Risk Factors Associated with Chronic Kidney Disease of Unknown Etiology (CKDu)

Download Risk Factors Associated with Chronic Kidney Disease of Unknown Etiology (CKDu) PDF Online Free

Author :
Publisher :
ISBN 13 : 9781369227833
Total Pages : 77 pages
Book Rating : 4.2/5 (278 download)

DOWNLOAD NOW!


Book Synopsis Risk Factors Associated with Chronic Kidney Disease of Unknown Etiology (CKDu) by : Krystal A. Jimenez

Download or read book Risk Factors Associated with Chronic Kidney Disease of Unknown Etiology (CKDu) written by Krystal A. Jimenez and published by . This book was released on 2016 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contrary to the conventional definition of CKD that is observed in developed countries, studies on CKD in developing countries demonstrate an atypical presentation of the disease, referenced as CKD of unknown origin (CKDu). CKD rates have been exponentially increasing in Nicaragua, particularly in sugarcane workers. This study assesses risk factors associated with this atypical presentation of CKD in patients from an occupational health clinic in rural Nicaragua.This was a cross-sectional study that included 512 patient records (2009 to 2014). Records were randomly selected and transcribed into an electronic database. The data was analyzed with a case-control perspective comparing patients with CKD from those without the disease. A logistic regression analysis was performed in order to examine the personal and occupational risks associated with CKD.Results of this study showed that patients with CKD were predominantly men, approximately ten years younger than patients without CKD, more commonly worked in agriculture, and had a lower prevalence of diabetes and hypertension. Regarding records of past medical history, there was poor agreement between physicians and patients. Moreover, the logistic regression model demonstrated that agricultural work has a 24-fold increase in the risk of CKD, which is not confounded by known risk factors for CKD.In conclusion, this study further characterizes the atypical presentation of CKD in Nicaragua. This study uniquely focuses on a specific population of workers that has not been previously studied. It also examines the association between particular occupational hazards and CKD, thus, furthering the understanding of CKD in Nicaragua.

Chronic Kidney Disease of Unknown Etiology in Sri Lanka: Quest for Understanding and Global Implications

Download Chronic Kidney Disease of Unknown Etiology in Sri Lanka: Quest for Understanding and Global Implications PDF Online Free

Author :
Publisher : RTI Press
ISBN 13 :
Total Pages : 4 pages
Book Rating : 4./5 ( download)

DOWNLOAD NOW!


Book Synopsis Chronic Kidney Disease of Unknown Etiology in Sri Lanka: Quest for Understanding and Global Implications by : Myles F. Elledge

Download or read book Chronic Kidney Disease of Unknown Etiology in Sri Lanka: Quest for Understanding and Global Implications written by Myles F. Elledge and published by RTI Press. This book was released on 2014-05-07 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research brief examines chronic kidney disease of unknown etiology (CKDu) in Sri Lanka. A new and growing public health challenge that has emerged in Sri Lanka, CKDu is epidemic in selected geographic areas of the country, primarily in its central and eastern dry zones. CKDu is not attributed to diabetes, hypertension, or other factors commonly associated with chronic kidney disease. A number of risk factors point to environmental triggers for the onset of CKDu, but evidence so far is insufficient to accurately pinpoint the potential cause or causes. Small studies conducted to date attempt to associate CKDu with agrochemicals, ayurvedic (traditional) medicines, water quality, or other environmental or lifestyle factors. This complex emerging health crisis requires an interdisciplinary approach, following strict field protocols and a rigorous environmental health risk assessment framework. Research and analysis to better understand CKDu are important for Sri Lanka and have global implications for understanding of similar geographic CKDu “hot spots” in Central America, Eastern Europe, and South Asia.

Socio Economic Impact of Chronic Kidney Disease of Unknown Etiology

Download Socio Economic Impact of Chronic Kidney Disease of Unknown Etiology PDF Online Free

Author :
Publisher :
ISBN 13 : 9789556121926
Total Pages : 45 pages
Book Rating : 4.1/5 (219 download)

DOWNLOAD NOW!


