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Author : Jacques Gérard Archambault
Publisher :
ISBN 13 :
Total Pages : 506 pages
Book Rating : 4.:/5 (181 download)
Download or read book Protein Adsorption to Polyethylene Oxide-grafted Surfaces written by Jacques Gérard Archambault and published by . This book was released on 2002 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Susan Jane Sofia Allgor
Publisher :
ISBN 13 :
Total Pages : 155 pages
Book Rating : 4.:/5 (356 download)
Download or read book Linear and Star-shaped Poly(ethylene Oxide) Grafted Surfaces written by Susan Jane Sofia Allgor and published by . This book was released on 1996 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Warren Taylor
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (862 download)
Download or read book Protein Adsorption at Polyethylene Oxide Brushes of Various Surface Coverage written by Warren Taylor and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis the protein resistive nature of polyethylene oxide brushes shall be investigated. Initially a novel grafting-to procedure for the production of high molecular weight and high grafting density PEO brushes will be presented. This procedure will allow the accurate control of the grafting density of PEO brushes. The crystallisation and oxidation of PEO brushes is also briefly investigated. Ex situ ellipsometry experiments will show that the adsorbed amount of protein is related to the surface coverage of polymer. supporting the random sequential adsorption theory (RSA-model) of Katira et al. However. through in situ QCM-D experiments it will be shown that RSA-model cannot fully describe the protein adsorption kinetics and may need to be revised to take these observations into account. We will show through use of an exponential model that the adsorption of protein at PEO brushes is a site blocking process and not an entropic process on the time scales measured here. Neutron reflectivity experiments on the INTER reflectometer instrument at ISIS show that the lysozyme protein is most likely adsorbing in the primary position at the gold- brush interface. The experiments presented in this thesis support the conclusion that the protein resistive nature of PEO brushes is that of a site blocking barrier.
![Download Protein Adsorption to Chemisorbed Polyethylene Oxide Thin Films [microform] PDF Online Free](https://books.google.com/books/content/images/frontcover/QCbetAEACAAJ?fife=w200-h370)
Author : Larry David Unsworth
Publisher : Library and Archives Canada = Bibliothèque et Archives Canada
ISBN 13 : 9780494079430
Total Pages : 175 pages
Book Rating : 4.0/5 (794 download)
Download or read book Protein Adsorption to Chemisorbed Polyethylene Oxide Thin Films [microform] written by Larry David Unsworth and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2005 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major area of biomaterials research is the development of surfaces that reduce or eliminate non-specific protein adsorption. End-tethered PEO has been shown to reduce protein and cell interactions at the tissue-material interface; the effects of polymer chain length, chain density and end-group chemistry are not yet completely understood. To date, there have been few detailed, systematic studies that have attempted to elucidate the effect of end-tethered PEO conformation, surface chain density, molecular weight (MW) and end-group chemistry on protein adsorption at the solid-liquid interface.
Author : Sal Thomas
Publisher :
ISBN 13 :
Total Pages : 338 pages
Book Rating : 4.:/5 (71 download)
Download or read book The Comparative Protein Repellency Study of Polyvinyl Pyrrolidone and Polyethylene Oxide Grafted to Plasma Polymerized Surfaces written by Sal Thomas and published by . This book was released on 2003 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ranjini Murthy
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (69 download)
Download or read book Enhancing Protein-resistance of PEO-modified Biomaterials written by Ranjini Murthy and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The ultimate goal of this dissertation research is to enhance the protein resistant nature of poly(ethylene oxide) (PEO) or poly(ethylene glycol) by introduction of a siloxane linker and to subsequently prepare coatings which prevent surface-induced thrombosis. The hydrophobicity and flexibility of the siloxane tether should impart both amphiphilicity and conformational mobility to the PEO chain to further decrease protein adhesion. Because adsorption of plasma (blood) proteins initiates the clotting process, coating surfaces based on these new PEO-silanes should prevent or significantly diminish thrombosis. Thus, these coatings would be extremely useful for bloodcontacting medical devices such as stents, grafts, arteriorintravenous shunts, and biosensors. Novel amphiphilic PEO-silanes were prepared with systematic variations to several key structural features, including: siloxane tether length, PEO segment length, and PEO architecture. Thus, PEO-silanes were prepared having the general formulas: [alpha]-(EtO)3Si(CH2)2-oligodimethylsiloxanen-block-[PEO-OCH3] (n = 0, 4, and 13; linear architecture) and [alpha]-(EtO)3Si(CH2)2-oligodimethylsiloxanen-block-[PEOm-OCH3]2 (n = 0, 4, and 13; m = 6 and 12 branched architecture). The reactive triethoxysilane [(EtO)3Si-] group serves as the crosslinking or grafting moiety. The PEO segment is distanced from the (EtO)3Si- group by an oligodimethylsiloxane tether which is both hydrophobic and exhibits a high degree of chain flexibility. Crosslinked silicone coatings and surfacegrafted coatings were prepared with amphiphilic linear PEO-silanes (a-c). Crosslinked silicone coatings were also prepared with branched PEO-silanes (1a-3a and 1b-3b). All coatings showed improved resistance to common plasma proteins compared to silicone coatings. Furthermore, protein adsorption generally decreased with siloxane tether length. For crosslinked PEO-modified silicone coating systems based on linear (a-c) and branched PEO-silanes (1a-3a and 1b-3b), longer tethers enhanced PEO reorganization to the film-water interface to enhance protein resistance. In the absence of surface reorganization for surface grafted coatings prepared with linear PEO-silanes, longer siloxane tethers better inhibited protein adsorption despite a moderate decrease in graft density (sigma) and decrease in surface hydrophilicity. This indicates that longer siloxane tethers enhance the configurational mobility of the PEO segments to better repel proteins.
Author :
Publisher :
ISBN 13 :
Total Pages : 105 pages
Book Rating : 4.:/5 (11 download)
Download or read book Polymer Layer Structure and Protein Rearrangements Impact written by and published by . This book was released on 2017 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein adsorption onto foreign material is the beginning of a biological process that results in induced thrombosis that leads to a response that may be detrimental to the body. The prevention of blood plasma protein adsorption is a major factor in promoting biocompatibility of biomaterials with blood plasma. The application of coating biomaterial surfaces with poly(ethylene oxide) (PEO) has been very popular in biocompatibility studies. Theoretical studies have created models that have based protein adsorption on surfaces coated with polymers on free energies (van der Waals, hydrophobic interactions, and steric repulsions). The random sequential adsorption (RSA) model is a theoretical model that postulates that randomly distributed polymers and their obstruction of adsorption sites is a major factor that affects the random placement of protein adsorption based on the availability of the remaining unobstructed adsorption sites. This work examines the simulation of how the arrangement of polymer layers prepared by self-assembled monolayers (SAM) and physical adsorption affects the diffusion of the arrangement of proteins on the surface based on the RSA model. The model in this work extends the RSA model by considering the exact arrangement of polymers on the surface as well as dynamic rearrangements of adsorbed proteins that lead to a more closely packed layer. The modified RSA models are compared to previously reported experimental protein adsorption on PEO grafted surfaces using SAMs as well as physically adsorbed copolymers of PEO. Our results show that accounting for underlying polymer arrangement and protein rearrangements post-adsorption significantly improves the predictions of the RSA model. The simulations are compared with experimental observations for the polymers: EG1OH, EG2OH, EG4OH, EG6OH, EG17OCH3, EG23OH, EG46OH, and EG115OH. The effect of polymer grafting density and polymer chain length of PEO on protein adsorption are also investigated. These results provide a more robust model for predicting protein surface adsorption on hydrophilic polymer coated surfaces as a function of the polymer chain length, grafting density, protein size, protein surface sub-diffusion, and polymer layer structure. This paves a path for the design of high performance anti-fouling surface coatings.
Author : Paul Hamilton-Brown
Publisher :
ISBN 13 :
Total Pages : 273 pages
Book Rating : 4.:/5 (768 download)
Download or read book A Surface Forces and Protein Adsorption Study of Grafted PEO Layers written by Paul Hamilton-Brown and published by . This book was released on 2006 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Andreas Taubert
Publisher : John Wiley & Sons
ISBN 13 : 3527649638
Total Pages : 616 pages
Book Rating : 4.5/5 (276 download)
Download or read book Biomaterials Surface Science written by Andreas Taubert and published by John Wiley & Sons. This book was released on 2013-07-12 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the interface of biology, chemistry, and materials science, this book provides an overview of this vibrant research field, treating the seemingly distinct disciplines in a unified way by adopting the common viewpoint of surface science. The editors, themselves prolific researchers, have assembled here a team of top-notch international scientists who read like a "who's who" of biomaterials science and engineering. They cover topics ranging from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices. As a result, the book explains the complex interplay of cell behavior and the physics and materials science of artificial devices. Of equal interest to young, ambitious scientists as well as to experienced researchers.
