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Selective Hplc Method
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Book Synopsis HPLC for Pharmaceutical Scientists by : Yuri V. Kazakevich
Download or read book HPLC for Pharmaceutical Scientists written by Yuri V. Kazakevich and published by John Wiley & Sons. This book was released on 2007-02-16 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.
Book Synopsis Selective HPLC Method by : Hayam M. Lotfy
Download or read book Selective HPLC Method written by Hayam M. Lotfy and published by LAP Lambert Academic Publishing. This book was released on 2012 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selective HPLC method, Stability indicating high performance liquid chromatographic method, simultaneous precise determination of promethazine (PROM) and sodium benzoate (SBENZ), even in the presence of the main oxidative degradation products of PROM, Promethazine (PROM), like other phenothiazines, may become photobiologically active via formation of photolytic products, a number of them being cytotoxic, determination of the comparative protective effect of different antioxidants usually added. Different stability studies were planned to show any interference in the separation of PROM from SBENZ especially in the presence of some common auto-oxidation supressants, such as buylated hydroxy toluene (BHT), buylate hydroxy anisole (BHA) or sodium metabisulfite
Book Synopsis High-performance Liquid Chromatography (HPLC) by : Yuegang Zuo
Download or read book High-performance Liquid Chromatography (HPLC) written by Yuegang Zuo and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes bibliographical references and index.
Book Synopsis Selective Sample Handling and Detection in High-Performance Liquid Chromatography by :
Download or read book Selective Sample Handling and Detection in High-Performance Liquid Chromatography written by and published by Elsevier. This book was released on 1987-12-01 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of a two-volume project which attempts to treat the sample handling and detection processes in a liquid chromatographic system in an integrated fashion. The need for more selective and sensitive chromatographic methods to help solve the numerous trace analysis problems in complex samples is undisputed. However, few workers realize the strong interdependence of the various steps - sample handling, separation and detection - which must be considered if one wants to arrive at an optimal solution. By introducing a strong element of selectivity and trace enrichment in the sample preparation step, fewer demands are placed on the quality of the chromatography and often a simple UV detector can be used. By using a selective detection mode, i.e. a reaction detector, the sample handling step can frequently be simplified and more easily automated. The impact of such a ``total system'' approach on handling series of highly complex samples such as environmental specimens or biological fluids can be easily imagined. Each chapter includes sufficient references to the literature to serve as a valuable starting point for more detailed investigation. Special emphasis is placed on the sample handling, and high priority has been given to the treatment of chemical principles applied to the topics presented, rather than to instrumentation. Written by experienced practitioners, this volume will be of interest to investigators in many areas of application, including environmental scientists and those active in the clinical, pharmaceutical and bioanalytical fields.
Book Synopsis Practical HPLC Method Development by : Lloyd R. Snyder
Download or read book Practical HPLC Method Development written by Lloyd R. Snyder and published by John Wiley & Sons. This book was released on 2012-12-03 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revision brings the reader completely up to date on the evolving methods associated with increasingly more complex sample types analyzed using high-performance liquid chromatography, or HPLC. The book also incorporates updated discussions of many of the fundamental components of HPLC systems and practical issues associated with the use of this analytical method. This edition includes new or expanded treatments of sample preparation, computer assisted method development, as well as biochemical samples, and chiral separations.
