Regulation of Membrane Na+-K+ ATPase

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Publisher : Springer
ISBN 13 : 3319247506
Total Pages : 434 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Regulation of Membrane Na+-K+ ATPase by : Sajal Chakraborti

Download or read book Regulation of Membrane Na+-K+ ATPase written by Sajal Chakraborti and published by Springer. This book was released on 2015-12-16 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Na+-K+ ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra ne domain adjacent to the isoform(s) of α-β subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na+-K+ ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.

The Na, K-ATPase

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Author :
Publisher : R. G. Landes
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Na, K-ATPase by : Jean-Daniel Horisberger

Download or read book The Na, K-ATPase written by Jean-Daniel Horisberger and published by R. G. Landes. This book was released on 1994 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text addresses the question, How does the sodium pump pump'. A variety of primary structure information is available, and progress has been made in the functional characterization of the Na, K-pump, making the answer to this question possible, within reach of currently used techniques

Basic Neurochemistry

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Publisher : Academic Press
ISBN 13 : 0080959016
Total Pages : 1121 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Basic Neurochemistry by : R. Wayne Albers

Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Academic Press. This book was released on 2011-11-02 with total page 1121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Na, K-ATPase and Related Cation Pumps

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Publisher :
ISBN 13 :
Total Pages : 752 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Na, K-ATPase and Related Cation Pumps by : Peter Leth Jørgensen

Download or read book Na, K-ATPase and Related Cation Pumps written by Peter Leth Jørgensen and published by . This book was released on 2003 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text focuses on research on the structure, molecular mechanisms, physiological regulation, and involvement in disease of Na, K-ATPase and other members of the family of cation pumps. Prominent members of this family include gastric H, K-ATPase, Ca-ATPase of sarcoplasmic and endoplasmic reticulum, plasma membrane Ca-ATPase, and plasma membrane of H-ATPase of fungi and higher plants, as well as heavy metal pumps. The volume includes details of the first high-resolution structure ever obtained of a P-type pump, the sarcoplasmic reticulum Ca-ATPase; this structure has great predictive power relative to all P-type pumps. There are 50 papers and 97 poster papers altogethe

The Enzymes of Biological Membranes

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Publisher : Springer Science & Business Media
ISBN 13 : 1468426583
Total Pages : 461 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis The Enzymes of Biological Membranes by : Anthony Martonosi

Download or read book The Enzymes of Biological Membranes written by Anthony Martonosi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of the information currently available on the transport systems of bacterial and animal cell membranes and their mode of coupling to metabolic supply of energy can be found in this volume. Consideration of the participating enzymes dictated the choice of topics: Several transport systems where little information is available on the enzymology of the process are not included, while separate chapters deal with y-glutamyl transpeptidase and intestinal disaccharidases which meet many of the requirements of transport enzymes. The volume also includes two chapters on photosynthetic membranes as a general introduction to the topic. Other aspects of biological transport and photosynthesis will be developed in detail in a forthcoming volume now in preparation. These chapters reveal the excitement and rapid advance of the field, the daily reports of new concepts, new techniques, and new experimental findings which instantly interact to generate further progress. Our aim was to provide a starting point for those who are just beginning, and an opportunity for others to stop, take stock, and start in a new direction. My warmest thanks to all who contributed to this volume.

Current Topics in Membranes and Transport

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Publisher : Academic Press
ISBN 13 : 0080585051
Total Pages : 395 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Current Topics in Membranes and Transport by :

Download or read book Current Topics in Membranes and Transport written by and published by Academic Press. This book was released on 1989-10-04 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes and Transport

Electrogenic Ion Pumps

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Publisher : Sinauer Associates, Incorporated
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Electrogenic Ion Pumps by : Peter Läuger

Download or read book Electrogenic Ion Pumps written by Peter Läuger and published by Sinauer Associates, Incorporated. This book was released on 1991 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrogenic ion pumps convert chemical, reduction-oxidation, or light energy- into ion concentration differences across all living cells. They are the engines that run cells. In this text, Dr Lunger develops the principles of physical chemistry required to understand the functions of these macromolecules.

