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Ribonucleases H
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Book Synopsis Ribonucleases, Part A: Functional Roles and Mechanisms of Action by :
Download or read book Ribonucleases, Part A: Functional Roles and Mechanisms of Action written by and published by Elsevier. This book was released on 2001-09-26 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first of two volumes provides up-to-date, methods-related information on ribonuclease functions, assays, and applications. Chapter topics include the identification of, characterization of, and assays for secreted ribonucleases; viral ribonucleases, artificial and engineered ribonucleases, and ribozymes. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Book Synopsis Ribonucleases H by : Robert J.. Crouch
Download or read book Ribonucleases H written by Robert J.. Crouch and published by . This book was released on 1998-01-01 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ribonucleases by : Giuseppe D'Alessio
Download or read book Ribonucleases written by Giuseppe D'Alessio and published by Academic Press. This book was released on 1997-02-11 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pancreatic ribonuclease, the focus of highly productive scientific research for more than half a century and the only enzyme to be the basis of four Nobel prizes, has recently undergone a resurgence in popularity for the recognition of an extended ribonuclease superfamily with functions ranging from tumour growth and inhibition to self-recognition and neurotoxicity. This volume highlights the functional diversity of ribonucleases and reveals the emerging research opportunities provided by these enzymes. * Never before has discussion of the entire family of ribonucleases and related enzymes been covered in a single volume* Core chapters focus on the latest structures and functions of pancreatic-type ribonucleases* Structures and functions of intracellular ribonucleases and nondigestive members of the family are also covered* How ribonucleases continue to serve as excellent systems with which to uncover the secrets of protein chemistry is demonstrated
Book Synopsis Ribonucleases by : Allen W. Nicholson
Download or read book Ribonucleases written by Allen W. Nicholson and published by Springer Science & Business Media. This book was released on 2011-10-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ribonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5’ or 3’ ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.
Book Synopsis Enzymatic Mechanism of Ribonucleases H by : James Lawrence Keck
Download or read book Enzymatic Mechanism of Ribonucleases H written by James Lawrence Keck and published by . This book was released on 1997 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microbial Ribonucleases by : Fujio Egami
Download or read book Microbial Ribonucleases written by Fujio Egami and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nuclease Methods and Protocols by : Catherine H. Schein
Download or read book Nuclease Methods and Protocols written by Catherine H. Schein and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleases, enzymes that restructure or degrade nucleic acid polymers, are vital to the control of every area of metabolism. They range from “housekeeping” enzymes with broad substrate ranges to extremely specific tools (1). Many types of nucleases are used in lab protocols, and their commercial and clinical uses are expanding. The purpose of Nuclease Methods and Protocols is to introduce the reader to some we- characterized protein nucleases, and the methods used to determine their activity, structure, interaction with other molecules, and physiological role. Each chapter begins with a mini-review on a specific nuclease or a nuclease-related theme. Although many chapters cover several topics, they were arbitrarily divided into five parts: Part I, “Characterizing Nuclease Activity,” includes protocols and assays to determine general (processive, distributive) or specific mechanisms. Methods to assay nuclease products, identify cloned nucleases, and determine their physiological role are also included here. Part II, “Inhibitors and Activators of Nucleases,” summarizes assays for measuring the effects of other proteins and small molecules. Many of these inhibitors have clinical relevance. Part III, “Relating Nuclease Structure and Function,” provides an overview of methods to determine or model the 3-D structure of nucleases and their complexes with substrates and inhibitors. A 3-D structure can greatly aid the rational design of nucleases and inhibitors for specific purposes. Part IV, “Nucleases in the Clinic,” summarizes assays and protocols suitable for use with t- sues and for nuclease based therapeutics.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1990 with total page 1440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Partially Folded Conformations of E. Coli Ribonuclease H by : Aaron K. Chamberlain
Download or read book Partially Folded Conformations of E. Coli Ribonuclease H written by Aaron K. Chamberlain and published by . This book was released on 1997 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 1616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis The Ribonuclease H of Human Immunodeficiency Virus by : Jen Ron Chiang
Download or read book The Ribonuclease H of Human Immunodeficiency Virus written by Jen Ron Chiang and published by . This book was released on 1994 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Therapeutic Modulation of Cytokines by : M. W. Bodmer
Download or read book Therapeutic Modulation of Cytokines written by M. W. Bodmer and published by CRC Press. This book was released on 1996-01-23 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ß. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.
Book Synopsis Protein Stability and Folding by : Wolfgang Pfeil
Download or read book Protein Stability and Folding written by Wolfgang Pfeil and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1998, we published the data compilation PROTEIN STABILITY AND FOLDING which covered the data from the early beginnings of thermodynamic studies of protein folding until 1996. Since then, the amount of available thermodynamic data has increased nearly twice. The data constitute very important additions to the information on the protein folding problem, the construction of mutant protein, and the practical application of proteins in various fields. The Supplement covers the period 1997-1999 and is designed to make the vast amount of present data accessible to multidisciplinary research where chemistry, physics, biology, and medicine are involved and also biotechnology, pharmaceutical and food research. At the same time the data could be helpful to identify problems unsolved so far, and to avoid unnecessary duplication of scientific work. The structure of the Supplement is the same as in the previous data compilation. However, some additional data characterizing protein-denaturant interaction and protein unfolding by trifluoroethanol have been added. In that context, some previous data have been reconsidered. The author wishes to thank everyone who provided data, ideas, or even unpublished results. Furthermore, support by the Deutsche Forschungsgemeinschaft (INK 16 BI-I) is gratefully acknowledged. Finally, I would like to thank the staff of Springer Verlag for their efforts and for excellent assistance during the production of the data collections.
Book Synopsis Folding of Ribonuclease H from Escherichia Coli by : Tanya Marie Raschke
Download or read book Folding of Ribonuclease H from Escherichia Coli written by Tanya Marie Raschke and published by . This book was released on 1999 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Medical Subject Headings by : National Library of Medicine (U.S.)
Download or read book Medical Subject Headings written by National Library of Medicine (U.S.) and published by . This book was released on 1995 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Esterases—Advances in Research and Application: 2012 Edition by :
Download or read book Esterases—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Esterases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Esterases. The editors have built Esterases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Esterases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Esterases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Artificial Nucleases by : Marina A. Zenkova
Download or read book Artificial Nucleases written by Marina A. Zenkova and published by Springer Science & Business Media. This book was released on 2004-01-07 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of agents capable of cleaving RNA and DNA has attracted considerable attention from researchers in the last few years, because of the immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology. There are essentially two classes of these agents - nucleases that occur naturally inside cells and synthetically produced artificial nucleases. The first class includes protein enzyme nucle ases and catalytic RNA structured ribozymes that perform cleavage of the phosphodiester bonds in nucleic acids according to a hydrolytic pathway in the course of different biochemical processes in the cell. A different pathway is used by some antibiotics which cleave DNA via redox-based mechanisms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents. The second class, artificial nucleases, are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets of the most important characteristics that are essential for catalysis. A dif ferent approach, in vitro selection, was also used to create artificial RNA and DNA enzymes capable of cleaving RNA. Being less efficient and specific as compared to the natural enzymes, the primitive mimics are smaller and robust and can function in a broad range of conditions.
