Rna Design

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CRISPR Guide RNA Design

Author : Tudor A. Fulga
Publisher : Humana
ISBN 13 : 9781071606865
Total Pages : 286 pages
Book Rating : 4.6/5 (68 download)

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Book Synopsis CRISPR Guide RNA Design by : Tudor A. Fulga

Download or read book CRISPR Guide RNA Design written by Tudor A. Fulga and published by Humana. This book was released on 2020-11-19 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume focuses on the CRISPR-associated guide RNA and how it can be designed, modified, and validated for a broad repertoire of purposes. Beginning with a section on computational design of target-specific guide RNAs, the book continues by covering chemical modifications to alter guide RNA stability, specificity, and efficiency, as well as to create inducible guide RNAs, append additional functional domains, and express guide RNAs in a conditional manner. It concludes with methods for measuring off-target guide RNA activity. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, CRISPR Guide RNA Design: Methods and Protocols provides a comprehensive pipeline for guide RNA design and aims to be an invaluable resource in applying this powerful technology to basic research and therapeutic applications.

RNA Design

Author : Alexander Churkin
Publisher : Springer Nature
ISBN 13 : 1071640798
Total Pages : 306 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis RNA Design by : Alexander Churkin

Download or read book RNA Design written by Alexander Churkin and published by Springer Nature. This book was released on with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:

RNA Therapeutics

Author : Mouldy Sioud
Publisher : Humana Press
ISBN 13 : 9781607616641
Total Pages : 527 pages
Book Rating : 4.6/5 (166 download)

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Book Synopsis RNA Therapeutics by : Mouldy Sioud

Download or read book RNA Therapeutics written by Mouldy Sioud and published by Humana Press. This book was released on 2011-03-04 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

Ant Colony Optimization and Swarm Intelligence

Author : Marco Dorigo
Publisher : Springer
ISBN 13 : 3540384839
Total Pages : 540 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Ant Colony Optimization and Swarm Intelligence by : Marco Dorigo

Download or read book Ant Colony Optimization and Swarm Intelligence written by Marco Dorigo and published by Springer. This book was released on 2006-08-29 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 5th International Workshop on Ant Colony Optimization and Swarm Intelligence, ANTS 2006, held in Brussels, Belgium, in September 2006. The 27 revised full papers, 23 revised short papers, and 12 extended abstracts presented were carefully reviewed and selected from 115 submissions.

Research in Computational Molecular Biology

Author : Jian Ma
Publisher : Springer Nature
ISBN 13 : 1071639897
Total Pages : 508 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Research in Computational Molecular Biology by : Jian Ma

Download or read book Research in Computational Molecular Biology written by Jian Ma and published by Springer Nature. This book was released on 2024 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zusammenfassung: This book constitutes the proceedings of the 28th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2024, held in Cambridge, MA, USA, during April 29-May 2, 2024. The 57 full papers included in this book were carefully reviewed and selected from 352 submissions. They were organized in topical sections as follows: theoretical and foundational algorithm contributions and more applied directions that engage with new technologies and intriguing biological questions

RNA Interference

Author : David R. Engelke
Publisher : Elsevier
ISBN 13 : 0080455395
Total Pages : 487 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis RNA Interference by : David R. Engelke

Download or read book RNA Interference written by David R. Engelke and published by Elsevier. This book was released on 2005-02-28 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses extensive methodology related to delivery methods high throughput strategies and prospects as a human therapy agent.* One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences

Riboswitches as Targets and Tools

Author :
Publisher : Academic Press
ISBN 13 : 0128013362
Total Pages : 468 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Riboswitches as Targets and Tools by :

Download or read book Riboswitches as Targets and Tools written by and published by Academic Press. This book was released on 2015-01-12 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in riboswitches as targets and tools and contains sections on such topics as constructing and optimizing artificial riboswitches, live cell imaging and intracellular sensors with artificial riboswitches, conditional control of gene expression with artificial riboswitches, using artificial riboswitches for protein evolution and pathway optimization, and anti-riboswitch drug screens. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods in riboswitches as targets and tools - Contains sections on such topics as constructing and optimizing artificial riboswitches, synthetic biology: live cell imaging and intracellular sensors with artificial riboswitches, synthetic biology: conditional control of gene expression with artificial riboswitches, synthetic biology: using artificial riboswitches for protein evolution and pathway optimization, anti-riboswitches drug screens

Clean Design

Author : Robin Wilson
Publisher : Greenleaf Book Group
ISBN 13 : 1626341907
Total Pages : 217 pages
Book Rating : 4.6/5 (263 download)

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Book Synopsis Clean Design by : Robin Wilson

Download or read book Clean Design written by Robin Wilson and published by Greenleaf Book Group. This book was released on 2015-04-07 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designer Robin Wilson shares tips and tricks to detoxify and beautify your interior spaces and to help you create a more stylish and healthy home. Author Robin Wilson, plagued by allergies and asthma since infancy, has become an expert in Clean Design—creating allergen-reduced home environments that comfort and protect families. Using Wilson’s four principles of design—sustainable, reusable, recyclable, and nontoxic—every room in the home, from attic to basement and entryway to bedroom, can look sensational and stylish while reducing “your wheezing and sneezing.” Clean Design leads to amazing results: fewer allergy symptoms and asthma attacks, easier breathing, and better overall health. Whether building a new home, renovating, or simply updating the design of their current home, Wilson offers suggestions for the best eco-friendly, healthy, nontoxic furniture, wall and floor coverings, and window treatments to dramatically improve indoor air quality and reduce household exposure to dust, pet dander, pollen, mold, dust mites, smoke, household chemicals, airborne toxins, and other allergy and asthma triggers. By making eco-friendly design choices, you will not only protect yourself and your loved ones, but also contribute to the health and sustainability of our planet at the same time. Using traditional solutions, new methods, and some of her grandmother’s secrets, Wilson empowers you to incorporate Clean Design into your home, influencing your lifestyle, increasing your family’s wellness, and proving that “eco-friendly can be beautiful!”

RNA Nanotechnology and Therapeutics

Author : Peixuan Guo
Publisher : CRC Press
ISBN 13 : 1000552675
Total Pages : 644 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis RNA Nanotechnology and Therapeutics by : Peixuan Guo

Download or read book RNA Nanotechnology and Therapeutics written by Peixuan Guo and published by CRC Press. This book was released on 2022-07-18 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, immunorecognition of RNA nanomaterials, RNA chemistry for nanoparticle synthesis, and conjugation and labeling. Presents the latest research and discoveries in RNA nanotechnology Features contributions from world-class experts in the field Covers RNA nanoparticles in therapeutics Describes self-assembled RNA nanoparticles

Biophysics of RNA Folding

Author : Rick Russell
Publisher : Springer Science & Business Media
ISBN 13 : 1461449545
Total Pages : 238 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Biophysics of RNA Folding by : Rick Russell

Download or read book Biophysics of RNA Folding written by Rick Russell and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.

The Algorithm Design Manual

Author : Steven S Skiena
Publisher : Springer Science & Business Media
ISBN 13 : 1848000707
Total Pages : 742 pages
Book Rating : 4.8/5 (48 download)

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Book Synopsis The Algorithm Design Manual by : Steven S Skiena

Download or read book The Algorithm Design Manual written by Steven S Skiena and published by Springer Science & Business Media. This book was released on 2009-04-05 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newly expanded and updated second edition of the best-selling classic continues to take the "mystery" out of designing algorithms, and analyzing their efficacy and efficiency. Expanding on the first edition, the book now serves as the primary textbook of choice for algorithm design courses while maintaining its status as the premier practical reference guide to algorithms for programmers, researchers, and students. The reader-friendly Algorithm Design Manual provides straightforward access to combinatorial algorithms technology, stressing design over analysis. The first part, Techniques, provides accessible instruction on methods for designing and analyzing computer algorithms. The second part, Resources, is intended for browsing and reference, and comprises the catalog of algorithmic resources, implementations and an extensive bibliography. NEW to the second edition: • Doubles the tutorial material and exercises over the first edition • Provides full online support for lecturers, and a completely updated and improved website component with lecture slides, audio and video • Contains a unique catalog identifying the 75 algorithmic problems that arise most often in practice, leading the reader down the right path to solve them • Includes several NEW "war stories" relating experiences from real-world applications • Provides up-to-date links leading to the very best algorithm implementations available in C, C++, and Java

Automata, Languages and Programming

Author : Jos C.M. Baeten
Publisher : Springer
ISBN 13 : 3540450610
Total Pages : 1218 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Automata, Languages and Programming by : Jos C.M. Baeten

Download or read book Automata, Languages and Programming written by Jos C.M. Baeten and published by Springer. This book was released on 2003-01-01 with total page 1218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The refereed proceedings of the 30th International Colloquium on Automata, Languages and Programming, ICALP 2003, held in Eindhoven, The Netherlands in June/July 2003. The 84 revised full papers presented together with six invited papers were carefully reviewed and selected from 212 submissions. The papers are organized in topical sections on algorithms, process algebra, approximation algorithms, languages and programming, complexity, data structures, graph algorithms, automata, optimization and games, graphs and bisimulation, online problems, verification, the Internet, temporal logic and model checking, graph problems, logic and lambda-calculus, data structures and algorithms, types and categories, probabilistic systems, sampling and randomness, scheduling, and geometric problems.

