Quantitative Histomorphometry Of Digital Pathology As A Companion Diagnostic

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Quantitative Histomorphometry of Digital Pathology as a Companion Diagnostic

Author : Ajay Nagesh Basavanhally
Publisher :
ISBN 13 :
Total Pages : 123 pages
Book Rating : 4.:/5 (872 download)

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Book Synopsis Quantitative Histomorphometry of Digital Pathology as a Companion Diagnostic by : Ajay Nagesh Basavanhally

Download or read book Quantitative Histomorphometry of Digital Pathology as a Companion Diagnostic written by Ajay Nagesh Basavanhally and published by . This book was released on 2014 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work involves the creation of an image-based companion diagnostic framework that employs quantitative features extracted from whole-slide, H & E stained digital pathology (DP) images to distinguish patients based on disease outcome, with a clinical application aimed at distinguishing estrogen receptor-positive (ER+) breast cancer (BCa) patients with good and poor outcomes. Quantitative histomorphometry (QH) -- the conversion of a digitized histopathology slide into a series of quantitative measurements of tumor morphology -- is a rapidly growing field aimed at introducing advanced image analytics into the histopathological workflow. The thrust towards personalized medicine has led to the development of companion diagnostic tools that measure gene expression, yielding quantitative outcome predictions for improved disease stratification and customized therapies, e.g. Oncotype DX (Genomic Health, Inc.) for ER+ BCa. Yet, tumor morphology is often correlated with genomic assays, suggesting that genotypic variations in biologically distinct classes of tumors lead to distinct patterns of tumor cell morphology and tissue architecture in histopathology. The application of this work to ER+ BCa is highly relevant to current clinical needs. Current treatment guidelines recommend that the majority of women with ER+ BCa receive chemotherapy in addition to hormonal therapy; yet, approximately half will not benefit from chemotherapy while still enduring its harmful side effects. Hence, there is a clear need for the development of automated prognostic tools to identify women with poorer outcomes who will likely benefit from chemotherapy. The primary novel contributions of this work are (1) a color standardization system for improving the consistency in appearance of tissue structures across images, (2) the identification of tissue structures and corresponding QH signatures with prognostic value in ER+ BCa, (3) a multi-field-of-view framework for robust integration of prognostic information across whole-slide DP images, and (4) a method for predicting classifier performance for a large data cohort based on the availability of limited training data. This work will pave the way for the development of novel companion diagnostic systems capable of producing quantitative and reproducible image-based risk scores. These risk scores will play a vital role in decision support by helping clinicians predict patient outcome and prescribing appropriate therapies.

Bone Pathology

Author : Jasvir S. Khurana
Publisher : Springer Science & Business Media
ISBN 13 : 1597453471
Total Pages : 419 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Bone Pathology by : Jasvir S. Khurana

Download or read book Bone Pathology written by Jasvir S. Khurana and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Pathology is the second edition of the book, A Compendium of Skeletal Pathology that published 10 years ago. Similar to the prior edition, this book complements standard pathology texts and blends new but relatively established information on the molecular biology of the bone. Serving as a bench-side companion to the surgical pathologist, this new edition reflects new advances in our understanding of the molecular biology of bone. New chapters on soft-tissue sarcomas and soft-tissue tumors have been added as well as several additional chapters such as Soft-tissue pathology and Biomechanics. The volume is written by experts who are established in the field of musculoskeletal diseases. Bone Pathology is a combined effort from authors of different specialties including surgeons, pathologists, radiologists and basic scientists all of whom have in common an interest in bone diseases. It will be of great value to surgical pathology residents as well as practicing pathologists, skeletal radiologists, orthopedic surgeons and medical students.

