Ricin Toxins

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Biological Toxins and Bioterrorism

Author : P. Gopalakrishnakone
Publisher : Springer
ISBN 13 : 9789400758681
Total Pages : 0 pages
Book Rating : 4.7/5 (586 download)

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Book Synopsis Biological Toxins and Bioterrorism by : P. Gopalakrishnakone

Download or read book Biological Toxins and Bioterrorism written by P. Gopalakrishnakone and published by Springer. This book was released on 2015-01-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological toxins are an important part of our world, a reality with which we need to cope, so in parallel with understanding their mechanisms of action and thereby improving our fundamental knowledge, there are successful efforts to utilize them as therapeutics against some debilitating human and animal diseases. In view of the complexity of different types of biotoxins and the broad range of toxin structure, physiology, utility, and countermeasures including regulatory issues, it was thus aimed to compile a book on biotoxins and bioweapons. This reference work in the Toxinology handbook series gathers together knowledge from around the globe about naturally inspired and manufactured biological weapons. The authors describe how they work; how authorities may detect their presence, prevent their use, and diagnose their impacts; and the means by which medical and paramedical professionals may treat victims. Also described are how they have been used to further our knowledge and what insights they have given us into evolutionary and physiological processes. Finally, it is also discussed how these toxins can be used as therapeutics and what the implications of such therapeutics are to their use as biothreat agents. This volume provides a reference accessible to scientists, educators, and medical experts alike with an interest in biotoxins, focusing on the major toxins used as bioweapons. Regulatory agencies will also benefit from the information provided in this book. Some in the intended audience may need to understand how they elicit their effects and how we can defend ourselves against them. Others may be interested in the sometimes colorful histories that surround this subset of biotoxins that can be and, in some cases, have been used as weapons.

Essentials of Glycobiology

Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Essentials of Glycobiology by : Ajit Varki

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Ricin Toxins

Author : Nilgun E. Tumer
Publisher : MDPI
ISBN 13 : 3039285122
Total Pages : 154 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Ricin Toxins by : Nilgun E. Tumer

Download or read book Ricin Toxins written by Nilgun E. Tumer and published by MDPI. This book was released on 2020-12-14 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: The plant toxin ricin is one of the most potent and lethal substances known. Due to its wide availability and the ease of production, ricin has been exploited as an agent of bioterrorism and biological warfare and is classified as a level B threat. Tons of ricin are produced annually worldwide as a by-product of castor oil, leading to exposure. Currently, there is no proven safe treatment for ricin intoxication. Ricin consists of an active A subunit (RTA) covalently linked to a cell binding B subunit (RTB). RTA depurinates a universally conserved adenine in the sarcin–ricin loop (SRL) of the large rRNA and inhibits protein synthesis. RTA-antibody complexes have been explored as immunotoxins against cancer cells. The articles published in this book address the history of ricin research, how ricin enters cells and traffics to the ribosome, how it inactivates ribosomes, how it induces inflammatory signaling pathways and programmed cell death, the design of therapies against ricin intoxication, and innovative assays for ricin detection.

Immunotoxins

Author : Arthur E. Frankel
Publisher : Springer Science & Business Media
ISBN 13 : 9780898389845
Total Pages : 606 pages
Book Rating : 4.3/5 (898 download)

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Book Synopsis Immunotoxins by : Arthur E. Frankel

Download or read book Immunotoxins written by Arthur E. Frankel and published by Springer Science & Business Media. This book was released on 1988-05-31 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

A Taste for Poison

Author : Neil Bradbury, Ph.D.
Publisher : St. Martin's Press
ISBN 13 : 1250270766
Total Pages : 234 pages
Book Rating : 4.2/5 (52 download)

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Book Synopsis A Taste for Poison by : Neil Bradbury, Ph.D.