Book Synopsis Socio Economic Impact of Chronic Kidney Disease of Unknown Etiology by : Chathura Jayampathi

Download or read book Socio Economic Impact of Chronic Kidney Disease of Unknown Etiology written by Chathura Jayampathi and published by . This book was released on 2015 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: With reference to Sri Lanka.

Sodium Intake in Populations

Download Sodium Intake in Populations PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309282985
Total Pages : 225 pages
Book Rating : 4.3/5 (92 download)

DOWNLOAD NOW!


Book Synopsis Sodium Intake in Populations by : Institute of Medicine

Download or read book Sodium Intake in Populations written by Institute of Medicine and published by National Academies Press. This book was released on 2013-08-27 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite efforts over the past several decades to reduce sodium intake in the United States, adults still consume an average of 3,400 mg of sodium every day. A number of scientific bodies and professional health organizations, including the American Heart Association, the American Medical Association, and the American Public Health Association, support reducing dietary sodium intake. These organizations support a common goal to reduce daily sodium intake to less than 2,300 milligrams and further reduce intake to 1,500 mg among persons who are 51 years of age and older and those of any age who are African-American or have hypertension, diabetes, or chronic kidney disease. A substantial body of evidence supports these efforts to reduce sodium intake. This evidence links excessive dietary sodium to high blood pressure, a surrogate marker for cardiovascular disease (CVD), stroke, and cardiac-related mortality. However, concerns have been raised that a low sodium intake may adversely affect certain risk factors, including blood lipids and insulin resistance, and thus potentially increase risk of heart disease and stroke. In fact, several recent reports have challenged sodium reduction in the population as a strategy to reduce this risk. Sodium Intake in Populations recognizes the limitations of the available evidence, and explains that there is no consistent evidence to support an association between sodium intake and either a beneficial or adverse effect on most direct health outcomes other than some CVD outcomes (including stroke and CVD mortality) and all-cause mortality. Some evidence suggested that decreasing sodium intake could possibly reduce the risk of gastric cancer. However, the evidence was too limited to conclude the converse-that higher sodium intake could possibly increase the risk of gastric cancer. Interpreting these findings was particularly challenging because most studies were conducted outside the United States in populations consuming much higher levels of sodium than those consumed in this country. Sodium Intake in Populations is a summary of the findings and conclusions on evidence for associations between sodium intake and risk of CVD-related events and mortality.

Epidemiology of Chronic Kidney Disease of Uncertain Etiology

Download Epidemiology of Chronic Kidney Disease of Uncertain Etiology PDF Online Free

Author :
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659536557
Total Pages : 128 pages
Book Rating : 4.5/5 (365 download)

DOWNLOAD NOW!


Book Synopsis Epidemiology of Chronic Kidney Disease of Uncertain Etiology by : J.M.K.B. Jayasekara

Download or read book Epidemiology of Chronic Kidney Disease of Uncertain Etiology written by J.M.K.B. Jayasekara and published by LAP Lambert Academic Publishing. This book was released on 2014-05-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Kidney Disease of Uncertain etiology (CKDU) patients were reported in several countries including Nicaragua, El Salvador, Andhra Pradesh in India and some parts of Sri Lanka. The deadly disease is progressively ravaging many poor rural communities in the North Central Region of Sri Lanka. It has resulted in the deaths of a large number of people, variously estimated at between 20 and 22 thousand, over the last 20 years. Many investigations have been launched and studies carried out to identify the causes of this disease, but no definitive answers have yet been found. The book "Epidemiology of chronic kidney disease of uncertain etiology " provides timely, balanced and controversial information for scientist and Medical professionals on geographical distribution, epidemiology, risk factors and methods of early detection of the disease.

