Quanitative Susceptibility Imaging Of Tissue Microstructure Using Ultra High Field Mri

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Quanitative Susceptibility Imaging of Tissue Microstructure Using Ultra-high Field MRI

Author : David Alexander Rudko
Publisher :
ISBN 13 :
Total Pages : 286 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Quanitative Susceptibility Imaging of Tissue Microstructure Using Ultra-high Field MRI by : David Alexander Rudko

Download or read book Quanitative Susceptibility Imaging of Tissue Microstructure Using Ultra-high Field MRI written by David Alexander Rudko and published by . This book was released on 2014 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis has used ultra-high field (UHF) magnetic resonance imaging (MRI) to investigate the fundamental relationships between tissue microstructure and such susceptibility-based contrast parameters as the apparent transverse relaxation rate (R2 *), the local Larmor frequency shift (LFS) and quantitative volume magnetic susceptibility (QS). The interaction of magnetic fields with biological tissues results in shifts in the LFS which can be used to distinguish underlying cellular architecture. The LFS is also linketo the relaxation properties of tissues in a gradient echo MRI sequence. Equally relevant, histological analysis has identified iron and myelin as two major sources of the LFS. As a result, computation of LFS and the associated volume magnetic susceptibility from MRI phase data may serve as a significant method for in vivo monitoring of changes in iron and myelin associated with normal, healthy aging, as well as neurological diseased processes. In this research, the cellular level underpinnings of the R2 * and LFS signals were examined in a model rat brain system using 9.4 T MRI. The study was carried out using biophysical modeling and correlation with quantitative histology. For the first time, multiple biophysical modeling schemes were compared in both gray and white matter of excised rat brain tissue. Suprisingly, R2 * dependence on tissue orientation has not been fully understood. Accordingly, scaling relations were derived for calculating the reversible, mesoscopic magnetic field component, R2 2 of the apparent transverse relaxation rate from the orientation dependence in gray and white matter. Our results demonstrate that the orientation dependence of R2 * and LFS in both white and cortical gray matter has a sinusoidal dependence on tissue orientation and a linear dependence on the volume fraction of myelin in the tissue. susceptibility processing pipeline was also developed and applied to the calculation of phase-combined LFS and QS maps. The processing pipeline was subsequently used to monitor myelin and iron changes in multiple sclerosis (MS) patients compared to healthy, age and gender-matched controls. With the use of QS and R2 * mapping, evidence of statistically significant increases in iron deposition in sub-cortical gray matter, as well as myelin degeneration along the white matter skeleton, were identified in MS patients. The magnetic susceptibility-based MRI methods were then employed as potential clinical biomarkers for disease severity monitoring of MS. It was demonstrated that the combined use of R2 * and QS, obtained from multi-echo gradient echo MRI, could serve as an improved metric for monitoring both gray and white matter changes in early MS.

Quantitative Magnetic Resonance Imaging

Author : Nicole Seiberlich
Publisher : Academic Press
ISBN 13 : 0128170581
Total Pages : 1094 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Quantitative Magnetic Resonance Imaging by : Nicole Seiberlich

Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

Ultra High Field Magnetic Resonance Imaging

Author : Pierre-Marie Robitaille
Publisher : Springer Science & Business Media
ISBN 13 : 0387496483
Total Pages : 487 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Ultra High Field Magnetic Resonance Imaging by : Pierre-Marie Robitaille

Download or read book Ultra High Field Magnetic Resonance Imaging written by Pierre-Marie Robitaille and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.

Ultra-high Field Magnetic Resonance Imaging: Mri Instrumentation And Clinical Implementation

Author : Shaileshkumar B. Raval, Ph.D.
Publisher : Index of Sciences Ltd
ISBN 13 : 1838088849
Total Pages : 340 pages
Book Rating : 4.8/5 (38 download)

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Book Synopsis Ultra-high Field Magnetic Resonance Imaging: Mri Instrumentation And Clinical Implementation by : Shaileshkumar B. Raval, Ph.D.

