Protecting Group Free Organic Synthesis

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Protecting-Group-Free Organic Synthesis

Author : Rodney A. Fernandes
Publisher : John Wiley & Sons
ISBN 13 : 1119295203
Total Pages : 283 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Protecting-Group-Free Organic Synthesis by : Rodney A. Fernandes

Download or read book Protecting-Group-Free Organic Synthesis written by Rodney A. Fernandes and published by John Wiley & Sons. This book was released on 2018-08-20 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protecting-group-free synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protecting-group-free synthesis. Following this, the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis using carbohydrates and of glycosyl derivatives, glycol-polymers and glyco-conjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protecting-group-free synthesis. A comprehensive account of established protecting-group-free (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical Protecting-Group-Free Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.

Greene's Protective Groups in Organic Synthesis

Author : Peter G. M. Wuts
Publisher : John Wiley & Sons
ISBN 13 : 1118589327
Total Pages : 1108 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Greene's Protective Groups in Organic Synthesis by : Peter G. M. Wuts

Download or read book Greene's Protective Groups in Organic Synthesis written by Peter G. M. Wuts and published by John Wiley & Sons. This book was released on 2012-12-20 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including... New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique Expanded coverage of the unexpected side reactions that occur with protective groups New chart covering the selective deprotection of silyl ethers 3,100 new references from the professional literature The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.

Protecting Groups in Organic Synthesis

Author : James R. Hanson
Publisher : Wiley-Blackwell
ISBN 13 : 9781850759577
Total Pages : 140 pages
Book Rating : 4.7/5 (595 download)

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Book Synopsis Protecting Groups in Organic Synthesis by : James R. Hanson

Download or read book Protecting Groups in Organic Synthesis written by James R. Hanson and published by Wiley-Blackwell. This book was released on 1999-11-15 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides, at postgraduate student level, an accessible introduction to a topic of central importance in organic synthesis. It covers the main functional groups requiring protection in organic synthesis, explaining why a particular protecting agent works and how an agent should be chosen. Emphasis is placed on what a protecting group is doing chemically to the structure that it is protecting. Attention is given to removal of the protecting group. This is a clear and thoughtful book, which concentrates on explaining the chemistry. It also provides a convenient point of entry to the primary literature.

Protective Groups in Organic Synthesis

Author : Theodora W. Greene
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Protective Groups in Organic Synthesis by : Theodora W. Greene

Download or read book Protective Groups in Organic Synthesis written by Theodora W. Greene and published by . This book was released on 1981-05-14 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive information on the most useful protective groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups. Discusses the chemistry of the classes of protective groups, as well as that of the individual protective groups within the class using structures, equations and references. Reactivity Charts for each class of protective group serve as an aid in their appropriate choice and provide estimates of their relative reactivities toward 108 prototype reagents.

Protective Groups in Organic Chemistry

Author : J. McOmie
Publisher : Springer Science & Business Media
ISBN 13 : 1468472186
Total Pages : 423 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Protective Groups in Organic Chemistry by : J. McOmie

Download or read book Protective Groups in Organic Chemistry written by J. McOmie and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.

Greene's Protective Groups in Organic Synthesis

Author : Peter G. M. Wuts
Publisher : John Wiley & Sons
ISBN 13 : 1118905121
Total Pages : 1400 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Greene's Protective Groups in Organic Synthesis by : Peter G. M. Wuts

Download or read book Greene's Protective Groups in Organic Synthesis written by Peter G. M. Wuts and published by John Wiley & Sons. This book was released on 2014-08-08 with total page 1400 pages. Available in PDF, EPUB and Kindle. Book excerpt: An indispensable reference for any practicing synthetic organic ormedicinal chemist, this book continues the tradition ofGreene’s as comprehensive in the overall scope of coverage,providing the most relevant and useful examples to illustrate eachmethodology. • Presents valuable material, on the application ofprotective groups in organic chemistry, that is not easily found bycasual searching • Helps chemists to plan, investigate, and carry outorganic syntheses in an efficient manner • Adds over 2800 new references to update since thepublication of the last edition • Reviews of the prior edition: "An essential bible forthe library or personal bookshelf of chemists performing complexsynthesis." (CHOICE, May 2007) "...the most up-to-date compilationavailable...should be an integral part of all institutionallibraries...it is also highly recommended thatindividuals...maintain their own copy..." (Journal of MedicinalChemistry, March 8, 2007) "...continues to be a comprehensive guideto the techniques for the formation and cleavage of protectivegroups." (Journal of the American Chemical Society, January 31,2007)

