Replacement Reduction And Refinement Of Animal Experiments In The Development And Control Of Biological Products

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Replacement, Reduction and Refinement of Animal Experiments in the Development and Control of Biological Products

Author : Fred Brown
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Replacement, Reduction and Refinement of Animal Experiments in the Development and Control of Biological Products by : Fred Brown

Download or read book Replacement, Reduction and Refinement of Animal Experiments in the Development and Control of Biological Products written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 1996 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past, animal experimentation has played an important part in the development and quality control of immunobiological products. These days, however, concern about animal welfare is growing and, consequently, increasing emphasis is placed on the use of in vitro methods. This book reports the proceedings of a symposium held at the Paul Ehrlich Institute in Langen, Germany, in November 1994, at which the application of the three Rs principle - replacement, reduction and refinement of the use of animal experiments - was evaluated and recommendations were given. A review of the history of animal experimentation is followed by reports of various international organizations (including the European Pharmacopoeia and the World Health Organization) about their activities with respect to upholding the three Rs principle. It is shown that significant progress has been made in the last few years in the fields of pyrogen testing, hormones, blood products and vaccines. Several new in vitro methods for potency, efficacy and safety testing of vaccines are presented and discussed. General problems such as harmonization, statistics and validation, serological methods and cell cultures are also addressed. Demonstrating that sound science and animal welfare are not irreconcilable, this volume is a valuable resource for all those concerned with the development and manufacture of biological products.

The Principles of Humane Experimental Technique

Author : William Moy Stratton Russell
Publisher : Hyperion Books
ISBN 13 :
Total Pages : 256 pages
Book Rating : 4.U/5 (183 download)

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Book Synopsis The Principles of Humane Experimental Technique by : William Moy Stratton Russell

Download or read book The Principles of Humane Experimental Technique written by William Moy Stratton Russell and published by Hyperion Books. This book was released on 1992 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Animal Experimentation: Working Towards a Paradigm Change

Author : Kathrin Herrmann
Publisher : BRILL
ISBN 13 : 9004391193
Total Pages : 749 pages
Book Rating : 4.0/5 (43 download)

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Book Synopsis Animal Experimentation: Working Towards a Paradigm Change by : Kathrin Herrmann

Download or read book Animal Experimentation: Working Towards a Paradigm Change written by Kathrin Herrmann and published by BRILL. This book was released on 2019-04-30 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Alternatives to Animals in the Development and Control of Biological Products for Human and Veterinary Use

Author : Fred Brown
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Alternatives to Animals in the Development and Control of Biological Products for Human and Veterinary Use by : Fred Brown

Download or read book Alternatives to Animals in the Development and Control of Biological Products for Human and Veterinary Use written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 1999 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the use of alternative in vitro reduction and refinement methods in the development and control of biological products has increased considerably in the last few years. The issues raised are of concern to the scientific community as well as to manufacturers, regulatory authorities and those involved in animal ethics and welfare. A large number of physicochemical, immunochemical, biochemical and cell biological methods have been proposed for the replacement, reduction and refining of animal tests in the development and control of human and veterinary vaccines and other biological products. However, the implementation, validation and ultimate regulatory acceptance of these procedures are still at a very early stage. This volume contains the proceedings of a meeting, which brought together research scientists, manufacturers and regulators with the aim of promoting an exchange of scientific knowledge and increasing awareness of the importance of validation studies.

Advancing Science and Elimination of the Use of Laboratory Animals for the Development and Control of Vaccines and Hormones

Author : Fred Brown
Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783805575096
Total Pages : 360 pages
Book Rating : 4.5/5 (75 download)

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Book Synopsis Advancing Science and Elimination of the Use of Laboratory Animals for the Development and Control of Vaccines and Hormones by : Fred Brown

Download or read book Advancing Science and Elimination of the Use of Laboratory Animals for the Development and Control of Vaccines and Hormones written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 2002 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation plays a major role in the development and control of biological products and large numbers of animals are used for routine batch control. During the past few years considerable attention has been paid to the concept of replacing, reducing and refining (the three Rs) the use of animals for this purpose. This volume contains the proceedings of an international meeting held in Utrecht in November 2001 in which the problems associated with applying the three Rs were discussed. Particular emphasis was given to the validation and regulatory acceptance of in vitro methods and new concepts of quality control. Those issues are important for the scientific community at large as well as manufacturers, regulatory authorities and everyone concerned with animal welfare.

Reducing, Refining and Replacing the Use of Animals in Toxicity Testing

Author : David G. Allen
Publisher : Royal Society of Chemistry
ISBN 13 : 1849736529
Total Pages : 386 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Reducing, Refining and Replacing the Use of Animals in Toxicity Testing by : David G. Allen

Download or read book Reducing, Refining and Replacing the Use of Animals in Toxicity Testing written by David G. Allen and published by Royal Society of Chemistry. This book was released on 2013 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thought-provoking book describes the ever-expanding "toolbox" of methods now available to reduce, refine, or replace animal usage in toxicity testing.

