Research Methods In Neurochemistry Vol 5

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Research Methods in Neurochemistry

Author : Neville Marks
Publisher : Springer Science & Business Media
ISBN 13 : 1461577489
Total Pages : 376 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Research Methods in Neurochemistry by : Neville Marks

Download or read book Research Methods in Neurochemistry written by Neville Marks and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: On picking up this first volume of a new series of books the reader may ask the two questions: (a) why research methods? and (b) why in neurochem istry? The answers to these questions are easy - they more than justify the volumes to come and show the strong need for their existence. It is customary to think of methods as a necessary but unexciting means to an end - to relegate advances in methodology to a minor role in the creative, original portion of advances in science. This is not the case; the pace-setting function of methodology is well illustrated in most areas of neurobiology. To formulate our questions to Nature (which is the essence of experimental design), methodology is needed; to get answers to our ques tions we have to devise yet new methods. The chapters of the present volume fully illustrate how the development of a new method can cut a new path how it can open new fields, just as the microscope founded histology. Heter ogeneity of structures presents a formidable challenge for methodology in the nervous system, yet methods for separating the structures are essential if we ever want to decipher the enigma of functional contribution of the ele ments to the whole. The problem is not only physical separation-clearly methods are essential to study complex structures in situ.

Research Methods in Neurochemistry

Author : Neville Marks
Publisher : Springer Science & Business Media
ISBN 13 : 1461577578
Total Pages : 325 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Research Methods in Neurochemistry by : Neville Marks

Download or read book Research Methods in Neurochemistry written by Neville Marks and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fifth volume of Research Methods in Neurochemistry represents a milestone in that it marks almost a decade since the inception of the series. Over these ten years there has been an almost exponential growth in neuro chemistry accompanied by numerous technical developments. This is the justification for our series; inevitably we have only been able to cover a frac tion of the methodological innovations of the last decade, but we have tried as much as possible to create a balance between the different approaches and philosophies in the study of the chemical basis of brain function. Thus our original format of grouping chapters under various headings-for instance, studies in intact tissues as distinct from studies describing constituents and isolated enzymes-appears to be justified. Studies on whole animals or tissues retaining cellular organization are vital in providing insights into the neurochemical mechanism underlying functional processes; at the same time, the eventual understanding of function can only be attained on the basis of knowledge of the molecular architecture of the tissue. In the present volume, Oldendorfs chapter on the transport of radiolabeled metabolites across the blood-brain barrier illustrates one side of this equation, whereas Poduslo's chapter on the separation of oligo dendroglia! cells provides new information on the role of these cells in myelogenesis and the distinctive chemical composition of glia as compared to neurons.

Research Methods in Neurochemistry, Vol. 5

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)

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Download or read book Research Methods in Neurochemistry, Vol. 5 written by and published by . This book was released on 1981 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Methods in Neurochemistry

Author : Neville Marks
Publisher : Springer Science & Business Media
ISBN 13 : 1461577519
Total Pages : 422 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Research Methods in Neurochemistry by : Neville Marks

Download or read book Research Methods in Neurochemistry written by Neville Marks and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Section I Ultrastructure and Fragmentation of Neural Tissue.- 1 Bulk Separation of Neuronal Cell Bodies and Glial Cells in the Absence of Added Digestive Enzymes.- I. Introduction.- II. Bulk Isolation Procedures Requiring No Added Digestive Enzyme(s).- A. The Procedure Developed in the Authors' Laboratory.- B. The Procedure of Nagata et al. (1971).- C. The Procedure of Iqbal and Tellez-Nagel (1972).- D. The Procedure of Jones et al. (1971).- III. General Procedural Comments.- IV. Cell Yield and Biochemical Characterization.- V. Applications in Cellular Neurochemistry.- A. Centrifugal Fractiona.

Research Methods in Neurochemistry, Vol 1

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)

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Download or read book Research Methods in Neurochemistry, Vol 1 written by and published by . This book was released on 1972 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Methods in Neurochemistry

Author : Neville Marks
Publisher : Springer
ISBN 13 : 9781461577614
Total Pages : 372 pages
Book Rating : 4.5/5 (776 download)

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Book Synopsis Research Methods in Neurochemistry by : Neville Marks

Download or read book Research Methods in Neurochemistry written by Neville Marks and published by Springer. This book was released on 2012-10-20 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Methods in Neurochemistry

Author : Neville Marks
Publisher : Springer Science & Business Media
ISBN 13 : 1461344581
Total Pages : 476 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Research Methods in Neurochemistry by : Neville Marks

