Radiolabeled Monoclonal Antibodies for Imaging and Therapy

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Publisher : Springer Science & Business Media
ISBN 13 : 1468455389
Total Pages : 851 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Radiolabeled Monoclonal Antibodies for Imaging and Therapy by : Suresh C. Srivastava

Download or read book Radiolabeled Monoclonal Antibodies for Imaging and Therapy written by Suresh C. Srivastava and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.

Cancer Imaging with Radiolabeled Antibodies

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Publisher : Springer Science & Business Media
ISBN 13 : 1461314976
Total Pages : 469 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Cancer Imaging with Radiolabeled Antibodies by : David M. Goldenberg

Download or read book Cancer Imaging with Radiolabeled Antibodies written by David M. Goldenberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Radiolabeled Monoclonal Antibodies for Cancer Diagnosis and Therapy

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (84 download)

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Book Synopsis Radiolabeled Monoclonal Antibodies for Cancer Diagnosis and Therapy by :

Download or read book Radiolabeled Monoclonal Antibodies for Cancer Diagnosis and Therapy written by and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Therapy with Radiolabeled Antibodies

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Author :
Publisher : CRC Press
ISBN 13 : 1351087304
Total Pages : 405 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Cancer Therapy with Radiolabeled Antibodies by : David M. Goldenberg

Download or read book Cancer Therapy with Radiolabeled Antibodies written by David M. Goldenberg and published by CRC Press. This book was released on 2018-01-18 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.

3rd Scandinavian Symposium on Radiolabeled Monoclonal Antibodies for Cancer Diagnosis and Therapy

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Publisher :
ISBN 13 :
Total Pages : 183 pages
Book Rating : 4.:/5 (694 download)

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Book Synopsis 3rd Scandinavian Symposium on Radiolabeled Monoclonal Antibodies for Cancer Diagnosis and Therapy by :

Download or read book 3rd Scandinavian Symposium on Radiolabeled Monoclonal Antibodies for Cancer Diagnosis and Therapy written by and published by . This book was released on 1993 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

International Symposium on Labeled and Unlabeled Antibody in Cancer Diagnosis and Therapy

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Author :
Publisher :
ISBN 13 :
Total Pages : 196 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis International Symposium on Labeled and Unlabeled Antibody in Cancer Diagnosis and Therapy by :

Download or read book International Symposium on Labeled and Unlabeled Antibody in Cancer Diagnosis and Therapy written by and published by . This book was released on 1987 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Targeted Radionuclide Therapy

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451153260
Total Pages : 564 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Targeted Radionuclide Therapy by : Tod W. Speer

Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Papers from 4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies for Cancer Diagnosis and Therapy

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Author :
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (123 download)

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Book Synopsis Papers from 4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies for Cancer Diagnosis and Therapy by :

Download or read book Papers from 4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies for Cancer Diagnosis and Therapy written by and published by . This book was released on 1996 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunoconjugate Therapy of Hematologic Malignancies

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Publisher : Springer Science & Business Media
ISBN 13 : 1461530768
Total Pages : 293 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Immunoconjugate Therapy of Hematologic Malignancies by : Steven T. Rosen

Download or read book Immunoconjugate Therapy of Hematologic Malignancies written by Steven T. Rosen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hybridoma technique for producing monoclonal antibodies, developed by Drs. Kohler and Millstein in 1975, revolutionized the field of tumor immunology. It is now clear that there are antigens associated with or restricted to human neoplasms that have biologic significance. Monoclonal antibodies have already been demonstrated to have great immunodiagnostic value and it is anticipated that they will become a component of our therapeutic armamentarium. Most investigators in the field, however, feel that the true potential of monoclonal antibodies in cancer therapy remains to be determined. Clearly the most encouraging results have been witnessed in the treatment of hematologic malignancies. This volume of CANCER TREATMENT AND RESEARCH explores the current state of the art of immunoconjugate therapy of hematologic malignancies. Immunoconjugate Therapy of Hematologic Malignancies provides an update of a rapidly advancing field. The preliminary experience of a number of investigators suggests a role for targeted therapy in the treatment of hematologic malignancies. At the present time, immunoconjugates have, in most instances, been reserved for patients with advanced refractory disease. However, it is anticipated in the future that these reagents will be utilized as a complement to traditional therapy or as post-remission consolidation in patients with minimal residual disease. The obstacles have been defined; solutions will require further research and creative imagination.

