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Role Of Eicosanoids On Cell Mediated Immunity To Listeria Monocytogenes And Its Implications On Cancer Therapy
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Book Synopsis Role of Eicosanoids on Cell-mediated Immunity to [Listeria Monocytogenes] and Its Implications on Cancer Therapy by : Courtney Elizabeth McDougal
Download or read book Role of Eicosanoids on Cell-mediated Immunity to [Listeria Monocytogenes] and Its Implications on Cancer Therapy written by Courtney Elizabeth McDougal and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: [Listeria monocytogenes] is an intracellular bacterium that elicits a robust CD8[+] T-cell response. Due to thisrobust response, it is both used as a model to understand how T-cell responses are primed, as well a cancer immunotherapeutic platform. Despite decades of research, intricacies as to how [L. monocytogenes] primes T-cell responses remains incompletely understood. We and others hypothesized that cytosolic innate pathways would be critical for generating immunity, as strains of [L. monocytogenes] that cannot access the cytosol fail to induce productive T-cell responses. Counterintuitively, however, activation of known cytosolic pathways such as type I IFN and inflammasomes lead to impaired responses. In this thesis, I identify the first known cytosolic innate pathway that is critical for generating immunity to [L. monocytogenes]. I show that production of lipid mediators of inflammation called eicosanoids, namely prostaglandin E[2] (PGE[2]) produced downstream of cyclooxygenase-2 (COX-2), are critical for immunity. Immunization of mice deficient in PGE[2] have impaired CD8[+] T-cell responses. Importantly, cytosolic access is critical to induce this pathway. In vivo, infection with wild-type [L. monocytogenes] elicits a 10- fold increase in PGE[2] production whereas vacuole-constrained strains fail to induce PGE[2] over mock-immunized controls. Furthermore, I identify that macrophages and dendritic cells specifically produce PGE[2] during cytosolic infection. Finally, I show that PGE[2] signals on two different receptors during [L. monocytogenes] infection, EP3 and EP4. EP3 signaling is critical for [L. monocytogenes]-stimulated immunity, whereas EP4 signaling impairs immunity. Taken together, my work identifies the first known cytosolic pathway critical for immunity to [L. monocytogenes], and suggests a model by which cytosolically-infected macrophages and dendritic cells produce PGE2 which subsequently signals through the EP3 and EP4 receptors.
Book Synopsis Inflammasome Activation Impairs Cell-mediated Immunity to Listeria Monocytogenes by : Erin M. Theisen
Download or read book Inflammasome Activation Impairs Cell-mediated Immunity to Listeria Monocytogenes written by Erin M. Theisen and published by . This book was released on 2017 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunity to Listeria Monocytogenes by : E R Unanue
Download or read book Immunity to Listeria Monocytogenes written by E R Unanue and published by Academic Press. This book was released on 2012-01-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Contributions from leading authorities Informs and updates on all the latest developments in the field
Book Synopsis A Study In Vitro of Cell Mediated Immunity to Listeria Monocytogenes by : Tobi Lynn Jones
Download or read book A Study In Vitro of Cell Mediated Immunity to Listeria Monocytogenes written by Tobi Lynn Jones and published by . This book was released on 1972 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4 by : Kenneth V. Honn
Download or read book Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4 written by Kenneth V. Honn and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. The new field of isoprostanes is also represented.