Cardiac Glycosides 1785–1985

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Publisher : Springer Science & Business Media
ISBN 13 : 3662112922
Total Pages : 544 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis Cardiac Glycosides 1785–1985 by : E. Erdmann

Download or read book Cardiac Glycosides 1785–1985 written by E. Erdmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bicentenary of William Withering's now famous medical report entitled "An Account of the Foxglove and Some of its Medical Uses" has given us the occasion to analyze the state of the art. Cardiac glycosides in 1985 are considered tobe the basis for medical treatment of myocardial failure, together with diuretics and vasodilators in the more severe cases. Nevertheless, the controversy as to their exact place in the treatment of heart failure with sinus rhythm has never ceased. Although cardiac glycosides are of unquestionable value in tachycardia caused by atrial fibrillation or atrial flutter, the chronic use of these drugs in sinus rhythm is not generally accepted. The development of tolerance has been reported. It is of interest that Withering hirnself wrote: "-let it (foxglove) be continued until it either acts on the kidneys, the stomach, the pulse, or the bowels; Iet it be stopped upon the first appearance of any of these effects, and I will maintain that the patient will not suffer from its exhibition, nor the practitioner be disappointed in any reasonable expectation. " In West Germany alone, more than three million patients (about 5% of the total population) are constantly taking cardiac glycosides. These drugs are the most prescribed medicaments in many countries. Thus, we considered it worthwhile and necessary to review in a critical way today's knowledge about the foxglove; to report new findings and to evaluate old Statements.

Na+K+-ATPase: Discovery, Functions and Regulation

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Publisher :
ISBN 13 : 9781536189681
Total Pages : 0 pages
Book Rating : 4.1/5 (896 download)

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Book Synopsis Na+K+-ATPase: Discovery, Functions and Regulation by : Mohammed Awad Ali

Download or read book Na+K+-ATPase: Discovery, Functions and Regulation written by Mohammed Awad Ali and published by . This book was released on 2021-01-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) is an enzyme located in the plasma membrane of most eukaryotic cells, responsible for maintaining ion concentration gradients against their concentration scale using ATP hydrolysis as a source of energy. The enzyme is involved in many cellular activities, including maintaining cell volume, transporting nutrition, electrical potential, neurotransmission, and any dysfunction or modification of enzyme activity is directly linked to many diseases, such as epilepsy, cardiovascular disease and hypertension, diabetes and other metabolic disorders, digoxin toxicity, fetal abnormalities, neurological disorders, and pulmonary conditions. In this book, the authors present current research on regulation strategies, Na⁺/K⁺-ATPase as a biomarker in diseased states, and the use of Na⁺/K⁺-ATPase in the physiological and ecological adaptations of insects. Other topics discussed in this compilation include the effects of hormonal and non-hormonal stimulation on Na+/K+-ATPase activity, the physiology and pathophysiology of Na+/K+-ATPase, Na⁺/K⁺-ATPase as a biomarker for energy metabolism and oxidative stress in diseased states, the neurotensin inhibitory effects of [3H]-Ouabain binding to striatal membranes and inversion by administration of clozapine, and Na+/K+-ATPase's important functional roles in human body.

The Sodium Pump

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Publisher : Springer Science & Business Media
ISBN 13 : 3642725112
Total Pages : 924 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis The Sodium Pump by : Ernst Bamberg

