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Protein Carbohydrate Interactions In Infectious Diseases
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Book Synopsis Protein-Carbohydrate Interactions in Infectious Diseases by : Carole A Bewley
Download or read book Protein-Carbohydrate Interactions in Infectious Diseases written by Carole A Bewley and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein-carbohydrate interactions is an exciting area of research with huge potential for development and exploration. These interactions are both widespread and diverse in biological processes and many play a crucial role in cellular recognition, attachment and adhesion. This is particularly true for host-pathogen interactions that lead to infectious diseases; as the surfaces of cells and pathogens display complex carbohydrate structures and carbohydrate binding proteins on their surface. Protein-Carbohydrate Interactions in Infectious Disease is part of the Biomolecular Science Series and provides a comprehensive overview of the subject, with contributions from leading experts in the field. Beginning with a general introduction, subsequent sections include: Atomic basis of protein-carbohydrate interactions, Structures and roles of Pseudomonas areuginosa lectins, Protein-carbohydrate interactions in enterobacterial infections, Retrocyclins: miniature lectins with potent antiviral activity, C-type lectin receptors that regulate pathogen recognition through the recognition of carbohydrates, Synthetic carbohydrate-based anti-malarial vaccines and glycobiology. With full colour throughout and an extensive bibliography this book is ideal for researchers interested in the area.
Book Synopsis Carbohydrate-Protein Interaction by : Adrienne E. Clarke
Download or read book Carbohydrate-Protein Interaction written by Adrienne E. Clarke and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate as the primary product of photosynthesis has a vital role in the maintenance of life on this planet. Until relatively recently, interest in complex carbohydrates focussed on their structural role in the extracellular matrix/ cell wall of animal, plant, and microbial cells and on their role as energy sources (e.g., starch and glycogen) and struc tural components (e.g., cellulose) in natural products. There was, however, indirect evidence that carbohydrates could play an informational role; this evidence was from the find ing last century that plant lectins caused specific agglutina tion of certain animal cells and, more recently, that the agglutination was mediated by interactions between the plant lectin and cell surface carbohydrates. It is now clear that endogenous carbohydrate binding proteins are important in cell-cell recognition phenomena in animal systems. Recently, impressive evidence has been presented that complex oligosaccharides, derived from cell walls, are also important in plant recognition events, for example in signalling the defence mechanisms of a plant to respond to attack by insects and microbial pathogens.
Book Synopsis Protein-Carbohydrate Interactions by : D. Wade Abbott
Download or read book Protein-Carbohydrate Interactions written by D. Wade Abbott and published by . This book was released on 2017 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume is a wide-ranging tool for studying protein-carbohydrate interactions that extend from traditional biochemical methods to state-of-the-art techniques. This book focuses on four different research themes: Part I describes methods for screening and quantifying CAZyme activity; Part II contains methods for investigating the interactions between proteins and carbohydrate ligands; Part III discusses methods for the visualization of carbohydrates and protein-carbohydrate complexes; and Part IV focuses on structural and "omic" approaches for studying systems of CAZymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Protein-Carbohydrate Interactions: Methods and Protocols is a valuable resource to the glycomics research community. In this continuously advancing field, the methods in this book highlight the biology of glycomics, thus driving biotechnological innovation and solutions for human health and sustainable resources within the emerging green community. ."--Prové de l'editor.
Book Synopsis Essentials of Glycobiology by : Ajit Varki
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Book Synopsis Immunobiology of Carbohydrates by : Simon Wong
Download or read book Immunobiology of Carbohydrates written by Simon Wong and published by Springer Science & Business Media. This book was released on 2003-10-31 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is unique in providing pertinent information on the various established roles carbohydrate play in the immune system and how the innate and adaptive immune systems respond to this type of microbial antigens. The editors selected only topics that have established basic and clinical relevance to this field. The topics from basic research are organised like a textbook, in order to guide the readers through complex sets of events that lead to clearance of or to immune responses toward carbohydrate antigens. The book is clear, concise and contains fully annotated summaries of the key basic and practical information on carbohydrate immunology from current literature. These topics are written by investigators from various disciplines (chemistry, medicine, biochemistry, glycobiology and immunology), creating a fine balance in the point of views presented in the book. It explores the challenges and rewards of understanding the importance of carbohydrates and glycoconjugates in health and disease, applying new knowledge from carbohydrate immunology in improving or developing novel sugar-based therapeutics, and vaccines and medicines. This book is most suitable for glycobiologists and immunologists, but many researchers whose interests, background and expertise are in any of the fifteen topics presented in this book will also find it appealing. It is also a valuable resource for postgraduate students, clinicians or anyone else who is curious about the role of carbohydrates in immunology, and would like to see the topics combined under one cover and in relation to each other.
Book Synopsis Carbohydrate-based Vaccines by : René Roy
Download or read book Carbohydrate-based Vaccines written by René Roy and published by ACS Symposium. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.
Book Synopsis The Immune System and Infectious Diseases by : Erwin Neter
Download or read book The Immune System and Infectious Diseases written by Erwin Neter and published by . This book was released on 1975 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein-Ligand Interactions by : Hans-Joachim Böhm
Download or read book Protein-Ligand Interactions written by Hans-Joachim Böhm and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed. An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Interactions: Computational Methods, Analysis And Applications by : M Michael Gromiha
Download or read book Protein Interactions: Computational Methods, Analysis And Applications written by M Michael Gromiha and published by World Scientific. This book was released on 2020-03-05 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is indexed in Chemical Abstracts ServiceThe interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design.This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules.