Download or read book Ultra-high Field Magnetic Resonance Imaging: Mri Instrumentation And Clinical Implementation written by Shaileshkumar B. Raval, Ph.D. and published by Index of Sciences Ltd. This book was released on 2021-04-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging“Magnetic Resonance Imaging” (MRI) is the most widely clinically used diagnostic tool for soft tissue imaging. This advanced technology and its applications are under continuous research and development, ranging from lower fields to ultra-high fields to the highest possible fields for preclinical (animal) and human imaging. Formerly known as Nuclear Magnetic Resonance Imaging (NMR), with the rising demands of clinical diagnosis requirements, it is under constant development and innovation in hospitals for populations around the world because of constant desire to go to higher fields that lead to unique research and clinical applications that aren’t achievable with other commercially and or research technologies. The basics of MRIThe human body is rich in hydrogen, when a human body is subjected to a large magnetic field, many of the free hydrogen nuclei align themselves with the direction of the magnetic field. MRI works on the principle of the directional magnetic field associated with charged particles in motion. MRI is also known as nuclear magnetic resonance imaging, a technique used to create images of parts of the human body based on the resonance of nuclei in motion under the effect of a magnetic field. Overview of the bookThis book’s lucid style makes it an easy read. It is written in a simple and comprehensible way, making it easy to followand readfor a large audience ranging from students to researchers. The areas covered include an overview of the theories and practical aspects of High-Field MRIwith each chapter Introduction, Challenges, Objectives, Methods(Materials), Results, Discussion, FutureWworks,including basic concepts, along with research-oriented and clinical concepts, technologies that are researched and developed, and implemented clinically, and published nationally and internationally recognized conferences, and publications with global awards recognition from ISMRM, TTS, and many other academic and industry organizationsthat are recognized worldwide. In this book, unexplored research theories are described along with a list of products, project developments, and completion of major and unattempted theories, which are considered to be challenging in high-field MRI. These unexplored research theories are further delved into to emerge with practical and translational products, as described in various chapters. These products are deemed to be of potential research and clinical use if implemented in clinical and hospital settings, to help thus could the patients as well as healthy populations to improve the standard of their lives. Advances in extremities and musculoskeletal imaging in patients undergoing transplants, including first-ever(never been implemented)technologies such as Ultra high field upper extremity RF coils, research publications, and intellectual properties have been explored in detail. Another major advancement discussed in this book is the Whole-body MRI RF high density transmit coil and receiver array designs(first evevr application of antenna design), published in national and international journals as intellectual properties. Various other aspects of these 4intellectual properties have been discussed such as instrumentation developed, design procedures, Electromagnetic Simulations (simulated versions), Novel whole head(Brain) MRI RF array, Innovative Visualization Techniques, Neuro and vascular flow imaging, Segmentation methods. Regenerative Imaging, Pre and post-operative (surgical) imaging, clinical implementations, pulse sequence developments and optimizations, imaging resultswith 3D volume Texture and Visualizations, also peer research and references from around the world, plus future works, and more have been entailed. This is a rather different book in terms of depth and detail in which the subject is dealt with in this book. The data is well represented with tables, equations, and nearly three hundred figures. Combining technologies, research, and clinical applications of innovations in the field of MRI, it is one of a kind and a treat for curious minds. The content is mainly focused on whole head imaging, whole-body imaging, and extremity imaging, describing their clinical applications and their implementation for high risk and high demand patient populations, healthy populations for enhanced human anatomical, biological, functional and physiological performances in a detailed manner. The research has been utilized by peers in their studies, research, publications, and learning as part of the research and clinical developments, and implementations. This book presents the author’s original research works and their applications in the real world to offer advanced innovations to the healthcare sector and improve quality and standard of life for the masses around the world and beyond as future goals as there are many aviations,Biomedical Applications and projects are in demand. The author’s research works have been publishedand awarded in various nationalllyand internationallyrecognized journals and presented in numerous conferences as well. The chapters of this book are each one of the many research publications by the author

Ultrahigh Field Magnetic Resonance Imaging

Author : Judy Alper
Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.:/5 (972 download)

