Proteostasis

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Protein Homeostasis, Second Edition

Author : Richard I. Morimoto
Publisher : Perspectives Cshl
ISBN 13 : 9781621822967
Total Pages : 562 pages
Book Rating : 4.8/5 (229 download)

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Book Synopsis Protein Homeostasis, Second Edition by : Richard I. Morimoto

Download or read book Protein Homeostasis, Second Edition written by Richard I. Morimoto and published by Perspectives Cshl. This book was released on 2019 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting in the aggregation of misfolded proteins-a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on how the proteostasis network functions in healthy cells and the diseases that result when protein quality control goes awry. The contributors examine the relevant biochemical attributes of proteins (e.g., solubility), the functions of normal protein aggregates (e.g., biofilm formation in bacteria), and the various heat shock proteins, chaperones, translocation machineries, proteasomes, signaling factors, and transcriptional programs involved in proteostasis. The roles of specific subcellular structures-the endoplasmic reticulum, mitochondria, ribosomes, lysosomes, and cytoplasm-in protein quality control are covered, as is the regulation of proteostasis at the organismal level (e.g., via neuronal activity). Discussions of the responses by cells when errors in protein quality control occur, the medical disorders that can result (e.g., Alzheimer disease), and pharmacologic approaches to ameliorate protein conformational disorders are also included. This book is therefore an essential reference for biochemists, cell biologists, and all biomedical scientists wishing to understand the pathological consequences of and potential therapies for proteostasis deficiencies in common human diseases.

Proteostasis and Disease

Author : Rosa Barrio
Publisher : Springer Nature
ISBN 13 : 3030382664
Total Pages : 350 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Proteostasis and Disease by : Rosa Barrio

Download or read book Proteostasis and Disease written by Rosa Barrio and published by Springer Nature. This book was released on 2020-04-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Proteostasis and Proteolysis

Author : Niki Chondrogianni
Publisher :
ISBN 13 : 9780367499327
Total Pages : 0 pages
Book Rating : 4.4/5 (993 download)

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Book Synopsis Proteostasis and Proteolysis by : Niki Chondrogianni

Download or read book Proteostasis and Proteolysis written by Niki Chondrogianni and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. Essential aspects of cell function are proeostasic and relevant for diseases such a cancer, obesity, and aging. Various pharmacological interventions can mitigate the impact of proteostatic breakdown. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system : the ubiquitin-proteasome system and autophagy. These systems and their regulation are affected by endogenous stress and environmental stimuli. Deregulation in proteolysis results in proteostasis failure : protein misfolding and accumulation of damaged and oxidized proteins resulting in neurodegenerative diseases such Alzheimer's, parkinson's, and Huntington's.

Protein Homeostasis

Author : Richard I. Morimoto
Publisher :
ISBN 13 : 9781936113064
Total Pages : 0 pages
Book Rating : 4.1/5 (13 download)

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Book Synopsis Protein Homeostasis by : Richard I. Morimoto

Download or read book Protein Homeostasis written by Richard I. Morimoto and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proper folding of proteins is crucial for cell function. Chaperones and enzymes that post-translationally modify newly synthesized proteins help ensure that proteins fold correctly, and the unfolded protein response functions as a homeostatic mechanism that removes misfolded proteins when cells are stressed. This book covers the entire spectrum of proteostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry.

Proteostasis and Proteolysis

Author : Niki Chondrogianni
Publisher : CRC Press
ISBN 13 : 1000474585
Total Pages : 277 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Proteostasis and Proteolysis by : Niki Chondrogianni

Download or read book Proteostasis and Proteolysis written by Niki Chondrogianni and published by CRC Press. This book was released on 2021-11-30 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy. Chapter 2 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.

Quality Control of Cellular Protein in Neurodegenerative Disorders

Author : Uddin, Md. Sahab
Publisher : IGI Global
ISBN 13 : 1799813185
Total Pages : 515 pages
Book Rating : 4.7/5 (998 download)

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Book Synopsis Quality Control of Cellular Protein in Neurodegenerative Disorders by : Uddin, Md. Sahab

Download or read book Quality Control of Cellular Protein in Neurodegenerative Disorders written by Uddin, Md. Sahab and published by IGI Global. This book was released on 2020-02-14 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.

Proteostasis and Chaperone Surveillance

Author : Laishram Rajendrakumar Singh
Publisher : Springer
ISBN 13 : 8132224671
Total Pages : 184 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Proteostasis and Chaperone Surveillance by : Laishram Rajendrakumar Singh

Download or read book Proteostasis and Chaperone Surveillance written by Laishram Rajendrakumar Singh and published by Springer. This book was released on 2015-11-26 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure, as well as the inhibition of proteostatic failure using small molecule compounds. It examines advances in the modulation of proteopathies, providing a comprehensive source of key mechanistic insights on these diseases. As such, the book offers a valuable resource for beginners and more experienced investigators alike who are looking for detailed and reliable information on protein homeostasis, the diseases that can develop due to related imbalances and the essential role of molecular and chemical chaperones.