Download or read book Research Methods in Neurochemistry written by Neville Marks and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the continued rapid expansion of neurochemical research, there has been no shortage of new developments in methodology for this third volume of Research Methods in Neurochemistry. As in previous volumes we have again tried to provide some balance in the subjects represented. The wisdom of this policy may be questioned since it can lead to delay in publica tion, but there are many approaches to the chemical study of the nervous system and a methods book needs to stand on its own as well as be part of a series. In one respect, however, the present volume departs from this policy, in that we have included two chapters on micromethods for analyzing amines and amino acids, both giving special emphasis to dansylation techniques. These chapters are complementary and we feel justified in publishing them in one volume in view of the importance of such micromethods for the study of neural systems. At the other end of the scale, particular attention may be drawn to the chapter by D. D. Gilboe and colleagues describing their remarkable procedures for studying metabolism in the isolated canine brain. We were fortunate also in persuading S. S. Oja to extend the general prin ciples of transport systems he described in Volume 2 to amino acids in brain slices. In addition, there are the usual chapters on components of neural tissues, which once again we have found convenient to divide into enzymes, macromolecules, and other constituents.

Research Methods in Neurochemistry

Author : Neville Marks
Publisher : Springer Science & Business Media
ISBN 13 : 1461577543
Total Pages : 450 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Research Methods in Neurochemistry by : Neville Marks

Download or read book Research Methods in Neurochemistry written by Neville Marks and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth volume of Research Methods in Neurochemistry includes chapters on different aspects of topics touched on in previous volumes and develops a number of new themes as well. The bias, though not entirely intended, is directed toward studies of macromolecules, both at the meta bolic level in relation to protein synthesis and at the structural level in rela tion to specific proteins and lipids. The new departures concern subjects in Section I with marked applied bias: biochemical studies of nervous system tumors and of the cerebrospinal fluid, both of which we hope will be of value to clinical as well as basic scientists. Biogenic amines and the enzymes involved in their metabolism figure again in Section II, where the powerful tool of mass spectrometry receives further treatment in relation to the analysis of dansyl derivatives of trace amines in the brain. Once again we remain grateful to the individual authors, both for their contributions and patience, and to Plenum Press for their continued interest and cooperation. Thanks are also due to colleagues and friends for their comments and criticisms on the series as a whole; suggestions for future volumes will always be welcome and should be sent to one of the editors. Richard Rodnight, London Neville Marks, New York March 1978 ix Contents Section I PROPERTIES OF INTACT NEURAL TISSUES Chapter 1 Biochemical Study of Tumors of the Nervous System. . . . . . . . . . . . . . . . 3 Norman Allen I. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 II. Human Brain Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 A. Autopsy Specimens. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Research Methods in Neurochemistry

Author : Neville Marks
Publisher :
ISBN 13 : 9781461577522
Total Pages : 436 pages
Book Rating : 4.5/5 (775 download)

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Book Synopsis Research Methods in Neurochemistry by : Neville Marks

Download or read book Research Methods in Neurochemistry written by Neville Marks and published by . This book was released on 2014-09-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Methods in Neurochemistry

Author : Neville Marks
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.:/5 (117 download)

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Download or read book Research Methods in Neurochemistry written by Neville Marks and published by . This book was released on 1981 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guide to Research Techniques in Neuroscience

Author : Matt Carter
Publisher : Academic Press
ISBN 13 : 0323915612
Total Pages : 416 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Guide to Research Techniques in Neuroscience by : Matt Carter

Download or read book Guide to Research Techniques in Neuroscience written by Matt Carter and published by Academic Press. This book was released on 2022-03-26 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more Clear, straightforward explanations of each technique for anyone new to the field A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture Detailed recommendations on where to find protocols and other resources for specific techniques "Walk-through" boxes that guide readers through experiments step-by-step

Research Methods in Neurochemistry, V.6

Author : Neville Marks
Publisher :
ISBN 13 :
Total Pages : 372 pages
Book Rating : 4.:/5 (117 download)

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Book Synopsis Research Methods in Neurochemistry, V.6 by : Neville Marks

Download or read book Research Methods in Neurochemistry, V.6 written by Neville Marks and published by . This book was released on 1985 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Methods in Neurochemistry

Author : Neville Marks
Publisher : Springer
ISBN 13 : 9780306360015
Total Pages : 368 pages
Book Rating : 4.3/5 (6 download)

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Book Synopsis Research Methods in Neurochemistry by : Neville Marks

