Recombination Variability And Evolution

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Recombination Variability and Evolution

Author : A.B. Korol
Publisher : Springer Science & Business Media
ISBN 13 : 9780412494109
Total Pages : 384 pages
Book Rating : 4.4/5 (941 download)

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Book Synopsis Recombination Variability and Evolution by : A.B. Korol

Download or read book Recombination Variability and Evolution written by A.B. Korol and published by Springer Science & Business Media. This book was released on 1994-08-31 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using an interdisciplinary approach, the authors provide an adaptionist interpretation of the basic features of recombination, its evolutionary significance as a key process in reproduction and its importance in genetic mapping. The book synthesizes much recent information in the fields of evloutionary genetics of recombination, the analysis of genetic markers and breeding applications. The authors analyse recombination through a consideration of computer models, large Drosophila populations and an empirical approach to current theories. Practically-orientated readers will be interested in the discussion of a wide spectrum of mapping methods and the new algorithms proposed for genetic mapping of quantitative loci.

Tempo and Mode in Evolution

Author : for the National Academy of Sciences
Publisher : National Academies Press
ISBN 13 : 0309552672
Total Pages : 336 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Tempo and Mode in Evolution by : for the National Academy of Sciences

Download or read book Tempo and Mode in Evolution written by for the National Academy of Sciences and published by National Academies Press. This book was released on 1995-02-09 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since George Gaylord Simpson published Tempo and Mode in Evolution in 1944, discoveries in paleontology and genetics have abounded. This volume brings together the findings and insights of today's leading experts in the study of evolution, including Ayala, W. Ford Doolittle, and Stephen Jay Gould. The volume examines early cellular evolution, explores changes in the tempo of evolution between the Precambrian and Phanerozoic periods, and reconstructs the Cambrian evolutionary burst. Long-neglected despite Darwin's interest in it, species extinction is discussed in detail. Although the absence of data kept Simpson from exploring human evolution in his book, the current volume covers morphological and genetic changes in human populations, contradicting the popular claim that all modern humans descend from a single woman. This book discusses the role of molecular clocks, the results of evolution in 12 populations of Escherichia coli propagated for 10,000 generations, a physical map of Drosophila chromosomes, and evidence for "hitchhiking" by mutations.

In the Light of Evolution

Author : National Academy of Sciences
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis In the Light of Evolution by : National Academy of Sciences

Download or read book In the Light of Evolution written by National Academy of Sciences and published by . This book was released on 2007 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.

The Genetics and Evolution of Intraspecific Variation in Meiotic Recombination Rate

Author : Richard J. Wang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (982 download)

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Book Synopsis The Genetics and Evolution of Intraspecific Variation in Meiotic Recombination Rate by : Richard J. Wang

Download or read book The Genetics and Evolution of Intraspecific Variation in Meiotic Recombination Rate written by Richard J. Wang and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombination is a fundamental evolutionary force. It introduces genetic diversity into populations by joining alleles in novel haplotypic combinations. Variation in rates of recombination pervades despite its conserved role in meiosis. The propensity for recombination differs across stretches of the genome within individuals, and differs between the genomes of individuals. Genetic investigation has successfully uncovered some of the patterns, loci, and architecture underlying differences in recombination rate. This dissertation examines recombination rate evolution within the house mouse species (Mus musculus). By focusing within species, the earliest forms of divergence and the connections between genomic scales are most easily explored. The ability to isolate genetic effects through experimental crosses in this model system is repeatedly leveraged. Mice derived from the Gough Island (GI) population, an isolated mouse population of recent colonists, are used throughout as closely-diverged wild representatives of the M. m. domesticus subspecies. Comparison of genetic maps from crosses with GI mice revealed pervasive polymorphism in recombination across the genome. Immunofluorescent cytology, a technique to visualize individual meiotic cells, was applied in two chapters to characterize recombination phenotypes in individual mice. This individual characterization enabled the detection of multiple quantitative trait loci (QTL) responsible for the evolution of genome-wide recombination rate within mouse subspecies. Cytological images were also processed by an innovative computational technique that calculated synaptonemal complex (SC) length, a meiotic phenotype closely associated with recombination rates. The high-throughput characterization of SC length enabled its genetic mapping, leading to the detection of the first QTL discovered for this trait. These results uncover new aspects of the genetics of recombination rate differences and provide a closely diverged, within species context for its evolution.

