Rna Design

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CRISPR Guide RNA Design

Author : Tudor A. Fulga
Publisher : Humana
ISBN 13 : 9781071606865
Total Pages : 286 pages
Book Rating : 4.6/5 (68 download)

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Book Synopsis CRISPR Guide RNA Design by : Tudor A. Fulga

Download or read book CRISPR Guide RNA Design written by Tudor A. Fulga and published by Humana. This book was released on 2020-11-19 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume focuses on the CRISPR-associated guide RNA and how it can be designed, modified, and validated for a broad repertoire of purposes. Beginning with a section on computational design of target-specific guide RNAs, the book continues by covering chemical modifications to alter guide RNA stability, specificity, and efficiency, as well as to create inducible guide RNAs, append additional functional domains, and express guide RNAs in a conditional manner. It concludes with methods for measuring off-target guide RNA activity. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, CRISPR Guide RNA Design: Methods and Protocols provides a comprehensive pipeline for guide RNA design and aims to be an invaluable resource in applying this powerful technology to basic research and therapeutic applications.

RNA Design

Author : Alexander Churkin
Publisher : Springer Nature
ISBN 13 : 1071640798
Total Pages : 306 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis RNA Design by : Alexander Churkin

Download or read book RNA Design written by Alexander Churkin and published by Springer Nature. This book was released on with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antisense RNA Design, Delivery, and Analysis

Author : Virginia Arechavala-Gomeza
Publisher : Humana
ISBN 13 : 9781071620120
Total Pages : 422 pages
Book Rating : 4.6/5 (21 download)

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Book Synopsis Antisense RNA Design, Delivery, and Analysis by : Virginia Arechavala-Gomeza

Download or read book Antisense RNA Design, Delivery, and Analysis written by Virginia Arechavala-Gomeza and published by Humana. This book was released on 2022-02-26 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work of newcomers to this vibrant and expanding field. This book was conceived thanks to the network DARTER (Delivery of Antisense RNA Therapeutics). DARTER is funded by the EU Cooperation of Science and Technology (COST), which aims to enhance interaction and collaborations between researchers in Europe and other countries.

RNA Folding

Author : Ronny Lorenz
Publisher : Springer Nature
ISBN 13 : 1071635190
Total Pages : 407 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis RNA Folding by : Ronny Lorenz

Download or read book RNA Folding written by Ronny Lorenz and published by Springer Nature. This book was released on with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt:

RNA Structure Prediction

Author : Risa Karakida Kawaguchi
Publisher : Springer Nature
ISBN 13 : 1071627686
Total Pages : 304 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis RNA Structure Prediction by : Risa Karakida Kawaguchi

Download or read book RNA Structure Prediction written by Risa Karakida Kawaguchi and published by Springer Nature. This book was released on 2023-01-27 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores recent progress in RNA secondary, tertiary structure prediction, and its application from an expansive point of view. Because of advancements in experimental protocols and devices, the integration of new types of data as well as new analysis techniques is necessary, and this volume discusses additional topics that are closely related to RNA structure prediction, such as the detection of structure-disrupting mutations, high-throughput structure analysis, and 3D structure design. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to quality research results. Authoritative and practical, RNA Structure Prediction serves as a valuable guide for both experimental and computational RNA researchers.

RNA Therapeutics Part A

Author :
Publisher : Elsevier
ISBN 13 : 0443223157
Total Pages : 328 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis RNA Therapeutics Part A by :

Download or read book RNA Therapeutics Part A written by and published by Elsevier. This book was released on 2024-02-13 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Therapeutics, Part A, Volume 203 presents the latest on a new class of medication based on RNA molecules. The book includes timely chapters that focus on An introduction to RNA therapeutics and potentials, The development and technologies of RNA therapeutics, Types of RNA therapeutics, Molecular mechanisms of RNA therapeutics, IT, and AI applications in RNA therapeutics, The application of data sciences and bioinformatics in RNA therapeutics, RNA therapeutics history and future perspectives, Recent applications of RNA therapeutic in clinics, Advantages and disadvantages of RNA therapeutics, RNA therapeutics for neurological disease, RNA therapeutics for metabolic disorders, and RNA therapeutics for metabolic disorders. - Discusses the history of RNA therapeutics, along with future perspectives - Presents the processes of RNA therapeutical developments - Covers recent applications of RNA therapeutics in clinics - Provides the advantages and disadvantages of RNA therapeutics