Bone Histomorphometry

Author : Erik Fink Eriksen
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781701228
Total Pages : 0 pages
Book Rating : 4.7/5 (12 download)

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Book Synopsis Bone Histomorphometry by : Erik Fink Eriksen

Download or read book Bone Histomorphometry written by Erik Fink Eriksen and published by Lippincott Williams & Wilkins. This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Whole Slide Imaging

Author : Anil V. Parwani
Publisher : Springer Nature
ISBN 13 : 3030833321
Total Pages : 253 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Whole Slide Imaging by : Anil V. Parwani

Download or read book Whole Slide Imaging written by Anil V. Parwani and published by Springer Nature. This book was released on 2021-10-29 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date and practical knowledge in all aspects of whole slide imaging (WSI) by experts in the field. This includes a historical perspective on the evolution of this technology, technical aspects of making a great whole slide image, the various applications of whole slide imaging and future applications using WSI for computer-aided diagnosis The goal is to provide practical knowledge and address knowledge gaps in this emerging field. This book is unique because it addresses an emerging area in pathology for which currently there is only limited information about the practical aspects of deploying this technology. For example, there are no established selection criteria for choosing new scanners and a knowledge base with the key information. The authors of the various chapters have years of real-world experience in selecting and implementing WSI solutions in various aspects of pathology practice. This text also discusses practical tips and pearls to address the selection of a WSI vendor, technology details, implementing this technology and provide an overview of its everyday uses in all areas of pathology. Chapters include important information on how to integrate digital slides with laboratory information system and how to streamline the “digital workflow” with the intent of saving time, saving money, reducing errors, improving efficiency and accuracy, and ultimately benefiting patient outcomes. Whole Slide Imaging: Current Applications and Future Directions is designed to present a comprehensive and state-of the-art approach to WSI within the broad area of digital pathology. It aims to give the readers a look at WSI with a deeper lens and also envision the future of pathology imaging as it pertains to WSI and associated digital innovations.

Bone Densitometry in Clinical Practice

Author : Sydney Lou Bonnick
Publisher : Springer Science & Business Media
ISBN 13 : 1592596592
Total Pages : 421 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Bone Densitometry in Clinical Practice by : Sydney Lou Bonnick

Download or read book Bone Densitometry in Clinical Practice written by Sydney Lou Bonnick and published by Springer Science & Business Media. This book was released on 2003-09-17 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Dr. Sydney Lou Bonnick’s text Bone Densitometry in Clinical Practice is an expansion of her highly regarded first edition, which has provided the bone densitometry community with simply the best, most accurate, and most precisely written resource in our field. Dr. Bonnick has applied her very careful and exact scientific approaches to expand and improve on her widely regarded initial text. In addition to the chapters in the first edition on the science of bone densitometry and its clinical appli- tion, this text has new chapters and a CD-ROM that come at a very critical time in our field. The clinical use of bone densitometry is increasing exponentially as more professional societies have endorsements and guidelines on the application of bone densitometry in the assessment and management of osteoporosis. The recent endorsement of population screening by the US Preventive Services Task Force (USPSTF) has now provided g- ernmental validation to this technology, whose proper use Dr. Bonnick has pioneered. In a new chapter, Dr. Bonnick compares the similarities and differences in the recent gui- lines from the USPSTF and the National Osteoporosis Foundation, American Assoc- tion of Clinical Endocrinologists, American College of Obstetrics and Gynecology, and the North American Menopause Society.

Mechanisms of Disease in Small Animal Surgery

Author : M. Joseph Bojrab
Publisher : Teton NewMedia
ISBN 13 : 9781591610380
Total Pages : 0 pages
Book Rating : 4.6/5 (13 download)

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Book Synopsis Mechanisms of Disease in Small Animal Surgery by : M. Joseph Bojrab

Download or read book Mechanisms of Disease in Small Animal Surgery written by M. Joseph Bojrab and published by Teton NewMedia. This book was released on 2010-01-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is an ideal resource for the individual performing or learning to perform a surgical procedure. The most qualified experts in the fields of surgery and pathophysiology explain in easy to understand and practical terms the mechanisms by which a disease affects each organ. Mechanisms of Disease in Small Animal Surgery not only helps the practicing veterinarian better understand the function of specific organs effected by disease; but also helps the practitioner explain it and the selected surgical treatment to the client in an easy to understand manner. The highly visual format contains over 500 highly quality illustrations and well conceived tables. It is enormously helpful to veterinary student studying for the boards.