Protecting Groups: Strategies and Applications in Carbohydrate Chemistry

Author : Sebastien Vidal
Publisher : John Wiley & Sons
ISBN 13 : 3527340106
Total Pages : 522 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Protecting Groups: Strategies and Applications in Carbohydrate Chemistry by : Sebastien Vidal

Download or read book Protecting Groups: Strategies and Applications in Carbohydrate Chemistry written by Sebastien Vidal and published by John Wiley & Sons. This book was released on 2019-04-29 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique overview of the most important protecting group strategies in carbohydrate chemistry Protecting Groups: Strategies and Applications in Carbohydrate Chemistry provides a detailed account of key strategies and methodologies for the protection of carbohydrates. Divided into two parts, the first focuses on groups that are used best to protect a specific position on a carbohydrate. In the second part, specific carbohydrate residues or compounds are discussed in the context of a specific protecting group strategy used to reach the desired regioisomer. This important book: -Features chapters on protecting groups at the primary and secondary positions of carbohydrates -Describes protecting group strategies towards sialic acid derivatives, glycofuranoses, sulfated glycosaminoglycans, and cyclodextrins -Provides information on automated glycan assembly -Includes a chapter on the industrial scale synthesis of heparin analogs Written by a team of leaders in the field, Protecting Groups: Strategies and Applications in Carbohydrate Chemistry is an indispensable guide for academics and industrial researchers interested in carbohydrate and natural product synthesis, pharmaceutical chemistry, and biochemistry.

Protecting Group Chemistry

Author : Jeremy Robertson
Publisher : Oxford University Press, USA
ISBN 13 : 9780198502753
Total Pages : 96 pages
Book Rating : 4.5/5 (27 download)

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Book Synopsis Protecting Group Chemistry by : Jeremy Robertson

Download or read book Protecting Group Chemistry written by Jeremy Robertson and published by Oxford University Press, USA. This book was released on 2000 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protecting Group Chemistry provides an overview of the general methods that are used to block the reactivity of - i.e. protect - specific functional grops thus allowing others, present within the same molecule, to be manipulated unambiguously. An introductory chapter outlines protecting group strategy, relevant aspects of functional group reactivity, temporary protection, and introduces the concept of protecting group devices as an aid to unifying the wide range of available methods. Therest of the book is divided on the basis of broad classes of the experimental conditions that lead to cleavage of each protecting group (acid/electrophile, base/nucleophile, oxidising or reducing agent). The treatment differs from traditional texts in that it places the emphasis on making a connection between the fundamental mechanisms of organic chemsitry - ionisation, substitution, addition, elimination, oxidation and reduction, etc. - and how a particular protecting group can best be selected in a given situation.

Organic Synthesis

Author : Michael B Smith
Publisher : Academic Press
ISBN 13 : 0128008075
Total Pages : 1106 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Organic Synthesis by : Michael B Smith

Download or read book Organic Synthesis written by Michael B Smith and published by Academic Press. This book was released on 2016-11-22 with total page 1106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. PowerPoint© presentations and answer keys are also available online to support instructors. Fully revised and updated throughout, and teorganized into 19 chapters for a more cogent and versatile presentation of concepts Includes reaction examples taken from literature research reported between 2010-2015 Features new full-color art and new chapter content on process chemistry and green organic chemistry Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Lecture presentations and other useful material for qualified course instructors

Protecting Groups

Author : Philip J. Kocienski
Publisher : Thieme Medical Publishers
ISBN 13 :
Total Pages : 286 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Protecting Groups by : Philip J. Kocienski

