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Protein Phosphorylation Analysis By Electrospray Mass Spectrometry
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Book Synopsis Protein Phosphorylation Analysis by Electrospray Mass Spectrometry by : Wolf D Lehmann
Download or read book Protein Phosphorylation Analysis by Electrospray Mass Spectrometry written by Wolf D Lehmann and published by Royal Society of Chemistry. This book was released on 2010-11-01 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an experienced and well-published individual, this unique reference source takes a forward-looking approach. It describes the concepts and practice of protein phosphorylation analysis by tandem mass spectrometry and related techniques. These include purification, enrichment, database searching, other software tools, synthesis, phosphatase treatment, phospho-specific staining methods, isoelectric focusing and element mass spectrometry. The book then goes on to cover the fragmentation behaviour of phosphopeptides in tandem MS (pos+neg ions) and the implementation of the particular features into an analytical strategy. The book ends with a summary and discussion of useful internet and software tools currently available.
Book Synopsis Proteomics of Biological Systems by : Bryan M. Ham
Download or read book Proteomics of Biological Systems written by Bryan M. Ham and published by John Wiley & Sons. This book was released on 2011-11-15 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphorylation is the addition of a phosphate (PO4) group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes, causing or preventing the mechanisms of diseases such as cancer and diabetes. This book shows how to use mass spectrometry to determine whether or not a protein has been correctly modified by the addition of a phosphate group. It also provides a combination of detailed, step-by-step methodology for phosphoproteomic sample preparation, mass spectral instrumental analysis, and data interpretation approaches. Furthermore, it includes the use of bioinformatic Internet tools such as the Blast2GO gene ontology (GO) tool, used to help understand and interpret complex data collected in these studies.
Book Synopsis Protein Mass Spectrometry by : Julian Whitelegge
Download or read book Protein Mass Spectrometry written by Julian Whitelegge and published by Elsevier. This book was released on 2008-10-09 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to be a central text for young graduate students interested in mass spectrometry as it relates to the study of protein structure and function as well as proteomics. It is a definite must-have work for:- libraries at academic institutions with Master and Graduate programs in biochemistry, molecular biology, structural biology and proteomics- individual laboratories with interests covering these areas - libraries and individual laboratories in the pharmaceutical and biotechnology industries. *Serves as an essential reference to those working in the field*Incorporates the contributions of prominent experts *Features comprehensive coverage and a logical structure
Book Synopsis Analysis of Protein Post-Translational Modifications by Mass Spectrometry by : John R. Griffiths
Download or read book Analysis of Protein Post-Translational Modifications by Mass Spectrometry written by John R. Griffiths and published by John Wiley & Sons. This book was released on 2016-10-18 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research
Book Synopsis Protein Phosphorylation and Differential Analysis by : Mark David Platt
Download or read book Protein Phosphorylation and Differential Analysis written by Mark David Platt and published by . This book was released on 2004 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroproteomics written by Oscar Alzate and published by CRC Press. This book was released on 2009-10-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Book Synopsis Analysis of Protein Phosphorylation Sites Using Affinity Enrichment and Mass Spectrometry by :
Download or read book Analysis of Protein Phosphorylation Sites Using Affinity Enrichment and Mass Spectrometry written by and published by . This book was released on 2003 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Plant Systems Biology by : Sacha Baginsky
Download or read book Plant Systems Biology written by Sacha Baginsky and published by Springer Science & Business Media. This book was released on 2007-06-25 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume aims to provide a timely view of the state-of-the-art in systems biology. The editors take the opportunity to define systems biology as they and the contributing authors see it, and this will lay the groundwork for future studies. The volume is well-suited to both students and researchers interested in the methods of systems biology. Although the focus is on plant systems biology, the proposed material could be suitably applied to any organism.
Book Synopsis Protein Analysis using Mass Spectrometry by : Mike S. Lee
Download or read book Protein Analysis using Mass Spectrometry written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2017-05-26 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
Book Synopsis Quantitative Proteomics by Mass Spectrometry by : Salvatore Sechi
Download or read book Quantitative Proteomics by Mass Spectrometry written by Salvatore Sechi and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a compendium of cutting-edge protocols for quantitative proteomics, and presents the most significant methods used in the field today. The focus on mass spectrometry (MS) is integral. Attention is given to state-of-the-art techniques for the characterization of the phosphoproteome and tandem MS for detection of inborn errors of metabolism. This volume is an indispensable resource in the search for novel biomarkers.
Book Synopsis Investigations on Protein Phosphorylation and Its Regulators by Top-Down Mass Spectrometry by : Zhijie Wu (Ph.D.)
Download or read book Investigations on Protein Phosphorylation and Its Regulators by Top-Down Mass Spectrometry written by Zhijie Wu (Ph.D.) and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The reversible phosphorylation of proteins is central to the regulation of most aspects of cell function, including cell cycle control, receptor-mediated signal transduction, cell differentiation and proliferation, and metabolism. Characterization of phosphorylation sites on phosphorylated proteins is crucial in signaling pathways, and quantification of phosphorylation level is shown to be relevant in understanding disease pathology. In the phosphorylation event, protein kinases are responsible for transporting phosphate groups to their substrate, and these proteins are expressed in relatively low abundance but in large varieties. In recent years, top-down proteomics has emerged as a powerful technology capable of characterizing and quantifying proteoforms arising from post-translational modifications, alternative splicing, and sequence variations at the intact protein level. In this dissertation, Chapter 1 investigated the impact of phosphorylation on phosphoprotein quantification by top-down mass spectrometry. Chapter 2 described a method to comprehensively characterize an intat phosphoprotein which is heavily phosphorylated. Chapter 3 is a pilot study on the development of a nanoproteomics platform to enable intact protein kinase enrichment for top-down mass spectrometry analysis. In Chapter 4, a universal and user-friendly software environment was developed for top-down proteomics community. Finally, Chapter 5 showed the development of a machine learning strategy for spectral deconvolution to aid top-down data analysis. I envision the development described in this dissertation will enable comprehensive characterization of phosphoproteins with accurate phosphoprotein quantification, enrichment of low-abundance proteins for mass spectrometry analysis, and high-throughput data analysis for top-down proteomics.