Download or read book Research Methods in Neurochemistry written by Neville Marks and published by Springer. This book was released on 1995-12-31 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: On picking up this first volume of a new series of books the reader may ask the two questions: (a) why research methods? and (b) why in neurochem istry? The answers to these questions are easy - they more than justify the volumes to come and show the strong need for their existence. It is customary to think of methods as a necessary but unexciting means to an end - to relegate advances in methodology to a minor role in the creative, original portion of advances in science. This is not the case; the pace-setting function of methodology is well illustrated in most areas of neurobiology. To formulate our questions to Nature (which is the essence of experimental design), methodology is needed; to get answers to our ques tions we have to devise yet new methods. The chapters of the present volume fully illustrate how the development of a new method can cut a new path how it can open new fields, just as the microscope founded histology. Heter ogeneity of structures presents a formidable challenge for methodology in the nervous system, yet methods for separating the structures are essential if we ever want to decipher the enigma of functional contribution of the ele ments to the whole. The problem is not only physical separation-clearly methods are essential to study complex structures in situ.

From Molecules to Networks

Author : Ruth Heidelberger
Publisher : Academic Press
ISBN 13 : 0080920837
Total Pages : 654 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis From Molecules to Networks by : Ruth Heidelberger

Download or read book From Molecules to Networks written by Ruth Heidelberger and published by Academic Press. This book was released on 2009-01-27 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook Discusses emerging new understanding of non-classical molecules that affect neuronal signaling Full colour, professional graphics throughout Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer’s disease

Neural Membranes

Author : Grace Y. Sun
Publisher : Springer Science & Business Media
ISBN 13 : 1461256364
Total Pages : 579 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Neural Membranes by : Grace Y. Sun

Download or read book Neural Membranes written by Grace Y. Sun and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most active and productive areas of biological science in the past decade has been the study of the biochemical and biophysical prop erties of cell membranes. There is little doubt that membranes are essen tial components of all cellular systems and that each type of membrane manifests specific and characteristic cellular functions. In the nervous system, important events such as neurotransmission, receptor binding, ion transport, axonal transport, and cell uptake are all known to take place within the neural cell membrane. Phospholipids, one of the major components of membranes, not only provide the membrane with its structural integrity and physical proper ties, but also play an important role in regulating membrane function. Attention has recently been focused on the asymmetric localization of these molecules, the identification of discrete metabolic pools of phospholipids within the membrane matrix, and their involvement in sig nal transmission. Although synaptic membranes generally lack an active mechanism for the de novo biosynthesis of phospholipids, a number of enzymic routes are present for their interconversions and for facilitating metabolic turnover. Metabolites generated during the interconversion reactions may also exert a great influence in modulating membrane func tions. The phosphogylcerides of neural membranes are especially enriched in polyunsaturated fatty acids. However, only very small amounts of these fatty acids are present in the free form, and they are maintained in dynamic equilibrium with the membrane phospholipids.

Structural Elements of the Nervous System

Author : Abel Lajtha
Publisher : Springer Science & Business Media
ISBN 13 : 1468445863
Total Pages : 725 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Structural Elements of the Nervous System by : Abel Lajtha

Download or read book Structural Elements of the Nervous System written by Abel Lajtha and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurochemistry, having the objective of elucidating biochemical processes subserving nervous activity, emerged as an application of chemistry to the of neurobiological problems as a post-World War II phenomenon. investigation However, only in the last 40 years has the chemical community recognized neurochemistry as a distinct, if hybrid, discipline. During this period great strides have been made. However, recently neurochemistry, along with neu rophysiology, neuropharmacology, neuroanatomy, and the behavioral sci ences, has emerged to form neuroscience, a new community of scientists with its own national society, journals, and meetings. Actually, this recently formed hybrid, neuroscience, is in the process of merging with another well-established discipline, molecular genetics (frequently called molecular biology, and itself a hybrid), which appears to have sufficient hybrid vigor to form yet a new community of scientists, which, for want of a more imaginative term, has been called molecular genetic neuroscience. Clearly, advantages resulting from such mergers or hybridizations accrue not only from the merging discipline (neurochemistry in this case) to the new community (molecular genetic neuroscience), but also in the reverse direction. This Foreword will be concerned primarily with examples of this latter process.

From Molecules to Networks

Author : John H. Byrne
Publisher : Academic Press
ISBN 13 : 0123982677
Total Pages : 692 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis From Molecules to Networks by : John H. Byrne

Download or read book From Molecules to Networks written by John H. Byrne and published by Academic Press. This book was released on 2014-05-23 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches 80% updated and new content New Chapter on "Biophysics of Voltage-Gated Ion Channels" New Chapter on "Synaptic Plasticity" Includes a chapter on the Neurobiology of Disease Highly referenced, comprehensive and quantitative Full color, professional graphics throughout All graphics are available in electronic version for teaching purposes