Rna Therapeutics For Cancers

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RNA Therapeutics

Author : Paloma H. Giangrande
Publisher : Academic Press
ISBN 13 : 0128217391
Total Pages : 474 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis RNA Therapeutics by : Paloma H. Giangrande

Download or read book RNA Therapeutics written by Paloma H. Giangrande and published by Academic Press. This book was released on 2022-04-10 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development. Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects

RNA Therapeutics Part B

Author :
Publisher : Elsevier
ISBN 13 : 0443235457
Total Pages : 360 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis RNA Therapeutics Part B by :

Download or read book RNA Therapeutics Part B written by and published by Elsevier. This book was released on 2024-03-06 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Therapeutics, Part B, Volume 204 updates on a new class of medication based on RNA molecules, with chapters on a variety of topics, including RNA therapeutics for cardiovascular disorders, RNA therapeutics for kidney injury, RNA therapeutics for beta-thalassemia, RNA therapeutics for infectious diseases, RNA therapeutics for reproductive diseases, Potential of RNA and transcriptomic data to drive drug repurposing for various diseases, RNA therapeutics for glioma/glioblastoma, RNA therapeutics for regenerative medicine, Advances in the liposome-based delivery systems for RNA therapeutics in cancer, Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics in cancer, and more. Covers RNA therapeutics' history and future perspectives Discusses the processes of RNA therapeutical development Presents recent applications of RNA therapeutic in clinics Provides the advantages and disadvantages of RNA therapeutics

RNA Therapeutics for Cancers

Author : Akihide Yoshimi
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis RNA Therapeutics for Cancers by : Akihide Yoshimi

Download or read book RNA Therapeutics for Cancers written by Akihide Yoshimi and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA therapeutics represent a promising class of drugs and some of the successful therapeutics have been recently transformed into clinics for several disorders. A growing body of evidence has underlined the involvement of aberrant expression of cancer-associate genes or RNA splicing in the pathogenesis of a variety of cancers. In addition, there have been >200 clinical trials of oligonucleotide therapeutics targeting a variety of molecules in cancers. Although there are no approved RNA therapeutics against cancers so far, some promising outcomes have been obtained in phase 1/2 clinical trials. We will review the recent advances in the study of cancer pathogenesis associated with RNA therapeutics and the development of RNA therapeutics for cancers.

RNA and Cancer

Author : Jane Y. Wu
Publisher : Springer Science & Business Media
ISBN 13 : 364231659X
Total Pages : 256 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis RNA and Cancer by : Jane Y. Wu

Download or read book RNA and Cancer written by Jane Y. Wu and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.

Messenger RNA Therapeutics

Author : Stefan Jurga
Publisher : Springer Nature
ISBN 13 : 3031084152
Total Pages : 451 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Messenger RNA Therapeutics by : Stefan Jurga

Download or read book Messenger RNA Therapeutics written by Stefan Jurga and published by Springer Nature. This book was released on 2022-09-20 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics.

Nucleic Acid Therapeutics in Cancer

Author : Alan M. Gewirtz
Publisher : Springer Science & Business Media
ISBN 13 : 1592597777
Total Pages : 300 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Nucleic Acid Therapeutics in Cancer by : Alan M. Gewirtz

Download or read book Nucleic Acid Therapeutics in Cancer written by Alan M. Gewirtz and published by Springer Science & Business Media. This book was released on 2004-03-25 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.

Gene Therapy for Cancer

Author : Kelly K. Hunt
Publisher : Springer Science & Business Media
ISBN 13 : 159745222X
Total Pages : 469 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Gene Therapy for Cancer by : Kelly K. Hunt

Download or read book Gene Therapy for Cancer written by Kelly K. Hunt and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

RNA Delivery Function for Anticancer Therapeutics

Author : Loutfy H. Madkour
Publisher : CRC Press
ISBN 13 : 1000532240
Total Pages : 860 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis RNA Delivery Function for Anticancer Therapeutics by : Loutfy H. Madkour

Download or read book RNA Delivery Function for Anticancer Therapeutics written by Loutfy H. Madkour and published by CRC Press. This book was released on 2022-01-26 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.