Book Synopsis Characterization of Protein Phosphorylation by Nanoflow HPLC-microElectrospray Ionization Mass Spectrometry by : Melanie Joy Schroeder
Download or read book Characterization of Protein Phosphorylation by Nanoflow HPLC-microElectrospray Ionization Mass Spectrometry written by Melanie Joy Schroeder and published by . This book was released on 2005 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mass Spectrometry-Based Proteomics by : Kris Gevaert
Download or read book Mass Spectrometry-Based Proteomics written by Kris Gevaert and published by Springer Nature. This book was released on 2023-09-04 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores contemporary techniques in mass spectrometry-based proteomics. After covering overall proteome coverage and the cellular surfaceome, the book delves into proximity-induced biotinylation, abduction of protein complexes in viral-like particles, and thermal proteome profiling, as well as protocols for identifying protein N-terminal acetylation, protein processing by proteases, protein N-glycosylation, and protein phosphorylation. The book also collects chapters on automated preparation of clinical samples, the analysis of formalin-fixed paraffin-embedded samples, protocols for the isolation of extracellular vesicles and for the monitoring of selected protein modifications in clinical samples, and, finally, structural proteomics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mass Spectrometry-Based Proteomics serves as an ideal guide to its subject for both novices in the field of proteomics as well as specialists.
Book Synopsis Proteome Research: Mass Spectrometry by : Peter James
Download or read book Proteome Research: Mass Spectrometry written by Peter James and published by Springer Science & Business Media. This book was released on 2000-10-26 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in large scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Mass spectrometry is the method of choice for the rapid large-scale identification of these proteomes and their modifications. This is the first book to extensively cover the applications of mass spectrometry to proteome research.
Book Synopsis Protein Phosphorylation by : Grahame Hardie
Download or read book Protein Phosphorylation written by Grahame Hardie and published by OUP Oxford. This book was released on 1999-10-14 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reversible phosphorylation is one of the major mechanisms of controlling protein activity in all eukaryotic cells. This new edition of Protein Phosphorylation: A Practical Approach provides a comprehensive description of current methods used to study protein phosphorylation and the kinases and phosphatases which catalyse it. It includes protocols for studying phosphorylation in intact cells; analysis of signal transduction pathways, kinase specificity, and kinase interactions; assay and purification of kinases and phosphatases; and identification of substrates. Also covered are cloning and expression protocols and advice on the crystallization of kinases and phosphatases. Protein Phosphorylation: A Practical Approach 2e will therefore be of great value to any researcher investigating aspects of reversible protein phosphrylation.
Book Synopsis Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry by : A. Peter Snyder
Download or read book Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry written by A. Peter Snyder and published by . This book was released on 1996 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents new ways of creating ions of polar and labile biopolymeric species with remarkable ease and efficiency. Introduces better characterization of proteins and other biological molecules. Presents major fundamental issues in such areas as immunology, biochemistry, and natural toxins. Demonstrates methods used to resolve the data from various biological process investigations into useful information. Provides an application-driven approach, presenting valuable insights into the experiments in the volume.
Book Synopsis Investigations on Protein Phosphorylation and Its Regulators by Top-Down Mass Spectrometry by : Zhijie Wu (Ph.D.)
Download or read book Investigations on Protein Phosphorylation and Its Regulators by Top-Down Mass Spectrometry written by Zhijie Wu (Ph.D.) and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The reversible phosphorylation of proteins is central to the regulation of most aspects of cell function, including cell cycle control, receptor-mediated signal transduction, cell differentiation and proliferation, and metabolism. Characterization of phosphorylation sites on phosphorylated proteins is crucial in signaling pathways, and quantification of phosphorylation level is shown to be relevant in understanding disease pathology. In the phosphorylation event, protein kinases are responsible for transporting phosphate groups to their substrate, and these proteins are expressed in relatively low abundance but in large varieties. In recent years, top-down proteomics has emerged as a powerful technology capable of characterizing and quantifying proteoforms arising from post-translational modifications, alternative splicing, and sequence variations at the intact protein level. In this dissertation, Chapter 1 investigated the impact of phosphorylation on phosphoprotein quantification by top-down mass spectrometry. Chapter 2 described a method to comprehensively characterize an intat phosphoprotein which is heavily phosphorylated. Chapter 3 is a pilot study on the development of a nanoproteomics platform to enable intact protein kinase enrichment for top-down mass spectrometry analysis. In Chapter 4, a universal and user-friendly software environment was developed for top-down proteomics community. Finally, Chapter 5 showed the development of a machine learning strategy for spectral deconvolution to aid top-down data analysis. I envision the development described in this dissertation will enable comprehensive characterization of phosphoproteins with accurate phosphoprotein quantification, enrichment of low-abundance proteins for mass spectrometry analysis, and high-throughput data analysis for top-down proteomics.