Author : Igal Szleifer
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (415 download)
Download or read book Protein Adsorption on Surfaces with Grafted Polymers written by Igal Szleifer and published by . This book was released on 1998 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Limin Wu
Publisher : John Wiley & Sons
ISBN 13 : 111888292X
Total Pages : 366 pages
Book Rating : 4.1/5 (188 download)
Download or read book Functional Polymer Coatings written by Limin Wu and published by John Wiley & Sons. This book was released on 2015-06-10 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on a variety of coatings, this book provides detailed discussion on preparation, novel techniques, recent developments, and design theories to present the advantages of each function and provide the tools for better product performance and properties. • Presents advantages and benefits of properties and applications of the novel coating types • Includes chapters on specific and novel coatings, like nanocomposite, surface wettability tunable, stimuli-responsive, anti-fouling, antibacterial, self-healing, and structural coloring • Provides detailed discussion on recent developments in the field as well as current and future perspectives • Acts as a guide for polymer and materials researchers in optimizing polymer coating properties and increasing product performance
Author : Kyoichi Saito
Publisher : Springer
ISBN 13 : 9811085633
Total Pages : 193 pages
Book Rating : 4.8/5 (11 download)
Download or read book Innovative Polymeric Adsorbents written by Kyoichi Saito and published by Springer. This book was released on 2018-04-05 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the reader with a story-based narrative of discovery and development of radiation-induced graft polymerization. The report presented here accomplishes this by relating the inspiring account of research and development based on long-term collaboration among a professor, an engineer, and an entrepreneur. Their goal, ultimately successful, was to come up with a method for grafting functional polymer chains onto existing trunk polymers. The desired outcome was to produce feasible forms for practical use as adsorbents such as porous hollow-fiber membranes, porous sheets, nonwoven fabrics, and fibers. Adsorbents that specifically and efficiently bind to target ions and molecules are essential for capturing uranium species in seawater and antibody drugs in biological fluids and for removing metal ions from ultrapure water and radioactive cesium ions from contaminated water. This unique volume, with its clearly written text and many illustrative figures and diagrams, demonstrates the advantages of the high-adsorption capacity and rate and the easy handling of new polymeric adsorbents over conventional adsorbents. The dynamic behavior of graft chains as described here is certain to appeal especially to chemists, physicists, and material scientists as well as to other readers with an interest in this valuable subject.
Author : Severian Dumitriu
Publisher : CRC Press
ISBN 13 : 9780203904671
Total Pages : 1192 pages
Book Rating : 4.9/5 (46 download)
Download or read book Polymeric Biomaterials, Revised and Expanded written by Severian Dumitriu and published by CRC Press. This book was released on 2001-11-29 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering nearly 7000 references-3900 more than the first edition-Polymeric Biomaterials, Second Edition is an up-to-the-minute source for plastics and biomedical engineers, polymer scientists, biochemists, molecular biologists, macromolecular chemists, pharmacists, cardiovascular and plastic surgeons, and graduate and medical students in these disciplines. Completely revised and updated, it includes coverage of genetic engineering, synthesis of biodegradable polymers, hydrogels, and mucoadhesive polymers, as well as polymers for dermacosmetic treatments, burn and wound dressings, orthopedic surgery, artificial joints, vascular prostheses, and in blood contacting systems.
Author : Stuart L. Cooper
Publisher : Woodhead Publishing
ISBN 13 : 0081006225
Total Pages : 720 pages
Book Rating : 4.0/5 (81 download)
Download or read book Advances in Polyurethane Biomaterials written by Stuart L. Cooper and published by Woodhead Publishing. This book was released on 2016-01-23 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Polyurethane Biomaterials brings together a thorough review of advances in the properties and applications of polyurethanes for biomedical applications. The first set of chapters in the book provides an important overview of the fundamentals of this material with chapters on properties and processing methods for polyurethane. Further sections cover significant uses such as their tissue engineering and vascular and drug delivery applications Written by an international team of leading authors, the book is a comprehensive and essential reference on this important biomaterial. Brings together in-depth coverage of an important material, essential for many advanced biomedical applications Connects the fundamentals of polyurethanes with state-of-the-art analysis of significant new applications, including tissue engineering and drug delivery Written by a team of highly knowledgeable authors with a range of professional and academic experience, overseen by an editor who is a leading expert in the field
Author : Rachel Williams
Publisher : Elsevier
ISBN 13 : 0857090763
Total Pages : 438 pages
Book Rating : 4.8/5 (57 download)
Download or read book Surface Modification of Biomaterials written by Rachel Williams and published by Elsevier. This book was released on 2010-11-25 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The surface modification of biomaterials plays a significant role in determining the outcome of biological-material interactions. With the appropriate modification a material’s surface can be tailored to improve biocompatibility, adhesion and cell interactions. Consequently surface modification is vital in the development and design of new biomaterials and medical devices. Surface modification of biomaterials reviews both established surface modifications and those still in the early stages of research and discusses how they can be used to optimise biological interactions and enhance clinical performance.Part one begins with chapters looking at various types and techniques of surface modification including plasma polymerisation, covalent binding of poly (ethylene glycol) (PEG), heparinisation, peptide functionalisation and calcium phosphate deposition before going on to examine metal surface oxidation and biomaterial surface topography to control cellular response with particular reference to technologies, cell behaviour and biomedical applications. Part two studies the analytical techniques and applications of surface modification with chapters on analysing biomaterial surface chemistry, surface structure, morphology and topography before moving onto discuss modifying biomaterial surfaces to optimise interactions with blood, control infection, optimise interactions with soft tissues, repair and regenerate nerve cells, control stem cell growth and differentiation and to optimise interactions with bone.The distinguished editor and international team of contributors to Surface modification of biomaterials have produced a unique overview and detailed chapters on a range of surface modification techniques which will provide an excellent resource for biomaterials researchers and scientists and engineers concerned with improving the properties of biomaterials. It will also be beneficial for academics researching surface modification. Reviews both established surface modifications and those still in the early stages of research and how they can be used to optimise biological interactions and enhance clinical performance Studies analytical techniques and applications of surface modification with chapters assessing biomaterial surface chemistry, surface structure, morphology and topography Discusses modifying biomaterial surfaces to optimise interactions with blood and soft tissues and also to repair and regenerate nerve cells and control infection
Author : Jang B. Rampal
Publisher : Springer Science & Business Media
ISBN 13 : 1588295893
Total Pages : 923 pages
Book Rating : 4.5/5 (882 download)
Download or read book Microarrays written by Jang B. Rampal and published by Springer Science & Business Media. This book was released on 2007-07-27 with total page 923 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microarray Technology, Volumes 1 and 2, present information in designing and fabricating arrays and binding studies with biological analytes while providing the reader with a broad description of microarray technology tools and their potential applications. The first volume deals with methods and protocols for the preparation of microarrays. The second volume details applications and data analysis, which is important in analyzing the enormous data coming out of microarray experiments. Among the topics discussed in Volume 1: Synthesis Methods, are matrices in the synthesis of microarrays, array optimization processes, array-based comparative genomic hybridization, 60-mer oligonucleotide probes, bifunctional reagents NTMTA and NTPAC, and high density arrays using digital microarray synthesis platforms. Other topics include multiplex ligation-dependent probe amplification (MLPA), hybridization conditions in situ-synthesized oligo arrays, peptide arrays, high density replication tools (HDRT), protocols for the quantification of oligo hybridization, glyco-bead arrays, and an investigation into the emerging nano technology. Microarray Technology, Volumes 1 and 2, provide ample information to all levels of scientists from novice to those intimately familiar with array technology.
Author : Baiyan Dong
Publisher :
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.:/5 (89 download)
Download or read book Generation of Antifouling Layers from Polyethylene Glycol by Cold Plasma Techniques on Stainless Steel and Polymer Surfaces written by Baiyan Dong and published by . This book was released on 2007 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