Autophagy in Health and Disease

Author : Roberta A. Gottlieb
Publisher : Academic Press
ISBN 13 : 0123851025
Total Pages : 241 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Autophagy in Health and Disease by : Roberta A. Gottlieb

Download or read book Autophagy in Health and Disease written by Roberta A. Gottlieb and published by Academic Press. This book was released on 2012-12-31 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes

HSF1 and Molecular Chaperones in Biology and Cancer

Author : Marc Laurence Mendillo
Publisher : Springer Nature
ISBN 13 : 3030402045
Total Pages : 185 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis HSF1 and Molecular Chaperones in Biology and Cancer by : Marc Laurence Mendillo

Download or read book HSF1 and Molecular Chaperones in Biology and Cancer written by Marc Laurence Mendillo and published by Springer Nature. This book was released on 2020-04-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Long-lived Proteins in Human Aging and Disease

Author : Roger J. W. Truscott
Publisher : John Wiley & Sons
ISBN 13 : 3527347283
Total Pages : 224 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Long-lived Proteins in Human Aging and Disease by : Roger J. W. Truscott

Download or read book Long-lived Proteins in Human Aging and Disease written by Roger J. W. Truscott and published by John Wiley & Sons. This book was released on 2021-04-19 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.

Factors Affecting Neurological Aging

Author : Colin R Martin
Publisher : Academic Press
ISBN 13 : 0128179910
Total Pages : 688 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Factors Affecting Neurological Aging by : Colin R Martin

Download or read book Factors Affecting Neurological Aging written by Colin R Martin and published by Academic Press. This book was released on 2021-06-01 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging Features sections on the genetic components that influence aging and diseases of aging Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations Includes more than 500 illustrations and tables

Metabolic Cardiomyopathy

Author : H. Böhles
Publisher : CRC Press
ISBN 13 : 9783887631048
Total Pages : 188 pages
Book Rating : 4.6/5 (31 download)

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Book Synopsis Metabolic Cardiomyopathy by : H. Böhles

Download or read book Metabolic Cardiomyopathy written by H. Böhles and published by CRC Press. This book was released on 2004 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.

Regulation of Heat Shock Protein Responses

Author : Alexzander A A Asea
Publisher : Springer
ISBN 13 : 3319747150
Total Pages : 471 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Regulation of Heat Shock Protein Responses by : Alexzander A A Asea

Download or read book Regulation of Heat Shock Protein Responses written by Alexzander A A Asea and published by Springer. This book was released on 2018-05-01 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.

Proteostasis

Author : Patricija van Oosten-Hawle
Publisher :
ISBN 13 : 9781855782013
Total Pages : 133 pages
Book Rating : 4.7/5 (82 download)

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Book Synopsis Proteostasis by : Patricija van Oosten-Hawle

Download or read book Proteostasis written by Patricija van Oosten-Hawle and published by . This book was released on 2016 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses

Author : Axel Mogk
Publisher : Frontiers Media SA
ISBN 13 : 2889741931
Total Pages : 334 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses by : Axel Mogk

Download or read book Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses written by Axel Mogk and published by Frontiers Media SA. This book was released on 2022-02-01 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cover Image for This Research Topic is Used With Permission of the Authors and Publishers of the Following Article: Winkler J, Seybert A, König L, Pruggnaller S, Haselmann U, Sourjik V, Weiss M, Frangakis AS, Mogk A, Bukau B.EMBO J. 2010 Mar 3;29(5):910-23. doi: 10.1038/emboj.2009.412. Epub 2010 Jan 21

Heat Shock Protein 90 in Human Diseases and Disorders

Author : Alexzander A. A. Asea
Publisher : Springer Nature
ISBN 13 : 3030231585
Total Pages : 607 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Heat Shock Protein 90 in Human Diseases and Disorders by : Alexzander A. A. Asea

Download or read book Heat Shock Protein 90 in Human Diseases and Disorders written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2019-11-04 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Proteins in Signaling Pathways

Author : Alexzander A. A. Asea
Publisher :
ISBN 13 : 9783030039530
Total Pages : 482 pages
Book Rating : 4.0/5 (395 download)

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Book Synopsis Heat Shock Proteins in Signaling Pathways by : Alexzander A. A. Asea

Download or read book Heat Shock Proteins in Signaling Pathways written by Alexzander A. A. Asea and published by . This book was released on 2019 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume offers an insightful overview of contemporary research on signaling pathways. These signaling processes are the comprehensive mechanisms by which all cellular organisms communicate internally and externally with their microenvironment. The volume is focused on heat shock proteins (HSP), which are uniquely involved in a number of critical signaling pathways. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. The knowledge gained from better understanding these mechanisms can help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.