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Regulation Of Human Endothelial Barrier Funtion By Cyclic Nucleotides Nitric Oxide And Protein Kinases
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Book Synopsis Regulation of Human Endothelial Barrier Funtion by Cyclic Nucleotides, Nitric Oxide and Protein Kinases by : Richard Draijer
Download or read book Regulation of Human Endothelial Barrier Funtion by Cyclic Nucleotides, Nitric Oxide and Protein Kinases written by Richard Draijer and published by . This book was released on 1996 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Human Endothelial Barrier Function by Cyclic Nucleotides, Nitric Oxide and Protein Kinaseson by : Richard Draijer
Download or read book Regulation of Human Endothelial Barrier Function by Cyclic Nucleotides, Nitric Oxide and Protein Kinaseson written by Richard Draijer and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Book Synopsis Regulation of Endothelial Barrier Function by : Sarah Y. Yuan
Download or read book Regulation of Endothelial Barrier Function written by Sarah Y. Yuan and published by Biota Publishing. This book was released on 2011-02-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood–tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell–cell and cell–matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care.
Book Synopsis Functional Roles of Proteins which Associate with Endothelial Nitric Oxide Synthase by : Nan Chen
Download or read book Functional Roles of Proteins which Associate with Endothelial Nitric Oxide Synthase written by Nan Chen and published by . This book was released on 2011 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide (NO) plays a key regulatory role in cardiovascular physiology due to its vasodilatory, anti-thrombotic and anti-atherogenic properties. In endothelial cells, the endothelial isoform of NO synthase (eNOS or NOS-3) catalyses the conversion of L-arginine to L-citrulline with the production of NO. NOS-3 activation is regulated by a number of factors, including Ca2+-calmodulin, phosphorylation of key residues, and interactions with associated proteins (including caveolin-l, and heat shock protein 90). The aims of this work were to clarify the roles of certain proteins, previously reported to associate with NOS-3, in NOS-3 regulation in human endothelial cells, as well as to identify novel protein associations with NOS-3 and to clarify the possible role of such associations . -- In human umbilical vein endothelial cells (HUVEC), I confirmed our previously reported finding that NOS-3 binds to the globular form of [beta]-actin (G-actin); of note, and not previously reported, we found that a wide variety of NOS-3 agonists (adenosine, salbutamol, histamine and thrombin) increased the degree ofNOS-3 / G-actin association, which was prevented by stabilization of [beta] -actin in its filamentous form (F-actin) using phalloidin. All agonists tested induced a marked increase in phosphorylation at Ser 1177 in NOS-3, as expected, but this was abolished by phalloidin pre-treatment. In studies of HEK293 cells transfected with either wild-type NOS-3 (wild type Ser 1177) or NOS-3 mutated at residue 1177 (1177 A or 1177D), I found that, whereas a marked association of [beta]-actin with NOS-3 was observed inlysates from cells transfected with wild-type NOS-3, the degree of this association was markedly attenuated III lysates isolated from cells transfected with either mutant form of NOS-3. -- I also demonstrated a novel interaction between NOS-3 and p-catenin in HUVEC.
Book Synopsis Cardiovascular Pharmacology: Endothelial Control by :
Download or read book Cardiovascular Pharmacology: Endothelial Control written by and published by Academic Press. This book was released on 2010-12-16 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions. Contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pediatric Hypertension by : Joseph Flynn
Download or read book Pediatric Hypertension written by Joseph Flynn and published by Springer Science & Business Media. This book was released on 2013-06-26 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Book Synopsis Fibrinolytics and Antifibrinolytics by : F. Bachmann
Download or read book Fibrinolytics and Antifibrinolytics written by F. Bachmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Book Synopsis Phosphodiesterases as Drug Targets by : Sharron H. Francis
Download or read book Phosphodiesterases as Drug Targets written by Sharron H. Francis and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Book Synopsis The Vascular Endothelium I by : Salvador Moncada
Download or read book The Vascular Endothelium I written by Salvador Moncada and published by Springer Science & Business Media. This book was released on 2006-12-22 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.
Book Synopsis Biochemistry of Signal Transduction in Myocardium by : Jos M.J. Lamers
Download or read book Biochemistry of Signal Transduction in Myocardium written by Jos M.J. Lamers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters in this volume are the Proceedings of the Satellite Symposium of the XVIth World Congress of the International Society for Heart Research on `Signal Transduction in Normal and Diseased Myocardium' which was held in Rotterdam at the Faculty of Medicine & Health Sciences of the Erasmus University, June 30 and July 1, 1995. Diverse and distinct auto-, para-, and endocrine stimuli arriving at the surface of endothelium, smooth muscle cells, cardiomyocytes and fibroblasts within the myocardium, engage cell type-specific receptors, which lead to transmission of signals across the cell plasma membrane and result in the production and activation of second messengers. The most common mechanism by which these second messengers function is via direct or indirect activation of specific protein kinases. The current challenge for scientists is to identify the specific substrates (e.g. metabolic enzymes, Ca2+-regulating proteins, transcription and mitotic factors) for the many protein kinases, to elucidate the biological significance of the cell type-specific expression heterogeneity of signalling proteins (e.g. membrane receptors, isoenzymes of protein kinase C, G-proteins) and to unravel the cross-talk interaction between the signalling systems (e.g. phospholipase C with adenylate cyclase and phospholipase C with phospholipase D). The multiplicity of receptor types, G-proteins, effector proteins, second messengers and protein kinases, their substrate proteins and the `cross-talk' interactions in the myocardium raises fundamental questions about the mechanisms that ensure the precision and timing of the myocardial responses to hormonal and pharmacological stimuli. This book provides an up-to-date source of information for all scientists and clinicians interested in the mechanisms by which external signals are transmitted to the interior and regulation of a variety of physiological, pathological and pharmacological responses.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1844 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endothelium written by and published by Academic Press. This book was released on 2016-07-20 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelium, the new volume in the Advances in Pharmacology series, presents readers with a variety of chapters that cover various endothelium-derived mediators and their changes with gender, and during vascular development, senescence, and hypertensive disorders. Topics include endothelium, nitric oxide, gap junctions, potassium channels, endothelin, vascular development, vascular permeability, gender, aging, and preeclampsia. With contributions from the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Contains contributions from the best authors in the field Provides an essential resource for pharmacologists, immunologists, and biochemists Covers endothelium-derived mediators and their changes
Book Synopsis Regulation of Endothelial Nitric Oxide Synthase by Intracellular Calcium and Phosphorylation by : Jacqueline M. Cale
Download or read book Regulation of Endothelial Nitric Oxide Synthase by Intracellular Calcium and Phosphorylation written by Jacqueline M. Cale and published by . This book was released on 2005 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Evgenia Gerasimovskaya Publisher :Springer Science & Business Media ISBN 13 :9048134358 Total Pages :240 pages Book Rating :4.0/5 (481 download)
Book Synopsis Extracellular ATP and adenosine as regulators of endothelial cell function by : Evgenia Gerasimovskaya
Download or read book Extracellular ATP and adenosine as regulators of endothelial cell function written by Evgenia Gerasimovskaya and published by Springer Science & Business Media. This book was released on 2010-04-26 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes. In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented. In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.