Oxford Textbook of Clinical Nephrology

Download Oxford Textbook of Clinical Nephrology PDF Online Free

Author :
Publisher : Oxford University Press
ISBN 13 : 0191017655
Total Pages : 3045 pages
Book Rating : 4.1/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Oxford Textbook of Clinical Nephrology by : Neil N. Turner

Download or read book Oxford Textbook of Clinical Nephrology written by Neil N. Turner and published by Oxford University Press. This book was released on 2015-10-29 with total page 3045 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

Space Fostering Latin American Societies

Download Space Fostering Latin American Societies PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 303038912X
Total Pages : 166 pages
Book Rating : 4.0/5 (33 download)

DOWNLOAD NOW!


Book Synopsis Space Fostering Latin American Societies by : Annette Froehlich

Download or read book Space Fostering Latin American Societies written by Annette Froehlich and published by Springer Nature. This book was released on 2020-05-04 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive overview of the role space is playing in unlocking Latin America’s developmental aspirations. It explains how space and its applications can be used to support the development of the full range and diversity of Latin American societies, while being driven by Latin American goals. The Latin American space sector is currently undergoing a phase of rapid and dynamic expansion, with new actors entering the field and with space applications increasingly used to support the continent’s social, economic, and political development. All across Latin America, attention is shifting to space as a fundamental part of the continental development agenda, and the creation of a Latin American space agency is evidence of this. Additionally, while in recent years, great advances in economic and social development have lifted many of Latin America’s people out of poverty, there is still much that needs to be done to fulfill the basic needs of the population and to afford them the dignity they deserve. To this end, space is already being employed in diverse fields of human endeavor to serve Latin America’s goals for its future, but there is still a need for further incorporation of space systems and data. The book is of great interest to researchers, professionals and students in fields such as Space Studies, International Relations, Governance, Social and Rural Development, and many others.

Chronic Kidney Disease in Disadvantaged Populations

Download Chronic Kidney Disease in Disadvantaged Populations PDF Online Free

Author :
Publisher : Academic Press
ISBN 13 : 0128043822
Total Pages : 400 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!


Book Synopsis Chronic Kidney Disease in Disadvantaged Populations by : Guillermo Garcia-Garcia

Download or read book Chronic Kidney Disease in Disadvantaged Populations written by Guillermo Garcia-Garcia and published by Academic Press. This book was released on 2017-07-08 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Kidney Disease in Disadvantaged Populations investigates the increased incidence and prevalence of kidney disease in vulnerable populations world-wide. The volume explores the complex interactions of genetic, biologic, cultural and socioeconomic factors such as the environment, and specific health behaviors that seem to be responsible for a significant proportion of the health disparities in these communities. Each chapter is written by leading experts in the field and analyzes the prevalence and incidence of pre-dialysis kidney disease in disadvantaged populations across both developed and developing countries. In addition, each contribution analyzes differentiated risk factors and compares the disparities in access to screening, prevention strategies, treatment protocols and renal replacement therapies. Chronic Kidney Disease in Disadvantaged Populations is essential reading for residents, fellows, clinicians and biomedical researchers working in nephrology, internal medicine, and epidemiology, especially those working in areas with high concentrations of disadvantaged populations. Presents a comprehensive account of both traditional and non-traditional risk factors for kidney disease Explores the mechanisms by which poverty increases the burden of kidney disease in these populations, barriers to access to renal health care, including renal replacement therapies, organ donation, and organ commercialization Offers the latest perspectives on outcomes in renal replacement therapies as well as prevention strategies

Prevention of Cardiovascular Disease

Download Prevention of Cardiovascular Disease PDF Online Free

Author :
Publisher : WHO
ISBN 13 : 9789241547178
Total Pages : 86 pages
Book Rating : 4.5/5 (471 download)

DOWNLOAD NOW!