Book Synopsis Selectivity and Detectability Optimizations in HPLC by : Satinder Ahuja
Download or read book Selectivity and Detectability Optimizations in HPLC written by Satinder Ahuja and published by John Wiley & Sons. This book was released on 1989-06-06 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: High Performance Liquid Chromatography Edited by Phyllis Brown and Richard Hartwick This contributed volume is designed to consolidate the basic theories of chromatography along with the more exciting developments in the field. This monograph addresses some questions that concern researchers in separation science, including: what is the current state of the art in liquid chromatography; has the development of liquid chromatography plateaued; if so, what new methods will take its place or complement it; and if not, where will the new frontiers be and what direction will liquid chromatography take? 1989 (0 471-84506-X) 688 pp. Quantitative Structure-Chromatographic Retention Relationships R. Kaliszan Written by a pioneer in the field, this book extends and updates research on quantitative structure retention relationships by consolidating and critically reviewing the extensive literature on the subject, while also providing the basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Among the topics covered are the nature of chromatographic interactions, molecular interpretation of distribution processes in chromatography, topological indices as retention descriptors, and multiparameter structure-chromatographic retention relationships. 1987 (0 471-85983-4) 303 pp. Detectors for Liquid Chromatography Edited by Edward S. Yeung With its singular coverage of this fast-growing field, Detectors for Liquid Chromatography presents the state of the art in this subject area. It offers a comprehensive examination of the basic principles behind the detector response, instrumentation, and selected applications for comparison and evaluation of potential. Specifically, topics given in-depth coverage include polarimetric, indirect absorbance, refractive index detectors, absorption detectors for HPLC, FTIR and fluorometric detection, detection based on electrical and electromechanical measurements, and mass spectroscopy as an on-line detector for HPLC. 1986 (0 471-82169-1) 366 pp.
Book Synopsis Optimization of Chromatographic Selectivity by : P.J. Schoenmakers
Download or read book Optimization of Chromatographic Selectivity written by P.J. Schoenmakers and published by Elsevier. This book was released on 1986-08-01 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first detailed description of method development in chromatography - the overall process of which may be summarized as: method selection, phase selection, selectivity optimization, and system optimization. All four aspects receive attention in this book. Chapter 1 gives a short introduction, describes chromatographic theory and nomenclature, and outlines the method development process. Chapter 2 describes guidelines for method selection, and quantitative concepts for characterizing and classifying chromatographic phases. Selective separation methods, from both gas and liquid chromatography are given in Chapter 3; the main parameters of each method are identified and simple, quantitative relations are sought to describe their effects. Criteria by which to judge the quality of separation are discussed in Chapter 4 with clear recommendations for different situations. The specific problems involved in the optimization of chromatographic selectivity are explained in Chapter 5. Optimization procedures, illustrated by examples, are extensively described and compared on the basis of a number of criteria. Suggestions are made both for the application of different procedures and for further research. The optimization of programmed analysis receives special attention in Chapter 6, and the last chapter summarizes the optimization of the chromatographic system, including the optimization of the efficiency, sensitivity and instrumentation. Those involved in developing chromatographic methods or wishing to improve existing methods will value the detailed, structured way in which the subject is presented. Because optimization procedures and criteria are described as elements of a complete optimization package, the book will help the reader to understand, evaluate and select current and future commercial systems.
Book Synopsis HPLC Made to Measure by : Stavros Kromidas
Download or read book HPLC Made to Measure written by Stavros Kromidas and published by John Wiley & Sons. This book was released on 2008-06-05 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only topical HPLC book to focus on optimization, this volume addresses the needs of HPLC users who wish to constantly improve their methods, in particular in terms of throughput, accuracy and cost-effectiveness. This handbook features contributions from such bestselling authors as John W. Dolan, Michael McBrien, Veronika R. Meyer, Uwe D. Neue, Lloyd R. Snyder, and Klaus K. Unger, as well as from scientists working for major companies, including Agilent, AstraZeneca, Merck, Schering, Tosoh Biosep, VWR, and Waters. It covers essential aspects of optimization in general, optimization in different LC-modi, hyphenated techniques and computer-aided optimization. The whole is rounded off with a section of user reports.
