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Selective Glycosylations
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Book Synopsis Selective Glycosylations by : Clay S. Bennett
Download or read book Selective Glycosylations written by Clay S. Bennett and published by John Wiley & Sons. This book was released on 2017-01-25 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive summary of novel approaches to the stereoselective construction of glycosidic linkages, covering modern glycosylation methods and their use and application in natural product synthesis and drug discovery. Clearly divided into five sections, the first describes recent advances in classical methodologies in carbohydrate chemistry, while the second goes on to deal with newer chemistries developed to control selectivity in glycosylation reactions. Section three is devoted to selective glycosylation reactions that rely on the use of catalytic promoters. Section four describes modern approaches for controlling regioselectivity in carbohydrate synthesis. The final section focuses on new developments in the construction of "unusual" sugars and is rounded off by a presentation of modern procedures for the construction of glycosylated natural products. By providing the latest advances in glycosylation as well as information on mechanistic aspects of the reaction, this is an invaluable reference for both specialists and beginners in this booming interdisciplinary field that includes carbohydrate chemistry, organic synthesis, catalysis, and biochemistry.
Book Synopsis Essentials of Glycobiology by : Ajit Varki
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Book Synopsis Handbook of Chemical Glycosylation by : Alexei V. Demchenko
Download or read book Handbook of Chemical Glycosylation written by Alexei V. Demchenko and published by John Wiley & Sons. This book was released on 2008-04-09 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since carbohydrate oligomers are still a challenge in synthetic chemistry, this book on recent developments fulfils a great need. Covering the chemistry necessary to synthesize exact copies of these structures, top authors from all around the world comprehensively deal with synthesis from anomeric halides, from miscellaneous glycosyl donors, and by indirect and special methods, as well as 1-oxygen-and 1-sulfur-substituted derivatives. They demonstrate the best approach for the stereoselective formation of the intermonomeric bond, making this essential reading for every biochemist working in biosynthesis, the exploration of biopathways and vaccines.
Book Synopsis Stereoselective Glycosylations by : Dionysia Varvara Pepe
Download or read book Stereoselective Glycosylations written by Dionysia Varvara Pepe and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fundamentals of Glycosylation by : Alok Raghav
Download or read book Fundamentals of Glycosylation written by Alok Raghav and published by BoD – Books on Demand. This book was released on 2022-01-26 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diverse phenomenon of post-translational modifications of biological macromolecules (proteins, lipids, and nucleic acids) includes phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation, and proteolysis. The mechanism of protein glycosylation has an important role in the regulation of human health. This book identifies the fundamentals of glycosylation that help in understanding the concepts of protein glycosylation and its significance.
Book Synopsis Glycochemical Synthesis by : Shang-Cheng Hung
Download or read book Glycochemical Synthesis written by Shang-Cheng Hung and published by John Wiley & Sons. This book was released on 2016-09-12 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development
Download or read book Glycosylation written by Stefana Petrescu and published by BoD – Books on Demand. This book was released on 2012-09-26 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, outlining the concepts of glycobiology, is a suite of reviews and articles written by a team of acknowledged researchers and covers some of the key topics in the field. Covering a wide range of theoretical and practical issues in the field of glycobiology, the Glycosylation book will be of an immediate value for students, academics and researchers involved in drug glycoengineering and biomedical research.
Book Synopsis Protein Glycosylation by : Roslyn M. Bill
Download or read book Protein Glycosylation written by Roslyn M. Bill and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Glycosylation provides clear, up-to-date, and integrated coverage of key topics in this field. Particular emphasis is placed on the biosynthetic pathways that result in a wide variety of identified protein-bound oligosaccharides. Protein Glycosylation begins with an overview of the chemical structures of mono- and oligosaccharides, to provide a scientific basis for the later chapters. The book includes discussions on the purification, function, and enzyme kinetics of selected glycosidases and glycotransferases, as well as a review of the roles of oligosaccharides in glycoprotein function and the in vivo role of glycoproteins themselves. Finally, the in vitro synthesis of glycoproteins is presented, together with future directions in glycobiology. Protein Glycosylation serves as an excellent text for upper-level undergraduate and graduate students as well as a reference for those scientists whose training is not in glycobiology but who are moving into this field.