RNA Therapeutics

Author : Mouldy Sioud
Publisher : Humana Press
ISBN 13 : 9781607616641
Total Pages : 527 pages
Book Rating : 4.6/5 (166 download)

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Book Synopsis RNA Therapeutics by : Mouldy Sioud

Download or read book RNA Therapeutics written by Mouldy Sioud and published by Humana Press. This book was released on 2011-03-04 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

Biophysics of RNA Folding

Author : Rick Russell
Publisher : Springer Science & Business Media
ISBN 13 : 1461449545
Total Pages : 238 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Biophysics of RNA Folding by : Rick Russell

Download or read book Biophysics of RNA Folding written by Rick Russell and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.

Therapeutic RNA Nanotechnology

Author : Kirill A. Afonin
Publisher : CRC Press
ISBN 13 : 1000263177
Total Pages : 1229 pages
Book Rating : 4.0/5 (2 download)

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Book Synopsis Therapeutic RNA Nanotechnology by : Kirill A. Afonin

Download or read book Therapeutic RNA Nanotechnology written by Kirill A. Afonin and published by CRC Press. This book was released on 2021-07-21 with total page 1229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties. The unknown immune properties of nucleic acid nanoparticles have been a major hurdle in their adaptation until the works herein began assessing their structure-activity relationships. This collection chronologically follows the path of investigating the recognition of design components to implementing them into nucleic acid nanostructures. RNA nanotechnology is an emerging platform for therapeutics with increasing clinical relevance as this approach becomes more widely used and approved for the treatment of various diseases. The latest research aims to take advantage of RNA’s modular nature for the design of nanostructures which can interact with their environments to communicate programmed messages with intracellular pathways. In doing so, nanoparticles can be used to elicit or elude responses by the immune system as desired in conjunction with their therapeutic applications.

RNA Nanotechnology and Therapeutics

Author : Peixuan Guo
Publisher : CRC Press
ISBN 13 : 1466505664
Total Pages : 614 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis RNA Nanotechnology and Therapeutics by : Peixuan Guo

Download or read book RNA Nanotechnology and Therapeutics written by Peixuan Guo and published by CRC Press. This book was released on 2013-07-09 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.

Gene Silencing by RNA Interference

Author : Muhammad Sohail
Publisher : CRC Press
ISBN 13 : 020348925X
Total Pages : 398 pages
Book Rating : 4.2/5 (34 download)

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Book Synopsis Gene Silencing by RNA Interference by : Muhammad Sohail

Download or read book Gene Silencing by RNA Interference written by Muhammad Sohail and published by CRC Press. This book was released on 2004-08-27 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maximizing the potential of RNA interference in functional genomics - as well as in the development of therapeutics - continues to be at the forefront of biomedical research. Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by r

RNA Interference

Author : David R. Engelke
Publisher : Elsevier
ISBN 13 : 0080455395
Total Pages : 487 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis RNA Interference by : David R. Engelke

Download or read book RNA Interference written by David R. Engelke and published by Elsevier. This book was released on 2005-02-28 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses extensive methodology related to delivery methods high throughput strategies and prospects as a human therapy agent.* One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences

Clean Design

Author : Robin Wilson
Publisher : Greenleaf Book Group
ISBN 13 : 1626341907
Total Pages : 217 pages
Book Rating : 4.6/5 (263 download)

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Book Synopsis Clean Design by : Robin Wilson

