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Regulation Of The Antibody Response To Pneumococcal Capsular Polysaccharides
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Book Synopsis Regulation of the Antibody Response to Pneumococcal Capsular Polysaccharides by : Axel Jeurissen
Download or read book Regulation of the Antibody Response to Pneumococcal Capsular Polysaccharides written by Axel Jeurissen and published by Leuven University Press. This book was released on 2005 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Ph.D. dissertation. S. pneumoniae is a major causative agent of serious infections. Besides, the emerging resistance of S. pneumoniae to multiple antibiotic drugs is a major concern in the treatment of infections caused by this micro-organism. Therefore it is important to study the molecular mechanisms that meditate the antibody response to caps-PS. The aim of the study is to better understand the regulation and the molecular mechanisms of the immune response to pneumococcal caps-PS. The present study was undertaken to determine the role of the CD40-CD40L interaction in the murine antibody response to pneumococcal caps-PS antigens.
Book Synopsis Humoral Immune Response to Pneumococcal Vaccination by : Helle Bossen Konradsen
Download or read book Humoral Immune Response to Pneumococcal Vaccination written by Helle Bossen Konradsen and published by . This book was released on 1996 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of the Antibody Response by : Bernhard Cinader
Download or read book Regulation of the Antibody Response written by Bernhard Cinader and published by . This book was released on 1971 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Ethanol Ingestion of Antibody Response to and Protective Efficacy of Vaccination with Pneumococcal Capsular Polysaccharide by : Jeffrey L. Hennriksen
Download or read book Effects of Ethanol Ingestion of Antibody Response to and Protective Efficacy of Vaccination with Pneumococcal Capsular Polysaccharide written by Jeffrey L. Hennriksen and published by . This book was released on 1997 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Antibody Responses to Pneumococcal Polysaccharides by Natural Killer Cells by : Mona Khater
Download or read book Regulation of Antibody Responses to Pneumococcal Polysaccharides by Natural Killer Cells written by Mona Khater and published by . This book was released on 1986 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Immune Response to Streptococcus Pneumoniae and Pneumococcal Polysaccharides by : Bradley Rabquer
Download or read book The Immune Response to Streptococcus Pneumoniae and Pneumococcal Polysaccharides written by Bradley Rabquer and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Streptococcus pneumoniae is a worldwide pathogen that colonizes the human nasopharynx. Pneumococcal vaccines have been developed which exploit the major virulence factor of S. pneumoniae, the capsular polysaccharide (PPS). Recently, research has begun to examine the variable region repertoire elicited by PPS vaccination in order to understand the structure-function relationship of anti-PPS antibodies. The majority of these studies have isolated PPS-specific B cells seven days post-vaccination, when PPS-specific B cells are most abundant. These studies have revealed restricted variable gene usage and considerable somatic mutations, indicative of a memory response. Although the mechanism of hypermutation produced in response to T cell independent (TI) antigens such as PPS remains to elucidated, somatic hypermutation continues to increase past seven days post-vaccination in response to T cell dependent (TD) antigens. Moreover, it has not been demonstrated that isolating PPS-specific B cells at seven days post-vaccination reflects long-term protective serum anti-PPS antibodies. We hypothesized that B cells isolated between 4-6 weeks post-vaccination reflect the physiologically relevant serum antibody response. Our results demonstrated differential variable gene usage between PPS-specific B cells isolated at 5-10 days and 4-6 weeks post-vaccination. In addition, light chain isotype analysis suggested that PPS-specific B cells isolated 5-10 days post-vaccination reflect the serum anti-PPS antibody at both 5-10 days and 4-6 weeks post-vaccination. Therefore, PPS-specific B cells should be isolated at 5-10 days post-vaccination for variable gene analysis. Moreover, the variable regions isolated at 5-10 days contained significant somatic mutations, indicative of a memory response. Concurrently, the majority of adults had anti-PPS antibody present prior to vaccination. Previous studies have indicated that previous exposure to polysaccharide antigen can affect subsequent polysaccharide-based vaccination. We therefore hypothesized that priming with PPS affects the subsequent immune response to vaccination. Our studies indicate that while prior vaccination with PPS does not affect subsequent vaccination with the pneumococcal conjugate vaccine (CPV), live colonization with S. pneumoniae enhances the magnitude of the response via a B cell dependent mechanism. These results demonstrate the importance of prior immunologic exposure on CPV vaccination, and that stimulation of the mucosal immune system may be advantageous prior to vaccination.