Book Synopsis Studies on Cell-mediated Immunity to Listeria Monocytogenes in Guinea Pigs and Modulation of Tumor Growth with Listeria by : Meher Manek Dustoor
Download or read book Studies on Cell-mediated Immunity to Listeria Monocytogenes in Guinea Pigs and Modulation of Tumor Growth with Listeria written by Meher Manek Dustoor and published by . This book was released on 1976 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Understanding Innate Immune Signaling During Listeria Monocytogenes Vaccination and Its Implications for Cancer Immunotherapy by : Zachary Taylor Morrow
Download or read book Understanding Innate Immune Signaling During Listeria Monocytogenes Vaccination and Its Implications for Cancer Immunotherapy written by Zachary Taylor Morrow and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Listeria monocytogenes is a gram-positive facultative intracellular pathogen that stimulates a robust CD8+ T-cell response and has been utilized for decades to understand various aspects of innate and adaptive immunity. Due to its ability to stimulate CD8+ T-cells, L. monocytogenes has been developed as a safe anti-tumor vaccine platform. Efforts to understand how L. monocytogenes primes CD8+ T-cell responses led to the observation that L. monocytogenes that fail to access the host cytosol do not prime robust CD8+ T-cell responses. This led us to hypothesize that activation of a cytosol-specific innate immune pathway was necessary for the optimal T-cell response toward L. monocytogenes. Counterintuitively, I show that two cytosol-specific innate immune pathways activated by L. monocytogenes, the production of type I interferon, and inflammasome activation are actively detrimental to, or are dispensable for the T-cell response, respectively. Type I interferon impairs the formation of memory precursor effector cells, leading to deficits in protective immunity, and is likely acting on antigen presenting cells. I aided in identifying that macrophages and dendritic cells produce PGE2 during L. monocytogenes infection. The production of PGE2 is the first cytosol-specific innate immune pathway identified that is necessary for the optimal T-cell response toward L. monocytogenes. I show that PGE2 production is dependent on the calcium-dependent cytosolic phospholipase A2 (cPLA2) and that calcium fluxes necessary for PGE2 production are likely emanating from inositol-triphosphate-signaling dependent endoplasmic reticulum receptors. Finally, in an altogether different approach, I show that L. monocytogenes can be engineered to express and secrete mammalian cytokines as an in-situ vaccine platform. Taken together, my work demonstrates how innate immune signaling informs adaptive T-cell responses during L. monocytogenes vaccination, and that L. monocytogenes can be engineered to modulate innate immune pathways resulting in a better vaccine platform. This thesis begins to unravel how the first cytosol-specific innate immune pathway necessary for T-cell priming is triggered and highlights new avenues for the therapeutic application of L. monocytogenes to combat cancer.
Book Synopsis Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5 by : Kenneth V. Honn
Download or read book Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5 written by Kenneth V. Honn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents a collection of contributions from the 6th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases held in Boston from September 12-15, 1999. The mission of this meeting was to bring together senior and junior investigators to both announce and examine their recent advancements in cutting-edge research on the roles and actions of lipid mediators and their impact in human physiology and disease pathogenesis. The meeting focused on new concepts in these areas of interest to both clinicians and researchers. The program included several outstanding plenary lectures and presentations by leading experts in the fields of cancer and inflammation. In addition, the Boston meeting presented three Young Investigator awards, one in each of the major focus areas. The meeting was exciting and proved to be very memorable. The program was developed with an emphasis on recent advances in molecular and of lipid mediators relevant in cellular mechanisims involved in the formation and actions inflammation and cancer. Plenary lectures were presented by Prof. Bengt Sammuelsson (Karolinska Institute, Stockholm; 1982 Nobel Laureate in Physiology or Medicine) and Prof. E. 1. Corey (Harvard University; 1990 Nobel Laureate in Chemistry). Both of these plenary lectures were held on Day 1, which set an exciting tone for this meeting. Immediately following these plenary lectures, three simultaneous breakout sessions were held, one of inflammation, a second on cancer and synthesis of novel inhibitors, and a third on enzymes-lipoxygenases/cyclooxygenases and inhibitors.