Download or read book Protecting Groups written by Philip J. Kocienski and published by Thieme Medical Publishers. This book was released on 2000 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The didactic presentation of the material makes this book an essential bench-top tool not only for specialists in organic chemistry, but also for students and all those involved in the preparation of organic molecules. Key Features: - a critical survey of the most used protecting groups, as used by organic chemists - organization based on functional groups: hydroxyl ; diol; carbonyl; carboxyl; amine - special emphasis placed on deprotection conditions applied to complex structures where selectivity is a prime issue - transformations accompanied by key experimental details - examples from the recent literature span a wide domain of organic synthesis - over 500 schemes aid visual retrieval - end-of-chapter list reviews which amplify topics covered.

Strategic Applications of Named Reactions in Organic Synthesis

Author : Laszlo Kurti
Publisher : Elsevier
ISBN 13 : 0080575412
Total Pages : 864 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Strategic Applications of Named Reactions in Organic Synthesis by : Laszlo Kurti

Download or read book Strategic Applications of Named Reactions in Organic Synthesis written by Laszlo Kurti and published by Elsevier. This book was released on 2005-04-29 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings

Modern Organic Synthesis

Author : George S. Zweifel
Publisher : John Wiley & Sons
ISBN 13 : 1119086760
Total Pages : 416 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Modern Organic Synthesis by : George S. Zweifel

Download or read book Modern Organic Synthesis written by George S. Zweifel and published by John Wiley & Sons. This book was released on 2017-03-13 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents

Advanced Free Radical Reactions for Organic Synthesis

Author : Hideo Togo
Publisher : Elsevier
ISBN 13 : 9780080524252
Total Pages : 270 pages
Book Rating : 4.5/5 (242 download)

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Book Synopsis Advanced Free Radical Reactions for Organic Synthesis by : Hideo Togo

Download or read book Advanced Free Radical Reactions for Organic Synthesis written by Hideo Togo and published by Elsevier. This book was released on 2004-01-14 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radical reactions have become increasingly important and a very attractive tool in organic synthesis in the last two decades, due to their powerful, selective, specific, and mild reaction abilities. Advanced Free Radical Reactions for Organic Synthesis reviews information on all types of practical radical reactions, e.g. cyclizations, additions, hydrogen-atom abstractions, decarboxylation reactions. The book usefully provides experimental details for the most important reactions as well as numerous references to the original literature. By covering both the fundamentals and synthetic applications it is therefore suitable for both new and experienced researchers, chemists, biochemists, natural product chemists and graduate students. This title is the definitive guide to radical chemistry for all scientists. Introduces and reviews the use of radicals to perform synthetic transformations Practical details are provided for the most important methods Numerous references to the original literature

Total Synthesis of Natural Products

Author : Jie Jack Li
Publisher : Springer Science & Business Media
ISBN 13 : 3642340652
Total Pages : 292 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Total Synthesis of Natural Products by : Jie Jack Li

Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

The Organic Chemistry of Sugars

Author : Daniel E. Levy
Publisher : CRC Press
ISBN 13 : 1420027956
Total Pages : 904 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Organic Chemistry of Sugars by : Daniel E. Levy

Download or read book The Organic Chemistry of Sugars written by Daniel E. Levy and published by CRC Press. This book was released on 2005-09-21 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonst

Classics in Total Synthesis

Author : K. C. Nicolaou
Publisher : John Wiley & Sons
ISBN 13 : 3527292314
Total Pages : 826 pages
Book Rating : 4.5/5 (272 download)

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Book Synopsis Classics in Total Synthesis by : K. C. Nicolaou

Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

Glycoscience

Author : Bertram O. Fraser-Reid
Publisher : Springer Science & Business Media
ISBN 13 : 3540361545
Total Pages : 2847 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Glycoscience by : Bertram O. Fraser-Reid

Download or read book Glycoscience written by Bertram O. Fraser-Reid and published by Springer Science & Business Media. This book was released on 2008-04-14 with total page 2847 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.