Spherical Nucleic Acids

Author : Chad A. Mirkin
Publisher : CRC Press
ISBN 13 : 1000092364
Total Pages : 455 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Spherical Nucleic Acids by : Chad A. Mirkin

Download or read book Spherical Nucleic Acids written by Chad A. Mirkin and published by CRC Press. This book was released on 2021-10-14 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spherical nucleic acids (SNAs) comprise a nanoparticle core, and a densely packed and highly oriented nucleic acid shell. They have novel structure-dependent properties that differ from those of linear nucleic acids and that makes them useful in chemistry, biology, the life sciences, medicine, materials science, and engineering. This book is a reprint volume that compiles 101 key papers that have been published by the Mirkin Group at Northwestern University, USA, and their collaborators over the past more than two decades. Volume 1 provides an overview and a historical framework of SNAs and discusses their enabling features, which set them apart from all other forms of matter. Volume 2 covers the general design rules for colloidal crystal engineering with DNA, spanning the building blocks and DNA- and RNA-based "programmable bonds" that can be utilized in preparing such structures. Volume 3 continues the discussion of colloidal crystallization processes and routes to hierarchical assembly, featuring dynamic nanoparticle superlattices and lattices prepared on surfaces or via templating strategies, and explores what one can uniquely learn from and do with colloidal crystals prepared from nucleic acid–functionalized nanomaterials in optics, plasmonics, and catalysis. Volume 4 covers the role of SNAs in biomedicine, especially as diagnostic probes both inside and outside of cells, and treatments based on gene regulation and immunotherapy.

Trends in Practical Applications of Agents and Multiagent Systems

Author : Pawel Pawlewski
Publisher : Springer Science & Business Media
ISBN 13 : 364212433X
Total Pages : 735 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Trends in Practical Applications of Agents and Multiagent Systems by : Pawel Pawlewski

Download or read book Trends in Practical Applications of Agents and Multiagent Systems written by Pawel Pawlewski and published by Springer Science & Business Media. This book was released on 2010-04-16 with total page 735 pages. Available in PDF, EPUB and Kindle. Book excerpt: PAAMS, the International Conference on Practical Applications of Agents and Multi-Agent Systems is an international yearly forum to present, to discuss, and to disseminate the latest developments and the most important outcomes related to real-world applications. It provides a unique opportunity to bring multi-disciplinary experts, academics and practitioners together to exchange their ex-perience in the development of Agents and Multi-Agent Systems. This volume presents the papers that have been accepted for the 2010 edition in the Special Sessions and Workshops. PAAMS'10 Special Sessions and Workshops are a very useful tool in order to complement the regular program with new or emerging topics of particular interest to the participating community. Special Sessions and Workshops that emphasize on multi-disciplinary and transversal aspects, as well as cutting-edge topics were especially encouraged and welcomed.

RNA Nanotechnology

Author : Bin Wang
Publisher : CRC Press
ISBN 13 : 9814411647
Total Pages : 468 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis RNA Nanotechnology by : Bin Wang

Download or read book RNA Nanotechnology written by Bin Wang and published by CRC Press. This book was released on 2014-04-02 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.

Plant Small RNA

Author : Praveen Guleria
Publisher : Academic Press
ISBN 13 : 012817336X
Total Pages : 638 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Plant Small RNA by : Praveen Guleria

Download or read book Plant Small RNA written by Praveen Guleria and published by Academic Press. This book was released on 2020-02-19 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Small RNA: Biogenesis, Regulation and Application describes the biosynthesis of small RNA in plant systems. With an emphasis on the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival, this books presents the basics and most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. In addition, it emphasizes the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival. Final sections cover the most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. - Presents foundational information about small RNA biology and regulation in plants - Includes small RNA pathway advances - Describes the application and scope of small RNA technology for agricultural stability

Sugarcane Biotechnology: Challenges and Prospects

Author : Chakravarthi Mohan
Publisher : Springer
ISBN 13 : 3319589466
Total Pages : 184 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Sugarcane Biotechnology: Challenges and Prospects by : Chakravarthi Mohan

Download or read book Sugarcane Biotechnology: Challenges and Prospects written by Chakravarthi Mohan and published by Springer. This book was released on 2017-08-09 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides exhaustive information on several recent technologies that are employed for sugarcane improvement through biotechnology and will be of great interest to plant scientists, biotechnologists, molecular biologists and breeders who work on sugarcane crop. Topics discussed in this volume include genomics and transcriptomics, transgenic sugarcane for trait improvement, potential candidate promoters, new strategies for transformation, molecular farming, sugarcane as biofuel, chloroplast transformation, and genome editing.