Joint Disease in the Horse

Author : C. Wayne McIlwraith
Publisher : Elsevier Health Sciences
ISBN 13 : 1455759694
Total Pages : 425 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Joint Disease in the Horse by : C. Wayne McIlwraith

Download or read book Joint Disease in the Horse written by C. Wayne McIlwraith and published by Elsevier Health Sciences. This book was released on 2015-09-23 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. McIlwraith's Joint Disease in the Horse, 2nd Edition is the only book to give you a full account of equine joint disease, combining a thorough, up-to-date survey of scientific advances with a practical guide to both medical and surgical treatments. With contributions from nationally and internationally recognized pioneers in the field, this groundbreaking text offers an overview of joint structure and function and translates the latest information on basic joint pathobiology into practical application for the clinician. Step-by-step guidance on injection techniques and medications, along with a survey of practical arthroscopic surgery and developments, make it a truly indispensable reference for all equine veterinarians treating sports and racing horses. UNIQUE! Unprecedented, state-of-the-art coverage of the pathology, pathogenesis, and clinical diagnosis of traumatic and degenerative joint disease, so you stay in the know. Section on general principles of joint pathobiology provides the background to evaluate and interpret the diagnostic and surgical aspects of disease. Explores treatments for traumatic arthritis and osteoarthritis and other joint entities, offering a broad range of options and up-to-date recommendations for problematic decisions. Addresses recent advances and results in arthroscopic surgery for the acute injury and results including fragment removal, fragment fixation, and synovectomy. Discussion of current research provides insight for difficult cases and calls out the directions in which future arthritis research is headed. More than 325 photographs and line drawings help engage and guide you through procedures and treatments. NEW! Full color throughout with new artwork and a range of new images including radiographs showing both the normal and the disease progression. NEW! Practical step-by-step approach demonstrates the authors' preferred injections methods and shows underlying anatomic correlations. NEW and UPDATED! Restructured and substantially revised to emphasize treatment options, making it a practical, concise, and accessible reference and text. NEW! All-new chapters on drugs and new biological therapies, including stem cells, IRAP, and PRP and thoroughly updated coverage of HA and corticosteroids. NEW! Covers advanced imaging, giving you the latest information available. NEW! Expert advice from Dr. McIlwraith, three new co-editors, and new contributors - all distinguished specialists in the field of joint disease in the horse. Lameness and surgical clinicians describe how to approach the various, specific disease conditions. Equine specific radiologists provide their opinions on the best imaging techniques for defining the disease and making interpretations.

Forensic Anthropology

Author : Angi M. Christensen
Publisher : Elsevier
ISBN 13 : 0124172903
Total Pages : 465 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Forensic Anthropology by : Angi M. Christensen

Download or read book Forensic Anthropology written by Angi M. Christensen and published by Elsevier. This book was released on 2013-12-30 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic Anthropology: Current Methods and Practice—winner of a 2015 Textbook Excellence Award (Texty) from The Text and Academic Authors Association—approaches forensic anthropology through an innovative style using current practices and real case studies drawn from the varied experiences, backgrounds, and practices of working forensic anthropologists. This text guides the reader through all aspects of human remains recovery and forensic anthropological analysis, presenting principles at a level that is appropriate for those new to the field, while at the same time incorporating evolutionary, biomechanical, and other theoretical foundations for the features and phenomena encountered in forensic anthropological casework. Attention is focused primarily on the most recent and scientifically valid applications commonly employed by working forensic anthropologists. Readers will therefore learn about innovative techniques in the discipline, and aspiring practitioners will be prepared by understanding the necessary background needed to work in the field today. Instructors and students will find Forensic Anthropology: Current Methods and Practice comprehensive, practical, and relevant to the modern discipline of forensic anthropology. - Winner of a 2015 Most Promising New Textbook Award from the Text and Academic Authors Association - Focuses on modern methods, recent advances in research and technology, and current challenges in the science of forensic anthropology - Addresses issues of international relevance such as the role of forensic anthropology in mass disaster response and human rights investigations - Includes chapter summaries, topicoriented case studies, keywords, and reflective questions to increase active student learning

Archaeological Science

Author : Michael P. Richards
Publisher : Cambridge University Press
ISBN 13 : 0521195225
Total Pages : 467 pages
Book Rating : 4.5/5 (211 download)

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Book Synopsis Archaeological Science by : Michael P. Richards

Download or read book Archaeological Science written by Michael P. Richards and published by Cambridge University Press. This book was released on 2020-01-16 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible and wide-ranging introduction to the exciting and expanding field of archaeological science, for students, professionals and academics.

Heptinstall's Pathology of the Kidney

Author : J. Charles Jennette
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781747509
Total Pages : 930 pages
Book Rating : 4.7/5 (475 download)

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Book Synopsis Heptinstall's Pathology of the Kidney by : J. Charles Jennette

Download or read book Heptinstall's Pathology of the Kidney written by J. Charles Jennette and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts in the field of renal disease offer careful pathologic descriptions, appropriate clinical correlations, and extensive discussions on causes and pathogenesis to clarify the clinicians understanding and help facilitate easy, accurate diagnosis. This updated edition features hundreds of razor-sharp illustrations along with more international contributors than before.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Author : Murray J. Favus
Publisher :
ISBN 13 :
Total Pages : 538 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism by : Murray J. Favus

Download or read book Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism written by Murray J. Favus and published by . This book was released on 1999 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anatomy and biology of bone matrix and cellular elements; Skeletal physiology; Mineral homeostasis; Clinical evaluation of bone and mineral disorders; Disorders of serum minerals; Metabolic bone diseases; Genetic, developmenal, and dysplastic skeletal disorders; Acquired disorders of cartilage and bone; Paget's disease; Extraskeletal (ectopic) calcification and ossification; Nephrolithiasis; Dentistry.

SEER, Surveillance, Epidemiology, and End Results Program

Author : SEER Program (National Cancer Institute (U.S.))
Publisher :
ISBN 13 :
Total Pages : 16 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis SEER, Surveillance, Epidemiology, and End Results Program by : SEER Program (National Cancer Institute (U.S.))

Download or read book SEER, Surveillance, Epidemiology, and End Results Program written by SEER Program (National Cancer Institute (U.S.)) and published by . This book was released on 2000 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Picture Processing and Psychopictorics

Author : B.S. Lipkin
Publisher : Elsevier
ISBN 13 : 0323146856
Total Pages : 535 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Picture Processing and Psychopictorics by : B.S. Lipkin

Download or read book Picture Processing and Psychopictorics written by B.S. Lipkin and published by Elsevier. This book was released on 1970-01-01 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Picture Processing and Psychopictorics explores the selected aspects of perception and picture processing involving variables that are relevant to psychopictoric research. This book is organized into four parts encompassing 18 chapters. The first three parts cover the three classes of psychophysical variables, namely, contrast and border, shape and geometry, and texture. These parts also deal with the factors that influence the detection of objects in complex images. The discussion then shifts to the role of these factors in perception, as well as the computer analysis and manipulation of images with respect to these factors. The fourth part describes the programming systems for online experimental design and image manipulation. This work will be of great value to psychologists concerned with determining how the human extracts information from visual stimuli and to computer scientist concerned with developing programs and equipment to extract similar information from images.

Fundamentals of Naturopathic Endocrinology

Author : Michael Friedman
Publisher :
ISBN 13 : 9780692267257
Total Pages : 377 pages
Book Rating : 4.2/5 (672 download)

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Book Synopsis Fundamentals of Naturopathic Endocrinology by : Michael Friedman

Download or read book Fundamentals of Naturopathic Endocrinology written by Michael Friedman and published by . This book was released on 2014-09-13 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Naturopathic Endocrinology is designed to be a textbook for professors and students of naturopathic medicine, a desk reference for clinicians treating patients with endocrine disorders, and a convenient resource for all healthcare professionals wanting to read more about naturopathic endocrinology research. The purpose of the book is to apply Naturopathic methods of understanding, diagnosing, treating, and preventing disease to a wide range of endocrine-related disorders. This book is divided into three sections: a student textbook of naturopathic endocrinology based on current research, a clinical handbook of naturopathic protocols to diagnose and treat the most common endocrine disorders; and a selection of key clinical studies and research reports written by leading medical doctors and scientists. Case studies from clinical practice illustrate the principles outlined in the text. This book enables students of naturopathic medicine to enter their clinical training with increased confidence in understanding and treating disorders of the endocrine system. The student can draw upon the substantial knowledge and clinical experience accumulated in these pages, as well as quickly call up the many scientific references provided from recent literature in medical journals, naturopathic and botanical medicine publications, and endocrinology textbooks. This book offers practicing physicians, nurses, and other healthcare professionals a very practical clinical companion, covering established diagnostic and therapeutic protocols for endocrine disorders in quick reference charts. This book does not aim to replace standard endocrinology textbooks but rather to complement them. It is very much a cooperative effort between naturopathic and medical doctors. The work of prominent medical doctors, such as Abram Hoffer, John Lee, Denis Wilson, and Alan R. Gaby, is published alongside the work or respected naturopathic doctors such as Gregory S. Kelly. Dr Michael Friedman is a graduate of The Canadian College of Naturopathic Medicine and a former Professor of Endocrinology at the University of Bridgeport. He lives in Montpelier, Vermont.