Download or read book The Sodium Pump written by Ernst Bamberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sodium of animal cell membranes converts the chemical energy obtained from the hydrolysis of adenosine 5' -triphosphate into a movement of the cations Na + and K + against an electrochemical gradient. The gradient is used subse quently as an energy source to drive the uptake of metabolic substrates in polar epithelial cells and to use it for purposes of communications in excitable cells. The biological importance of the sodium pump is evident from the fact that be tween 20-70% of the cell's metabolic energy is consumed for the pumping pro cess. Moreover, the sodium pump is an important biological system involved in regulatory processes like the maintenance of the cells' and organism's water me tabolism. It is therefore understandable that special cellular demands are han dled better by special isoforms of the sodium pump, that the expression of the sodium pump and their isoforms is regulated by hormones as is the activity of the sodium pump via hormone-regulated protein kinases. Additionally, the sodium pump itself seems to be a receptor for a putative new group of hormones, the endogenous digitalis-like substances, which still have to be defined in most cases in their structure. This group of substances has its chemically well known coun terpart in steroids from plant and toad origin which are generally known as "car diac glycosides". They are in medical use since at least 200 years in medicine in the treatment of heart diseases.

Surface Charges of the Membrane Crucially Affect Regulation of Na, K-ATPase by Phospholemman (FXYD1)

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (865 download)

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Book Synopsis Surface Charges of the Membrane Crucially Affect Regulation of Na, K-ATPase by Phospholemman (FXYD1) by : Erica Cirri

Download or read book Surface Charges of the Membrane Crucially Affect Regulation of Na, K-ATPase by Phospholemman (FXYD1) written by Erica Cirri and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Regulation of Potassium Transport Across Biological Membranes

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Publisher :
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Regulation of Potassium Transport Across Biological Membranes by : Luis Reuss

Download or read book Regulation of Potassium Transport Across Biological Membranes written by Luis Reuss and published by . This book was released on 1990 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Potassium is quantitatively the main cation of the intracellular fluid compartment and, therefore, plays major roles in the maintenance and regulation of cell volume. In addition, potassium is thought to participate in the regulation of a number of functions common to most or all cells, including differentiation and growth. Finally, transport of potassium ions across the cell membranes influences not only the intracellular content (and chemically activity) of the cation but also the extracellular concentration, particularly in the case of tissues possessing extracellular compartments in which ionic diffusion and blood-flow mediated extraction are restricted. This is of paramount importance in excitable tissues, in which the potassium concentration gradient across the cell membrane is the main determinant of the membrane voltage and, hence, of automatism and/or excitability. (JES).

Insulin Action

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792381136
Total Pages : 206 pages
Book Rating : 4.3/5 (811 download)

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Book Synopsis Insulin Action by : Ashok K. Srivastava

Download or read book Insulin Action written by Ashok K. Srivastava and published by Springer Science & Business Media. This book was released on 1998-05-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.

Current Topics in Membranes

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Publisher : Academic Press
ISBN 13 : 0080585108
Total Pages : 477 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Current Topics in Membranes by :

Download or read book Current Topics in Membranes written by and published by Academic Press. This book was released on 1992-01-08 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes

Regulation of Cardiac Contractility

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Publisher : Biota Publishing
ISBN 13 : 1615041753
Total Pages : 46 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Regulation of Cardiac Contractility by : R. John Solaro

Download or read book Regulation of Cardiac Contractility written by R. John Solaro and published by Biota Publishing. This book was released on 2011-04-01 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension generation and shortening capability of the molecular motors (myosin cross-bridges) of the sarcomeres as determined by the rates and extent of Ca activation, the turnover kinetics of the cross-bridges, and the relative Ca responsiveness of the sarcomeres. Engagement of the regulatory signaling cascades controlling contractility occurs with occupancy and signal transduction by receptors for neurohumors of the autonomic nervous system as well as growth and stress signaling pathways. Contractility is also determined by the prevailing conditions of pH, temperature, and redox state. Short-term control of contractility is fully expressed during exercise. In long-term responses to stresses on the heart, contractility is modified by cellular remodeling and altered signaling that may compensate for a time but which ultimately may fail, leading to disorders.

The Sodium Pump

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Publisher : Rockefeller Univ. Press
ISBN 13 :
Total Pages : 400 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Sodium Pump by : Society of General Physiologists. Symposium

Download or read book The Sodium Pump written by Society of General Physiologists. Symposium and published by Rockefeller Univ. Press. This book was released on 1991 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of the Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: