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Author : Willis H. Riesen
Publisher :
ISBN 13 :
Total Pages : 88 pages
Book Rating : 4.3/5 ( download)
Download or read book Research on Oxygen Toxicity at the Cellular Level written by Willis H. Riesen and published by . This book was released on 1966 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Olen R. Brown
Publisher :
ISBN 13 :
Total Pages : 32 pages
Book Rating : 4.:/5 (227 download)
Download or read book Mechanisms of Oxygen Toxicity at the Cellular Level written by Olen R. Brown and published by . This book was released on 1982 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies using vitamins, precursors, and intermediates with analysis of carbohydrate, amino acid, lipid, protein, RNA and DNA synthesis and of enzyme activities in suspected pathways support the following events during oxygen intoxication of Escherichia coli. Biosynthesis of several amino acids are inhibited. Within less than 5 minutes valine is limiting for protein synthesis (subsequently 9 other amino acids become limiting). The resultant unloaded tRNA's stimulate the 'stringent response' (production of the powerful inhibitor guanosine tetraphosphate) which completely stops biosynthesis. Some of these sites (including quinolinate phosphoribosyl transferase, required for NAD synthesis) should be relevant to man. The data suggest that the vitamins thiamin pyrophosphate and niacin should be tested as potential protective agents against the toxicity in man of oxygen and of chemicals which produce cellular oxidative stress.
Author : Willis H. Riesen
Publisher :
ISBN 13 :
Total Pages : 84 pages
Book Rating : 4.3/5 (91 download)
Download or read book Research on Oxygen Toxicity at the Cellular Level written by Willis H. Riesen and published by . This book was released on 1966 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of pure oxygen atmospheres at reduced pressure in manned spacecraft has stimulated new research interest. Exposure of humans to pure oxygen at total pressures of 5 to 7 psia for up to 30 days has generally produced only subjective and occasional symptomatic distress. Nevertheless, studies with animals have clearly documented toxicity if the exposure to pure oxygen is at higher total pressures. The selection of suitable oxygen atmospheres for manned space flight and the development of protective measures against toxic manifestations will be considerably facilitated by a clearer understanding of the toxic syndrome. Rats, dogs, and monkeys were exposed to pure (98.5%) oxygen at 1 atm and 1/3 atm in a closed, recirculating chamber and in a nonrecirculating chamber. Rats exposed to a pressure of 1 atm showed significant reduction in efficiency of liver mitochondrial oxidative phosphorylation. Weight loss accompanied this change. Insignificant changes were found in liver or lung mitochondrial oxygen consumption; liver or lung NAD, NADH, or NAD/NADH; and arterial blood lactate and pyruvate, and lactate/pyruvate ratio. A composite index of oxygen toxicity was derived from a multivariant data analysis. Exposure of rats to pure oxygen at 1/3 atm showed slight elevation in P/O ratio in 7 days. The ratio returned to normal in 2 weeks and remained so for 8 months. No significant weight changes were observed. Only preliminary experiments with the dogs and monkeys were conducted, therefore no conclusions can as yet be made. There is an indication that monkeys are more resistant to oxygen toxicity at 1 atm than rats.
Author : D. Danon
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.3/5 ( download)
Download or read book Influence of Oxygen Toxicity on the Rate of Red Cell Aging written by D. Danon and published by . This book was released on 1967 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roland N. Pittman
Publisher : Biota Publishing
ISBN 13 : 1615047212
Total Pages : 117 pages
Book Rating : 4.6/5 (15 download)
Download or read book Regulation of Tissue Oxygenation, Second Edition written by Roland N. Pittman and published by Biota Publishing. This book was released on 2016-08-18 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Author : Olen R. Brown
Publisher :
ISBN 13 :
Total Pages : 36 pages
Book Rating : 4.:/5 (227 download)
Download or read book Mechanisms of Oxygen Toxicity at the Cellular Level written by Olen R. Brown and published by . This book was released on 1972 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most significant finding has been the demonstration that even five minute exposures to oxygen at four atmospheres produces a severe, but reversible (upon removal from hyperoxia), inhibition of active transport of glucose, using Escherichia coli as a model cell system. Experimental data is so far consistent with the current operating theory that a site in membrane transport is the primary target in acute oxygen toxicity at the cell level. The inhibition of transport apparently is not due to lack of energy (ATP) for transport, nor to oxidative destruction of the membrane, but the true mechanism is unknown. (Modified author abstract).