Veterinary Hematology

Author : William J. Reagan
Publisher : John Wiley & Sons
ISBN 13 : 1119064813
Total Pages : 146 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Veterinary Hematology by : William J. Reagan

Download or read book Veterinary Hematology written by William J. Reagan and published by John Wiley & Sons. This book was released on 2019-05-21 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, Veterinary Hematology: Atlas of Common Domestic and Non-Domestic Species continues to offer veterinarians and veterinary technicians an essential guide to veterinary hematology. Comprehensive in scope, the atlas presents the fundamentals of both normal and abnormal blood cell morphologies, with coverage of a wide range of species, including dogs, cats, horses, ruminants, llamas, rats, mice, nonhuman primates, ferrets, rabbits, guinea pigs, birds, amphibians, and reptiles. Designed as a useful and accessible guide, the updated third edition presents more than 300 color images and includes a new chapter that describes the best techniques for using hematology instruments. The authors—noted experts on the topic—clearly show how to identify and interpret the hematological changes that may occur in a variety of species. In addition, a companion website offers a wealth of additional hematological images. This vital atlas: Provides an updated edition of the popular veterinary hematology atlas for veterinarians, veterinary students, and veterinary technicians Contains a new instructive chapter on hematology instrumentation Presents hundreds of high-quality color photographs that help in identification Covers a range of species from dogs and cats to birds and reptiles Features a companion website that provides a wealth of hematological images Written for both novice and experienced veterinarians, Veterinary Hematology provides a complete resource to blood morphologic abnormalities in domestic and non-domestic species.

Environmental Medicine

Author : Committee on Curriculum Development in Environmental Medicine
Publisher : National Academies Press
ISBN 13 : 0309568722
Total Pages : 988 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Environmental Medicine by : Committee on Curriculum Development in Environmental Medicine

Download or read book Environmental Medicine written by Committee on Curriculum Development in Environmental Medicine and published by National Academies Press. This book was released on 1995-05-12 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: People are increasingly concerned about potential environmental health hazards and often ask their physicians questions such as: "Is the tap water safe to drink?" "Is it safe to live near power lines?" Unfortunately, physicians often lack the information and training related to environmental health risks needed to answer such questions. This book discusses six competency based learning objectives for all medical school students, discusses the relevance of environmental health to specific courses and clerkships, and demonstrates how to integrate environmental health into the curriculum through published case studies, some of which are included in one of the book's three appendices. Also included is a guide on where to obtain additional information for treatment, referral, and follow-up for diseases with possible environmental and/or occupational origins.

International Conference for Innovation in Biomedical Engineering and Life Sciences

Author : Fatimah Ibrahim
Publisher : Springer
ISBN 13 : 9811002665
Total Pages : 340 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis International Conference for Innovation in Biomedical Engineering and Life Sciences by : Fatimah Ibrahim

Download or read book International Conference for Innovation in Biomedical Engineering and Life Sciences written by Fatimah Ibrahim and published by Springer. This book was released on 2015-11-26 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volumes presents the proceedings of ICIBEL 2015, organized by the Centre for Innovation in Medical Engineering (CIME) under Innovative Technology Research Cluster, University of Malaya. It was held in Kuala Lumpur, Malaysia, from 6-8 December 2015. The ICIBEL 2015 conference promotes the latest researches and developments related to the integration of the Engineering technology in medical fields and life sciences. This includes the latest innovations, research trends and concerns, challenges and adopted solution in the field of medical engineering and life sciences.