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Author : Henrik Vorum
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (468 download)
Download or read book Reversible Ligand Binding to Human Serum Albumin written by Henrik Vorum and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Andrea Bellelli
Publisher : John Wiley & Sons
ISBN 13 : 111923848X
Total Pages : 309 pages
Book Rating : 4.1/5 (192 download)
Download or read book Reversible Ligand Binding written by Andrea Bellelli and published by John Wiley & Sons. This book was released on 2018-01-09 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the physical background of ligand binding and instructs on how experiments should be designed and analyzed Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions—providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s). Topics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions. Bridges theory of ligand binding and allostery with experiments Applies historical and physical insight to provide a clear understanding of ligand binding Written by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allostery Based on FEBS Advanced Course lectures on the topic Reversible Ligand Binding: Theory and Experiment is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.
Author : Alessio Bocedi
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.:/5 (14 download)
Download or read book Ligand Binding to Human Serum Albumin written by Alessio Bocedi and published by . This book was released on 2006 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Torgny Sjödin
Publisher :
ISBN 13 : 9789155404987
Total Pages : 37 pages
Book Rating : 4.4/5 (49 download)
Download or read book Studies on Human Serum Albumin and Its Ligand Binding Properties written by Torgny Sjödin and published by . This book was released on 1976 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ulrich Kragh-Hansen
Publisher :
ISBN 13 :
Total Pages : 32 pages
Book Rating : 4.:/5 (256 download)
Download or read book Structure and Ligand Binding Properties of Human Serum Albumin written by Ulrich Kragh-Hansen and published by . This book was released on 1989 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : TORGNY SJOEDIN
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book Studies on Human Serum Albumin and Its Ligand Binding Proporties written by TORGNY SJOEDIN and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bent Honoré
Publisher :
ISBN 13 : 9788716148483
Total Pages : 26 pages
Book Rating : 4.1/5 (484 download)
Download or read book Conformational Changes in Human Serum Albumin Induced by Ligand Binding written by Bent Honoré and published by . This book was released on 1990 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : B. Ravindranath
Publisher : Ellis Horwood
ISBN 13 :
Total Pages : 510 pages
Book Rating : 4.3/5 (91 download)
Download or read book Principles and Practice of Chromatography written by B. Ravindranath and published by Ellis Horwood. This book was released on 1989 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chung-Eun Ha
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (318 download)
Download or read book The Effects of Site-directed Mutagenesis and Ethanol on the Ligand Binding Properties of Human Serum Albumin written by Chung-Eun Ha and published by . This book was released on 1999 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jesper Østergaard
Publisher :
ISBN 13 : 9788778345523
Total Pages : 80 pages
Book Rating : 4.3/5 (455 download)
Download or read book Aspects of Reversible Drug-human Serum Albumin Binding written by Jesper Østergaard and published by . This book was released on 2003 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Theodore Peters Jr.
Publisher : Academic Press
ISBN 13 : 0080527043
Total Pages : 455 pages
Book Rating : 4.0/5 (85 download)
Download or read book All About Albumin written by Theodore Peters Jr. and published by Academic Press. This book was released on 1995-12-21 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, All About Albumin summarizes the chemistry, genetics, metabolism, clinical implications, and commercial aspects of albumin. It provides the most up-to-date sequences, structures, and compositions of many species, and includes more than 2000 references. Includes up-to-date sequences, structures, and compositions of many species Reviews the protein chemistry, genetic control, and metabolism of albumin Covers medical and cell culture applications in vivo and in vitro, with a section on handling albumin in the laboratory Presents the relationship of albumin to its superfamily with an updated scheme for their evolution First complete coverage of all aspects of serum albumin in one volume, with more than 2000 references
Author :
Publisher : Academic Press
ISBN 13 : 0080582184
Total Pages : 489 pages
Book Rating : 4.0/5 (85 download)
Download or read book Lipoproteins, Apolipoproteins, and Lipases written by and published by Academic Press. This book was released on 1994-03-10 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains eight chapters that present both new and reviewed information fundamental to a clear understanding of lipid catabolism and transport at the molecular level. Three-dimensional structures of important serum lipoproteins, apolipoproteins, and lipases, utilizing X-ray data when available, are emphasized, and an attempt is made to relate structures to function. Amphipathic helix Apolipoprotein E Lipophorin Structure of serum albumin Lipid binding proteins Apolipoprotein B Low-density lipoprotein
Author :
Publisher :
ISBN 13 :
Total Pages : 342 pages
Book Rating : 4.:/5 (124 download)
Download or read book Thermodynamics of Ligand Binding and Global Structural Stability of Human Serum Albumin written by and published by . This book was released on 2021 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein structure is integral to its function. For the past 70 years differential scanning calorimetry has been used to measure protein structural stability. More recently it has been used to study macromolecular interactions. Interactions between proteins and ligands can manifest on differential scanning calorimetry melting curves or thermograms. Utilizing differential scanning calorimetry thermograms to detect or diagnose diseases has been a major goal in disease diagnostics. However, correlating specific ligand-protein interactions, as manifested in a thermogram, with a disease-specific plasma thermogram, has proven elusive. Modified human serum albumin was utilized to develop a process to capture and retrieve ligands from plasma. This process was demonstrated for two ligands that bind human serum albumin and subsequently perturb plasma thermograms. Human serum albumin was covalently modified by attachment of biotin to lysine residues. An investigation was performed to determine if modifications of human serum albumin affected the ability of the protein to bind ligands, in order to design better capture reagents. An analytical differential scanning calorimetry method was devised for determining, quantitatively accurate, ligand binding constants to human serum albumin. To further validate our method, an additional 29 drug/ligands were examined to determine their binding constants to human serum albumin.
Author : B.B. Biswas
Publisher : Springer
ISBN 13 : 9781489917294
Total Pages : 436 pages
Book Rating : 4.9/5 (172 download)
Download or read book Proteins: Structure, Function, and Engineering written by B.B. Biswas and published by Springer. This book was released on 2013-05-24 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here, researchers review the latest breakthroughs in protein research. Their contributions explore emerging principles and techniques and survey important classes of proteins that will play key roles in the field's future. Articles examine the possibility of a Boltzman-like distribution in protein substructures, the new technique of Raman spectroscopy, and compact intermediate states of protein folding. This well-illustrated volume also features coverage of proteins that bind nucleic acids.
Author : Li Di
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.0/5 (85 download)
Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Author : Victor M. Rosenoer
Publisher : Elsevier
ISBN 13 : 1483156885
Total Pages : 427 pages
Book Rating : 4.4/5 (831 download)
Download or read book Albumin: Structure, Function and Uses written by Victor M. Rosenoer and published by Elsevier. This book was released on 2014-05-18 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Albumin Structure, Function and Uses reviews the many facets of serum albumin, including its history and evolutionary development, structure and function, synthesis, degradation, distribution and transport, and metabolic behavior. The use, misuse, and abuse of albumin in the treatment of disease are also discussed. This book is comprised of 17 chapters and begins with a commentary on how albumin is used, misused, and abused in the treatment of disease such as peptic ulcer, and a description of the real indications for its use. Concepts in albumin purification are then examined, along with the amino acid sequence of serum albumin and some aspects of its structure and conformational properties. Subsequent chapters explore the phylogenetics of albumin; albumin binding sites; clinical implications of drug-albumin interaction; genetics of human serum albumin; and hepatic synthesis of export proteins. Albumin catabolism and intracellular transport are also considered, together with surgical and clinical aspects of albumin metabolism. This monograph should be a useful resource for biochemists and clinicians.
Author : Martin A. Masuelli
Publisher :
ISBN 13 : 9781536167870
Total Pages : 220 pages
Book Rating : 4.1/5 (678 download)
Download or read book Bovine Serum Albumin written by Martin A. Masuelli and published by . This book was released on 2020-01-07 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serum albumin is a large protein present in cow serum protein (BSA, Bovine Serum Albumin) rich in essential amino acids and compounds with disulfide bridges and thiol groups. This protein passes into breast milk from the bloodstream by diffusion, has antioxidant capacity and protects fats from oxidation. Albumin has the ability to inhibit tumor factors and bind to fat, mobilize them in the body to perform other functions such as obtaining energy or forming membranes. It is also able to block the conversion of angiotensin I into angiotensin II (vasoconstrictor) which gives it antihypertensive action. In addition, it has the ability to reduce cholesterol absorption, complex heavy metals and is an opioid agonist (acts on opioid receptors and promotes analgesia). BSA is the most studied and produced protein worldwide in the last 80 years. This protein brings large dividends to the world economy with a very prominent and favorable annual growth at a cost of 100 USD per gram. This book brings new contributions to the science and industry of this biopolymer. The audience of this book is very wide from students, teachers and researchers (doctors, pharmacists, biochemists and industrialists of this sector). Therefore, this book has a great future and many readers to whom it is addressed.
