a sophisticated, accurate, and clear explanation of aging Gives a clear explanation of the fundamental role of cell aging in age-related disease Offers a unified model for the role of epigenetic and telomere changes in cell aging Outlines effective approaches to intervention in the fundamental aging process Introduces upcoming interventions intended to both cure and prevent age-related diseases

A Centum of Valuable Plant Bioactives

Author : Muhammad Mushtaq
Publisher : Academic Press
ISBN 13 : 0128229241
Total Pages : 784 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis A Centum of Valuable Plant Bioactives by : Muhammad Mushtaq

Download or read book A Centum of Valuable Plant Bioactives written by Muhammad Mushtaq and published by Academic Press. This book was released on 2021-08-31 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: During last couple of decades, a great deal of research has explored what exactly plants contain (bioactives) and how these molecules may interact with human physiology at the molecular level. It is extremely important to know what happens to plant bioactives or their biological activities when processed or isolated under various reaction conditions. Huge numbers of extraction or food manufacturing methodologies are adversely affecting the quality of these phytonutrients so there is a prompt need to highlight these processes/methods and replace them with more novel, efficient, green, or eco-friendly ones. A Centum of Valuable Plant Bioactives is a comprehensive resource on the top 100 plant bioactives available. Chapters are grouped together by bioactives, with sections on carotenes, xanthophylls, terpenoids, steroids, polyphenols and more. This is an essential guide for botanists, food technologists and chemists, nutritionists and pharmacists. Highlights the top 100 plant bioactives, their biogenesis, distribution, extraction/purification, and metabolism Contains the latest advances in botanic biology, analytical chemistry and food technology Explores potential applications including food additives, digestion and health, chemoprevention and biotherapy