Retinoid Therapy

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9401163499
Total Pages : 312 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Retinoid Therapy by : W.J. Cunliffe

Download or read book Retinoid Therapy written by W.J. Cunliffe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The impact of the retinoids in clinical practice has primarily been in dermatology. When Dr Werner Bollag began his basic research and screening programme in the early 1960's, the expectation was that the retinoids would have a major impact on oncology. However, the laboratory and clinical experiences of Bollag and his colleagues in Switzerland, Stuttgen and Orfanos in Germany, led to publications on both etretinates (Tigason) and isotretinoin (Roaccutane) in the years between 1972 and 1976 in the field of dermatology. In fact the first symposium on retinoid research held in Berlin in 1981 was almost entirely dermatological. A year later a retinoid workshop in Iowa was designed to provide a forum for dermatolog ists from the USA involved in specific protocols investigating oral retinoids. In the UK, research into the retinoids began rather later than in Continental Europe or in the USA, although Tigason was first marketed here. It was felt in late 1982 that as many dermatologists had relatively little experience with these compounds it would be appropriate to hold an International Symposium on retinoid therapy in the UK. Thus on 16-18 May 1983 in London, 37 speakers from 11 countries addressed an audience of 300, aminly UK, dermatologists. The scientific organizing committee consisted of but two persons Dr William Cunliffe of Leeds General Infirmary, representing the European Society of Dermatolo gical Research, and myself from Roche Clinical Research. The Symposium was held under the auspices of the ESDR and of Roche Products Limited.

Retinoids in Dermatology

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Author :
Publisher : CRC Press
ISBN 13 : 0429852614
Total Pages : 508 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Retinoids in Dermatology by : Ayse Serap Karadag

Download or read book Retinoids in Dermatology written by Ayse Serap Karadag and published by CRC Press. This book was released on 2019-10-28 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoids are valuable drugs in the dermatologic armamentarium, being employed in daily clinical practice. The text provides an in-depth update on the latest thinking on pharmacology, clinical use, side effects, and follow-up of retinoid therapy in dermatology; it also addresses topics related to retinoid use in special circumstances, such as vulnerable populations, concomitant surgery, and aesthetic procedures. CONTENTS: The background of retinoids * Mechanism of action of vitamin A * Mechanism of action of topical retinoids * Mechanism of action of isotretinoin * Mechanism of action of acitretin * Mechanism of action of bexarotene * Mechanism of action of alitretinoin * Effects of retinoids at the cellular level (differentiation, apoptosis, autophagy, cell cycle regulation, and senescence) * Effects of retinoids at the systemic level * New aspects of isotretinoin teratogenicity * Mucocutaneous side effects * Ophthalmologic side effects * Musculoskeletal side effects * Neurologic side effects * Psychiatric side effects * Gastrointestinal side effects * Endocrine and metabolic side effecs * Other systemic side effects: Cardiovascular, pulmonary, otolaryngorhinologic, genitourinary, renal, and immunologic * Retinoids in acne * Retinoids in hidradenitis suppurativa/acne inversa * Retinoids in rosacea * Retinoids in hair disorders * Retinoids in psoriasis * Retinoids in keratinization disorders * Retinoids in antiaging therapy * Retinoids in other skin diseases * Retinoids in lymphoma * Retinoids in cutaneous chemoprophylaxis * Guide to good clinical practice for vulnerable populations (infancy, childhood, fertile period, elderly) * Retinoids and concomitant surgery * Retinoids and concomitant aesthetic procedures * Laboratory and clinical follow-up * Teratogenicity and registry programs * Management of vitamin A and retinoid side effects * Future and novel unexplored indications of retinoids Published in association with the Journal of Dermatological Treatment.

The Retinoids

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118627903
Total Pages : 608 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis The Retinoids by : Pascal Dollé

Download or read book The Retinoids written by Pascal Dollé and published by John Wiley & Sons. This book was released on 2015-05-18 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.

Retinoids

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Publisher : Springer Science & Business Media
ISBN 13 : 3642680232
Total Pages : 500 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Retinoids by : C.E. Orfanos

Download or read book Retinoids written by C.E. Orfanos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels of both unchanged drug and main metabolite (corre sponding carboxylic acid) were observed up to 140 days after cessation of the therapy. An apparent half-life of elimination of 80-100 days can be calculated. The drug appears to be stored at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are excreted in the bile in high amounts (60-80% of dose). No drug appeared unchanged in the excreta after i. v. administration to rats. References 1. Bollag W (1971) Effects of vitamin A acid (NSC-122758) on transplantable and chemically-induced tumors. Cancer Chemother Rep 55:53-58 2.

Retinoid Therapy

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Author :
Publisher : Kluwer Academic Publishers
ISBN 13 : 9780852007402
Total Pages : 376 pages
Book Rating : 4.0/5 (74 download)

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Book Synopsis Retinoid Therapy by : W. J. CUNLIFFE

Download or read book Retinoid Therapy written by W. J. CUNLIFFE and published by Kluwer Academic Publishers. This book was released on 1983-01-01 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Retinoids, New Trends in Research and Therapy

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Author :
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis Retinoids, New Trends in Research and Therapy by : Jean-Hilaire Saurat

Download or read book Retinoids, New Trends in Research and Therapy written by Jean-Hilaire Saurat and published by S. Karger AG (Switzerland). This book was released on 1985 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Comprehensive Dermatologic Drug Therapy

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323612121
Total Pages : 858 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Comprehensive Dermatologic Drug Therapy by : Stephen E. Wolverton

Download or read book Comprehensive Dermatologic Drug Therapy written by Stephen E. Wolverton and published by Elsevier Health Sciences. This book was released on 2019-12-14 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed with practical usability in mind, Comprehensive Dermatologic Drug Therapy, 4th Edition, helps you safely and effectively treat the skin disorders you’re likely to see in your practice. Dr. Stephen E. Wolverton and new associate editor Dr. Jashin J. Wu lead a team of global experts to bring you concise, complete guidance on today's full spectrum of topical, intralesional, and systemic drugs. You’ll prescribe with confidence thanks to expert coverage of which drugs to use, when to use them, and adverse effects to monitor. Includes new drug interaction tables, drug risk profiles, and FDA guidelines, as well as two new appendices that summarize chapter questions and summarize highest-risk drug interactions. Covers the best uses for new biologic therapeutics. Contains new chapters covering medical decision-making principles, PDE-4 and JAK inhibitors, interleukin 17 inhibitors, interleukin 23 inhibitors, additional biologic therapeutics, and hedgehog pathway inhibitors. Contains quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Features a highly detailed, disease-specific index, as well as purchase information for major drugs. Helps you assess your knowledge and prepare for certification or recertification with about 800 review questions and answers throughout the book.

Retinoids and Carotenoids in Dermatology

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Author :
Publisher : CRC Press
ISBN 13 : 1420021184
Total Pages : 390 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Retinoids and Carotenoids in Dermatology by : Anders Vahlquist

Download or read book Retinoids and Carotenoids in Dermatology written by Anders Vahlquist and published by CRC Press. This book was released on 2007-06-20 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology. Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of

Retinoids in Oncology

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Publisher : CRC Press
ISBN 13 : 9780824790486
Total Pages : 356 pages
Book Rating : 4.7/5 (94 download)

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Book Synopsis Retinoids in Oncology by : Waun Ki Hong

Download or read book Retinoids in Oncology written by Waun Ki Hong and published by CRC Press. This book was released on 1993-05-11 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease site, this book: describes the effects of retinoids on squamous differentiation in normal, pre-malignant, and malignant epithelial tissues; addresses the mechanisms by which cultured keratinocytes respond to retinoids; considers the antitumor activity of combination therapy with retinoids and cytokines; reviews the toxicity profiles of the vitamin A molecule and the synthetically derived retinoid compounds and their effects on humans; examines the use of retinoids in the prevention of basal cell carcinoma and squamous cell carcinoma (SCC) and in the therapy of advanced SCC; and summarizes data on the potential of retinoids to prevent epithelial cancer, to act as adjuvants to current therapies in early stages of the disease and to aid in the management of both solid tumours and hematologic malignancies.;A guide for the many disciplines involved in the preclinical studies and direct care of cancer patients, this book serves as useful reading for clinical, surgical and radiation oncologists; clinical immunologists; dermatologists; obstetricians/gynaecologists; haematologists; otolaryngologists; internists; nutritionists; and pulmonary-disease specialists.

The Retinoids: v. 2

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Author :
Publisher : Academic Press
ISBN 13 : 1483296377
Total Pages : 463 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis The Retinoids: v. 2 by : BAERT ET BAERT ET AL

Download or read book The Retinoids: v. 2 written by BAERT ET BAERT ET AL and published by Academic Press. This book was released on 2014-06-28 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids: v. 2

Retinoids in Oncology

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642797067
Total Pages : 280 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Retinoids in Oncology by : Laurent Degos

Download or read book Retinoids in Oncology written by Laurent Degos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments with respect to the biology and clinical use of retinoids in cancer therapy and prevention are comprehensively covered by experts in this new field. Newer aspects of molecular mechanisms of retinoid effects, the cellular biology and the developmental effects of these compounds are presented together with a comprehensive description of the latest findings of retinoid pharmacology, toxicology and clinical effects in a wide range of hematological and solid malignancies.

The Retinoids

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118628276
Total Pages : 608 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis The Retinoids by : Pascal Dollé

Download or read book The Retinoids written by Pascal Dollé and published by John Wiley & Sons. This book was released on 2015-04-13 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.

Cosmetic Dermatology

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Publisher : John Wiley & Sons
ISBN 13 : 1118655486
Total Pages : 560 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Cosmetic Dermatology by : Zoe Diana Draelos

Download or read book Cosmetic Dermatology written by Zoe Diana Draelos and published by John Wiley & Sons. This book was released on 2015-10-08 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Back for a new edition, Zoe Draelos' outstanding resource to cosmetic dermatology again provides a highly-illustrated, clinical guide to the full range of cosmetic skin treatments. Bringing together experts from research, industry, surgery and practice, it is structured in four distinct parts for easy navigation by the busy clinician: Basic Concepts - giving an overview of the physiology pertinent to cosmetic dermatology and the delivery systems by which treatments can take effect; Hygiene Products - evaluating cleansing and moisturising products; Adornment - looking at aesthetic techniques such as cosmetics, nail protheses and hair treatment; Antiaging - ie, injectables, resurfacing and skin contouring techniques, and the rapidly growing area of Cosmeceuticals. With over 300 high-quality images and key summary boxes throughout, this new edition incorporates the newest procedural innovations in this rapidly developing field. Perfect for all dermatologists, especially those specialising in cosmetic dermatology and whether hospital-based or in private practice, it provides the complete cosmetic regimen for your patients and will be an indispensable tool to consult over and over again.

Advances in Psoriasis

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Publisher : Springer
ISBN 13 : 1447144325
Total Pages : 337 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Advances in Psoriasis by : Jeffrey M. Weinberg

Download or read book Advances in Psoriasis written by Jeffrey M. Weinberg and published by Springer. This book was released on 2014-08-28 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has become increasingly clear that psoriatic disease, both of the skin and joints, can be a significant diagnostic and therapeutic challenge for the physician and a debilitating illness for the patient. Genetic and immunologic advances have increased our understanding of the pathophysiology of psoriasis and psoriatic arthritis and there is a need for practically oriented evidence based references to describe the management options open to clinicians. The speed at which developments are occurring in the field also necessitates a novel approach to keeping up with these changes in practice and the need is for a reference that that be updated regularly as the subject requires. Psoriasis is an incredibly fast-moving discipline within dermatology. Guidelines, treatment options and management all change at incredible speed. There is a requirement to provide a comprehensive reference resource to provide practical, user friendly information for the dermatology profession to aid in the decision-making process. Psoriasis is a graphical subdiscipline of medicine and therefore this will have copious illustrations. As a fast moving discipline the emphasis must be on annual updates to ensure that readers are kept up to date on the important areas of development.

Retinoids

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Author :
Publisher : IARC
ISBN 13 : 9789283230045
Total Pages : 360 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Retinoids by : IARC Working Group on the Evaluation of Cancer-preventive Agents

Download or read book Retinoids written by IARC Working Group on the Evaluation of Cancer-preventive Agents and published by IARC. This book was released on 1999 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug-Induced Liver Disease

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Author :
Publisher : CRC Press
ISBN 13 : 0203909127
Total Pages : 790 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Drug-Induced Liver Disease by : Neil Kaplowitz

Download or read book Drug-Induced Liver Disease written by Neil Kaplowitz and published by CRC Press. This book was released on 2002-10-16 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.

Hepatotoxicity

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Author :
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 848 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.