Author : O. R. Brown
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.:/5 (227 download)
Download or read book Mechanisms of Oxygen Toxicity at the Cellular Level written by O. R. Brown and published by . This book was released on 1978 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygen at elevated pressures is toxic for life forms from microbes to man. Growth is inhibited in Escherichia coli and results primarily from poisoning of specific enzymes in the following biosynthetic pathways: branched-chain and aromatic amino acids, NAD-niacin, phosphoribosylpyrosphosphate (PRPP) and reverse glycolysis. Inhibition of amino acid biosynthesis indirectly stops protein synthesis and induces 'stringency' (production of pp-guainine-pp, a powerful inhibitor of metabolic processes) which accounts for inhibition in metabolic processes where there is no observed enzymatic poisoning. Inhibitions in the PRPP, NAD-niacin, and reverse glycolysis pathways are significant to bacterial (and perhaps to human) oxygen toxicity where products of the pathways protect. (Summary, p. 2-3)
Author : Tom S. Neuman
Publisher : Elsevier Health Sciences
ISBN 13 : 1416034064
Total Pages : 637 pages
Book Rating : 4.4/5 (16 download)
Download or read book Physiology and Medicine of Hyperbaric Oxygen Therapy written by Tom S. Neuman and published by Elsevier Health Sciences. This book was released on 2008-06-05 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized leaders in hyperbaric oxygen therapy (HBOT) research and practice, this exciting new book provides evidence-based, practical, useful information for anyone involved in HBOT. It outlines the physiologic principles that constitute the basis for understanding the clinical implications for treatment and describes recent advances and current research, along with new approaches to therapy. This book is an essential tool for anyone who cares for patients with difficult-to-heal wounds, wounds from radiation therapy, carbon monoxide poisoning, and more. Provides comprehensive coverage of pathophysiology and clinically relevant information so you can master the specialty. Covers the relevance of HBOT in caring for diverse populations including critical care patients, infants and pediatric patients, and divers. Features a section on the technical aspects of HBOT to provide insight into the technology and physics regarding HBO chambers. Presents evidence to support the effectiveness of HBOT as well as the possible side effects. Describes situations where HBOT would be effective through indication-specific chapters on chronic wounds, radiation and crush injuries, decompression sickness, and more.
Author : Lawrence J. Berliner
Publisher : Springer Nature
ISBN 13 : 303047318X
Total Pages : 237 pages
Book Rating : 4.0/5 (34 download)
Download or read book Measuring Oxidants and Oxidative Stress in Biological Systems written by Lawrence J. Berliner and published by Springer Nature. This book was released on 2020-08-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Author : Jack D. Hackney
Publisher :
ISBN 13 :
Total Pages : 181 pages
Book Rating : 4.:/5 (326 download)
Download or read book Study of Effects of Oxygen Toxicity on Lung Cell Division written by Jack D. Hackney and published by . This book was released on 1974 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Giuseppe Buonocore
Publisher : Springer
ISBN 13 : 9783319294872
Total Pages : 0 pages
Book Rating : 4.2/5 (948 download)
Download or read book Neonatology written by Giuseppe Buonocore and published by Springer. This book was released on 2018-10-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addition, detailed information is provided on epidemiology and fetal medicine; therapeutic issues such as the organization of care, transport services, and home care after discharge; legal issues; nutrition; and the consequences of medication use during pregnancy, maternal drug abuse and smoking, and maternal diabetes. The inclusion of summaries, tables, and carefully selected guidelines and recommendations will supply practitioners with quick references and instant solutions during daily practice. The book will be a superb resource for all involved in the care of newborn babies, including neonatologists, pediatricians, pediatric surgeons, anesthesiologists, midwives, and nursing staff. It is published within the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.
