Role of Glial Cells of the Central and Peripheral Nervous System in the Pathogenesis of Neurodegenerative Disorders

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Publisher : Frontiers Media SA
ISBN 13 : 288976236X
Total Pages : 189 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Role of Glial Cells of the Central and Peripheral Nervous System in the Pathogenesis of Neurodegenerative Disorders by : Guanghui Wang

Download or read book Role of Glial Cells of the Central and Peripheral Nervous System in the Pathogenesis of Neurodegenerative Disorders written by Guanghui Wang and published by Frontiers Media SA. This book was released on 2022-05-26 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Etiology of Parkinson's Disease

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Author :
Publisher : CRC Press
ISBN 13 : 9780824788230
Total Pages : 600 pages
Book Rating : 4.7/5 (882 download)

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Book Synopsis Etiology of Parkinson's Disease by : Jonas H. Ellenberg

Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Glial Cells: Managers of Neuro-immunity

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Publisher : Frontiers Media SA
ISBN 13 : 2889198359
Total Pages : 226 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Glial Cells: Managers of Neuro-immunity by : Carlos Barcia

Download or read book Glial Cells: Managers of Neuro-immunity written by Carlos Barcia and published by Frontiers Media SA. This book was released on 2016-05-30 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune responses within the brain are still scarcely explored. Nerve tissue damage is accompanied by the activation of glial cells, primarily microglia and astroglia, and such activation is responsible for the release of cytokines and chemokines that maintain the local inflammatory response and actively recruit lymphocytes and monocytes to the damaged areas. Theoretically, these responses are designed to repair the brain damage. However, alterations, or a chronic perpetuation of these responses may underlie a number of neuro-pathologies. It is thought that each inflammatory scenario within the brain have a specific biochemical footprint characterized by the release of determined cytokines, chemokines and growing factors able to define particular immunological responses. Alongside, glial cells transform their cell body, become larger and develop higher number of branches adopting an active morphological phenotype. These changes are related with the search of interactions with other cells, such as bystander resident cells of the brain parenchyma, but also cells homing from the blood stream. In this process, microglia and astrocytes communicates with other cells by the formation of specific intercellular connections that are still poorly understood. These interactions are complex and entail the arrangement of cytoskeletal compounds, secretory and phagocytic domains. In this particular crosstalk there is a two-way communication in which glial cells and target cells come together establishing interfaces with specific information exchange. This way, glial cells orchestrate the particular response recruiting cellular subsets within the central nervous system and organizing the resolution of the brain damage. In this Frontiers Research Topic, we compile a selection of articles unfolding diverse aspects of glial-derived inflammation, focused on neurodegenerative diseases and other nervous system disorders, with special emphasis on microglia/macrophages as leading actors managing neuro-immunity.

The Functional Roles of Glial Cells in Health and Disease

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461546850
Total Pages : 376 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis The Functional Roles of Glial Cells in Health and Disease by : Rebecca Matsas

Download or read book The Functional Roles of Glial Cells in Health and Disease written by Rebecca Matsas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thirty-five years ago, when Stephen Kuffler and his colleagues at Harvard initiated a new era of research on the properties and functions of neuroglial cells, very few neuro scientists were impressed at the time with the hypothesis that neuroglial cells could have another, though more subtle, role to play in the nervous system than to provide static support to neurons. Today, very few neuroscientists are unaware of the fact that multiple interactions between neurons and glial cells have been described, and that they consti tute the basis for understanding the function and the pathology of the nervous system. Glial cells outnumber neurons and make up about one-half of the bulk of the nervous system. They are divided into two major classes: first, the macroglia, which include astrocytes and oligodendrocytes in the central nervous system, and the Schwann cells in the peripheral nervous system; and second, the microglial cells. These different classes of glial cells have different functions and contribute in different ways in the devel opment, function, and the pathology of the nervous system.