Book Synopsis Catalysts for Stereoselective Glycosylations by : Gary A. Bradshaw
Download or read book Catalysts for Stereoselective Glycosylations written by Gary A. Bradshaw and published by . This book was released on 2017 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Sugar Code by : Hans-Joachim Gabius
Download or read book The Sugar Code written by Hans-Joachim Gabius and published by John Wiley & Sons. This book was released on 2013-12-06 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
Book Synopsis The S-benzoxazolyl Leaving Group in Selective Glycosylation Reactions by : Benjamin N. Harris
Download or read book The S-benzoxazolyl Leaving Group in Selective Glycosylation Reactions written by Benjamin N. Harris and published by . This book was released on 2010 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glycoscience written by Joachim Thiem and published by Springer Science & Business Media. This book was released on 1997 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation This book presents the state of the art in the synthesis very complex saccharide structures, written by leading scientists at the forefront of this rapidly growing field. Reflecting the particular significance in recent years of efficient and selective procedures employing enzymes for preparative purposes in the carbohydrate field, a major proportion of the articles focus on these biocatalytic methods. In addition, recent strategies for the construction of unusual carbohydrates structures employing novel and creative methodologies are highlighted. Further, particular emphasis is placed on very complex saccharide structures as well as on special solutions to problems that are particularly challenging.
Author :Bertram O. Fraser-Reid Publisher :Springer Science & Business Media ISBN 13 :3540361545 Total Pages :2847 pages Book Rating :4.5/5 (43 download)
Book Synopsis Glycoscience by : Bertram O. Fraser-Reid
Download or read book Glycoscience written by Bertram O. Fraser-Reid and published by Springer Science & Business Media. This book was released on 2008-04-14 with total page 2847 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.
Book Synopsis Synthetic and Physical Organic Studies of Stereoselective Glycosylation Reactions Using Glycosyl Iodides by : Mohamed H. El-Badri
Download or read book Synthetic and Physical Organic Studies of Stereoselective Glycosylation Reactions Using Glycosyl Iodides written by Mohamed H. El-Badri and published by . This book was released on 2007 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Glycosylation by : Harald S. Conradt
Download or read book Protein Glycosylation written by Harald S. Conradt and published by . This book was released on 1991 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antibody Glycosylation by : Marija Pezer
Download or read book Antibody Glycosylation written by Marija Pezer and published by Springer Nature. This book was released on 2021-10-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis A de Novo Approach Towards Glycosylation Using Iterative Pd-/B-dual Catalysis by : Sumit O. Bajaj
Download or read book A de Novo Approach Towards Glycosylation Using Iterative Pd-/B-dual Catalysis written by Sumit O. Bajaj and published by . This book was released on 2015 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates containing natural products regularly play an impressive role in the biological activities, like target binding, tissue targeting, cell-cell interaction, cell-cell recognition and membrane transportation. Despite of the important biological properties, these highly complex oligosaccharide natural products are still challenging synthetic targets to make. The O'Doherty group has been using a de novo asymmetric approach to build on the desired functionality and chirality within the molecule starting from achiral moiety. The importance of this approach comes from the fact that all the stereocenter(s)/chirality in the molecule are built using an achiral starting material (2-acetyl furan), in contrast to the traditional approaches which starts from the known carbohydrate starting materials. This approach relies on a highly dia-stereoselective Palladium (0)-catalyzed glycosylation reaction to control the anomeric stereochemistry, followed by post-glycosylation transformations (Luche reduction, Upjohn dihydroxylation) to install the desired functionality and stereochemistry in the sugar moiety. In this regard, we have developed Pd-/B-dual catalysis for the regio- and stereo-selective synthesis of complex