Sample Size Determination

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Sample Size Determination and Power

Author : Thomas P. Ryan
Publisher : John Wiley & Sons
ISBN 13 : 1118439228
Total Pages : 230 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Sample Size Determination and Power by : Thomas P. Ryan

Download or read book Sample Size Determination and Power written by Thomas P. Ryan and published by John Wiley & Sons. This book was released on 2013-05-28 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive approach to sample size determination and power with applications for a variety of fields Sample Size Determination and Power features a modern introduction to the applicability of sample size determination and provides a variety of discussions on broad topics including epidemiology, microarrays, survival analysis and reliability, design of experiments, regression, and confidence intervals. The book distinctively merges applications from numerous fields such as statistics, biostatistics, the health sciences, and engineering in order to provide a complete introduction to the general statistical use of sample size determination. Advanced topics including multivariate analysis, clinical trials, and quality improvement are addressed, and in addition, the book provides considerable guidance on available software for sample size determination. Written by a well-known author who has extensively class-tested the material, Sample Size Determination and Power: Highlights the applicability of sample size determination and provides extensive literature coverage Presents a modern, general approach to relevant software to guide sample size determination including CATD (computer-aided trial design) Addresses the use of sample size determination in grant proposals and provides up-to-date references for grant investigators An appealing reference book for scientific researchers in a variety of fields, such as statistics, biostatistics, the health sciences, mathematics, ecology, and geology, who use sampling and estimation methods in their work, Sample Size Determination and Power is also an ideal supplementary text for upper-level undergraduate and graduate-level courses in statistical sampling.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Determining Sample Size and Power in Research Studies

Author : J. P. Verma
Publisher : Springer Nature
ISBN 13 : 9811552045
Total Pages : 138 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Determining Sample Size and Power in Research Studies by : J. P. Verma

Download or read book Determining Sample Size and Power in Research Studies written by J. P. Verma and published by Springer Nature. This book was released on 2020-07-20 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses sample size and power in the context of research, offering valuable insights for graduate and doctoral students as well as researchers in any discipline where data is generated to investigate research questions. It explains how to enhance the authenticity of research by estimating the sample size and reporting the power of the tests used. Further, it discusses the issue of sample size determination in survey studies as well as in hypothesis testing experiments so that readers can grasp the concept of statistical errors, minimum detectable difference, effect size, one-tail and two-tail tests and the power of the test. The book also highlights the importance of fixing these boundary conditions in enhancing the authenticity of research findings and improving the chances of research papers being accepted by respected journals. Further, it explores the significance of sample size by showing the power achieved in selected doctoral studies. Procedure has been discussed to fix power in the hypothesis testing experiment. One should usually have power at least 0.8 in the study because having power less than this will have the issue of practical significance of findings. If the power in any study is less than 0.5 then it would be better to test the hypothesis by tossing a coin instead of organizing the experiment. It also discusses determining sample size and power using the freeware G*Power software, based on twenty-one examples using different analyses, like t-test, parametric and non-parametric correlations, multivariate regression, logistic regression, independent and repeated measures ANOVA, mixed design, MANOVA and chi-square.

Sample Size Methodology

Author : M. M. Desu
Publisher : Elsevier
ISBN 13 : 0323139566
Total Pages : 151 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Sample Size Methodology by : M. M. Desu

Download or read book Sample Size Methodology written by M. M. Desu and published by Elsevier. This book was released on 2012-12-02 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important problems in designing an experiment or a survey is sample size determination and this book presents the currently available methodology. It includes both random sampling from standard probability distributions and from finite populations. Also discussed is sample size determination for estimating parameters in a Bayesian setting by considering the posterior distribution of the parameter and specifying the necessary requirements. The determination of the sample size is considered for ranking and selection problems as well as for the design of clinical trials. Appropriate techniques for attacking the general question of sample size determination in problems of estimation, tests of hypotheses, selection, and clinical trial design are all presented, and will help the reader in formulating an appropriate problem of sample size and in obtaining the solution. The book can be used as a text in a senior-level or a graduate course on sample size methodology.Annotated list of tables in appendixSupplemental problems at the end of book

Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials

Author : Meinhard Kieser
Publisher : Springer Nature
ISBN 13 : 3030495280
Total Pages : 391 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials by : Meinhard Kieser

Download or read book Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials written by Meinhard Kieser and published by Springer Nature. This book was released on 2020-11-19 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design, where the required sample size is determined in the planning stage and is not changed afterwards. It covers sample size calculation methods for superiority, non-inferiority, and equivalence trials, as well as comparisons between two and more than two groups. A wide range of further topics is discussed, including sample size calculation for multiple comparisons, safety assessment, and multi-regional trials. There is often some uncertainty about the assumptions to be made when calculating the sample size upfront. Part III presents methods that allow to modify the initially specified sample size based on new information that becomes available during the ongoing trial. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses. The application is illustrated using numerous clinical trial examples, and software code implementing the methods is provided. The book offers theoretical background and practical advice for biostatisticians and clinicians from the pharmaceutical industry and academia who are involved in clinical trials. Covering basic as well as more advanced and recently developed methods, it is suitable for beginners, experienced applied statisticians, and practitioners. To gain maximum benefit, readers should be familiar with introductory statistics. The content of this book has been successfully used for courses on the topic.

Sample Size Determination in Clinical Trials with Multiple Endpoints

Author : Takashi Sozu
Publisher : Springer
ISBN 13 : 3319220055
Total Pages : 98 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Sample Size Determination in Clinical Trials with Multiple Endpoints by : Takashi Sozu

Download or read book Sample Size Determination in Clinical Trials with Multiple Endpoints written by Takashi Sozu and published by Springer. This book was released on 2015-08-20 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area. The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also briefly examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespecified non-ordering of endpoints.

Adequacy of Sample Size in Health Studies

Author : Stanley Lemeshow
Publisher : Wiley
ISBN 13 : 9780471925170
Total Pages : 252 pages
Book Rating : 4.9/5 (251 download)

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Book Synopsis Adequacy of Sample Size in Health Studies by : Stanley Lemeshow

Download or read book Adequacy of Sample Size in Health Studies written by Stanley Lemeshow and published by Wiley. This book was released on 1990-01-14 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical rather than theoretical, it provides epidemiologists and other health workers with a good basic knowledge of sampling principles and methods and their potential in the medical field. Focusing on the determination of adequate sample sizes under different situations, the book is divided into two parts; the first provides solutions to typical problems of various survey and study designs, and the second offers a clear, concise exposition of the theory behind the processes of determining sample size. Features many reference tables.

Sample Size Calculations

Author : Paul Mathews
Publisher : Mathews Malnar and Bailey
ISBN 13 : 0615324614
Total Pages : 341 pages
Book Rating : 4.6/5 (153 download)

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Book Synopsis Sample Size Calculations by : Paul Mathews

Download or read book Sample Size Calculations written by Paul Mathews and published by Mathews Malnar and Bailey. This book was released on 2010 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sample Size Calculations: Practical Methods for Engineers and Scientists presents power and sample size calculations for common statistical analyses including methods for means, standard deviations, proportions, counts, regression, correlation, and measures of agreement. Topics of special interest to quality engineering professionals include designed experiments, reliability studies, statistical process control, acceptance sampling, process capability analysis, statistical tolerancing, and gage error studies. The book emphasizes approximate methods, but exact methods are presented when the approximate methods fail. Monte Carlo and bootstrap methods are introduced for situations that don't satisfy the assumptions of the analytical methods. Solutions are presented for more than 170 example problems and solutions for selected example problems using PASS, MINITAB, Piface, and R are posted on the Internet.