Neuron-Glia Interaction in Neuroinflammation

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Publisher : Springer Science & Business Media
ISBN 13 : 1461483131
Total Pages : 192 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Neuron-Glia Interaction in Neuroinflammation by : Akio Suzumura

Download or read book Neuron-Glia Interaction in Neuroinflammation written by Akio Suzumura and published by Springer Science & Business Media. This book was released on 2013-09-13 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accumulation on glia is an active pathological element in many neurological disorders. Gliosis produces neuroinflammation through both neurotrophic and inflammatory means, but the exact mechanism through which this happens remain unclear. It is suspected that damage to neurons activates the growth of glial cells. The proposed book focuses on the interaction between neurons and glia to help elucidate the pathophysiology of neuroinflammation in neurological disorders.​

Brain Neurotrauma

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Publisher : CRC Press
ISBN 13 : 9781466565982
Total Pages : 0 pages
Book Rating : 4.5/5 (659 download)

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Book Synopsis Brain Neurotrauma by : Firas H. Kobeissy

Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. In addition, a section is devoted to models of mild CNS injury, including blast and sport-related injuries. This book, with its diverse coherent content, is a valuable and comprehensive reference for individuals interested in the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Glia and Inflammation in Neurodegenerative Disease

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Author :
Publisher : Nova Science Publishers
ISBN 13 :
Total Pages : 290 pages
Book Rating : 4.X/5 (3 download)

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Book Synopsis Glia and Inflammation in Neurodegenerative Disease by : M. A. Yenari

Download or read book Glia and Inflammation in Neurodegenerative Disease written by M. A. Yenari and published by Nova Science Publishers. This book was released on 2006 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain has long been considered an immune privileged organ, meaning that inflammatory cells are excluded due to a relatively impenetrable blood brain barrier (BBB). However, this is not to say that the central nervous system is incapable of eliciting immune responses, as resident inflammatory cells exist within the brain parenchyma. Microglia have long been thought to be the brain's resident immune cell with myeloid lineage similar to monocytes and macrophages. In this volume, the authors review the current state of knowledge with regard to immune responses and cell-cell interactions as they pertain to a variety of neurodegenerative diseases. The changing role of inflammation with development is considered. They also present a summary of the various therapeutic strategies employed both in the laboratory and at the clinical level.

Glial Cells in Health and Disease of the CNS

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Publisher : Springer
ISBN 13 : 3319407643
Total Pages : 348 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Glial Cells in Health and Disease of the CNS by : Rommy von Bernhardi

Download or read book Glial Cells in Health and Disease of the CNS written by Rommy von Bernhardi and published by Springer. This book was released on 2016-10-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.

Dynamic Properties of Glia Cells

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Author :
Publisher : Pergamon
ISBN 13 :
Total Pages : 494 pages
Book Rating : 4.:/5 (42 download)

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Book Synopsis Dynamic Properties of Glia Cells by : Ernest Schoffeniels

Download or read book Dynamic Properties of Glia Cells written by Ernest Schoffeniels and published by Pergamon. This book was released on 1978 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Peripheral Immune System and Neurodegenerative Disease

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Publisher : Frontiers Media SA
ISBN 13 : 2889769755
Total Pages : 141 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Peripheral Immune System and Neurodegenerative Disease by : Ke Zhang

Download or read book Peripheral Immune System and Neurodegenerative Disease written by Ke Zhang and published by Frontiers Media SA. This book was released on 2022-09-15 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Role of Glia in Alzheimer's Disease

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Publisher : Frontiers Media SA
ISBN 13 : 2889457648
Total Pages : 128 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis The Role of Glia in Alzheimer's Disease by : Beatriz G. Perez-Nievas

Download or read book The Role of Glia in Alzheimer's Disease written by Beatriz G. Perez-Nievas and published by Frontiers Media SA. This book was released on 2019-03-20 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: We believe that the role of glia is the next frontier to be explored in Alzheimer’s disease research. This eBook is an update on both the current knowledge of astrocytes and microglia involvement in Alzheimer’s disease pathophysiology, and some of the techniques available to study them.