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Book Synopsis Ultrahigh Field Magnetic Resonance Imaging by : Judy Alper

Download or read book Ultrahigh Field Magnetic Resonance Imaging written by Judy Alper and published by . This book was released on 2016 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) may be used to provide detailed images of the human body with excellent soft tissue contrast. Alongside its current widespread clinical applications for diagnosis and treatment, MRI allows researchers to measure structure and function of different tissue types in order to advance our understanding of human biology and enable new medical applications of MRI. In particular, diseases affecting nerves and vessels, such as trigeminal neuralgia, with uncertain etiology can be studied using multiple MRI modalities so that treatment planning can we more effective and patient outcomes can be improved. Ultrahigh field MRI scanners, such as those operating at 7-‐tesla (7T), provide increased signal-‐to-‐noise ratio, which can be translated to higher spatial resolution. Additional advantages of high magnetic field MRI include enhanced vascular contrast as well as improved spectral separation and quantification for MR spectroscopy. These benefits over MRI at lower field strengths make ultrahigh field MRI a powerful new tool for performing quantitative image analysis with increased accuracy. One quantitative application of MRI is the detection and visualization of cells labeled with magnetic nanoparticles. This unconventional use of the imaging modality enables very effective imaging of cells or lesions tagged with these particles. The projects explored herein consist of such quantitative image analysis using advanced imaging techniques, including ultrahigh field MRI.

Susceptibility Weighted Imaging in MRI

Author : E. Mark Haacke
Publisher : John Wiley & Sons
ISBN 13 : 111814807X
Total Pages : 817 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Susceptibility Weighted Imaging in MRI by : E. Mark Haacke

Download or read book Susceptibility Weighted Imaging in MRI written by E. Mark Haacke and published by John Wiley & Sons. This book was released on 2014-03-25 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI Susceptibility Weighted Imaging discusses the promising new MRI technique called Susceptibility Weighted Imaging (SWI), a powerful tool for the diagnosis and treatment of acute stroke, allowing earlier detection of acute stroke hemorrhage and easier detection of microbleeds in acute ischemia. The book is edited by the originators of SWI and features contributions from the top leaders in the science. Presenting an even balance between technical/scientific aspects of the modality and clinical application, this book includes over 100 super high-quality radiographic images and 100 additional graphics and tables.

Fast Quantitative Magnetic Resonance Imaging

Author : Guido Buonincontri
Publisher : Springer Nature
ISBN 13 : 303101667X
Total Pages : 124 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Fast Quantitative Magnetic Resonance Imaging by : Guido Buonincontri

Download or read book Fast Quantitative Magnetic Resonance Imaging written by Guido Buonincontri and published by Springer Nature. This book was released on 2022-05-31 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among medical imaging modalities, magnetic resonance imaging (MRI) stands out for its excellent soft-tissue contrast, anatomical detail, and high sensitivity for disease detection. However, as proven by the continuous and vast effort to develop new MRI techniques, limitations and open challenges remain. The primary source of contrast in MRI images are the various relaxation parameters associated with the nuclear magnetic resonance (NMR) phenomena upon which MRI is based. Although it is possible to quantify these relaxation parameters (qMRI) they are rarely used in the clinic, and radiological interpretation of images is primarily based upon images that are relaxation time weighted. The clinical adoption of qMRI is mainly limited by the long acquisition times required to quantify each relaxation parameter as well as questions around their accuracy and reliability. More specifically, the main limitations of qMRI methods have been the difficulty in dealing with the high inter-parameter correlations and a high sensitivity to MRI system imperfections. Recently, new methods for rapid qMRI have been proposed. The multi-parametric models at the heart of these techniques have the main advantage of accounting for the correlations between the parameters of interest as well as system imperfections. This holistic view on the MR signal makes it possible to regress many individual parameters at once, potentially with a higher accuracy. Novel, accurate techniques promise a fast estimation of relevant MRI quantities, including but not limited to longitudinal (T1) and transverse (T2) relaxation times. Among these emerging methods, MR Fingerprinting (MRF), synthetic MR (syMRI or MAGIC), and T1‒T2 Shuffling are making their way into the clinical world at a very fast pace. However, the main underlying assumptions and algorithms used are sometimes different from those found in the conventional MRI literature, and can be elusive at times. In this book, we take the opportunity to study and describe the main assumptions, theoretical background, and methods that are the basis of these emerging techniques. Quantitative transient state imaging provides an incredible, transformative opportunity for MRI. There is huge potential to further extend the physics, in conjunction with the underlying physiology, toward a better theoretical description of the underlying models, their application, and evaluation to improve the assessment of disease and treatment efficacy.