Download or read book A Taste for Poison written by Neil Bradbury, Ph.D. and published by St. Martin's Press. This book was released on 2022-02-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A fascinating tale of poisons and poisonous deeds which both educates and entertains.” --Kathy Reichs A brilliant blend of science and crime, A TASTE FOR POISON reveals how eleven notorious poisons affect the body--through the murders in which they were used. As any reader of murder mysteries can tell you, poison is one of the most enduring—and popular—weapons of choice for a scheming murderer. It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict? In a fascinating blend of popular science, medical history, and true crime, Dr. Neil Bradbury explores this most morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes—some notorious, some forgotten, some still unsolved—are the equally compelling stories of the poisons involved: eleven molecules of death that work their way through the human body and, paradoxically, illuminate the way in which our bodies function. Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin & tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom, A Taste for Poison leads readers on a riveting tour of the intricate, complex systems that keep us alive—or don’t.

Forging a Poison Prevention and Control System

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309091942
Total Pages : 369 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Forging a Poison Prevention and Control System by : Institute of Medicine

Download or read book Forging a Poison Prevention and Control System written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-16 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Poisoning is a far more serious health problem in the U.S. than has generally been recognized. It is estimated that more than 4 million poisoning episodes occur annually, with approximately 300,000 cases leading to hospitalization. The field of poison prevention provides some of the most celebrated examples of successful public health interventions, yet surprisingly the current poison control "system" is little more than a loose network of poison control centers, poorly integrated into the larger spheres of public health. To increase their effectiveness, efforts to reduce poisoning need to be linked to a national agenda for public health promotion and injury prevention. Forging a Poison Prevention and Control System recommends a future poison control system with a strong public health infrastructure, a national system of regional poison control centers, federal funding to support core poison control activities, and a national poison information system to track major poisoning epidemics and possible acts of bioterrorism. This framework provides a complete "system" that could offer the best poison prevention and patient care services to meet the needs of the nation in the 21st century.

Poisonous Plants and Phytochemicals in Drug Discovery

Author : Andrew G. Mtewa
Publisher : John Wiley & Sons
ISBN 13 : 1119650232
Total Pages : 444 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Poisonous Plants and Phytochemicals in Drug Discovery by : Andrew G. Mtewa

Download or read book Poisonous Plants and Phytochemicals in Drug Discovery written by Andrew G. Mtewa and published by John Wiley & Sons. This book was released on 2020-12-22 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

Genetically Engineered Toxins

Author : Arthur Frankel
Publisher : CRC Press
ISBN 13 : 9780824784546
Total Pages : 516 pages
Book Rating : 4.7/5 (845 download)

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Book Synopsis Genetically Engineered Toxins by : Arthur Frankel

Download or read book Genetically Engineered Toxins written by Arthur Frankel and published by CRC Press. This book was released on 1992-06-19 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Reviewing difficult problems and their solutions, Genetically Engineered Toxins discusses techniques for clo;ning, expressing, and purifying recombinant toxins and genetically modified recombinant toxins; documents structure-function relationships in toxins, including comparative information; supplies theory and illustrations of chimeric toxins; delineates the preclinical assessments of new reagents; and summarizes approaches to drug design.;With over 1100 literature citations, Genetically Engineered Toxins is an invaluable resource for biochemists, molecular biologists, biotechnologists, pharmacologists, toxicologists, X-ray crystallographers, enzymologists, oncologists, hematologists, immunologists, rheumatologists, botanists, and graduate-level students in molecular biology, biotechnology, and clinical oncology courses.

Biological Safety

Author : Dawn P. Wooley
Publisher : John Wiley & Sons
ISBN 13 : 155581963X
Total Pages : 759 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Biological Safety by : Dawn P. Wooley

Download or read book Biological Safety written by Dawn P. Wooley and published by John Wiley & Sons. This book was released on 2020-07-02 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological safety and biosecurity protocols are essential to the reputation and responsibility of every scientific institution, whether research, academic, or production. Every risk—no matter how small—must be considered, assessed, and properly mitigated. If the science isn't safe, it isn't good. Now in its fifth edition, Biological safety: Principles and Practices remains the most comprehensive biosafety reference. Led by editors Karen Byers and Dawn Wooley, a team of expert contributors have outlined the technical nuts and bolts of biosafety and biosecurity within these pages. This book presents the guiding principles of laboratory safety, including: the identification, assessment, and control of the broad variety of risks encountered in the lab; the production facility; and, the classroom. Specifically, Biological Safety covers protection and control elements—from biosafety level cabinets and personal protection systems to strategies and decontamination methods administrative concerns in biorisk management, including regulations, guidelines, and compliance various aspects of risk assessment covering bacterial pathogens, viral agents, mycotic agents, protozoa and helminths, gene transfer vectors, zooonotic agents, allergens, toxins, and molecular agents as well as decontamination, aerobiology, occupational medicine, and training A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological safety is also a critical reference for laboratory managers, and those responsible for managing biohazards in a range of settings, including basic and agricultural research, clinical laboratories, the vivarium, field study, insectories, and greenhouses.

A is for Arsenic

Author : Kathryn Harkup
Publisher : Bloomsbury Publishing
ISBN 13 : 1472911318
Total Pages : 321 pages
Book Rating : 4.4/5 (729 download)

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Book Synopsis A is for Arsenic by : Kathryn Harkup

Download or read book A is for Arsenic written by Kathryn Harkup and published by Bloomsbury Publishing. This book was released on 2015 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Agatha Christie's detailed plotting is what makes her books so compelling. Christie used poison to kill her characters more often than any other murder method, with the poison itself being a central part of the novel, and her choice of deadly substances was far from random; the chemical and physiological characteristics of each poison provide vital clues to discovery of the murderer. With gunshots or stabbings the cause of death is obvious, but not so with poisons. How is it that some compounds prove so deadly, and in such tiny amounts?Christie demonstrated her extensive chemical knowledge (much of it gleaned from her working in a chemists during both world wars) in many of her novels, but this is rarely appreciated by the reader. A is for Arsenic celebrates the use of science in Christie's work. Written by Christie fan and research chemist Kathryn Harkup, each chapter takes a different novel and investigates the poison (or poisons) the murderer used. A is for Arsenic looks at why certain chemicals kill, how they interact with the body, and the feasibility of obtaining, administering and detecting these poisons, both at the time the novel was written and today. This book is published as part of the 125th anniversary celebration of Christie's birth.Fourteen novels. Fourteen poisons. Just because its fiction doesn't mean its all made-up ...

Molecular Action of Toxins and Viruses

Author : P. Cohen
Publisher : Elsevier
ISBN 13 : 0444600973
Total Pages : 387 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Molecular Action of Toxins and Viruses by : P. Cohen

Download or read book Molecular Action of Toxins and Viruses written by P. Cohen and published by Elsevier. This book was released on 2012-12-02 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Action of Toxins and Viruses investigates the molecular action of bacterial toxins and viruses and its striking similarity to the mechanisms by which many neural and hormonal stimuli control normal cell functions. Topics covered include the biological activity of diphteria toxin; the role of cholera toxin in the regulation of hormone-sensitive adenylate cyclase; toxic lectins and related proteins; and bacterial cytolysins (membrane-damaging toxins). Comprised of nine chapters, this volume begins with a discussion on the biosynthesis and biological activity of diphtheria toxin, toxin-resistant mutant cells, and the entry of toxin into cells and fragment A in the cytoplasm of living cells. The reader is then systematically introduced to the use of cholera toxin as a probe to study the regulation and interaction of adenylate cyclase components; the toxic action of lectins and related proteins such as abrin, ricin, and modeccin; and the ability of bacterial cytolysins to damage cell membranes. The remaining chapters focus on the mechanism of action of colicin E2, colicin E3, and cloacin DF13; similarities in the action of different bacterial toxins; the role of cell membranes in infection with bacterial viruses and colicins; and the life cycle and infection mechanisms of bacteriophage T4. The book concludes with an analysis of the involvement of protein kinases in viral transformation. This monograph will be of interest to students, practitioners, and researchers in fields ranging from molecular biology and biochemistry to cell biology, bacteriology, and physiology.

Medical Toxicology of Natural Substances

Author : Donald G. Barceloux
Publisher : John Wiley & Sons
ISBN 13 : 1118382765
Total Pages : 1196 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Medical Toxicology of Natural Substances by : Donald G. Barceloux

Download or read book Medical Toxicology of Natural Substances written by Donald G. Barceloux and published by John Wiley & Sons. This book was released on 2012-03-07 with total page 1196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest and information in the field of medical toxicology has grown rapidly, but there has never been a concise, authoritative reference focused on the subjects of natural substances, chemical and physical toxins, drugs of abuse, and pharmaceutical overdoses. Medical Toxicology of Natural Substances finally gives you an easily accessible resource for vital toxicological information on foods, plants, and animals in key areas in the natural environment.