The Role of Glia in Neurotoxicity

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Author :
Publisher : CRC Press
ISBN 13 : 1420039741
Total Pages : 477 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Role of Glia in Neurotoxicity by : Michael Aschner

Download or read book The Role of Glia in Neurotoxicity written by Michael Aschner and published by CRC Press. This book was released on 2004-12-28 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases.

Neuronal-glial Cell Interrelationships

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Publisher : Springer Science & Business Media
ISBN 13 : 3642684661
Total Pages : 379 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Neuronal-glial Cell Interrelationships by : T.A. Sears

Download or read book Neuronal-glial Cell Interrelationships written by T.A. Sears and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: need for an interdisciplinary approach to research, although scientifically desirable and laudable, is not easily met by the individual investigator, a statement which I must now qualify lest it be taken as a faint-hearted view of the problems which confront us in this or any other field of disease-orientated re search. In recent years the growth and scope of MS research parallels, in fact reflects, that which has occurred more generally concern ing research at all levels of complexity into the nature and modes of operation of the nervous systems of different animals. With respect to these developments Cowan (2) has observed that "this has led to the gradual emergence of a new, interdisciplinary ap proach to the study of the nervous system which has come to be known as Neuroscience. " At the center of neuroscience stands man striving to comprehend hirnself, not only in terms of the nuts and bolts of his own ner vous system and that of lower animals, but perhaps preoccupied most of all with the higher level nervous functions of perception, volition, cognition, and mentation, which characterize his "self. " The investigation of these processes depends ultimately on re search on man hirnself and the analysis of these processes in depth often must wait on Nature's own experiments to provide, through disease, the chance anatomical or biochemical lesions which dissect human behavior and expose the residual functions for scientific study.

Systems Biology of Free Radicals and Antioxidants

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Publisher : Springer
ISBN 13 : 9783642300172
Total Pages : 0 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Systems Biology of Free Radicals and Antioxidants by : Ismail Laher

Download or read book Systems Biology of Free Radicals and Antioxidants written by Ismail Laher and published by Springer. This book was released on 2014-06-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.

Neuroinflammation and Neurodegeneration

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Publisher : Springer
ISBN 13 : 149391071X
Total Pages : 606 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Neuroinflammation and Neurodegeneration by : Phillip K. Peterson

Download or read book Neuroinflammation and Neurodegeneration written by Phillip K. Peterson and published by Springer. This book was released on 2014-07-08 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Neuroinflammation — From Bench to Bedside

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540430902
Total Pages : 260 pages
Book Rating : 4.4/5 (39 download)

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Book Synopsis Neuroinflammation — From Bench to Bedside by : H. Kettenmann

Download or read book Neuroinflammation — From Bench to Bedside written by H. Kettenmann and published by Springer Science & Business Media. This book was released on 2002-05-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the subject of neuroinflammation and attempts to take the reader on a journey from the bench to the bedside. The microglia and their response to brain injury as well as the importance of the chemokine family are discussed. The relevance of neuroinflammation in experimental models of BSE, scrapie and vCJD as well as Alzheimer's disease, stroke and multiple sclerosis is investigated before proceeding to clinical aspects of neuroinflammation and its involvement in human disease pathophysiology. The book provides an excellent introduction to the field of neuroinflammation and its involvement in human neurodegenerative disease.

Neuroglia in Neurodegenerative Diseases

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Author :
Publisher : Springer Nature
ISBN 13 : 9811399131
Total Pages : 405 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Neuroglia in Neurodegenerative Diseases by : Alexei Verkhratsky

Download or read book Neuroglia in Neurodegenerative Diseases written by Alexei Verkhratsky and published by Springer Nature. This book was released on 2019-10-03 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.