oligosaccharide class of natural products which in turn help us to expand the SAR network towards the anti-cancer studies. Oligo-mannose related motifs got most attention as they are ubiquitously present on the surface of the mammalian cells and has been looked as an emerging field towards the studies related to cancer/HIV vaccine development. Building oligosaccharide motifs in a regioselective manner was always seen as a challenge, to address this issue we have developed and utilized the Pd-/B-dual catalysis for the regioselective glycosylation of mannose related oligosaccharides based on protecting group free approach. Working towards this goal, we successfully bis-glycosylated alpha-D-mannose to form trisaccharides and pentasaccharide oligomannose motifs using the Pd-/B-catalysis. Mezzettiasides, a class of partially acetylated highly complex oligosaccharide natural products possess anti-cancer activities in the micromolar range and were isolated from the fruit and stem bark of Mezzettia leptopoda. They are divided into 3 subclass i.e., disaccharides (Mezzettiaside-9-11), trisaccharides (Mezzettiaside 2-3 and 8), tetrasaccharides (Mezzettiaside 5-7) attached to each other in 1,3-linked fashion. Inspired from the synthesis and biological importance of a related class of natural products, the cleistriosides and cleistetrosides, we synthesized and evaluated the SAR studies of mezzettiasides by exploiting a de novo asymmetric approach (i.e., building chirality in the molecules from achiral starting material). This highly divergent first total synthesis features the iterative use of Pd-/B-dual catalyst using nucleophilic boron/electrophilic palladium for the regio-/stereo-selective glycosylation. It is worth noting that syntheses of all this 10 divergent members were completed in a range of 13-22 linear steps, yet only 42 total steps were required. Only 1 protecting group (AcCl) was used throughout the synthesis of 9 final products whereas, for the synthesis of 10th member, the same protecting group (AcCl) was used two times. Along the line, four new disaccharide unnatural analogues were synthesized for studying the different acetylation pattern (Ac/n-Pr/i-Pr/t-Bu) and concluded that smaller the group, better the activity and less sterically hindered acetylating agent are more potent than the sterically hindered ones. Chapter 2 describes this in details. Based on the developed Pd-/B-dual catalyzed glycosylation methodology, we planned to utilize this concept towards the synthesis of digitoxin analogues using protecting group free strategy, planning towards the synthesis of digitoxin 1,3-linked analogues. Digitoxin is a naturally occurring cardiac glycoside which has been used in the treatment of congestive heart failure but due to toxicity, it's applications in the clinics are limited. Recent study focuses digitoxin's potential application in cancer and viral (HCMV) infections. In this regards, we and several other groups have recently reported that digitoxin can be studied towards its potential as an anti-cancer agent. Our final goal is to synthesize the novel molecule(s) which will selectively target the tumor cells while maintaining the efficacy and high potency with low toxicity. In this regard, we have made a library of digitoxin oligosaccharide (mono- to tetra-saccharides) with [alpha]-L/D and performed SAR studies. From the SAR studies it was concluded that sugar stereochemistry plays an important role in the anticancer studies. Chapter 3 describes this in detail. With the great success of 1,3-linked digitoxin oligosaccharide analogues, we planned to shift our focus towards the amino version of the digitoxin. As amines are the most interesting pharmaceuticals and are present as a backbone in the most active molecules, may be because amine containing compound are much more soluble, can form H-bonding, interact with the proteins and can pass through the membrane faster and has a tremendous effect on the potency. Working towards this aim of synthesizing digitoxin amino analogues, we invested our Pd-/B- methodology for the synthesis of mono and di-saccharide amino analogues and finally compared the importance of -NH2 vs -OH group towards the potency by varying the installation of amine group on different carbohydrate chain. Along this path, we have also successfully glycosylated the natural digitoxin molecule on the C-4 position of the last digitoxose sugar so that we can make the tetrasaccharide amino compounds with [alpha]-L/D stereochemistry and check its applications towards the cancer cell lines.