Chemical and Biological Terrorism

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309061954
Total Pages : 303 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Chemical and Biological Terrorism by : Institute of Medicine

Download or read book Chemical and Biological Terrorism written by Institute of Medicine and published by National Academies Press. This book was released on 1999-03-12 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The threat of domestic terrorism today looms larger than ever. Bombings at the World Trade Center and Oklahoma City's Federal Building, as well as nerve gas attacks in Japan, have made it tragically obvious that American civilians must be ready for terrorist attacks. What do we need to know to help emergency and medical personnel prepare for these attacks? Chemical and Biological Terrorism identifies the R&D efforts needed to implement recommendations in key areas: pre-incident intelligence, detection and identification of chemical and biological agents, protective clothing and equipment, early recognition that a population has been covertly exposed to a pathogen, mass casualty decontamination and triage, use of vaccines and pharmaceuticals, and the psychological effects of terror. Specific objectives for computer software development are also identified. The book addresses the differences between a biological and chemical attack, the distinct challenges to the military and civilian medical communities, and other broader issues. This book will be of critical interest to anyone involved in civilian preparedness for terrorist attack: planners, administrators, responders, medical professionals, public health and emergency personnel, and technology designers and engineers.

Health Aspects of Castor Bean Dust

Author :
Publisher :
ISBN 13 :
Total Pages : 158 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Health Aspects of Castor Bean Dust by :

Download or read book Health Aspects of Castor Bean Dust written by and published by . This book was released on 1967 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicology and Human Environments

Author : Ernest Hodgson
Publisher : Academic Press
ISBN 13 : 0124158137
Total Pages : 452 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Toxicology and Human Environments by : Ernest Hodgson

Download or read book Toxicology and Human Environments written by Ernest Hodgson and published by Academic Press. This book was released on 2012-09-28 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

Bioterrorism and Infectious Agents

Author : I.W. Fong
Publisher : Springer Science & Business Media
ISBN 13 : 1441912665
Total Pages : 284 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Bioterrorism and Infectious Agents by : I.W. Fong

Download or read book Bioterrorism and Infectious Agents written by I.W. Fong and published by Springer Science & Business Media. This book was released on 2010-03-18 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiled by two leading experts in the field, this volume provides a concise, timely, and authoritative review of some of the most problematic infections of the new century. It presents issues and new ideas for preventing and controlling infectious diseases.

The Killer Bean of Calabar and Other Stories

Author : Peter Macinnis
Publisher : Allen & Unwin
ISBN 13 : 1741154375
Total Pages : 257 pages
Book Rating : 4.7/5 (411 download)

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Book Synopsis The Killer Bean of Calabar and Other Stories by : Peter Macinnis

Download or read book The Killer Bean of Calabar and Other Stories written by Peter Macinnis and published by Allen & Unwin. This book was released on 2004-07-01 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: A triumphantly toxic tome. As a dedicated Macinnis fan, I relish this latest display of erudition, story-telling and fun. One of his very best.' Robyn Williams, Head, ABC Science Unit Was Abraham Lincoln really as mad as a hatter? Who poisoned Phar Lap? Can wallpaper really kill? Was Jack the Ripper an arsenic eater? Painting a broad canvas, from the early Egyptians to the arsenical tube wells in Bangladesh and the Sarin gas attacks in a Tokyo subway, The Killer Bean of Calabar explores the accidental and intentional tales of poisons and their use throughout history. Historically difficult substances to trace, poisons have been used by many for their own dastardly purposes, from the Great Poisoners such as Nero and Madame de Brinvilliers to the mass gassings of World War II. But the truly great poisoners are those who make selective use of poisons to save human life, not the few who use poison to take human life. Most of the medicines we take are themselves poisons - therapeutic only by virtue of being more deadly to our viruses than to us. Poisons are all around us - from the plants in our gardens and lead in our homes, to the bacteria and toxins in our bodies. With ripping yarns and unusual views of famous people, Macinnis explains the whys and wherefores of poisons and poisoning.