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Rat Genomics
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Download or read book Rat Genomics written by Ignacio Anegon and published by Humana Press. This book was released on 2012-04-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Grown exponentially by the genomic revolution, the use of the rat as a model of choice for physiological studies continues in popularity and at a much greater depth of understanding. In Rat Genomics: Methods and Protocols, world-wide experts provide both practical information for researchers involved in genomic research in the rat along with a more contextual discussion about the usefulness of the rat in physiological or translational research in different organs and systems. The volume extensively covers topics including genome sequencing, quantitative trait loci mapping, and the identification of single nucleotide polymorphisms as well as the development of transgenic technologies such as nuclear cloning, lentiviral-mediated transgenesis, gene knock-down using RNA interference, gene knock-out by mutagenesis, and zinc finger nucleases plus exciting advances in the obtention of rat embryonic cell lines. As a volume in the highly successful Methods in Molecular BiologyTM series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Comprehensive and up-to-date, Rat Genomics: Methods and Protocols thoroughly covers the current techniques used in labs around the world and overviews the applications of the data obtained, making it certain to be useful to the scientific community as a key source of references and methods.
Download or read book Rat Genomics written by G. Thomas Hayman and published by Methods in Molecular Biology. This book was released on 2020-07-13 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rat Genomics written by Humana Press and published by . This book was released on 2007 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetics of the Norway Rat by : Roy Robinson
Download or read book Genetics of the Norway Rat written by Roy Robinson and published by Elsevier. This book was released on 2013-10-22 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of the Norway Rat details the various genetic traits of Norway rat. The book covers a wide spectrum of trait inheritance, from color variation up to the various genetic mutation and quirks. The coverage of the text includes growth, metabolism, reproduction, and endocrinology. Several chapters also cover the physiological traits that include skeleton, viscera, sensory organs, and nervous. The text also takes into consideration the immunogenetics, pharmacogenetics, psychogenetics, and cytogenetics of the species studied. The book will be of great interest to mammalian geneticists. Researchers who are using rats as a test subject in their research will also benefit from the text.
Book Synopsis Microbial Status and Genetic Evaluation of Mice and Rats by : National Research Council
Download or read book Microbial Status and Genetic Evaluation of Mice and Rats written by National Research Council and published by National Academies Press. This book was released on 2000-10-30 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats. In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.
Book Synopsis Comparative Anatomy and Histology by : Piper M. Treuting
Download or read book Comparative Anatomy and Histology written by Piper M. Treuting and published by Academic Press. This book was released on 2017-08-29 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their model rodents Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images
Book Synopsis Microbial and Phenotypic Definition of Rats and Mice by : National Research Council
Download or read book Microbial and Phenotypic Definition of Rats and Mice written by National Research Council and published by National Academies Press. This book was released on 1999-08-26 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.
Book Synopsis Life History of the Kangaroo Rat by : Charles Taylor Vorhies
Download or read book Life History of the Kangaroo Rat written by Charles Taylor Vorhies and published by Good Press. This book was released on 2019-12-10 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Life History of the Kangaroo Rat" is research on a kangaroo rat's morphology, looks, build, and habits. The book is written by the entomologist from the Agricultural Experiment Station, University of Arizona, Charles T. Vorhies, and the biologist from the Bureau of Biological Survey, U. S. Department of Agriculture. It shares details of how kangaroo rats build their homes, store their food, their natural enemies, and many more.
Author :Professor of Molecular Biology Lee M Silver, Professor Dr Publisher :Oxford University Press on Demand ISBN 13 :9780195075540 Total Pages :362 pages Book Rating :4.0/5 (755 download)
Book Synopsis Mouse Genetics by : Professor of Molecular Biology Lee M Silver, Professor Dr
Download or read book Mouse Genetics written by Professor of Molecular Biology Lee M Silver, Professor Dr and published by Oxford University Press on Demand. This book was released on 1995 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.