Assessing Cellular Microstructure in Biological Tissues using In Vivo Diffusion-Weighted Magnetic Resonance

Author : Julien Valette
Publisher : Frontiers Media SA
ISBN 13 : 2889458415
Total Pages : 193 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Assessing Cellular Microstructure in Biological Tissues using In Vivo Diffusion-Weighted Magnetic Resonance by : Julien Valette

Download or read book Assessing Cellular Microstructure in Biological Tissues using In Vivo Diffusion-Weighted Magnetic Resonance written by Julien Valette and published by Frontiers Media SA. This book was released on 2019-05-16 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques have opened new doors for examining biological tissues in vivo. By combining sensitization to diffusion using magnetic field gradients with a variety of imaging and localization schemes, diffusion-weighted MRI and diffusion-weighted MRS allow investigating translational diffusion of endogenous molecules, such as water or metabolites, in biological tissues, most commonly the brain but also other organs such as the prostate. The typical voxel resolution of MRI or MRS is in the millimeter to centimeter range, much lower than the cellular scale. However, as molecules are typically diffusing over just a few µm during the duration of the measurement (the “diffusion time”) and encounter numerous biological membranes at these scales, the average cellular microstructure has a critical influence on the measured diffusion signal. Hence, diffusion-weighted MRI and diffusion-weighted MRS are sensitive to tissue microstructure at a scale well below the nominal imaging resolution. However, the connection between diffusion properties and tissue microstructure remains indirect, so any attempt to quantify microstructure will rely on modeling. The goal of this Research Topic was to gather experts in various acquisition and modeling strategies and show how these approaches, despite their own strengths and weaknesses, can yield unique information about cellular microstructure, and sometimes complement each other.

Ultra High Field Magnetic Resonance Imaging

Author : Pierre-Marie Robitaille
Publisher : Springer
ISBN 13 : 9780387342313
Total Pages : 508 pages
Book Rating : 4.3/5 (423 download)

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Book Synopsis Ultra High Field Magnetic Resonance Imaging by : Pierre-Marie Robitaille

Download or read book Ultra High Field Magnetic Resonance Imaging written by Pierre-Marie Robitaille and published by Springer. This book was released on 2006-10-12 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.

Quantitative MRI of the Spinal Cord

Author : Julien Cohen-Adad
Publisher : Academic Press
ISBN 13 : 0123972825
Total Pages : 331 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Quantitative MRI of the Spinal Cord by : Julien Cohen-Adad

Download or read book Quantitative MRI of the Spinal Cord written by Julien Cohen-Adad and published by Academic Press. This book was released on 2014-01-16 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply them to the spinal cord. Quantitative MRI of the Spinal Cord introduces the theory behind each quantitative technique, reviews each theory’s applications in the human spinal cord and describes its pros and cons, and suggests a simple protocol for applying each quantitative technique to the spinal cord. Chapters authored by international experts in the field of MRI of the spinal cord Contains “cooking recipes —examples of imaging parameters for each quantitative technique—designed to aid researchers and clinicians in using them in practice Ideal for clinical settings

Interrogating Tissue Perfusion and Oxygenation Using Dynamic Magnetic Resonance Imaging and Quantitative Susceptibility Mapping

Download Interrogating Tissue Perfusion and Oxygenation Using Dynamic Magnetic Resonance Imaging and Quantitative Susceptibility Mapping PDF Online Free