Book Synopsis Transforming Glycoscience by : National Research Council
Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Book Synopsis Dairy-Derived Ingredients by : M Corredig
Download or read book Dairy-Derived Ingredients written by M Corredig and published by Elsevier. This book was released on 2009-10-26 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in technologies for the extraction and modification of valuable milk components have opened up new opportunities for the food and nutraceutical industries. New applications for dairy ingredients are also being found. Dairy-derived ingredients reviews the latest research in these dynamic areas. Part one covers modern approaches to the separation of dairy components and manufacture of dairy ingredients. Part two focuses on the significant area of the biological functionality of dairy components and their nutraceutical applications, with chapters on milk oligosaccharides, lactoferrin and the role of dairy in food intake and metabolic regulation, among other topics. The final part of the book surveys the technological functionality of dairy components and their applications in food and non-food products. Dairy ingredients and food flavour, applications in emulsions, nanoemulsions and nanoencapsulation, and value-added ingredients from lactose are among the topics covered. With its distinguished editor and international team of contributors, Dairy-derived ingredients is an essential guide to new developments for the dairy and nutraceutical industries, as well as researchers in these fields. Summarises modern approaches to the separation of dairy components and the manufacture of dairy ingredients Assesses advances in both the biological and technological functionality of dairy components Examines the application of dairy components in both food and non-food products
Book Synopsis Carbohydrate Antigens by : Per J. Garegg
Download or read book Carbohydrate Antigens written by Per J. Garegg and published by . This book was released on 1993 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed from a symposium at the Fourth Chemical Congress of North America (202nd National Meeting of the ACS) in New York City, August 1991, chapter-papers present research on topics including how proteins recognize and bind oligosaccharides, synthesis and immunological properties of glycopeptide T-cell determinants, Vibrio cholerae polysaccharide studies, and purification of oligosaccharide antigens by weak affinity chromatography. Annotation copyright by Book News, Inc., Portland, OR
Book Synopsis Carbohydrate Microarrays by : Yann Chevolot
Download or read book Carbohydrate Microarrays written by Yann Chevolot and published by Humana Press. This book was released on 2011-11-09 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate microarrays emerged as a key technology for the deciphering of the glycospace by providing a multiplex technology where tens to hundreds of carbohydrates/protein interactions can be probed in parallel. Carbohydrate Microarrays: Methods and Protocols aims to give the reader the theoretical and experimental clues necessary for the fabrication and implementation of carbohydrate microarrays. This requires three essential steps: 1) to obtain the carbohydrate probes (monosacharides, oligosacchrides, polysacchairdes, glycoconjugates or glycoclusters), 2) to immobilize these probes, and 3) to implement the protocols for biological/biochemical interaction with the desired target. This volume gives an overview of carbohydrate microarray and carbohydrate chemistry and illustrates different detection techniques and their applications. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Carbohydrate Microarrays: Methods and Protocols compiles a catalogue of protocols on carbohydrate microarrays to span the needs of researchers around the globe.
Book Synopsis Carbohydrate-Based Interactions at the Molecular and the Cellular Level by : Kieran L. Hudson
Download or read book Carbohydrate-Based Interactions at the Molecular and the Cellular Level written by Kieran L. Hudson and published by Springer. This book was released on 2018-05-28 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH–pi interactions associated with the properties of the interacting partners. Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications.
Book Synopsis Animal Lectins by : Gerardo R. Vasta PhD
Download or read book Animal Lectins written by Gerardo R. Vasta PhD and published by CRC Press. This book was released on 2008-10-09 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces Groundbreaking Approaches for Assessing Lectin Function Lectins and their ligands are under quite a heavy microscope due to their potential applications to pharmacology, immunology, cancer therapy, and agriculture. With growing interest in the glycobiology field, the body of research related to lectin roles has grown at an explosive rate
Book Synopsis Diarrhea and Malnutrition by : Lincoln Chen
Download or read book Diarrhea and Malnutrition written by Lincoln Chen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are several reasons why a consolidation of recent advances in our understanding of the interaction of diarrhea and malnutrition is indi cated and timely. It is now widely recognized that diarrhea is a major cause of morbidity and mortality among children of poor countries. Due to recent advances in laboratory and field diagnostic techniques, many of the previously unrecognized etiologic agents responsible for diarrhea have been identified, thereby providing new scientific knowledge for rational control strategies. Increasingly these advances suggest that the morbidity burden of diarrhea may be of equal, if not greater, public health consequence than mortality. Diarrhea only rarely causes disease severe enough to require institutionalized medical care. The vast major ity of diseases are of mild or moderate severity, and because of high prev alence, diarrhea imposes an enormous morbidity burden and exerts a sig nificant negative impact on child growth and development. Moreover, the effects of successive episodes of diarrhea are likely to be cumulative. In contrast to several other childhood infections, the treatment of the diarrheal diseases is feasible because it uses simple, effective, and low cost medical technologies. Within the context of these developments, there has been a major resurgence of international interest in, and commitment to, the control of the diarrheal diseases. The World Health Organization recently has launched a global program for the control of diarrhea, and simulta neously, an independent international research center on diarrhea has been established in Bangladesh.