Download or read book Clean Design written by Robin Wilson and published by Greenleaf Book Group. This book was released on 2015-04-07 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designer Robin Wilson shares tips and tricks to detoxify and beautify your interior spaces and to help you create a more stylish and healthy home. Author Robin Wilson, plagued by allergies and asthma since infancy, has become an expert in Clean Design—creating allergen-reduced home environments that comfort and protect families. Using Wilson’s four principles of design—sustainable, reusable, recyclable, and nontoxic—every room in the home, from attic to basement and entryway to bedroom, can look sensational and stylish while reducing “your wheezing and sneezing.” Clean Design leads to amazing results: fewer allergy symptoms and asthma attacks, easier breathing, and better overall health. Whether building a new home, renovating, or simply updating the design of their current home, Wilson offers suggestions for the best eco-friendly, healthy, nontoxic furniture, wall and floor coverings, and window treatments to dramatically improve indoor air quality and reduce household exposure to dust, pet dander, pollen, mold, dust mites, smoke, household chemicals, airborne toxins, and other allergy and asthma triggers. By making eco-friendly design choices, you will not only protect yourself and your loved ones, but also contribute to the health and sustainability of our planet at the same time. Using traditional solutions, new methods, and some of her grandmother’s secrets, Wilson empowers you to incorporate Clean Design into your home, influencing your lifestyle, increasing your family’s wellness, and proving that “eco-friendly can be beautiful!”

The Algorithm Design Manual

Author : Steven S Skiena
Publisher : Springer Science & Business Media
ISBN 13 : 1848000707
Total Pages : 742 pages
Book Rating : 4.8/5 (48 download)

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Book Synopsis The Algorithm Design Manual by : Steven S Skiena

Download or read book The Algorithm Design Manual written by Steven S Skiena and published by Springer Science & Business Media. This book was released on 2009-04-05 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newly expanded and updated second edition of the best-selling classic continues to take the "mystery" out of designing algorithms, and analyzing their efficacy and efficiency. Expanding on the first edition, the book now serves as the primary textbook of choice for algorithm design courses while maintaining its status as the premier practical reference guide to algorithms for programmers, researchers, and students. The reader-friendly Algorithm Design Manual provides straightforward access to combinatorial algorithms technology, stressing design over analysis. The first part, Techniques, provides accessible instruction on methods for designing and analyzing computer algorithms. The second part, Resources, is intended for browsing and reference, and comprises the catalog of algorithmic resources, implementations and an extensive bibliography. NEW to the second edition: • Doubles the tutorial material and exercises over the first edition • Provides full online support for lecturers, and a completely updated and improved website component with lecture slides, audio and video • Contains a unique catalog identifying the 75 algorithmic problems that arise most often in practice, leading the reader down the right path to solve them • Includes several NEW "war stories" relating experiences from real-world applications • Provides up-to-date links leading to the very best algorithm implementations available in C, C++, and Java

Plant Small RNA

Author : Praveen Guleria
Publisher : Academic Press
ISBN 13 : 012817336X
Total Pages : 638 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Plant Small RNA by : Praveen Guleria

Download or read book Plant Small RNA written by Praveen Guleria and published by Academic Press. This book was released on 2020-02-19 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Small RNA: Biogenesis, Regulation and Application describes the biosynthesis of small RNA in plant systems. With an emphasis on the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival, this books presents the basics and most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. In addition, it emphasizes the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival. Final sections cover the most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. - Presents foundational information about small RNA biology and regulation in plants - Includes small RNA pathway advances - Describes the application and scope of small RNA technology for agricultural stability

RNA Nanotechnology

Author : Bin Wang
Publisher : CRC Press
ISBN 13 : 9814411647
Total Pages : 468 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis RNA Nanotechnology by : Bin Wang

Download or read book RNA Nanotechnology written by Bin Wang and published by CRC Press. This book was released on 2014-04-02 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.

Computational studies of RNA and DNA

Author : Jirí Šponer
Publisher : Springer Science & Business Media
ISBN 13 : 1402048513
Total Pages : 638 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Computational studies of RNA and DNA by : Jirí Šponer

Download or read book Computational studies of RNA and DNA written by Jirí Šponer and published by Springer Science & Business Media. This book was released on 2006-10-05 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book integrates modern computational studies of nucleic acids, ranging from advanced electronic structure quantum chemical calculations through explicit solvent molecular dynamics (MD) simulations up to mesoscopic modelling, with the main focus given to the MD field. It gives an equal emphasis to the leading methods and applications while successes as well as pitfalls of the computational techniques are discussed.