Safety of Biologics Therapy

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Publisher : Springer
ISBN 13 : 3319304720
Total Pages : 623 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Safety of Biologics Therapy by : Brian A. Baldo

Download or read book Safety of Biologics Therapy written by Brian A. Baldo and published by Springer. This book was released on 2016-08-12 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.

Radiolabelling of Monoclonal Antibodies with 64Cu for Cancer Diagnosis and Therapy

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Publisher :
ISBN 13 :
Total Pages : 308 pages
Book Rating : 4.:/5 (223 download)

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Book Synopsis Radiolabelling of Monoclonal Antibodies with 64Cu for Cancer Diagnosis and Therapy by : Martalena Ramli

Download or read book Radiolabelling of Monoclonal Antibodies with 64Cu for Cancer Diagnosis and Therapy written by Martalena Ramli and published by . This book was released on 2003 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Radiolabeled Compounds for Diagnosis and Treatment of Cancer

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Author :
Publisher : Mdpi AG
ISBN 13 : 9783036524276
Total Pages : 262 pages
Book Rating : 4.5/5 (242 download)

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Book Synopsis Radiolabeled Compounds for Diagnosis and Treatment of Cancer by : Krishan Kumar

Download or read book Radiolabeled Compounds for Diagnosis and Treatment of Cancer written by Krishan Kumar and published by Mdpi AG. This book was released on 2021-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiopharmaceuticals are used in the diagnosis and treatment of various diseases, especially cancer. In general, radiopharmaceuticals are either salts of radionuclides or radionuclides bound to biologically active molecules, drugs, or cells. Tremendous progress has been made in discovering, developing, and commercializing numerous radiopharmaceuticals for the imaging and therapy of cancer. Significant research is ongoing in academia and the pharmaceutical industry to develop more novel radiolabeled compounds as potential radiopharmaceuticals for unmet needs. This Special Issue aims to focus on all aspects of the design, characterization, evaluation, and development of novel radiolabeled compounds for the diagnosis and treatment of cancer and the application of new radiochemistry and methodologies for the development of novel radiolabeled compounds. Outstanding contributions presented in this Special Issue will significantly add to the field of radiopharmaceuticals.

Monoclonal Antibody Therapy of Human Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 1461326273
Total Pages : 171 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Monoclonal Antibody Therapy of Human Cancer by : Kenneth A. Foon

Download or read book Monoclonal Antibody Therapy of Human Cancer written by Kenneth A. Foon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system. Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system.

Papers from 4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies in Diagnosis and Therapy of Cancer

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Author :
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (246 download)

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Book Synopsis Papers from 4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies in Diagnosis and Therapy of Cancer by :

Download or read book Papers from 4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies in Diagnosis and Therapy of Cancer written by and published by . This book was released on 1996 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies in Diagnosis and Therapy of Cancer

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Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (596 download)

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Book Synopsis 4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies in Diagnosis and Therapy of Cancer by :

Download or read book 4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies in Diagnosis and Therapy of Cancer written by and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systemic Radiotherapy with Monoclonal Antibodies

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Publisher : Springer Science & Business Media
ISBN 13 : 3642799523
Total Pages : 200 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Systemic Radiotherapy with Monoclonal Antibodies by : Marie-Luise Sautter-Bihl

Download or read book Systemic Radiotherapy with Monoclonal Antibodies written by Marie-Luise Sautter-Bihl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radio labeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.

Radiolabeled Monoclonal Antibodies for Imaging and Therapy

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (727 download)

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Book Synopsis Radiolabeled Monoclonal Antibodies for Imaging and Therapy by :

Download or read book Radiolabeled Monoclonal Antibodies for Imaging and Therapy written by and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This meeting focused on areas of research on radiolabeled monoclonal antibodies. Topics covered included the production, purification, and fragmentation of monoclonal antibodies and immunochemistry of hybridomas; the production and the chemistry of radionuclides; the radiohalogenation and radiometal labeling techniques; the in-vivo pharmacokinetics of radiolabeled antibodies; the considerations of immunoreactivity of radiolabeled preparations; the instrumentation and imaging techniques as applied to radioimmunodetection; the radiation dosimetry in diagnostic and therapeutic use of labeled antibodies; the radioimmunoscintigraphy and radioimmunotherapy studies; and perspectives and directions for future research. Tutorial as well as scientific lectures describing the latest research data on the above topics were presented. Three workshop panels were convened on ''Methods for Determining Immunoreactivity of Radiolabeled Monoclonal Antibodies - Problems and Pitfalls, '' Radiobiological and Dosimetric Considerations for Immunotherapy with Labeled Antibodies, '' and ''The Human Anti-Mouse Antibody Response in Patients.''