Introductory Business Statistics 2e

Author : Alexander Holmes
Publisher :
ISBN 13 :
Total Pages : 1801 pages
Book Rating : 4./5 ( download)

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Book Synopsis Introductory Business Statistics 2e by : Alexander Holmes

Download or read book Introductory Business Statistics 2e written by Alexander Holmes and published by . This book was released on 2023-12-13 with total page 1801 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introductory Business Statistics 2e aligns with the topics and objectives of the typical one-semester statistics course for business, economics, and related majors. The text provides detailed and supportive explanations and extensive step-by-step walkthroughs. The author places a significant emphasis on the development and practical application of formulas so that students have a deeper understanding of their interpretation and application of data. Problems and exercises are largely centered on business topics, though other applications are provided in order to increase relevance and showcase the critical role of statistics in a number of fields and real-world contexts. The second edition retains the organization of the original text. Based on extensive feedback from adopters and students, the revision focused on improving currency and relevance, particularly in examples and problems. This is an adaptation of Introductory Business Statistics 2e by OpenStax. You can access the textbook as pdf for free at openstax.org. Minor editorial changes were made to ensure a better ebook reading experience. Textbook content produced by OpenStax is licensed under a Creative Commons Attribution 4.0 International License.

Sample-Size Determination in Quantitative Social Work Research

Author : Patrick Dattalo
Publisher : Oxford University Press
ISBN 13 : 0198043082
Total Pages : 176 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Sample-Size Determination in Quantitative Social Work Research by : Patrick Dattalo

Download or read book Sample-Size Determination in Quantitative Social Work Research written by Patrick Dattalo and published by Oxford University Press. This book was released on 2008-01-11 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: A researcher's decision about the sample to draw in a study may have an enormous impact on the results, and it rests on numerous statistical and practical considerations that can be difficult to juggle. Computer programs help, but no single software package exists that allows researchers to determine sample size across all statistical procedures. This pocket guide shows social work students, educators, and researchers how to prevent some of the mistakes that would result from a wrong sample size decision by describing and critiquing four main approaches to determining sample size. In concise, example-rich chapters, Dattalo covers sample-size determination using power analysis, confidence intervals, computer-intensive strategies, and ethical or cost considerations, as well as techniques for advanced and emerging statistical strategies such as structural equation modeling, multilevel analysis, repeated measures MANOVA and repeated measures ANOVA. He also offers strategies for mitigating pressures to increase sample size when doing so may not be feasible. Whether as an introduction to the process for students or as a refresher for experienced researchers, this practical guide is a perfect overview of a crucial but often overlooked step in empirical social work research.

Sample Size Calculations in Clinical Research

Author : Shein-Chung Chow
Publisher : CRC Press
ISBN 13 : 1351727117
Total Pages : 825 pages
Book Rating : 4.3/5 (517 download)

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Book Synopsis Sample Size Calculations in Clinical Research by : Shein-Chung Chow

Download or read book Sample Size Calculations in Clinical Research written by Shein-Chung Chow and published by CRC Press. This book was released on 2017-08-15 with total page 825 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Second Edition: "... this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered ..." – Journal of the Royal Statistical Society Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation. Features: Compares the relative merits and disadvantages of statistical methods for sample size calculations Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.

Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

Author : Chul Ahn
Publisher : CRC Press
ISBN 13 : 1466556269
Total Pages : 262 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research by : Chul Ahn

Download or read book Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research written by Chul Ahn and published by CRC Press. This book was released on 2014-12-09 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study. Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies. The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement. Addressing the overarching theme of sample size determination for correlated outcomes, this book provides a useful resource for biostatisticians, clinical investigators, epidemiologists, and social scientists whose research involves trials with correlated outcomes. Each chapter is self-contained so readers can explore topics relevant to their research projects without having to refer to other chapters.

How to Practice Academic Medicine and Publish from Developing Countries?

Author : Samiran Nundy
Publisher : Springer Nature
ISBN 13 : 9811652481
Total Pages : 475 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis How to Practice Academic Medicine and Publish from Developing Countries? by : Samiran Nundy

Download or read book How to Practice Academic Medicine and Publish from Developing Countries? written by Samiran Nundy and published by Springer Nature. This book was released on 2021-10-23 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access book. The book provides an overview of the state of research in developing countries – Africa, Latin America, and Asia (especially India) and why research and publications are important in these regions. It addresses budding but struggling academics in low and middle-income countries. It is written mainly by senior colleagues who have experienced and recognized the challenges with design, documentation, and publication of health research in the developing world. The book includes short chapters providing insight into planning research at the undergraduate or postgraduate level, issues related to research ethics, and conduct of clinical trials. It also serves as a guide towards establishing a research question and research methodology. It covers important concepts such as writing a paper, the submission process, dealing with rejection and revisions, and covers additional topics such as planning lectures and presentations. The book will be useful for graduates, postgraduates, teachers as well as physicians and practitioners all over the developing world who are interested in academic medicine and wish to do medical research.

Institutional Animal Care and Use Committee Guidebook

Author :
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Institutional Animal Care and Use Committee Guidebook by :

Download or read book Institutional Animal Care and Use Committee Guidebook written by and published by . This book was released on 2002 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sample Size Determination in Health Studies

Author : S. Kaggwa Lwanga
Publisher :
ISBN 13 :
Total Pages : 100 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Sample Size Determination in Health Studies by : S. Kaggwa Lwanga

Download or read book Sample Size Determination in Health Studies written by S. Kaggwa Lwanga and published by . This book was released on 1991 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual presents the practical and statistical information needed to help investigators decide how large a sample to select from a population targeted for a health study or survey. Designed to perform a "cookbook" function, the book uses explanatory text and abundant tabular calculations to vastly simplify the task of determining the minimum sample size needed to obtain statistically valid results. The objective is to assist those investigators, undertaking health studies at local or district level, who lack detailed knowledge of statistical methodology. Acknowledging that the size of a sample will depend on the aims, nature, and scope of the study, the first part of the book provides a practical farmework for working through the steps of sample size determination once a proposed study and its objectives have been clearly defined. The second part of the book features more than 50 pages of tables that enable the reader to determine the sample size required, under simple random sampling, in a given type of study without recourse to complicated calculations.

Quantifying the User Experience

Author : Jeff Sauro
Publisher : Morgan Kaufmann
ISBN 13 : 0128025484
Total Pages : 374 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Quantifying the User Experience by : Jeff Sauro

Download or read book Quantifying the User Experience written by Jeff Sauro and published by Morgan Kaufmann. This book was released on 2016-07-12 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantifying the User Experience: Practical Statistics for User Research, Second Edition, provides practitioners and researchers with the information they need to confidently quantify, qualify, and justify their data. The book presents a practical guide on how to use statistics to solve common quantitative problems that arise in user research. It addresses questions users face every day, including, Is the current product more usable than our competition? Can we be sure at least 70% of users can complete the task on their first attempt? How long will it take users to purchase products on the website? This book provides a foundation for statistical theories and the best practices needed to apply them. The authors draw on decades of statistical literature from human factors, industrial engineering, and psychology, as well as their own published research, providing both concrete solutions (Excel formulas and links to their own web-calculators), along with an engaging discussion on the statistical reasons why tests work and how to effectively communicate results. Throughout this new edition, users will find updates on standardized usability questionnaires, a new chapter on general linear modeling (correlation, regression, and analysis of variance), with updated examples and case studies throughout. - Completely updated to provide practical guidance on solving usability testing problems with statistics for any project, including those using Six Sigma practices - Includes new and revised information on standardized usability questionnaires - Includes a completely new chapter introducing correlation, regression, and analysis of variance - Shows practitioners which test to use, why they work, and best practices for application, along with easy-to-use Excel formulas and web-calculators for analyzing data - Recommends ways for researchers and practitioners to communicate results to stakeholders in plain English

Sample Size Tables for Clinical Studies

Author : David Machin
Publisher : John Wiley & Sons
ISBN 13 : 1444357964
Total Pages : 319 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Sample Size Tables for Clinical Studies by : David Machin

Download or read book Sample Size Tables for Clinical Studies written by David Machin and published by John Wiley & Sons. This book was released on 2011-08-26 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides statisticians and researchers with the statistical tools - equations, formulae and numerical tables - to design and plan clinical studies and carry out accurate, reliable and reproducible analysis of the data so obtained. There is no way around this as incorrect procedure in clinical studies means that the researcher's paper will not be accepted by a peer-reviewed journal. Planning and analysing clinical studies is a very complicated business and this book provides indispensible factual information. Please go to http://booksupport.wiley.com and enter 9781405146500 to easily download the supporting materials.