Author : Loutfy H. Madkour
Publisher : Academic Press
ISBN 13 : 0128224967
Total Pages : 782 pages
Book Rating : 4.1/5 (282 download)
Download or read book Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms written by Loutfy H. Madkour and published by Academic Press. This book was released on 2020-06-27 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. - Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress - Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention - Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress - Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment
Author : Eduardo Bancalari
Publisher : Elsevier Health Sciences
ISBN 13 : 0323568750
Total Pages : 464 pages
Book Rating : 4.3/5 (235 download)
Download or read book The Newborn Lung written by Eduardo Bancalari and published by Elsevier Health Sciences. This book was released on 2018-06-19 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today’s practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. Stay fully up to date in this fast-changing field with The Newborn Lung, 3rd Edition. The most current clinical information throughout, including key management strategies that may reduce some of the chronic sequelae of neonatal respiratory failure. New content on the role of microbiome in lung injury and lung development. Current coverage of non-invasive respiratory support, perinatal events and their influence on lung development and injury, cell-based lung therapy, automation of respiratory support, and oxygenation targeting in preterm infants. Consistent chapter organization to help you find information quickly and easily. The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set! Gastroenterology and Nutrition Hematology, Immunology and Genetics Hemodynamics and Cardiology Infectious Disease and Pharmacology New Volume! Nephrology and Fluid/Electrolyte Physiology Neurology The Newborn Lung
Author : D.L. Gilbert
Publisher : Springer Science & Business Media
ISBN 13 : 1461258901
Total Pages : 414 pages
Book Rating : 4.4/5 (612 download)
Download or read book Oxygen and Living Processes written by D.L. Gilbert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of oxygen study is immense. No single work on the subject can be comprehensive, and this volume makes no such claim. Indeed, coverage here is selective and the selection is somewhat personal. However, the choice of topics is vast There are chapters on the history of oxygen, oxygen in the universe, the biochemistry of oxygen, and clinical uses of oxygen. An alternate title could have been, "Some things you always wanted to know about oxygen, but didn't know where to find them easily." Some information in this wide-ranging work can not be found elsewhere. This book is intended not only for specialists, but also for nonspecialists engaged in or curious about any field of oxygen study, particularly if they wish to know more about other fields of oxygen. Thus, those who are interested in oxygen and are historians, astronomers, chemists, geochemists, evolutionists, biochemists, physiolo gists, pathologists, or clinicians will find here much of extreme value. It is intended to be read and understood at the graduate or advanced undergraduate level. This volume is divided into four parts. The first constitutes the background for Parts II and III, and the last integrates the preceding material with an overall perspective on oxygen in living organisms.
Author : Joseph Priestley
Publisher :
ISBN 13 :
Total Pages : 112 pages
Book Rating : 4.:/5 (42 download)
Download or read book The Discovery of Oxygen written by Joseph Priestley and published by . This book was released on 1894 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Donegan
Publisher : CRC Press
ISBN 13 : 9814316059
Total Pages : 250 pages
Book Rating : 4.8/5 (143 download)
Download or read book Cadmium Telluride Quantum Dots written by John Donegan and published by CRC Press. This book was released on 2013-12-03 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last two decades, semiconductor quantum dots—small colloidal nanoparticles—have garnered a great deal of scientific interest because of their unique properties. Among nanomaterials, CdTe holds special technological importance as the only known II–VI material that can form conventional p–n junctions. This makes CdTe very important for the development of novel optoelectronic devices such as light-emitting diodes, solar cells, and lasers. Moreover, the demand for water-compatible light emitters and the most common biological buffers give CdTe quantum dots fields a veritable edge in biolabeling and bioimaging. Cadmium Telluride Quantum Dots: Advances and Applications focuses on CdTe quantum dots and addresses their synthesis, assembly, optical properties, and applications in biology and medicine. It makes for a very informative reading for anyone involved in nanotechnology and will also benefit those scientists who are looking for a comprehensive account on the current state of quantum dot–related research.
Author : Eric P. Kindwall
Publisher :
ISBN 13 :
Total Pages : 994 pages
Book Rating : 4.:/5 (318 download)
Download or read book Hyperbaric Medicine Practice written by Eric P. Kindwall and published by . This book was released on 1999 with total page 994 pages. Available in PDF, EPUB and Kindle. Book excerpt:
