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Quantitative Analysis On The Origins Of Morphologically Abnormal Cells In Temporal Lobe Epilepsy
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Book Synopsis Quantitative Analysis on the Origins of Morphologically Abnormal Cells in Temporal Lobe Epilepsy by : Shatrunjai P. Singh
Download or read book Quantitative Analysis on the Origins of Morphologically Abnormal Cells in Temporal Lobe Epilepsy written by Shatrunjai P. Singh and published by . This book was released on 2015 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a common and devastating neurological disease with no real preventive or cure. In most cases of acquired epilepsy, an initial precipitating injury to the brain is followed by a silent period which eventually culminates into the development of spontaneous, recurrent seizures. This interval between the primary insult and the first seizure is referred to as the latent period of epileptogenesis and is characterized by abnormal morphological and physiological changes in the hippocampus. In the studies described herein, I aim to elucidate changes in the different phases of epileptogenesis with the end goal of deciphering critical epileptogenic mechanisms. To study the initial stages of epileptogenesis, I employed the early kindling model. In this protocol, it is possible to administer a limited number of stimulations sufficient to produce a lifelong enhanced sensitivity to stimulus evoked seizures without associated spontaneous seizures. In these experiments, I characterized the morphology of GFP-expressing granule cells from Thy-1 GFP mice either one day or one month after the last evoked seizure. I observed several morphological changes at the one day time point, which all normalized to control levels at the one month time point. Interestingly, I did not observe the presence of basal dendrites, frequently observed in other models of epilepsy. These findings demonstrate that the early stages of kindling epileptogenesis produces transient morphological changes but not the dramatic pathological rearrangements of dentate granule cell structure seen in typical models associated with spontaneous seizures. To study epileptogenesis after the incidence of spontaneous, recurrent seizures, I used the pilocarpine model of epilepsy. Our lab has previously used this model to show that adult hippocampal neurogenesis is profoundly altered under epileptic conditions, leading to the production of morphologically abnormal dentate granule cells. Under epileptic conditions, these adult generated cells migrate to ectopic locations and develop misoriented basal dendrites. Although it has been established that these abnormal cells are newly-generated, it is not known whether they arise ubiquitously throughout the progenitor cell pool or are derived from a smaller number of bad actor progenitors. To explore this question, I describe clonal analysis experiments conducted in epileptic mice expressing the brainbow fluorescent protein reporter construct in dentate granule cell progenitors. Brain sections were rendered translucent so that entire hippocampi could be reconstructed and all fluorescently-labeled cells identified. The findings revealed that a small number of progenitors produced the majority of ectopic cells in epileptic mice, indicating that either the affected progenitors or their local micro-environments had become pathological. By contrast, granule cells with basal dendrites were equally distributed among clonal groups. These findings strongly predict that distinct mechanisms regulate different aspects of granule cell pathology in epilepsy. The experiments described here utilize different models of epilepsy and employ cutting edge technology to provide valuable insight into the process of epileptogenesis. The results and ideas presented here are intended to advance our knowledge of epilepsy and eventually lead to better antiepileptic therapies.
Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels
Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Book Synopsis The Epilepsies by : Chrysostomos P. Panayiotopoulos
Download or read book The Epilepsies written by Chrysostomos P. Panayiotopoulos and published by Springer. This book was released on 2005 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.
Book Synopsis SIDS Sudden Infant and Early Childhood Death by : Roger W. Byard
Download or read book SIDS Sudden Infant and Early Childhood Death written by Roger W. Byard and published by . This book was released on 2018-04 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers aspects of sudden infant and early childhood death, ranging from issues with parental grief, to the most recent theories of brainstem neurotransmitters. It also deals with the changes that have occurred over time with the definitions of SIDS (sudden infant death syndrome), SUDI (sudden unexpected death in infancy) and SUDIC (sudden unexpected death in childhood). The text will be indispensable for SIDS researchers, SIDS organisations, paediatric pathologists, forensic pathologists, paediatricians and families, in addition to residents in training programs that involve paediatrics. It will also be of use to other physicians, lawyers and law enforcement officials who deal with these cases, and should be a useful addition to all medical examiner/forensic, paediatric and pathology departments, hospital and university libraries on a global scale. Given the marked changes that have occurred in the epidemiology and understanding of SIDS and sudden death in the very young over the past decade, a text such as this is very timely and is also urgently needed.
Book Synopsis Seizures and Epilepsy by : Jerome Engel Jr
Download or read book Seizures and Epilepsy written by Jerome Engel Jr and published by Oxford University Press. This book was released on 2013-01-31 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.
Book Synopsis Atlas of EEG, Seizure Semiology, and Management by : Karl E. Misulis
Download or read book Atlas of EEG, Seizure Semiology, and Management written by Karl E. Misulis and published by Oxford University Press. This book was released on 2013-12 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This resource is an illustrated guide to the performance and interpretation of EEG and management of epilepsy. This second edition has been thoroughly revised and updated, and features hundreds of detailed EEGs covering the science in extensive scope and detail, beginning with basic electronics and physiology, followed by EEG interpretation, epilepsy diagnosis, and ultimately epilepsy management. It also includes all basic classifications and definitions of seizures and epilepsy.
Book Synopsis Cognitive Plasticity in Neurologic Disorders by : Joseph I. Tracy
Download or read book Cognitive Plasticity in Neurologic Disorders written by Joseph I. Tracy and published by Oxford University Press, USA. This book was released on 2014-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.