Book Synopsis Pneumonia, with Special Reference to Pneumococcus Lobar Pneumonia by : Roderick Heffron
Download or read book Pneumonia, with Special Reference to Pneumococcus Lobar Pneumonia written by Roderick Heffron and published by Harvard University Press. This book was released on 1979 with total page 1110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunisation against infectious diseases by : David Salisbury
Download or read book Immunisation against infectious diseases written by David Salisbury and published by The Stationery Office. This book was released on 2006-12-11 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third edition of this publication which contains the latest information on vaccines and vaccination procedures for all the vaccine preventable infectious diseases that may occur in the UK or in travellers going outside of the UK, particularly those immunisations that comprise the routine immunisation programme for all children from birth to adolescence. It is divided into two sections: the first section covers principles, practices and procedures, including issues of consent, contraindications, storage, distribution and disposal of vaccines, surveillance and monitoring, and the Vaccine Damage Payment Scheme; the second section covers the range of different diseases and vaccines.
Book Synopsis The Pneumococcus by : Elaine I. Tuomanen
Download or read book The Pneumococcus written by Elaine I. Tuomanen and published by . This book was released on 2004 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art examination of research in this field and the impact of this gram-positive pathogen on human disease. * Provides coverage of topics in basic microbiology such as details of DNA transformation, molecular and medical epidemiology, the molecular basis of invasive disease, and various interactions with host defenses. * Presents important historical information on the field of pneumococcal research and suggests strategies for future investigation. * Serves as a valuable source of information for graduate and medical school students, infectious disease specialists, and field researchers in the pathogenesis of gram-positive bacteria.
Book Synopsis Carbohydrate Antigens by : Per J. Garegg
Download or read book Carbohydrate Antigens written by Per J. Garegg and published by . This book was released on 1993 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed from a symposium at the Fourth Chemical Congress of North America (202nd National Meeting of the ACS) in New York City, August 1991, chapter-papers present research on topics including how proteins recognize and bind oligosaccharides, synthesis and immunological properties of glycopeptide T-cell determinants, Vibrio cholerae polysaccharide studies, and purification of oligosaccharide antigens by weak affinity chromatography. Annotation copyright by Book News, Inc., Portland, OR
Book Synopsis Handbook on Immunosenescence by : Tamas Fulop
Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Book Synopsis Synthetic Oligosaccharides by : Pavol Kováč
Download or read book Synthetic Oligosaccharides written by Pavol Kováč and published by . This book was released on 1994 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews the use of synthetic oligosaccharides in biochemistry, immunology, pharmaceutical and medicinal chemistry. Presents strategies for synthesis of complex oligosaccharides. Discusses the mechanisms of interaction between carbohydrates and biologically important proteins, such as enzymes, immunoglobulins, and receptor proteins. Valuable reading for biochemists, immunologists, pharmaceutical chemists, organic synthetic chemists, pharmacologists, and researchers in the life sciences.
Book Synopsis Pneumococcal Vaccines: The Impact of Conjugate Vaccine by : Keith P. Klugman
Download or read book Pneumococcal Vaccines: The Impact of Conjugate Vaccine written by Keith P. Klugman and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Blood Group Substances by : Elvin A. Kabat
Download or read book Blood Group Substances written by Elvin A. Kabat and published by Elsevier. This book was released on 2013-10-22 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood Group Substances: Their Chemistry and Immunochemistry focuses on the characteristics, reactions, sources, and transformations of blood group substances. The book first offers information on human blood group factors and the methods and reagents used in testing for blood group antibodies and antigens. Topics include autoantibody formation and hemolytic anemia, panagglutinable erythrocytes, effects of temperature on hemagglutination, and effects of periodate on blood group substances. The text also ponders on the sources and purification of blood group substances. The publication examines the chemical and immunochemical characterization of blood group substances and immunochemical similarities and differences among blood group substances from various species. The text then takes a look at antibodies to blood group substances and their biological effects, including purification and concentration of blood group antibodies; studies with antibodies labeled with radioactive isotopes; and passage of antibodies through the placenta. The manuscript is a valuable reference for readers interested in blood group substances.
Book Synopsis Carbohydrate-based Vaccines by : René Roy
Download or read book Carbohydrate-based Vaccines written by René Roy and published by ACS Symposium. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.
Book Synopsis Phagocytosis of Bacteria and Bacterial Pathogenicity by : Joel D. Ernst
Download or read book Phagocytosis of Bacteria and Bacterial Pathogenicity written by Joel D. Ernst and published by Cambridge University Press. This book was released on 2006-09-07 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.
Book Synopsis IgG Subclass Deficiencies by : Roland J. Levinsky
Download or read book IgG Subclass Deficiencies written by Roland J. Levinsky and published by . This book was released on 1988 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