Author : Bo Xu
Publisher :
ISBN 13 :
Total Pages : 124 pages
Book Rating : 4.:/5 (876 download)

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Book Synopsis Interrogating Tissue Perfusion and Oxygenation Using Dynamic Magnetic Resonance Imaging and Quantitative Susceptibility Mapping by : Bo Xu

Download or read book Interrogating Tissue Perfusion and Oxygenation Using Dynamic Magnetic Resonance Imaging and Quantitative Susceptibility Mapping written by Bo Xu and published by . This book was released on 2014 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) is a widely used non-invasive imaging technique, with rich contrast for interrogation of tissue physiology and pathology. MRI can be used to examine hemodynamic conditions like perfusion and oxygenation qualitatively and quantitatively. This dissertation reports new techniques that employ dynamic imaging and quantitative susceptibility mapping (QSM) to overcome technical challenges for improved MRI perfusion imaging and oxygenation quantification. Perfusion imaging after gadolinium contrast agent administration is a common clinical practice, where dynamic MRI technique is used to track contrast bolus. It is desirable to have high temporal resolution to capture blood dynamics, as well as high spatial resolution to depict small lesions. Unfortunately, these requirements are limited by hardware and physiological conditions. In this dissertation, a dynamic MRI technique was realized, using fast spiral acquisition and a constrained image reconstruction algorithm, to achieve high temporal-spatial resolution for liver perfusion imaging. Tissue susceptibility provides unique contrast in MRI. Recent development of QSM technique has been applied in various clinical applications. In this dissertation, the dynamic imaging method was extended to multi-echo acquisition and combined with QSM to map gadolinium contrast agent concentration during the first passage for cerebral perfusion mapping. Blood oxygenation is determined by the amount of deoxyhemoglobin in red blood cell. Magnetic susceptibility of deoxyhemoglobin is a source of MR contrast for imaging oxygenation. This dissertation reports correction schemes in both data acquisition and image reconstruction of QSM for improved blood oxygenation quantification.

Techniques for in Vivo High-resolution MR Imaging of Connective Tissue Microstructure

Author : Hee Kwon Song
Publisher :
ISBN 13 :
Total Pages : 163 pages
Book Rating : 4.:/5 (244 download)

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Book Synopsis Techniques for in Vivo High-resolution MR Imaging of Connective Tissue Microstructure by : Hee Kwon Song

Download or read book Techniques for in Vivo High-resolution MR Imaging of Connective Tissue Microstructure written by Hee Kwon Song and published by . This book was released on 1999 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mathematics and Physics of Emerging Biomedical Imaging

Author : Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging
Publisher : National Academies Press
ISBN 13 : 0309552923
Total Pages : 261 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Mathematics and Physics of Emerging Biomedical Imaging by : Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging

Download or read book Mathematics and Physics of Emerging Biomedical Imaging written by Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging and published by National Academies Press. This book was released on 1996-03-13 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.

MRI from Picture to Proton

Author : Donald W. McRobbie
Publisher : Cambridge University Press
ISBN 13 : 1316688259
Total Pages : 405 pages
Book Rating : 4.3/5 (166 download)

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Book Synopsis MRI from Picture to Proton by : Donald W. McRobbie

Download or read book MRI from Picture to Proton written by Donald W. McRobbie and published by Cambridge University Press. This book was released on 2017-04-13 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: MR is a powerful modality. At its most advanced, it can be used not just to image anatomy and pathology, but to investigate organ function, to probe in vivo chemistry, and even to visualise the brain thinking. However, clinicians, technologists and scientists struggle with the study of the subject. The result is sometimes an obscurity of understanding, or a dilution of scientific truth, resulting in misconceptions. This is why MRI from Picture to Proton has achieved its reputation for practical clarity. MR is introduced as a tool, with coverage starting from the images, equipment and scanning protocols and traced back towards the underlying physics theory. With new content on quantitative MRI, MR safety, multi-band excitation, Dixon imaging, MR elastography and advanced pulse sequences, and with additional supportive materials available on the book's website, this new edition is completely revised and updated to reflect the best use of modern MR technology.