Book Synopsis Prevention of Cardiovascular Disease by : World Health Organization

Download or read book Prevention of Cardiovascular Disease written by World Health Organization and published by WHO. This book was released on 2007-01-01 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication provides guidance on reducing disability and premature deaths from coronary heart disease, cerebrovascular disease and peripheral vascular disease in people at high risk who have not yet experienced a cardiovascular event. People with established cardiovascular disease are at very high risk of recurrent events and are not the subject of these guidelines. They have been addressed in previous WHO guidelines. The risk prediction charts that accompany these guidelines allow treatment to be targeted according to simple predictions of absolute cardiovascular risk. Recommendations are made for management of major cardiovascular risk factors through changes in lifestyle and prophylactic drug therapies. The guidelines provide a framework for the development of national guidance on prevention of cardiovascular disease that takes into account the particular political economic social and medical circumstances.

Chronic Kidney Disease

Download Chronic Kidney Disease PDF Online Free

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 953513843X
Total Pages : 307 pages
Book Rating : 4.5/5 (351 download)

DOWNLOAD NOW!


Book Synopsis Chronic Kidney Disease by : Thomas Rath

Download or read book Chronic Kidney Disease written by Thomas Rath and published by BoD – Books on Demand. This book was released on 2018-02-21 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also in the developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population, and only a minority of patients reach end-stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In the 13 chapters, this book sheds light on the different aspects related to pathophysiology and clinical aspects of CKD, providing interesting insights into not only inflammation and cardiovascular risk but also the interplay of hormones and the functional aspects of endothelial function. In addition, chapters dealing with genetic aspects of polycystic kidney disease and also the clinical handling of patients with CKD and peritoneal dialysis will be beneficial for the open-minded reader.

Renal Fibrosis: Mechanisms and Therapies

Download Renal Fibrosis: Mechanisms and Therapies PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 9811388717
Total Pages : 709 pages
Book Rating : 4.8/5 (113 download)

DOWNLOAD NOW!


Book Synopsis Renal Fibrosis: Mechanisms and Therapies by : Bi-Cheng Liu

Download or read book Renal Fibrosis: Mechanisms and Therapies written by Bi-Cheng Liu and published by Springer. This book was released on 2019-08-09 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

Leptospirosis and the Kidney

Download Leptospirosis and the Kidney PDF Online Free

Author :
Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783318065398
Total Pages : 0 pages
Book Rating : 4.0/5 (653 download)

DOWNLOAD NOW!


Book Synopsis Leptospirosis and the Kidney by : Chih-Wei Yang

Download or read book Leptospirosis and the Kidney written by Chih-Wei Yang and published by S. Karger AG (Switzerland). This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leptospirosis is the most common zoonotic disease worldwide, involving at least 1 million patients annually. Kidney is the preferential colonization site where Leptospira accumulates during systemic infection, primarily in the interstitium and in renal tubule epithelial cells. In acute kidney injury (AKI), the main histological findings are acute tubulo-interstitial nephritis and acute tubular necrosis, characterized by hypokalemia and non-oliguria. The injury caused by leptospira outer membrane protein components involves innate immunity Toll-like receptor pathways and activation of complement and immune cascades in the kidney, together with extracellular matrix accumulation when the kidney infection progress to chronic kidney disease (CKD). Significantly, recent studies indicate that leptospira may induce CKD in humans either with AKI-CKD continuum or subclinical leptospira infection leading to CKD. Leptospirosis kidney disease thus represents a newly discovered and previously overlooked area requiring intensive medical and public health attention and investigation. In this book, leading experts in the field contribute their cutting-edge clinical and research experiences for the understanding of leptospirosis kidney disease. The outstanding feature of this publication is emphasizing kidney injury and disease induced by leptospirosis, an underestimated infection involving multiple organs. The book contributes information on current knowledge of leptospirosis kidney disease and a new perspective for future research.

Chronic Kidney Disease of Undetermined Cause (CKDu)

Download Chronic Kidney Disease of Undetermined Cause (CKDu) PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (125 download)

DOWNLOAD NOW!