Advancing Science and Elimination of the Use of Laboratory Animals for the Development and Control of Vaccines and Hormones

Author : Fred Brown
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Advancing Science and Elimination of the Use of Laboratory Animals for the Development and Control of Vaccines and Hormones by : Fred Brown

Replacement, Reduction and Refinement of Animal Testing in the Quality Control of Human Vaccines

Author :
Publisher :
ISBN 13 : 9789279541742
Total Pages : 23 pages
Book Rating : 4.5/5 (417 download)

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Book Synopsis Replacement, Reduction and Refinement of Animal Testing in the Quality Control of Human Vaccines by :

Download or read book Replacement, Reduction and Refinement of Animal Testing in the Quality Control of Human Vaccines written by and published by . This book was released on 2015 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines are recognised as a highly cost effective tool for preventing infectious diseases. They are derived from biological sources and due to the complexity of composition and heterogeneity of products, vaccine lots undergo legally required quality control before they are released. Traditionally, laboratory animals have played an important role in quality control of vaccines and still, many laboratory animals are used in Europe for this purpose. Over the last decades, Replacement, Reduction and Refinement (3Rs) methods to classical animal tests have been developed by control authorities, academia and vaccine manufacturers. The purpose of this report is to inform the EURL ECVAM stakeholders on ongoing activities in development and validation of 3Rs methods for the quality control of vaccines for human use. The focus of the report is on methods for lot release testing (e.g. safety, pyrogenicity, potency) and projects related to the implementation of the consistency approach to established vaccines such as diphtheria, tetanus, pertussis and rabies vaccines.

Animals in Biomedical Research

Author : Coenraad F. M. Hendriksen
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 316 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Animals in Biomedical Research by : Coenraad F. M. Hendriksen

Download or read book Animals in Biomedical Research written by Coenraad F. M. Hendriksen and published by Elsevier Publishing Company. This book was released on 1991 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This selection of articles reflects the growing concern for experimental animals and the continuing moral dilemma surrounding the use of animals in research. The increase in knowledge, improvement of health care and creation of useful products that is derived from experimentation on animals, carries the cost of pain and distress that the animals experience, but if such experimentation was not carried out, the alleviation of suffering in the longterm for both man and animals would not be possible. This book addresses on a technical and scientific level, the obligations that man has to animals and to their welfare. It provides insight and information on the high level of professionalism required in the handling of research animals and discusses whether the use of animals in research could be reduced, replaced or refined so as to limit distress. Experimental scientists will find the articles of interest in their endeavor to minimise distress by improving the scientific quality of experimental work.

Alternatives to Animal Testing

Author : Hajime Kojima
Publisher : Springer
ISBN 13 : 9811324476
Total Pages : 130 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Alternatives to Animal Testing by : Hajime Kojima

Download or read book Alternatives to Animal Testing written by Hajime Kojima and published by Springer. This book was released on 2018-12-27 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.

Alternatives to Animal Testing

Author : Michael Balls
Publisher : Royal Society of Chemistry
ISBN 13 : 0854042113
Total Pages : 137 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Alternatives to Animal Testing by : Michael Balls

Download or read book Alternatives to Animal Testing written by Michael Balls and published by Royal Society of Chemistry. This book was released on 2006 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the industries involved. Alternatives to Animal Testing, written by leading experts in the field, discusses the issues involved and approaches that can be taken. Topics include; the safety evaluation of chemicals, international validation and barriers to the validation of alternative tests, in vitro testing for endocrine disruptors, intelligent approaches to safety evaluation of chemicals, alternative tests and the regulatory framework. The book provides an up-to-date discussion of the current state of development of alternatives to animal testing and is ideal for professionals and academics in the field. It would also be of use for graduate students wishing to pursue a career in the pharmaceutical and cosmetic industries.

Alternatives to Animal Testing

Author : Horst Spielmann
Publisher :
ISBN 13 : 9781013274299
Total Pages : 136 pages
Book Rating : 4.2/5 (742 download)

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Book Synopsis Alternatives to Animal Testing by : Horst Spielmann

Download or read book Alternatives to Animal Testing written by Horst Spielmann and published by . This book was released on 2020-10-09 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments - replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Guide for the Care and Use of Laboratory Animals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Developments in Biological Standardization

Author :
Publisher :
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.:/5 (43 download)

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Book Synopsis Developments in Biological Standardization by :

Download or read book Developments in Biological Standardization written by and published by . This book was released on 1996 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:

International Animal Research Regulations

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309252113
Total Pages : 102 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis International Animal Research Regulations by : National Research Council

Download or read book International Animal Research Regulations written by National Research Council and published by National Academies Press. This book was released on 2012-06-26 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.

Alternatives to Animal Use in Research, Testing, and Education

Author :
Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Alternatives to Animal Use in Research, Testing, and Education by :

Download or read book Alternatives to Animal Use in Research, Testing, and Education written by and published by . This book was released on 1986 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Management of Animal Care and Use Programs in Research, Education, and Testing

Author : Robert H. Weichbrod
Publisher : CRC Press
ISBN 13 : 1498748457
Total Pages : 917 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Management of Animal Care and Use Programs in Research, Education, and Testing by : Robert H. Weichbrod

Download or read book Management of Animal Care and Use Programs in Research, Education, and Testing written by Robert H. Weichbrod and published by CRC Press. This book was released on 2017-09-07 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).