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Author : Encarna Alejandre-Durán
Publisher :
ISBN 13 :
Total Pages : 154 pages
Book Rating : 4.:/5 ( download)
Download or read book Recent Research Development in DNA Repair and Mutagenesis written by Encarna Alejandre-Durán and published by . This book was released on 2002 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Breehn R. Landseer
Publisher : Nova Publishers
ISBN 13 : 9781600213854
Total Pages : 412 pages
Book Rating : 4.2/5 (138 download)
Download or read book New Research on DNA Repair written by Breehn R. Landseer and published by Nova Publishers. This book was released on 2007 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a major defence against environmental damage to cells DNA repair is present in all organisms including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. DNA repair is involved in processes that minimise cell killing, mutations, replication errors, persistence of DNA damage and genomic instability. Abnormalities in these processes have been implicated in cancer and ageing. This book presents leading-edge research from around the world in this frontal field.
Author :
Publisher :
ISBN 13 : 9780929600871
Total Pages : 1118 pages
Book Rating : 4.6/5 (8 download)
Download or read book DNA Repair and Mutagenesis written by and published by . This book was released on 2006 with total page 1118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely reorganized, the new edition presents a significant overhaul of the existing chapters and introduces important new material, reflective of the major changes and developments that have occurred in the field over the last decade. As with the first edition, this new volume presents the field within a strong historical framework and all aspects of biological responses to DNA damage are detailed. The book consists of 30 chapters divided into five main parts, covering: sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage. Basic principles are appropriately stressed; however, the book focuses on the significant progress to date and future research directions.
Author : Errol C. Friedberg
Publisher :
ISBN 13 :
Total Pages : 736 pages
Book Rating : 4.3/5 (91 download)
Download or read book DNA Repair and Mutagenesis written by Errol C. Friedberg and published by . This book was released on 1995 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a major revision and updating of the classic work in the field of DNA repair by Errol Friedberg published in 1985. The authors have extensively revised the original text and provided more than 4000 references to current primary research literature. In addition, there are four new chapters on mutagenesis. The book will serve as an important reference resource for all courses in DNA repair and mutagenesis, and for molecular biologists working in many areas of cancer research.
Author : Lawrence Panasci
Publisher : Springer Science & Business Media
ISBN 13 : 1461447410
Total Pages : 317 pages
Book Rating : 4.4/5 (614 download)
Download or read book Advances in DNA Repair in Cancer Therapy written by Lawrence Panasci and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.
Author : G.P. Pfeifer
Publisher : Springer Science & Business Media
ISBN 13 : 9780306452376
Total Pages : 476 pages
Book Rating : 4.4/5 (523 download)
Download or read book Technologies for Detection of DNA Damage and Mutations written by G.P. Pfeifer and published by Springer Science & Business Media. This book was released on 1996-07-31 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: ''Useful and timely.'' ---Mutagenesis ''Of considerable value.'' ---Journal of Medical Genetics ''Quite readable....a comprehensive overview....perfectly covers the needs of those researchers who have to decide on the best strategy to identify damage or mutations at the molecular level.'' ---Trends in Cell Biology ''The formats of the presentations are uniform and ample and up-to-date references are provided at the end of each chapter...will be welcomed by postgraduate researchers of all ages and should retain its usefulness for a long time.'' ---Endeavour, 21(4), 1997 This important resource thoroughly reviews a wide range of techniques used in mutagenesis research-ranging from established techniques to recently developed methodologies-based on the polymerase chain reaction. DNA damage analysis, DNA repair assays, and mutation detection are a few of the techniques featured. Chapters present detailed experimental protocols benefiting researchers and students in the fields of toxicology, biotechniques, molecular biology, photobiology, medical genetics, and oncology.
Author : Errol C. Friedberg
Publisher :
ISBN 13 : 9781936113545
Total Pages : 0 pages
Book Rating : 4.1/5 (135 download)
Download or read book DNA Repair, Mutagenesis, and Other Responses to DNA Damage written by Errol C. Friedberg and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular DNA is constantly bombarded with environmental and chemical assaults that damage its molecular structure. In addition, the normal process of DNA replication is prone to error and may introduce mutations that can be passed to daughter cells. If left unrepaired, these DNA lesions can have serious consequences, such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the mechanisms that cells use to recognize and repair various types of DNA damage. Contributors discuss base excision repair, nucleotide excision repair, mismatch repair, homologous recombination, nonhomologous end joining, the SOS response, and other pathways in prokaryotes and eukaryotes, and describe how these processes are linked to DNA replication, transcription, and cell cycle controls. The repair of telomeric and mitochondrial DNA is described, as is the influence of chromatin structure on DNA repair. This volume also includes discussion of human genetic diseases that involve defects in DNA damage repair. It is an essential reference for molecular and cell biologists, medical geneticists, cancer biologists, and all who want to understand how cells maintain genomic integrity.
Author : Ashis K. Basu
Publisher : MDPI
ISBN 13 : 3038971294
Total Pages : 275 pages
Book Rating : 4.0/5 (389 download)
Download or read book Chemically-Induced DNA Damage, Mutagenesis, and Cancer written by Ashis K. Basu and published by MDPI. This book was released on 2018-08-27 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS
Author : Fumio Hanaoka
Publisher : Springer
ISBN 13 : 443155873X
Total Pages : 555 pages
Book Rating : 4.4/5 (315 download)
Download or read book DNA Replication, Recombination, and Repair written by Fumio Hanaoka and published by Springer. This book was released on 2016-01-22 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
Author : A. Castellani
Publisher : Springer Science & Business Media
ISBN 13 : 1475750161
Total Pages : 377 pages
Book Rating : 4.4/5 (757 download)
Download or read book DNA Damage and Repair written by A. Castellani and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: The First International Congress on DNA Damage and Repair was held in Rome, Italy, July 12-17, 1987. It was organized by the Italian Com mission for Nuclear Alternative Energy Sources. The subject of DNA damage and repair involves almost all the fields ofbidogical sciences. Some of the more prominent ones include carcino genesis, photobiology, radiation biology, aging, enzymology, genetics, and molecular biology. These individual fields have their own interna tional meetings and although the meetings often have sessions devoted to DNA repair, they do not bring together a wide diversity of international workers in the field to exchange ideas. The purpose of the Congress was to facilitate such an exchange among scientists representing many fields of endeavor and many countries. The 37 manuscripts in this volume, presented by the invited spea kers during the four and half days of the Congress, encompass the field of DNA damage and repair. They cover biological systems ranging from mo lecules to humans and deal with damages and repair after treatment of cells with various types of radiations, chemicals, and exogenous and en dogenous oxidative damages. The Congress and its Proceedings are dedicated to two international leaders in the field of DNA damage and repair, Alexander Hollaender of the United States and Adriano Buzzati Traverso of Italy. Hollaender, who died in December 1986, was one of the first investigators to recognize the damage to DNA was important in cell killing and mutagenesis. His early work indicated that cells could recover from radiation injury.
Author : Nicholas E. Geacintov
Publisher : John Wiley & Sons
ISBN 13 : 3527642110
Total Pages : 446 pages
Book Rating : 4.5/5 (276 download)
Download or read book The Chemical Biology of DNA Damage written by Nicholas E. Geacintov and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries. A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.
Author : The Royal Society
Publisher : National Academies Press
ISBN 13 : 0309671132
Total Pages : 239 pages
Book Rating : 4.3/5 (96 download)
Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309070864
Total Pages : 348 pages
Book Rating : 4.3/5 (9 download)
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author : Clark Chen
Publisher : BoD – Books on Demand
ISBN 13 : 9535111140
Total Pages : 676 pages
Book Rating : 4.5/5 (351 download)
Download or read book New Research Directions in DNA Repair written by Clark Chen and published by BoD – Books on Demand. This book was released on 2013-05-22 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.
Author : T.R. Lindahl
Publisher : Springer
ISBN 13 : 9789401105385
Total Pages : 103 pages
Book Rating : 4.1/5 (53 download)
Download or read book DNA Repair and Recombination written by T.R. Lindahl and published by Springer. This book was released on 2011-10-06 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic instability is a major threat to living organisms. To counteract the damaging effects posed by endogenous and environmental agents, such as chemicals or radiation, micro-organisms devote several percent of their genome to encode proteins that function in the repair and recombination of DNA. For many years, a relatively small group of scientists have carefully delineated the molecular mechanisms of these repair processes, using the simplest model systems available, namely Escherichia coli and Saccharomyces cerevisiae. These studies, which until recently had only moderate impact outside of the field, now provide the cornerstone for exciting new research into analogous processes in human cells. The reason for this is the revelation that the biochemical pathways for the accurate replication, repair and recombination of DNA have been conserved through evolution. New research shows that human cells use DNA repair mechanisms that are analogous to those found in bacteria to overcome the damaging effects of environmental mutagens and carcinogens. Of particular significance is the observation that certain cancers are caused by defects in DNA repair enzymes. For example, the human inherited non-polyposis colon cancer is now known to be caused by defects in the enzymes that repair DNA mismatches. Because much detailed information has been accumulated in studies of analogous mismatch repair proteins from bacteria, rapid progress can now be made.
Author : Yaroslav Blume
Publisher : IOS Press
ISBN 13 : 1586035746
Total Pages : 372 pages
Book Rating : 4.5/5 (86 download)
Download or read book Cell Biology and Instrumentation written by Yaroslav Blume and published by IOS Press. This book was released on 2006 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular processes, signaled by UV radiation, contribute to the behavior of plants under various stresses in the environment. This book aims to introduce developments and instrumentation for cell biology, to update our understanding of the effects of UV radiation, and to evaluate how plants use UV signals to protect against damage.
Author : Leonard Hayflick
Publisher :
ISBN 13 : 9780345401557
Total Pages : 0 pages
Book Rating : 4.4/5 (15 download)
Download or read book How and why We Age written by Leonard Hayflick and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "How long can humans live? Is immortality possible? Just what is the aging process? The aging and inevitable death of the human body have inspired more myths and outrageous quackery than anything else subject to scientific inquiry. . . . Now comes a most fascinating book, insightful and scholarly, to provide what answers have emerged so far." --San Francisco Chronicle Here, at last, preeminent cell biologist Leonard Hayflick presents the truth about human aging. Based on more than thirty years of pioneering research in the field, How and Why We Age explores not only how our major biological systems change as we grow older, but also examines the intangible alterations in our modes of thinking and feeling, our moods and sexual desires, our personality traits and our memories. With the immediacy of the latest scientific discoveries, Dr. Hayflick explains how aging affects every part of the body, and dispels many of the most persistent aging myths, to show that: * Hearts do not naturally get weaker with age. * Regular exercise and a low-fat diet won't slow aging. * Curing cancer would only add two years to the average sixty-five-year-old American life. Curing heart disease, however would add fourteen years. * Only five percent of people over the age of sixty-five are in nursing homes * No human has lived--or probably can live--past 120 years. Gracefully written, clearly organized, and packed with essential facts and statistics, How and Why We Age is a landmark study of the aging process for readers of all ages. "Written in clear, nontechnical language, it is an excellent introduction to the scientific and demographic literature on this multifacetedsubject." --Nature