Gene Genealogies, Variation and Evolution: A primer in coalescent theory

Author : Jotun Hein
Publisher : Oxford University Press, USA
ISBN 13 : 9780191546150
Total Pages : 298 pages
Book Rating : 4.5/5 (461 download)

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Book Synopsis Gene Genealogies, Variation and Evolution: A primer in coalescent theory by : Jotun Hein

Download or read book Gene Genealogies, Variation and Evolution: A primer in coalescent theory written by Jotun Hein and published by Oxford University Press, USA. This book was released on 2004-12-09 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. - Professor Montgomery Slatkin (Berkeley);the authors are outstanding experts in the field, and the book is topical and timely. - Professor David Balding (Imperial College);Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. - Professor Joe Felsenstein (University of Washington)

Handbook of Statistical Genetics

Author : David J. Balding
Publisher : John Wiley & Sons
ISBN 13 : 9780470997628
Total Pages : 1616 pages
Book Rating : 4.9/5 (976 download)

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Book Synopsis Handbook of Statistical Genetics by : David J. Balding

Download or read book Handbook of Statistical Genetics written by David J. Balding and published by John Wiley & Sons. This book was released on 2008-06-10 with total page 1616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.

Genetic Variation

Author : Rafael Trindade Maia
Publisher : BoD – Books on Demand
ISBN 13 : 183881096X
Total Pages : 298 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Genetic Variation by : Rafael Trindade Maia

Download or read book Genetic Variation written by Rafael Trindade Maia and published by BoD – Books on Demand. This book was released on 2021-05-19 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic diversity is one of the measures of biodiversity and has consequences in biological variation. It is crucial to understand the evolutionary and adaptative processes in all living species. This book is an interdisciplinary and integrated work that will contribute to the knowledge of academics from different areas of biological sciences. This collection of scientific papers was chosen and analyzed to offer readers a broad and integrated view of the importance of genetic diversity in the evolution and adaptation of living beings, as well as practical applications of the information needed to analyze this diversity in different organisms. This book was edited by geneticist researchers and provides academics with up-to-date and quality information on the subject.

Elements of Evolutionary Genetics

Author : Brian Charlesworth
Publisher : Roberts
ISBN 13 :
Total Pages : 776 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Elements of Evolutionary Genetics by : Brian Charlesworth

Download or read book Elements of Evolutionary Genetics written by Brian Charlesworth and published by Roberts. This book was released on 2010-02-03 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook shows readers how models of the genetic processes involved in evolution are made (including natural selection, migration, mutation, and genetic drift in finite populations), and how the models are used to interpret classical and molecular genetic data. The material is intended for advanced level undergraduate courses in genetics and evolutionary biology, graduate students in evolutionary biology and human genetics, and researchers in related fields who wish to learn evolutionary genetics. The topics covered include genetic variation, DNA sequence variability and its measurement, the different types of natural selection and their effects (e.g. the maintenance of variation, directional selection, and adaptation), the interactions between selection and mutation or migration, the description and analysis of variation at multiple sites in the genome, genetic drift, and the effects of spatial structure.

Analyses of Adaptive Evolution and Recombination Rate Variation in Drosophila

Author : Ramesh Ratnappan
Publisher :
ISBN 13 :
Total Pages : 159 pages
Book Rating : 4.:/5 (832 download)

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Book Synopsis Analyses of Adaptive Evolution and Recombination Rate Variation in Drosophila by : Ramesh Ratnappan

Download or read book Analyses of Adaptive Evolution and Recombination Rate Variation in Drosophila written by Ramesh Ratnappan and published by . This book was released on 2011 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: The observed reduction in fitness at low temperatures strongly supports the hypothesis that temperature is a key factor delimiting the distribution of these two species in their current habitats. Recombination is an important evolutionary parameter that influences the amount of variation present within a species and the potential to adapt to biotic/abiotic changes. As such, it is a key parameter in population genetics models of selection. To date, however, no study has been able to measure the variation in recombination with high resolution (ideally at the level of single genes) while also capturing variation in recombination rates within a species. Further, there is a need to understand how the two outcomes of meiotic recombination (cross-over and gene conversion) are distributed across genomes.

Variation

Author : Benedikt Hallgrímsson
Publisher : Elsevier
ISBN 13 : 0080454461
Total Pages : 594 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Variation by : Benedikt Hallgrímsson

Download or read book Variation written by Benedikt Hallgrímsson and published by Elsevier. This book was released on 2011-05-04 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Darwin's theory of evolution by natural selection was based on the observation that there is variation between individuals within the same species. This fundamental observation is a central concept in evolutionary biology. However, variation is only rarely treated directly. It has remained peripheral to the study of mechanisms of evolutionary change. The explosion of knowledge in genetics, developmental biology, and the ongoing synthesis of evolutionary and developmental biology has made it possible for us to study the factors that limit, enhance, or structure variation at the level of an animals' physical appearance and behavior. Knowledge of the significance of variability is crucial to this emerging synthesis. Variation situates the role of variability within this broad framework, bringing variation back to the center of the evolutionary stage. Provides an overview of current thinking on variation in evolutionary biology, functional morphology, and evolutionary developmental biology Written by a team of leading scholars specializing on the study of variation Reviews of statistical analysis of variation by leading authorities Key chapters focus on the role of the study of phenotypic variation for evolutionary, developmental, and post-genomic biology