Download or read book Rat Genome written by and published by . This book was released on 1998 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Year of the Rat by : Amy Lynn Zinski
Download or read book The Year of the Rat written by Amy Lynn Zinski and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in genome sequencing exploded after the first DNA sequencings and the launch of the Human Genome Project (HGP) in 1990. It was realized that specific genes and mutations have potential causal relationships with phenotypes and diseases. Thus one year after the HGP was completed (2004), the first rat genome was sequenced, as knowing the genome of a thoroughly researched model organism would hasten new discoveries in genomics such as linkage disequilibriums, population structures, gene discovery, and genome to phenome studies. Sequencing technology and platforms, have produced increasingly greater sequencing depth and accurate reads, leading to significant advancement in the rat genome assembly over the last 20 years. This has led to the discovery of genome variants in rats, which have been widely used to detect quantitative trait loci underlying complex phenotypes based on gene, haplotype, and sweep association analyses. Studies using DNA variants can also yield important information about strain, chromosome and gene functional evolutions. Phenome programs have advanced in parallel resulting in over 10 databases containing genome and/or phenome information. To discover bridges between genomes and phenomes, new approaches in systems genetics and integrative genomics have been developed. Our genome sequencing study along with a behavioral study, literature review, and computational approach to relate the developmental stages of the rat to humans contribute novel genomic and phenotypic data that enhance the utility of the rat as a model organism for human health and diseases. Here, we present new WGS and phenotypic data comparing inbred and outbred rat strains that will serve as foundational knowledge in determining genotype-to-phenotype relations. Our WGS completed on NIH-HS and Wistar rats revealed over 3.6 million genetic variants, including 117,060 that reside within 7,788 genes in pathways related to drug metabolism; muscle development; protein, amino acid, and lipid metabolism; DNA and RNA processing; cell division; and regulation of epigenetic processes. Our phenotypic data highlights behavioral differences between inbred and outbred Wistar rats – such as risk-taking behaviors. With this data, we plan to continue detailing the differences between inbred and outbred rat strains and eventually elucidate cellular mechanisms that describe genotypic differences resulting phenotypic variations.
Book Synopsis Genome Mapping and Genomics in Laboratory Animals by : Paul Denny
Download or read book Genome Mapping and Genomics in Laboratory Animals written by Paul Denny and published by Springer Science & Business Media. This book was released on 2013-01-13 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mapping of animal genomes has generated huge databases and several new concepts and strategies, which are useful to elucidate origin, evolution and phylogeny. Genetic and physical maps of genomes further provide precise details on chromosomal location, function, expression and regulation of academically and economically important genes. The series Genome Mapping and Genomics in Animals provides comprehensive and up-to-date reviews on genomic research on a large variety of selected animal systems, contributed by leading scientists from around the world. Laboratory animals are those species that by accident of evolution, domestication and selective breeding are amenable to maintenance and study in a laboratory environment. Many of these species are studied as 'models' for the biology and pathology of humans. Laboratory animals included in this volume are sea-urchin, nematode worm, fruit fly, sea squirts, puffer fishes, medaka fish, African clawed frog, mouse and rat.
Download or read book Rat Genome Database written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Rat Genome Database (RGD) curates and integrates rat genetic and genomic data and provides access to this data to support research using the rat as a genetic model for the study of human disease.
Book Synopsis Microbial and Phenotypic Definition of Rats and Mice by : National Research Council
Download or read book Microbial and Phenotypic Definition of Rats and Mice written by National Research Council and published by National Academies Press. This book was released on 1999-07-26 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.
Book Synopsis Origins of Inbred Mice by : Herbert C. III Morse
Download or read book Origins of Inbred Mice written by Herbert C. III Morse and published by Elsevier. This book was released on 2012-12-02 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: Origins of Inbred Mice documents the proceedings of a symposium on the state of knowledge on inbred mice held in Bethesda, Maryland, in 1978. The book is organized into seven parts. Part I provides introductory remarks on the history of the development of inbred mice. Part II contains papers that examine mutations of inbred strains of mice. Part III contains studies dealing with viruses that affect inbred mice, including those that cause leukemia and mammary tumors. Part IV examines histocompatibility genes and their antigens; cell surface antigens of mouse leukemia; the characteristics of genes of the Tla region of the mouse; and the use of recombinant inbred strains in gene mapping. Part V presents studies on differences among sublines of inbred mouse strains. The papers in Part VI focus on wild mice, covering their classification and biochemical polymorphisms. Finally, Part VIII discusses the viruses, T locus, and histocompatibility antigens of wild mice.
Book Synopsis The Mouse In Animal Genetics And Breeding Research by : Eugene J Eisen
Download or read book The Mouse In Animal Genetics And Breeding Research written by Eugene J Eisen and published by World Scientific. This book was released on 2005-06-27 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields.
Book Synopsis Rat Genetics, Genomics and Model Systems for Human Diseases by : Society for the Spontaneously Hypertensive Rat
Download or read book Rat Genetics, Genomics and Model Systems for Human Diseases written by Society for the Spontaneously Hypertensive Rat and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