Book Synopsis Recombinant Listeria Monocytogenes as an Anti-tumor Vaccine and a Probe to Study Innate and Acquired Immunity by : Kevin Wendell Bruhn
Download or read book Recombinant Listeria Monocytogenes as an Anti-tumor Vaccine and a Probe to Study Innate and Acquired Immunity written by Kevin Wendell Bruhn and published by . This book was released on 2004 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury by : Kenneth V. Honn
Download or read book Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury written by Kenneth V. Honn and published by Springer. This book was released on 1991-07-31 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 1st International Conference, October 11-14, 1989, Detroit, Michigan, USA
Book Synopsis Mechanisms of Listeria Monocytogenes-mediated Modulation of Tumor Growth by : Amy Margaret Fulton
Download or read book Mechanisms of Listeria Monocytogenes-mediated Modulation of Tumor Growth written by Amy Margaret Fulton and published by . This book was released on 1977 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Analysis of Innate and Adaptive Immune Responses to Listeria Monocytogenes Infection by :
Download or read book Analysis of Innate and Adaptive Immune Responses to Listeria Monocytogenes Infection written by and published by . This book was released on 2013 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Use of a Listeria Monocytogenes Protein to Stimulate Immune Responses and Anti-tumor Effects by : Amber Leigh Ortiz
Download or read book Use of a Listeria Monocytogenes Protein to Stimulate Immune Responses and Anti-tumor Effects written by Amber Leigh Ortiz and published by . This book was released on 2017 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer (NK) cells are a type of innate immune cell that secrete IFN when activated. IFN has pro-inflammatory effects and can act on tumor cells to kill them or inhibit their proliferation. NK cells can also exert direct anti-tumor cytolytic activity. Previous work showed that the Listeria monocytogenes (Lm) p60 protein indirectly promotes activation of NK cells to mediate cytokine production. The p60 protein contains two divergent LysM domains and one SH3 domain. The LysM1 domain is responsible for the immune stimulatory activity of the p60 protein and is present with the SH3 domain in a fragment of p60 termed "L1S." Like p60, recombinant L1S binds dendritic cells (DC) to stimulate their secretion of cytokines such as interleukin-18 (IL-18) and license them to promote activation of NK cells. The studies in this thesis investigated the nature of immune cell activation by L1S in vitro and in vivo through direct lung instillation. I found that instillation with wildtype L1S induced recruitment of inflammatory neutrophils and promoted accumulation of activated, IFN-producing, NK cells with increased cytolytic activity. I further showed that instillation of tumor-bearing mice with wildtype L1S protein significantly reduced burdens of established tumors. IFN and NK cells were required for these therapeutic effects. Further studies utilized simulated structure analysis and site-directed mutagenesis to explore the effects of specific amino acids in the LysM1 domain on the function of recombinant L1S protein. Specific amino acids in the LysM1 region were identified as critical for eliciting NK cell activity. Thus, my studies have improved our understanding of L1S immunostimulatory function and demonstrated its potential in vivo use for stimulation of NK cell anti-tumor responses.
Book Synopsis Immunity to Listeria Monocytogenes by :
Download or read book Immunity to Listeria Monocytogenes written by and published by . This book was released on 1997 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Peptidoglycan Acetylation of Listeria Monocytogenes in Pathogenesis and Innate Immunity by : Aimee Lynn Geissler
Download or read book The Role of Peptidoglycan Acetylation of Listeria Monocytogenes in Pathogenesis and Innate Immunity written by Aimee Lynn Geissler and published by . This book was released on 2008 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cell-mediated Immunity During a Listeria Monocytogenes Infection by : Janneke Nicoline Samsom
Download or read book Cell-mediated Immunity During a Listeria Monocytogenes Infection written by Janneke Nicoline Samsom and published by . This book was released on 1996 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury by : Santosh Nigam
Download or read book Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury written by Santosh Nigam and published by Springer. This book was released on 2012-11-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent decades eicosanoids have been attracting an increasing amount of attention as a result of their important physiological roles in many areas of biology and medicine. The eicosanoids comprise the prostaglandins, thromboxanes and leukotrienes and are products of arachidonic acid, an essential polyunsaturated fatty acid stored in tissue phospholipids. Disturbances of eicosanoids and their metabolic products play a regulatory role in many types of cell injuries and diseases. One of the most exciting areas of eicosanoid research pinpoints their participation in the control of cell proliferation and differentiation. Eicosanoids form a link between different fields of research into such areas as cancer, inflammation and radiation-induced injury. This link provided the impetus for the development of the conference series of which the present volume represents the proceedings of the Second International Conference, held in Berlin in October 1991.
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