RNA Interference and Cancer Therapy

Author : Lekha Dinesh Kumar
Publisher : Humana
ISBN 13 : 9781493992195
Total Pages : 416 pages
Book Rating : 4.9/5 (921 download)

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Book Synopsis RNA Interference and Cancer Therapy by : Lekha Dinesh Kumar

Download or read book RNA Interference and Cancer Therapy written by Lekha Dinesh Kumar and published by Humana. This book was released on 2019-05-17 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume collects a repertoire of techniques for the adoption and exploitation of RNA interference (RNAi) as a fertile strategy to develop the bio-drugs of future in the vital field of cancer research. Exploring the immense ‘bench to bedside’ potential of RNAi as a therapeutic molecule, the book focuses many of its chapters on nanoparticle-based targeted deliveries, including aptamers, as well as techniques for using RNAi technology to combat various cancers in preclinical studies. Each of the 26 chapters is authored by the pioneers in the respective areas and thus provides a practical and empirical account of the techniques that could be used as benchmark tools in the area of cancer research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, RNA Interference and Cancer Therapy: Methods and Protocols provides the necessary guidance for both novice and professional researchers who intend to discover and innovate newer means of using RNAi technology to combat cancer, one of the greatest scourges of human health.

RNA Therapeutics

Author : Mouldy Sioud
Publisher : Humana Press
ISBN 13 : 9781607616641
Total Pages : 527 pages
Book Rating : 4.6/5 (166 download)

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Book Synopsis RNA Therapeutics by : Mouldy Sioud

Download or read book RNA Therapeutics written by Mouldy Sioud and published by Humana Press. This book was released on 2011-03-04 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

RNA Modification in Human Cancers: Roles and Therapeutic Implications

Author : You Zhou
Publisher : Frontiers Media SA
ISBN 13 : 2889745678
Total Pages : 514 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis RNA Modification in Human Cancers: Roles and Therapeutic Implications by : You Zhou

Download or read book RNA Modification in Human Cancers: Roles and Therapeutic Implications written by You Zhou and published by Frontiers Media SA. This book was released on 2022-04-26 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Applications of Noncoding RNAs in Cancer

Author : Subash Gupta
Publisher : Academic Press
ISBN 13 : 0128245514
Total Pages : 479 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Clinical Applications of Noncoding RNAs in Cancer by : Subash Gupta

Download or read book Clinical Applications of Noncoding RNAs in Cancer written by Subash Gupta and published by Academic Press. This book was released on 2022-01-19 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. Presents a beginning chapter summary to help readers understand the content thoroughly Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy Discusses one cancer type per chapter making the content easy to reference

RNA Therapeutics Part B

Author :
Publisher : Elsevier
ISBN 13 : 0443235449
Total Pages : 358 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis RNA Therapeutics Part B by :

Download or read book RNA Therapeutics Part B written by and published by Elsevier. This book was released on 2024-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Therapeutics, Part B, Volume 204 updates on a new class of medication based on RNA molecules, with chapters on a variety of topics, including RNA therapeutics for cardiovascular disorders, RNA therapeutics for kidney injury, RNA therapeutics for beta-thalassemia, RNA therapeutics for infectious diseases, RNA therapeutics for reproductive diseases, Potential of RNA and transcriptomic data to drive drug repurposing for various diseases, RNA therapeutics for glioma/glioblastoma, RNA therapeutics for regenerative medicine, Advances in the liposome-based delivery systems for RNA therapeutics in cancer, Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics in cancer, and more.

Cancer and Noncoding RNAs

Author : Jayprokas Chakrabarti
Publisher : Academic Press
ISBN 13 : 0128134372
Total Pages : 578 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cancer and Noncoding RNAs by : Jayprokas Chakrabarti

Download or read book Cancer and Noncoding RNAs written by Jayprokas Chakrabarti and published by Academic Press. This book was released on 2017-10-13 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

RNA Therapeutics

Author : Mouldy Sioud
Publisher : Humana Press
ISBN 13 : 9781607616641
Total Pages : 527 pages
Book Rating : 4.6/5 (166 download)

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Book Synopsis RNA Therapeutics by : Mouldy Sioud

New Advances in RNA Targeting

Author : Olga N. Ilinskaya
Publisher : Frontiers Media SA
ISBN 13 : 2889637751
Total Pages : 251 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis New Advances in RNA Targeting by : Olga N. Ilinskaya

Download or read book New Advances in RNA Targeting written by Olga N. Ilinskaya and published by Frontiers Media SA. This book was released on 2020-06-04 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Rna-based Mechanisms In Cancer

Author : Gary Brewer
Publisher : World Scientific
ISBN 13 : 9811248672
Total Pages : 513 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Rna-based Mechanisms In Cancer by : Gary Brewer

Download or read book Rna-based Mechanisms In Cancer written by Gary Brewer and published by World Scientific. This book was released on 2023-10-12 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression.We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address 'where do we go from here' and stimulate the reader's thinking about these important problems.This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics.