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Senescence The Last Half Of Li
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Book Synopsis The Evolution of Senescence in the Tree of Life by : Richard P. Shefferson
Download or read book The Evolution of Senescence in the Tree of Life written by Richard P. Shefferson and published by Cambridge University Press. This book was released on 2017-02-23 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The existing theories on the evolution of senescence assume that senescence is inevitable in all organisms. However, recent studies have shown that this is not necessarily true. A better understanding of senescence and its underlying mechanisms could have far-reaching consequences for conservation and eco-evolutionary research. This book is the first to offer interdisciplinary perspectives on the evolution of senescence in many species, setting the stage for further developments. It brings together new insights from a wide range of scientific fields and cutting-edge research done on a multitude of different animals (including humans), plants and microbes, giving the reader a complete overview of recent developments and of the controversies currently surrounding the topic. Written by specialists from a variety of disciplines, this book is a valuable source of information for students and researchers interested in ageing and life history traits and populations.
Book Synopsis Recent Advances in Cytometry, Part B by :
Download or read book Recent Advances in Cytometry, Part B written by and published by Academic Press. This book was released on 2011-07-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytometry is one of the most rapidly growing methodologies available for basic cell and molecular biology, cytogenetics, immunology, oncology, environmental sciences and also various fields of clinical medicine. This new edition, split into 2 Parts, is an almost completely new book, with nearly all of the chapters devoted to new topics. Like the previous volumes on cytometry published as part of the Methods in Cell Biology series, it provides a comprehensive description of particular cytometric methods and reviews their applications. Chapters present the theoretical foundations of the described methods, their applicability in experimental laboratory and clinical settings, and describes common traps and pitfalls such as problems with data interpretation, comparison with alternative assays, and choosing the optimal assay. - Comprehensive presentation of cytometric methods covering theoretical applications, applicability, potential pitfalls, and comparisions to alternative assays - Discusses many new assays developed since the previous edition - Presents recent developments in cytometric intrumentation/technology
Book Synopsis Newton Free Library Bulletin by : Newton Free Library
Download or read book Newton Free Library Bulletin written by Newton Free Library and published by . This book was released on 1917 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Basic Science Notes by : Walter Reed Army Institute of Research
Download or read book Basic Science Notes written by Walter Reed Army Institute of Research and published by . This book was released on 1949 with total page 890 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cargoes for Crusoes by : Grant Martin Overton
Download or read book Cargoes for Crusoes written by Grant Martin Overton and published by New York : D. Appleton. This book was released on 1924 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular, Cellular, and Metabolic Fundamentals of Human Aging by : Evandro Fei Fang
Download or read book Molecular, Cellular, and Metabolic Fundamentals of Human Aging written by Evandro Fei Fang and published by Academic Press. This book was released on 2022-10-23 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology. - Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer's disease - Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging - Highlights recurring themes and key principles shared across the hallmarks of aging - Considers NAD+ depletion and defective autophagy as emerging aspects that impact human aging
Book Synopsis MicroRNAs in Medicine by : Charles H. Lawrie
Download or read book MicroRNAs in Medicine written by Charles H. Lawrie and published by John Wiley & Sons. This book was released on 2013-10-30 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics. Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.
