Targeted Learning

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Publisher : Springer Science & Business Media
ISBN 13 : 1441997822
Total Pages : 628 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Targeted Learning by : Mark J. van der Laan

Download or read book Targeted Learning written by Mark J. van der Laan and published by Springer Science & Business Media. This book was released on 2011-06-17 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.

Applied Longitudinal Data Analysis for Epidemiology

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Publisher : Cambridge University Press
ISBN 13 : 110703003X
Total Pages : 337 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Applied Longitudinal Data Analysis for Epidemiology by : Jos W. R. Twisk

Download or read book Applied Longitudinal Data Analysis for Epidemiology written by Jos W. R. Twisk and published by Cambridge University Press. This book was released on 2013-05-09 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to the most important techniques available for longitudinal data analysis, essential for non-statisticians and researchers.

Measurement Error and Misclassification in Statistics and Epidemiology

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Publisher : CRC Press
ISBN 13 : 0203502760
Total Pages : 213 pages
Book Rating : 4.2/5 (35 download)

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Book Synopsis Measurement Error and Misclassification in Statistics and Epidemiology by : Paul Gustafson

Download or read book Measurement Error and Misclassification in Statistics and Epidemiology written by Paul Gustafson and published by CRC Press. This book was released on 2003-09-25 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mismeasurement of explanatory variables is a common hazard when using statistical modeling techniques, and particularly so in fields such as biostatistics and epidemiology where perceived risk factors cannot always be measured accurately. With this perspective and a focus on both continuous and categorical variables, Measurement Error and Misclassi

Studies in econometric method

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Publisher :
ISBN 13 :
Total Pages : 323 pages
Book Rating : 4.:/5 (954 download)

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Book Synopsis Studies in econometric method by : Wm.C. Hood

Download or read book Studies in econometric method written by Wm.C. Hood and published by . This book was released on 1953 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Evaluation of Surrogate Endpoints

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Publisher : Springer Science & Business Media
ISBN 13 : 9780387202778
Total Pages : 440 pages
Book Rating : 4.2/5 (27 download)

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Book Synopsis The Evaluation of Surrogate Endpoints by : Geert Molenberghs

Download or read book The Evaluation of Surrogate Endpoints written by Geert Molenberghs and published by Springer Science & Business Media. This book was released on 2005-02-28 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the latest research on a sensitive and controversial topic in a professional and well researched manner. Provides practical outlook as well as model guidelines and software tools that should be of interest to people who use the software tools described and those who do not. Related title by Co-author Geert Molenbergh has sold more than 3500 copies world wide. Provides dual viewpoints: from scientists in the industry as well as regulatory authorities.

Applied Survival Analysis Using R

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Publisher : Springer
ISBN 13 : 3319312456
Total Pages : 245 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Applied Survival Analysis Using R by : Dirk F. Moore

Download or read book Applied Survival Analysis Using R written by Dirk F. Moore and published by Springer. This book was released on 2016-05-11 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Survival Analysis Using R covers the main principles of survival analysis, gives examples of how it is applied, and teaches how to put those principles to use to analyze data using R as a vehicle. Survival data, where the primary outcome is time to a specific event, arise in many areas of biomedical research, including clinical trials, epidemiological studies, and studies of animals. Many survival methods are extensions of techniques used in linear regression and categorical data, while other aspects of this field are unique to survival data. This text employs numerous actual examples to illustrate survival curve estimation, comparison of survivals of different groups, proper accounting for censoring and truncation, model variable selection, and residual analysis. Because explaining survival analysis requires more advanced mathematics than many other statistical topics, this book is organized with basic concepts and most frequently used procedures covered in earlier chapters, with more advanced topics near the end and in the appendices. A background in basic linear regression and categorical data analysis, as well as a basic knowledge of calculus and the R system, will help the reader to fully appreciate the information presented. Examples are simple and straightforward while still illustrating key points, shedding light on the application of survival analysis in a way that is useful for graduate students, researchers, and practitioners in biostatistics.

Analysis of Survival Data with Dependent Censoring

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Publisher : Springer
ISBN 13 : 9811071640
Total Pages : 94 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Analysis of Survival Data with Dependent Censoring by : Takeshi Emura

Download or read book Analysis of Survival Data with Dependent Censoring written by Takeshi Emura and published by Springer. This book was released on 2018-04-05 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to copula-based statistical methods for analyzing survival data involving dependent censoring. Primarily focusing on likelihood-based methods performed under copula models, it is the first book solely devoted to the problem of dependent censoring. The book demonstrates the advantages of the copula-based methods in the context of medical research, especially with regard to cancer patients’ survival data. Needless to say, the statistical methods presented here can also be applied to many other branches of science, especially in reliability, where survival analysis plays an important role. The book can be used as a textbook for graduate coursework or a short course aimed at (bio-) statisticians. To deepen readers’ understanding of copula-based approaches, the book provides an accessible introduction to basic survival analysis and explains the mathematical foundations of copula-based survival models.

Nonparametric Regression and Generalized Linear Models

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Publisher : CRC Press
ISBN 13 : 1482229757
Total Pages : 197 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Nonparametric Regression and Generalized Linear Models by : P.J. Green

Download or read book Nonparametric Regression and Generalized Linear Models written by P.J. Green and published by CRC Press. This book was released on 1993-05-01 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonparametric Regression and Generalized Linear Models focuses on the roughness penalty method of nonparametric smoothing and shows how this technique provides a unifying approach to a wide range of smoothing problems. The emphasis is methodological rather than theoretical, and the authors concentrate on statistical and computation issues. Real data examples are used to illustrate the various methods and to compare them with standard parametric approaches. The mathematical treatment is self-contained and depends mainly on simple linear algebra and calculus. This monograph will be useful both as a reference work for research and applied statisticians and as a text for graduate students.

Group Sequential Methods with Applications to Clinical Trials

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Publisher : CRC Press
ISBN 13 : 9781584888581
Total Pages : 416 pages
Book Rating : 4.8/5 (885 download)

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Book Synopsis Group Sequential Methods with Applications to Clinical Trials by : Christopher Jennison

Download or read book Group Sequential Methods with Applications to Clinical Trials written by Christopher Jennison and published by CRC Press. This book was released on 1999-09-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.

Methods and Applications of Statistics in Clinical Trials, Volume 1

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Publisher : John Wiley & Sons
ISBN 13 : 1118595912
Total Pages : 937 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Methods and Applications of Statistics in Clinical Trials, Volume 1 by : Narayanaswamy Balakrishnan

Download or read book Methods and Applications of Statistics in Clinical Trials, Volume 1 written by Narayanaswamy Balakrishnan and published by John Wiley & Sons. This book was released on 2014-03-05 with total page 937 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete guide to the key statistical concepts essential for the design and construction of clinical trials As the newest major resource in the field of medical research, Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs presents a timely and authoritative reviewof the central statistical concepts used to build clinical trials that obtain the best results. The referenceunveils modern approaches vital to understanding, creating, and evaluating data obtained throughoutthe various stages of clinical trial design and analysis. Accessible and comprehensive, the first volume in a two-part set includes newly-written articles as well as established literature from the Wiley Encyclopedia of Clinical Trials. Illustrating a variety of statistical concepts and principles such as longitudinal data, missing data, covariates, biased-coin randomization, repeated measurements, and simple randomization, the book also provides in-depth coverage of the various trial designs found within phase I-IV trials. Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs also features: Detailed chapters on the type of trial designs, such as adaptive, crossover, group-randomized, multicenter, non-inferiority, non-randomized, open-labeled, preference, prevention, and superiority trials Over 100 contributions from leading academics, researchers, and practitioners An exploration of ongoing, cutting-edge clinical trials on early cancer and heart disease, mother-to-child human immunodeficiency virus transmission trials, and the AIDS Clinical Trials Group Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs is an excellent reference for researchers, practitioners, and students in the fields of clinicaltrials, pharmaceutics, biostatistics, medical research design, biology, biomedicine, epidemiology,and public health.

Chain Event Graphs

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Publisher : CRC Press
ISBN 13 : 1498729614
Total Pages : 255 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Chain Event Graphs by : Rodrigo A. Collazo

Download or read book Chain Event Graphs written by Rodrigo A. Collazo and published by CRC Press. This book was released on 2018-01-29 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by some major contributors to the development of this class of graphical models, Chain Event Graphs introduces a viable and straightforward new tool for statistical inference, model selection and learning techniques. The book extends established technologies used in the study of discrete Bayesian Networks so that they apply in a much more general setting As the first book on Chain Event Graphs, this monograph is expected to become a landmark work on the use of event trees and coloured probability trees in statistics, and to lead to the increased use of such tree models to describe hypotheses about how events might unfold. Features: introduces a new and exciting discrete graphical model based on an event tree focusses on illustrating inferential techniques, making its methodology accessible to a very broad audience and, most importantly, to practitioners illustrated by a wide range of examples, encompassing important present and future applications includes exercises to test comprehension and can easily be used as a course book introduces relevant software packages Rodrigo A. Collazo is a methodological and computational statistician based at the Naval Systems Analysis Centre (CASNAV) in Rio de Janeiro, Brazil. Christiane Görgen is a mathematical statistician at the Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany. Jim Q. Smith is a professor of statistics at the University of Warwick, UK. He has published widely in the field of statistics, AI, and decision analysis and has written two other books, most recently Bayesian Decision Analysis: Principles and Practice (Cambridge University Press 2010).

Topics in Biostatistics

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Publisher : Springer Science & Business Media
ISBN 13 : 1588295311
Total Pages : 530 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Topics in Biostatistics by : Walter T. Ambrosius

Download or read book Topics in Biostatistics written by Walter T. Ambrosius and published by Springer Science & Business Media. This book was released on 2007-07-06 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a multidisciplinary survey of biostatics methods, each illustrated with hands-on examples. It introduces advanced methods in statistics, including how to choose and work with statistical packages. Specific topics of interest include microarray analysis, missing data techniques, power and sample size, statistical methods in genetics. The book is an essential resource for researchers at every level of their career.

Proceedings of the Second Seattle Symposium in Biostatistics

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Publisher : Springer Science & Business Media
ISBN 13 : 1441990763
Total Pages : 332 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Proceedings of the Second Seattle Symposium in Biostatistics by : Danyu Lin

Download or read book Proceedings of the Second Seattle Symposium in Biostatistics written by Danyu Lin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a selection of papers presented at the Second Seattle Symposium in Biostatistics: Analysis of Correlated Data. The symposium was held in 2000 to celebrate the 30th anniversary of the University of Washington School of Public Health and Community Medicine. It featured keynote lectures by Norman Breslow, David Cox and Ross Prentice and 16 invited presentations by other prominent researchers. The papers contained in this volume encompass recent methodological advances in several important areas, such as longitudinal data, multivariate failure time data and genetic data, as well as innovative applications of the existing theory and methods. This volume is a valuable reference for researchers and practitioners in the field of correlated data analysis.

Ensemble Machine Learning

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Publisher : Springer Science & Business Media
ISBN 13 : 1441993258
Total Pages : 332 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Ensemble Machine Learning by : Cha Zhang

Download or read book Ensemble Machine Learning written by Cha Zhang and published by Springer Science & Business Media. This book was released on 2012-02-17 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is common wisdom that gathering a variety of views and inputs improves the process of decision making, and, indeed, underpins a democratic society. Dubbed “ensemble learning” by researchers in computational intelligence and machine learning, it is known to improve a decision system’s robustness and accuracy. Now, fresh developments are allowing researchers to unleash the power of ensemble learning in an increasing range of real-world applications. Ensemble learning algorithms such as “boosting” and “random forest” facilitate solutions to key computational issues such as face recognition and are now being applied in areas as diverse as object tracking and bioinformatics. Responding to a shortage of literature dedicated to the topic, this volume offers comprehensive coverage of state-of-the-art ensemble learning techniques, including the random forest skeleton tracking algorithm in the Xbox Kinect sensor, which bypasses the need for game controllers. At once a solid theoretical study and a practical guide, the volume is a windfall for researchers and practitioners alike.

Statistical Models in Epidemiology, the Environment, and Clinical Trials

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Publisher : Springer Science & Business Media
ISBN 13 : 9780387989242
Total Pages : 300 pages
Book Rating : 4.9/5 (892 download)

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Book Synopsis Statistical Models in Epidemiology, the Environment, and Clinical Trials by : M.Elizabeth Halloran

Download or read book Statistical Models in Epidemiology, the Environment, and Clinical Trials written by M.Elizabeth Halloran and published by Springer Science & Business Media. This book was released on 1999-10-29 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This IMA Volume in Mathematics and its Applications STATISTICAL MODELS IN EPIDEMIOLOGY, THE ENVIRONMENT,AND CLINICAL TRIALS is a combined proceedings on "Design and Analysis of Clinical Trials" and "Statistics and Epidemiology: Environment and Health. " This volume is the third series based on the proceedings of a very successful 1997 IMA Summer Program on "Statistics in the Health Sciences. " I would like to thank the organizers: M. Elizabeth Halloran of Emory University (Biostatistics) and Donald A. Berry of Duke University (Insti tute of Statistics and Decision Sciences and Cancer Center Biostatistics) for their excellent work as organizers of the meeting and for editing the proceedings. I am grateful to Seymour Geisser of University of Minnesota (Statistics), Patricia Grambsch, University of Minnesota (Biostatistics); Joel Greenhouse, Carnegie Mellon University (Statistics); Nicholas Lange, Harvard Medical School (Brain Imaging Center, McLean Hospital); Barry Margolin, University of North Carolina-Chapel Hill (Biostatistics); Sandy Weisberg, University of Minnesota (Statistics); Scott Zeger, Johns Hop kins University (Biostatistics); and Marvin Zelen, Harvard School of Public Health (Biostatistics) for organizing the six weeks summer program. I also take this opportunity to thank the National Science Foundation (NSF) and the Army Research Office (ARO), whose financial support made the workshop possible. Willard Miller, Jr.

Toxicological Effects of Methylmercury

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Publisher : National Academies Press
ISBN 13 : 0309171717
Total Pages : 364 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Effects of Methylmercury by : National Research Council

Download or read book Toxicological Effects of Methylmercury written by National Research Council and published by National Academies Press. This book was released on 2000-09-27 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mercury is widespread in our environment. Methylmercury, one organic form of mercury, can accumulate up the aquatic food chain and lead to high concentrations in predatory fish. When consumed by humans, contaminated fish represent a public health risk. Combustion processes, especially coal-fired power plants, are major sources of mercury contamination in the environment. The U.S. Environmental Protection Agency (EPA) is considering regulating mercury emissions from those plants. Toxicological Effects of Methylmercury reviews the health effects of methylmercury and discusses the estimation of mercury exposure from measured biomarkers, how differences between individuals affect mercury toxicity, and appropriate statistical methods for analysis of the data and thoroughly compares the epidemiological studies available on methylmercury. Included are discussions of current mercury levels on public health and a delineation of the scientific aspects and policy decisions involved in the regulation of mercury. This report is a valuable resource for individuals interested in the public health effects and regulation of mercury. The report also provides an excellent example of the implications of decisions in the risk assessment process for a larger audience.

Mendelian Randomization

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Publisher : CRC Press
ISBN 13 : 146657318X
Total Pages : 222 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Mendelian Randomization by : Stephen Burgess

Download or read book Mendelian Randomization written by Stephen Burgess and published by CRC Press. This book was released on 2015-03-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the Terminology and Methods of Mendelian Randomization for Epidemiological StudiesMendelian randomization uses genetic instrumental variables to make inferences about causal effects based on observational data. It, therefore, can be a reliable way of assessing the causal nature of risk factors, such as biomarkers, for a wide range of disea