Book Synopsis Chronic Kidney Disease of Undetermined Cause (CKDu) by : Sophie Annalisa Hamilton

Download or read book Chronic Kidney Disease of Undetermined Cause (CKDu) written by Sophie Annalisa Hamilton and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Health Policy in Britain's Model Colony

Download Health Policy in Britain's Model Colony PDF Online Free

Author :
Publisher : Orient Blackswan
ISBN 13 : 9788125027591
Total Pages : 336 pages
Book Rating : 4.0/5 (275 download)

DOWNLOAD NOW!


Book Synopsis Health Policy in Britain's Model Colony by : Margaret Jones

Download or read book Health Policy in Britain's Model Colony written by Margaret Jones and published by Orient Blackswan. This book was released on 2004 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Was Western medicine a positive benefit of colonialism or one of its agents of oppression? This question has prompted a vigorous historical and political debate and is explored here in the context of the 'model' British colony of Ceylon. In this study, Margaret Jones emphasises the need for both a broad perspective and a more complex analysis. Colonial medicine is critiqued not merelyu in the political and economic context of imperialism but also against the background of human needs and rights. Her research is underscored by a detailed analysis of public health measures and services in Ceylon. One of its key findings is the accommodation achieved between Western and indigenous medicine. Throughout this work, Jones provides nuanced readings of the categories of colonised and coloniser, as well as the concept of colonial medicine. Health Policy in Britain's Model Colony provides an understanding of historical trends while simultaneously avoiding generalisations that subsume events and actions. Written in a compelling and lucid style, it is a path-breaking contribution to the history of medicine.

Global Tuberculosis Report 2015

Download Global Tuberculosis Report 2015 PDF Online Free

Author :
Publisher : World Health Organization
ISBN 13 : 9241565055
Total Pages : 204 pages
Book Rating : 4.2/5 (415 download)

DOWNLOAD NOW!


Book Synopsis Global Tuberculosis Report 2015 by : World Health Organization

Download or read book Global Tuberculosis Report 2015 written by World Health Organization and published by World Health Organization. This book was released on 2015 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1. Introduction -- chapter 2. Disease burden and 2015 targets assessment -- chapter 3. TB case notifications and treatment outcomes -- chapter 4. Drug-resistant TB -- chapter 5. Diagnostics and laboratory strengthening -- chapter 6. Addressing the co-epidemics of TB and HIV -- chapter 7. Financing -- chapter 8. Research and development -- Annexes.

Nephrology and Public Health Worldwide

Download Nephrology and Public Health Worldwide PDF Online Free

Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 331806937X
Total Pages : 369 pages
Book Rating : 4.3/5 (18 download)

DOWNLOAD NOW!


Book Synopsis Nephrology and Public Health Worldwide by : G.B. Silva Junior

Download or read book Nephrology and Public Health Worldwide written by G.B. Silva Junior and published by Karger Medical and Scientific Publishers. This book was released on 2021-11-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.

Review of Literature on Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

Download Review of Literature on Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka PDF Online Free

Author :
Publisher : IWMI
ISBN 13 : 9290907886
Total Pages : 46 pages
Book Rating : 4.2/5 (99 download)

DOWNLOAD NOW!


Book Synopsis Review of Literature on Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka by : Andrew Noble

Download or read book Review of Literature on Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka written by Andrew Noble and published by IWMI. This book was released on 2014-05-16 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manuscript undertakes a review of current published information (peer-reviewed and grey literature) on Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka. It attempts to provide an overview of the possible environmentally-induced causal factors that have been implicated in the development of the disease, and identifies the gaps in research and recommends potential areas for future research. The review specifically captures the potential role that agriculture and water resources may play as causal factors in the development of the disease, and calls for a systematic approach and stresses the need for an integrated multi-disciplinary research effort to address the problem.