MRI of the Lung

Author : Hans-Ulrich Kauczor
Publisher : Springer Science & Business Media
ISBN 13 : 354034618X
Total Pages : 315 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis MRI of the Lung by : Hans-Ulrich Kauczor

Download or read book MRI of the Lung written by Hans-Ulrich Kauczor and published by Springer Science & Business Media. This book was released on 2008-11-12 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade significant developments have been achieved in the field of magnetic resonance imaging (MRI), enabling MRI to enter the clinical arena of chest imaging. Standard protocols can now be implemented on up-to-date scanners, allowing MRI to be used as a first-line imaging modality for various lung diseases, including cystic fibrosis, pulmonary hypertension and even lung cancer. The diagnostic benefits stem from the ability of MRI to visualize changes in lung structure while simultaneously imaging different aspects of lung function, such as perfusion, respiratory motion, ventilation and gas exchange. On this basis, novel quantitative surrogates for lung function can be obtained. This book provides a comprehensive overview of how to use MRI for imaging of lung disease. Special emphasis is placed on benign diseases requiring regular monitoring, given that it is patients with these diseases who derive the greatest benefit from the avoidance of ionizing radiation.

Quantitative Susceptibility Mapping

Author :
Publisher :
ISBN 13 :
Total Pages : 213 pages
Book Rating : 4.:/5 (917 download)

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Book Synopsis Quantitative Susceptibility Mapping by :

Download or read book Quantitative Susceptibility Mapping written by and published by . This book was released on 2013 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Application-specific Optimization of Quantitative Susceptibility Mapping for Clinical Imaging

Author : Alexey Victorovich Dimov
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Application-specific Optimization of Quantitative Susceptibility Mapping for Clinical Imaging by : Alexey Victorovich Dimov

Download or read book Application-specific Optimization of Quantitative Susceptibility Mapping for Clinical Imaging written by Alexey Victorovich Dimov and published by . This book was released on 2017 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) is a noninvasive clinical imaging modality with very rich contrasts based on the physical properties of the imaged tissues. MRI can be used for quantification of volumetric distributions of various biomolecules and chemical elements - such as triglycerides, calcium and iron - that regarded as participants in normal tissue biochemistry, and whose dysregulations are often manifested in pathologic processes. This dissertation reports optimization steps undertaken to overcome technical challenges in quantitative susceptibility mapping (QSM) in different parts of human body. Often in QSM it is assumed that susceptibility is the only contributor to the observed field inhomogeneity, which may be a valid assumption for neuroimaging applications. However, multiple molecules found in biological tissues (e.g., triglycerides of fat) have a resonance frequency different from that of water, and this resonance frequency offset is referred to as chemical shift. This chemical shift affects the phase of the MRI signal. Although ways to estimate field inhomogeneity in the presence of chemical shift have been proposed, they often rely on the a priori knowledge of the chemical spectrum. Unfortunately, variability of chemical spectra have been reported. In this dissertation, an automated joint estimation of the chemical shift and the susceptibility from an MRI dataset is reported, where the chemical shift is also treated as an unknown variable subject to optimization. QSM may become a useful diagnostic tool for noninvasive assessment of bone health without the use of ionizing radiation, however this application has been a challenging task challenging because QSM requires complete measurements of phase everywhere within the region of interest, and cortical bone typically has very low or no signal at conventional echo times in gradient echo (GRE) imaging. An additional problem arises from intermingling of fat and water protons in the bone marrow, necessitating the application of water–fat separation techniques for field mapping. In this dissertation, a novel signal model is proposed, feasibility of using QSM for measuring bone MRI signal is investigated, and the inherent technical issues involved in this application are highlighted. QSM has been widely applied in neuroimaging. In particular, due to its ability to accurately map iron deposits in deep brain nuclei, QSM promises precise targeting of the subthalamic nucleus (STN) in deep brain stimulation surgery (DBS). This dissertation reports results of comparison between QSM and standard-of-care T2w imaging of the STN, and their performance in high-resolution presugrical anatomic imaging.