Book Synopsis Interphase Between Aging and Neurodegenerative Diseases by : Walter E. Müller
Download or read book Interphase Between Aging and Neurodegenerative Diseases written by Walter E. Müller and published by Frontiers Media SA. This book was released on 2020-01-21 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this Research Topic is to discuss the latest developments in aging and neurodegenerative diseases. Aging represents the major risk factor of the two most relevant neurodegenerative diseases Parkinson’s disease (PD) and Alzheimer’s disease (AD). It is generally accepted that symptoms of PD correlate with the severity of degeneration of dopaminergic substantia nigra neurons. In most cases neuronal loss during aging is not sufficient to cause clinical symptoms but only leads to a preclinical state of PD. However, in a small number of our population, neurodegeneration by aging gets accelerated by individual (e.g. brain injuries), environmental (e.g. toxins) and genetic (e.g. mutations of the alpha-synuclein gene) factors to reach the critical threshold for clinical symptoms during lifetime. Thus, neurodegeneration in PD appears to represent the common final pathway of “normal brain aging” and all other risk factors including genetics and the accumulation of the neurotoxic alpha-synuclein protein. While aging alone is generally agreed to be sufficient for at least the preclinical state of PD, the situation in AD seems to be different. Aging as the major and well documented risk factor of AD has been neglected for decades. Biochemical mechanisms of brain aging and the cognitive deficits of “normal brain aging” were seen as two not related and independent processes not related to AD. AD has always been characterized for decades by the presence of histopathological alterations (extracellular amyloid- containing plaques and intracellular tangles of hyperphosphorylated tau-protein), by neurodegeneration (synaptic deficits and finally neuronal loss), as well as by severe cognitive deficits clinically often accompanied by neuropsychiatric symptoms like delusions, as already described in the first famous patient Auguste D at the Psychiatric Hospital of Frankfurt. If or if not one or both of the two histopathological hallmarks play a causative role remains unclear until now. The discovery of homocygotic risk genes in most of the very rare (probably less than 1%) cases of early onset AD which share increased production of β-amyloid (Aβ) as one (but probably not the only one) common property led to the hypothesis of Aβ as the major causative factor for the development of AD. It was neglected that plaques density in the brain of AD patients did not correlate with presence and severity of clinical symptoms, while synaptic deficits did so even in first observations already published many years ago. Based on the Amyloid hypothesis, many drug treatments to remove Aβ plaques were developed. Even if all seemed to remove Aβ to some extent, all strategies failed to improve the symptoms of dementia. Thus, other concepts to explain the development of clinical symptoms of AD over time are needed. These should include the brain aging process not only as a statistical but also as a causative contributing factor. These concepts should not only relay on cell or animal models but should much more take into account the disease and the patients. A closer look at the situation in PD will certainly be helpful.
Book Synopsis Telomeres and Telomerase in Aging, Disease, and Cancer by : K. Lenhard Rudolph
Download or read book Telomeres and Telomerase in Aging, Disease, and Cancer written by K. Lenhard Rudolph and published by Springer Science & Business Media. This book was released on 2007-11-07 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.
Book Synopsis Journal of the American Medical Association by :
Download or read book Journal of the American Medical Association written by and published by . This book was released on 1922 with total page 1134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes proceedings of the association, papers read at the annual sessions, and lists of current medical literature.
Book Synopsis Books of 1921-1925 by : Chicago Public Library
Download or read book Books of 1921-1925 written by Chicago Public Library and published by . This book was released on 1927 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Books of 1912- written by and published by . This book was released on 1922 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Geriatrics Problem by : Arthur L. Barbakoff
Download or read book The Geriatrics Problem written by Arthur L. Barbakoff and published by . This book was released on 1940 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Autophagy and Senescence in Cancer Therapy by :
Download or read book Autophagy and Senescence in Cancer Therapy written by and published by Academic Press. This book was released on 2021-04-13 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. - Addresses the relationship between autophagy and senescence in cancer therapy - Covers autophagy and senescence in tumor dormancy - Explores autophagy and senescence in disease recurrence
Download or read book The Booklist written by and published by . This book was released on 1922 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Booklist written by and published by . This book was released on 1922 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Abiotic Stress Signaling in Plants: Functional Genomic Intervention, Volume II by : Girdhar Kumar Pandey
Download or read book Abiotic Stress Signaling in Plants: Functional Genomic Intervention, Volume II written by Girdhar Kumar Pandey and published by Frontiers Media SA. This book was released on 2024-01-31 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of the Abiotic Stress Signaling in Plants: Functional Genomic Intervention series: Abiotic Stress Signaling in Plants: Functional Genomic Intervention Abiotic stresses such as high temperature, low-temperature, drought and salinity limit crop productivity worldwide. Understanding plant responses to these stresses is essential for rational engineering of crop plants. In Arabidopsis, the signal transduction pathways for abiotic stresses, light, several phytohormones and pathogenesis have been elucidated. A significant portion of plant genomes (most studies are Arabidopsis and rice genome) encodes for proteins involves in signaling such as receptor, sensors, kinases, phosphatases, transcription factors and transporters/channels. Despite decades of physiological and molecular effort, knowledge pertaining to how plants sense and transduce low and high temperature, low-water availability (drought), water-submergence and salinity signals is still a major question before plant biologist. One major constraint hampering our understanding of these signal transduction processes in plants has been the lack or slow pace of application of molecular genomic and genetics knowledge in the form of gene function.