Book Synopsis Neuroimaging in Epilepsy by : Harry Chugani, MD
Download or read book Neuroimaging in Epilepsy written by Harry Chugani, MD and published by Oxford University Press. This book was released on 2010-11-23 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Perhaps the most important achievements in the field of epileptology in the past two decades have been in the neuroimaging and genetic breakthroughs as applied to patients with epilepsy. Indeed, neuroimaging has become a vital part in the study of epilepsy, affecting broad aspects of the disorder ranging from diagnosis and classification to treatment and prognosis. Neuroimaging in epilepsy encompasses many different approaches that have reached various levels of expertise across epilepsy centers worldwide. This book discusses every imaging modality used to gather information on epilepsy. Each technique is described by world experts and epilepsy centers worldwide.
Book Synopsis Clinical Neuroradiology by : Frederik Barkhof
Download or read book Clinical Neuroradiology written by Frederik Barkhof and published by Springer. This book was released on 2019-04-16 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This superbly illustrated textbook, endorsed by the European Society of Neuroradiology, explains in detail the clinical importance of neuroradiology in complementing history taking and physical examination during the workup of patients suspected of having neurological, neurosurgical, or psychiatric disorders. The role of imaging of the brain and spinal cord is described across the full range of relevant conditions, including, for example, cerebrovascular diseases, trauma, CSF disorders, developmental malformations, autoimmune diseases, epilepsy, tumors and tumor-like conditions, neurodegenerative diseases, metabolic conditions, and bipolar and depressive disorders. The structured approach to imaging and image analysis will ensure that the book is an invaluable resource for neuroradiologists in training and clinicians alike. Starting from the clinical indication, suggestions for imaging protocols are provided and checklists of common findings and aspects key to interpretation are presented. The book is published within the SpringerReference program, which combines thorough coverage with access to living editions constantly updated via a dynamic peer-review process.
Book Synopsis Introduction to Epilepsy by : Gonzalo Alarcón
Download or read book Introduction to Epilepsy written by Gonzalo Alarcón and published by Cambridge University Press. This book was released on 2012-04-26 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.
Book Synopsis Imaging Biomarkers in Epilepsy by : Andrea Bernasconi
Download or read book Imaging Biomarkers in Epilepsy written by Andrea Bernasconi and published by Cambridge University Press. This book was released on 2019-01-10 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.
Book Synopsis Secondary Schizophrenia by : Perminder S. Sachdev
Download or read book Secondary Schizophrenia written by Perminder S. Sachdev and published by Cambridge University Press. This book was released on 2010-02-04 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience – understanding and conquering this most mysterious of human diseases.
Download or read book Experimental Epilepsy written by and published by Elsevier. This book was released on 1965-01-01 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Epilepsy
Book Synopsis Magnetic Resonance in Epilepsy by : Ruben Kuzniecky
Download or read book Magnetic Resonance in Epilepsy written by Ruben Kuzniecky and published by Academic Press. This book was released on 2005-01-19 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders. *Provides a crucial update of recent advances in imaging techniques*Timely publication as subject of neuroimaging is a very "hot" area in both clinical epilepsy and basic neuroscience research*Editors are well-respected in this field
Book Synopsis The Neuropathology of Schizophrenia by : Paul J. Harrison
Download or read book The Neuropathology of Schizophrenia written by Paul J. Harrison and published by . This book was released on 2000-08-24 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is schizophrenia? This is one of the most controversial questions in psychiatry and mental health research; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a balanced, comprehensive and up-to-date overview of the neuropathology of schizophrenia and its interpretation, covering the latest evidence derived from all fields of research, from brain scans to microscopy. The authors include many of the foremost international authorities in this rapidly developing field.
Book Synopsis Oxford Textbook of Epilepsy and Epileptic Seizures by : Samden Lhatoo
Download or read book Oxford Textbook of Epilepsy and Epileptic Seizures written by Samden Lhatoo and published by Oxford University Press, USA. This book was released on 2012-12-20 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the scientific basis, clinical diagnosis, and treatment of epilepsy and epileptic seizures, and is complemented by an online edition.
Book Synopsis Diffusion-Weighted MR Imaging of the Brain, Head and Neck, and Spine by : Toshio Moritani
Download or read book Diffusion-Weighted MR Imaging of the Brain, Head and Neck, and Spine written by Toshio Moritani and published by Springer Nature. This book was released on 2021-05-30 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated book, now in an updated and extended third edition, systematically covers the use of diffusion-weighted (DW) MR imaging in all major areas of neuroradiology, including imaging of the head and neck and the spine as well as the brain. The authors guide the reader from the basic principles of DW imaging through to the use of cutting-edge diffusion sequences such as diffusion tensor (DTI) and kurtosis (DKI), fiber tractography, high b value, intravoxel incoherent motion (IVIM), neurite orientation dispersion and density imaging (NODDI), and oscillating gradient spin echo (OGSE). Pathology, pathophysiology, and patient management and treatment are all thoroughly discussed. Since the early descriptions by LeBihan and colleagues of the ability to image and measure the micromovement of water molecules in the brain, diffusion imaging and its derivatives have contributed ever more significantly to the evaluation of multiple disease processes. In comprehensively describing the state of the art in the field, this book will be of high value not only for those who deal routinely with neuro-MR imaging but also for readers who wish to establish a sound basis for understanding diffusion images in the hope of extending these principles into more exotic areas of neuroimaging.