Book Synopsis Selective and Sensitive Detection Methods for HPLC Analysis of Selected Medicinal Plants by : Stephan Johannes Ziegler
Download or read book Selective and Sensitive Detection Methods for HPLC Analysis of Selected Medicinal Plants written by Stephan Johannes Ziegler and published by . This book was released on 1988 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis HPLC Method Development for Pharmaceuticals by : Satinder Ahuja
Download or read book HPLC Method Development for Pharmaceuticals written by Satinder Ahuja and published by Elsevier. This book was released on 2011-09-21 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase
Book Synopsis Development And Validation Of Chromatographic Methods For Simultaneous Quantification Of Drugs In Bulk And In Their Formulations: HPLC And HPTLC Techniques by : Satish Y. Gabhe
Download or read book Development And Validation Of Chromatographic Methods For Simultaneous Quantification Of Drugs In Bulk And In Their Formulations: HPLC And HPTLC Techniques written by Satish Y. Gabhe and published by diplom.de. This book was released on 2015-08-01 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details: 1. Development and validation of a HPTLC-densitometric method for concurrent estimation of metformin hydrochloride, pioglitazone hydrochloride and gliclazide in combined dosage form. 2. Development and validation of a HPTLC method for simultaneous estimation of moxifloxacin hydrochloride and dexamethasone sodium phosphate in combined pharmaceutical dosage form. 3. Development and validation of a RP-HPLC method for simultaneous estimation of ciprofloxacin hydrochloride and dexamethasone in combined dosage form, which is a better alternative to existing ones. The developed analytical methods are simple, selective, accurate, robust, and precise with shorter analysis time for the analysis of drug/s in combined pharmaceutical dosage forms. All the developed HPTLC and HPLC methods have been validated as per ICH Q2 (R1) guideline. Developed analytical methods could boost analytical researchers to work more efficiently in the field of analytical method development and validation of Pharmaceutical dosage forms.
Book Synopsis Selection of the HPLC Method in Chemical Analysis by : Serban C. Moldoveanu
Download or read book Selection of the HPLC Method in Chemical Analysis written by Serban C. Moldoveanu and published by Elsevier. This book was released on 2016-11-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selection of the HPLC Method in Chemical Analysis serves as a practical guide to users of high-performance liquid chromatography and provides criteria for method selection, development, and validation. High-performance liquid chromatography (HPLC) is the most common analytical technique currently practiced in chemistry. However, the process of finding the appropriate information for a particular analytical project requires significant effort and pre-existent knowledge in the field. Further, sorting through the wealth of published data and literature takes both time and effort away from the critical aspects of HPLC method selection. For the first time, a systematic approach for sorting through the available information and reviewing critically the up-to-date progress in HPLC for selecting a specific analysis is available in a single book. Selection of the HPLC Method in Chemical Analysis is an inclusive go-to reference for HPLC method selection, development, and validation. Addresses the various aspects of practice and instrumentation needed to obtain reliable HPLC analysis results Leads researchers to the best choice of an HPLC method from the overabundance of information existent in the field Provides criteria for HPLC method selection, development, and validation Authored by world-renowned HPLC experts who have more than 60 years of combined experience in the field
Book Synopsis Retention and Selectivity in Liquid Chromatography by : R.M. Smith
Download or read book Retention and Selectivity in Liquid Chromatography written by R.M. Smith and published by Elsevier. This book was released on 1995-01-13 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together a number of studies which examine the ways in which the retention and selectivity of separations in high-performance liquid chromatography are dependent on the chemical structure of the analytes and the properties of the stationary and mobile phases. Although previous authors have described the optimisation of separations by alteration of the mobile phase, little emphasis has previously been reported of the influence of the structure and properties of the analyte. The initial chapters describe methods based on retention index group increments and log P increments for the prediction of the retention of analytes and the ways in which these factors are influenced by mobile phases and intramolecular interactions. The values of a wide range of group increments in different eluents are tabulated. Different scales of retention indices in liquid chromatography are described for the comparison of separations, the identification of analytes and the comparison of stationary phases. Applications of these methods in the pharmaceutical, toxicology, forensic, metabolism, environmental, food and other fields are reviewed. The effects of different mobile phases on the selectivity of the retention indices are reported. A compilation of sources of reported retention index values are given. Methods for the comparison of stationary phases based on the interactions of different analytes are covered, including lipophilic and polar indices, shape selectivity comparisons, their application to novel stationary phases, and chemometric methods for column comparisons.
Book Synopsis Separation Methods in Drug Synthesis and Purification by : Klara Valko
Download or read book Separation Methods in Drug Synthesis and Purification written by Klara Valko and published by Elsevier. This book was released on 2000-10-13 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: Separation Methods in Drug Synthesis and Purification
Book Synopsis Software-assisted Method Development In High Performance Liquid Chromatography by : Szabolcs Fekete
Download or read book Software-assisted Method Development In High Performance Liquid Chromatography written by Szabolcs Fekete and published by World Scientific. This book was released on 2018-08-01 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'The book is a useful contribution in the field of HPLC, and may represent a valuable tool for chromatography practitioners in different fields, as well as teachers and instructors. The 12 chapters provide comprehensive insights of current day retention and resolution modelling in HPLC, and its applications for small and large molecule analysis. It may be a useful reference for specialists in pharmaceuticals but not limited to … It may be a valuable resource to assist scientists involved in method development, aiming to achieve the best results with reduced costs, time, and efforts.'Analytical and Bioanalytical ChemistryThis handbook gives a general overview of the possibilities in recent developments in chromatographic retention modeling. As a result of the latest developments in modeling software, several new features are now accessible, opening a new level in HPLC method development.Many of these current possibilities in software assisted liquid chromatographic method modeling for analytical purposes are presented. Several modes of chromatography, including Reversed-Phase Liquid Chromatography (RPLC), Ion Exchange Chromatography (IEX), Hydrophobic Interaction Chromatography (HIC), and Hydrophilic Interaction Liquid Chromatography (HILIC) are explained in detail. For all these chromatographic modes, the most important variables for tuning retention and selectivity are exposed.Beside the industrial and practical benefits of retention modeling, the possibilities in teaching and education are also illustrated. Finally, numerous representative industrial examples are shown, to highlight the benefits, time and cost savings offered by state-of-the-art software assisted HPLC method development.
Book Synopsis High Performance Liquid Chromatography by : W.J. Lough
Download or read book High Performance Liquid Chromatography written by W.J. Lough and published by CRC Press. This book was released on 1995-09-30 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: High performance liquid chromatography (HPLC) has long been recognized as one of the most useful and versatile analytical techniques. It has now progressed from being a highly expensive method of analysis to a routine technique with wide applications. Consequently there is a requirement in many chemistry and chemistry-related courses for students to acquire a detailed understanding of the principles and practice of HPLC. Written in a manner suitable for undergraduate students studying analytical chemistry and learning about chromatographic analytical techniques applied to pharmaceutical analysis, biochemistry and related disciplines, High-performance Liquid Chromatography: Fundamental Principles and Practice introduces the fundamentals of HPLC. Loosely structured in three parts, the text begins with a thorough introduction of the subject and then progresses through the essential knowledge of the instrumentation needed for HPLC. The final part covers with the applications of HPLC in real-world situations. Developed by a team of international experts from a wide cross-section of disciplines, the text is relevant to a wide range of courses.
Book Synopsis Multidimensional HPLC of Polymers by : Harald Pasch
Download or read book Multidimensional HPLC of Polymers written by Harald Pasch and published by Springer Science & Business Media. This book was released on 2013-06-12 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the principle ideas of combining different analytical techniques in multi-dimensional analysis schemes. It reviews the basic principles and instrumentation of multi-dimensional chromatography and the hyphenation of liquid chromatography with selective spectroscopic detectors and presents experimental protocols for the analysis of complex polymers. It is the consequent continuation of "HPLC of Polymers" from 1999 by the same authors. Like its 'predecessor', this book discusses the theoretical background, equipment, experimental procedures and applications for each separation technique, but in contrast treats multi-dimensional and coupled techniques. "Multidimensional HPLC of Polymers" intends to review the state of the art in polymer chromatography and to summarize the developments in the field during the last 15 years. With its tutorial and laboratory manual style it is written for beginners as well as for experienced chromatographers, and will enable its readers (polymer chemists, physicists and material scientists, as well as students of polymer and analytical sciences) to optimize the experimental conditions for their specific separation problems.