Genetic Variation for Recombination in Barley

Author : Torbjörn Säll
Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Genetic Variation for Recombination in Barley by : Torbjörn Säll

Download or read book Genetic Variation for Recombination in Barley written by Torbjörn Säll and published by . This book was released on 1989 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of Plant Viruses

Author : Chuni L. Mandahar
Publisher : Springer Science & Business Media
ISBN 13 : 1461550637
Total Pages : 304 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Molecular Biology of Plant Viruses by : Chuni L. Mandahar

Download or read book Molecular Biology of Plant Viruses written by Chuni L. Mandahar and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two decades ago, recombinant DNA technology or genetic engineering ushered in a new era in the study of plant viruses. The major breakthrough came in the eighties, primarily due to the development of new methods for RNA reverse transcription and cDNA cloning, along with restriction enzyme mapping and rapid nucleotide sequencing. An information explosion in various molecular aspects of plant viruses was caused by these studies. Current research efforts investigate the study of viral genomes, genetic maps, genes and gene expression, gene products, and genetic basis of virus functions and biological properties. Molecular Biology of Plant Viruses analyzes, collates and reviews such published information. Additionally, it demonstrates the mechanisms of genetic variability; brings out the molecular basis of virus transport in plants and of virus transmission by vectors and of disease symptomatology; and discusses molecular biology of viroids and transgenic plants. It also treats the recently discovered genetic phenomenon of gene silencing and the gene-for-gene interactions between the hosts and plant viruses. Molecular Biology of Plant Viruses is an excellent reference, providing insight into the exciting research developments made in the field.

Crumbling Genome

Author : Alexey S. Kondrashov
Publisher : John Wiley & Sons
ISBN 13 : 1118952138
Total Pages : 407 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Crumbling Genome by : Alexey S. Kondrashov

Download or read book Crumbling Genome written by Alexey S. Kondrashov and published by John Wiley & Sons. This book was released on 2017-05-16 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre ]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.

The Princeton Guide to Evolution

Author : David A. Baum
Publisher : Princeton University Press
ISBN 13 : 1400848067
Total Pages : 888 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis The Princeton Guide to Evolution by : David A. Baum

Download or read book The Princeton Guide to Evolution written by David A. Baum and published by Princeton University Press. This book was released on 2013-11-04 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Princeton Guide to Evolution is a comprehensive, concise, and authoritative reference to the major subjects and key concepts in evolutionary biology, from genes to mass extinctions. Edited by a distinguished team of evolutionary biologists, with contributions from leading researchers, the guide contains some 100 clear, accurate, and up-to-date articles on the most important topics in seven major areas: phylogenetics and the history of life; selection and adaptation; evolutionary processes; genes, genomes, and phenotypes; speciation and macroevolution; evolution of behavior, society, and humans; and evolution and modern society. Complete with more than 100 illustrations (including eight pages in color), glossaries of key terms, suggestions for further reading on each topic, and an index, this is an essential volume for undergraduate and graduate students, scientists in related fields, and anyone else with a serious interest in evolution. Explains key topics in some 100 concise and authoritative articles written by a team of leading evolutionary biologists Contains more than 100 illustrations, including eight pages in color Each article includes an outline, glossary, bibliography, and cross-references Covers phylogenetics and the history of life; selection and adaptation; evolutionary processes; genes, genomes, and phenotypes; speciation and macroevolution; evolution of behavior, society, and humans; and evolution and modern society

Fitness Landscapes and the Origin of Species (MPB-41)

Author : Sergey Gavrilets
Publisher : Princeton University Press
ISBN 13 : 069111983X
Total Pages : 497 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis Fitness Landscapes and the Origin of Species (MPB-41) by : Sergey Gavrilets

Download or read book Fitness Landscapes and the Origin of Species (MPB-41) written by Sergey Gavrilets and published by Princeton University Press. This book was released on 2004-07-26 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fitness landscapes -- The Bateson-Dobzhansky-Muller model -- Speciation via the joint action of distruptive natural selection and nonrandom mating.

Handbook of Statistical Genomics

Author : David J. Balding
Publisher : John Wiley & Sons
ISBN 13 : 1119429250
Total Pages : 1828 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Handbook of Statistical Genomics by : David J. Balding

Download or read book Handbook of Statistical Genomics written by David J. Balding and published by John Wiley & Sons. This book was released on 2019-07-09 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

Cell Biology by the Numbers

Author : Ron Milo
Publisher : Garland Science
ISBN 13 : 1317230698
Total Pages : 400 pages
Book Rating : 4.3/5 (172 download)

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Book Synopsis Cell Biology by the Numbers by : Ron Milo

Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid