Progress Report On Alzheimers Disease 2009 Translating New Knowledge

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Progress Report on Alzheimer's Disease (2009); Translating New Knowledge

Author : Barry Leonard
Publisher : DIANE Publishing
ISBN 13 : 1437944809
Total Pages : 64 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Progress Report on Alzheimer's Disease (2009); Translating New Knowledge by : Barry Leonard

Download or read book Progress Report on Alzheimer's Disease (2009); Translating New Knowledge written by Barry Leonard and published by DIANE Publishing. This book was released on 2011-05 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. investment in Alzheimer¿s research through the Nat. Inst. of Health (NIH) has resulted in accelerating progress on several research fronts and laid the groundwork for future discovery. This report highlights key findings related to: discovery of new genes and biological mechanisms that cause Alzheimer¿s disease; earlier disease detection using neuro-imaging and biomarkers; links between Alzheimer¿s and other age-related diseases; rapid translation of lab findings to potential treatments; lifestyle factors that may protect against the disease; successful cognitive aging; clinical trials underway now to prevent or treat Alzheimer¿s and cognitive decline; research-tested strategies to support caregivers. Illus. This is a print on demand report.

An Unintended Journey

Author : Janet Yagoda Shagam
Publisher : Prometheus Books
ISBN 13 : 1616147520
Total Pages : 430 pages
Book Rating : 4.6/5 (161 download)

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Book Synopsis An Unintended Journey by : Janet Yagoda Shagam

Download or read book An Unintended Journey written by Janet Yagoda Shagam and published by Prometheus Books. This book was released on 2013-07-16 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the 2009 census, more than five million people living in the United States have Alzheimer's disease or some other form of dementia. Not reported in these statistics are the fifteen million family caregivers who, in total, contribute seventeen billion hours of unpaid care each year. This book addresses the needs and challenges faced by adult children and other family members who are scrambling to make sense of what is happening to themselves and the loved ones in their care. The author, an experienced medical and science writer known for her ability to clearly explain complex and emotionally sensitive topics, is also a former family caregiver herself. Using both personal narrative and well-researched, expert-verified content, she guides readers through the often-confusing and challenging world of dementia care. She carefully escorts caregivers through the basics of dementia as a brain disorder, its accompanying behaviors, the procedures used to diagnose and stage the disease, and the legal aspects of providing care for an adult who is no longer competent. She also covers topics not usually included in other books on dementia: family dynamics, caregiver burnout, elder abuse, incontinence, finances and paying for care, the challenges same-sex families face, and coping with the eventuality of death and estate management. Each chapter begins with a real-life vignette taken from the author's personal experience and concludes with "Frequently Asked Questions" and "Worksheets" sections. The FAQs tackle specific issues and situations that often make caregiving such a challenge. The worksheets are a tool to help readers organize, evaluate, and self-reflect. A glossary of terms, an appendix, and references for further reading give readers a command of the vocabulary clinicians use and access to valuable resources.

Psychiatric Mental Health Nursing

Author : Mary C Townsend
Publisher : F.A. Davis
ISBN 13 : 0803669860
Total Pages : 1075 pages
Book Rating : 4.8/5 (36 download)

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Book Synopsis Psychiatric Mental Health Nursing by : Mary C Townsend

Download or read book Psychiatric Mental Health Nursing written by Mary C Townsend and published by F.A. Davis. This book was released on 2017-10-19 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clearly written, comprehensive coverage of psychiatric mental-health nursing delivers what nursing students need to meet the challenges of health care today. Its evidence-based, holistic approach to nursing practice focuses on both physiological and psychological disorders. Designed to be used in longer psychiatric mental-health nursing courses, this text provides students with a comprehensive grounding in therapeutic approaches as well as must-know DSM-5 disorders and nursing interventions.

Community Series In Mental-Health-Related Stigma and Discrimination: Prevention, Role, and Management Strategies, volume II

Author : Renato de Filippis
Publisher : Frontiers Media SA
ISBN 13 : 2832545718
Total Pages : 240 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Community Series In Mental-Health-Related Stigma and Discrimination: Prevention, Role, and Management Strategies, volume II by : Renato de Filippis

Download or read book Community Series In Mental-Health-Related Stigma and Discrimination: Prevention, Role, and Management Strategies, volume II written by Renato de Filippis and published by Frontiers Media SA. This book was released on 2024-03-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is the second volume of the "Community Series In Mental-Health-Related Stigma and Discrimination: Prevention, Role, and Management Strategies". Please see the first volume here. Despite the tremendous progress and successes achieved in diagnostics, therapy, and rehabilitation in psychiatry over the past few decades, the stigma towards mental health patients, their relatives and caregivers, and healthcare professionals is still present. Social stigma, in particular, represents a major obstacle to maintaining adequate mental health care. This increases reluctance to seek help delays patients' diagnosis and limits their compliance and adherence to treatment. In the long term, this reduces psychiatric rehabilitation effectiveness and causes a burden to healthcare providers and society alike. The main goal of this Research Topic is to evaluate the impact and role of stigma, in all its forms, on individuals with psychiatric disorders, their caregivers, and mental health providers.

Animal Experimentation: Working Towards a Paradigm Change

Author : Kathrin Herrmann
Publisher : BRILL
ISBN 13 : 9004391193
Total Pages : 749 pages
Book Rating : 4.0/5 (43 download)

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Book Synopsis Animal Experimentation: Working Towards a Paradigm Change by : Kathrin Herrmann

Download or read book Animal Experimentation: Working Towards a Paradigm Change written by Kathrin Herrmann and published by BRILL. This book was released on 2019-04-30 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Alzheimer's Disease

Author : Anne Brown Rodgers
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.:/5 (277 download)

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Book Synopsis Alzheimer's Disease by : Anne Brown Rodgers

Download or read book Alzheimer's Disease written by Anne Brown Rodgers and published by . This book was released on 2008 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Author : Agustín Ibáñez
Publisher : Frontiers Media SA
ISBN 13 : 2889454940
Total Pages : 217 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America by : Agustín Ibáñez

Download or read book Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America written by Agustín Ibáñez and published by Frontiers Media SA. This book was released on 2018-06-21 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Mediating Alzheimer's

Author : Scott Selberg
Publisher : U of Minnesota Press
ISBN 13 : 145296758X
Total Pages : 337 pages
Book Rating : 4.4/5 (529 download)

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Book Synopsis Mediating Alzheimer's by : Scott Selberg

Download or read book Mediating Alzheimer's written by Scott Selberg and published by U of Minnesota Press. This book was released on 2022-05-24 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of the representational culture of Alzheimer’s disease and how media technologies shape our ideas of cognition and aging With no known cause or cure despite a century of research, Alzheimer’s disease is a true medical mystery. In Mediating Alzheimer’s, Scott Selberg examines the nature of this enduring national health crisis by looking at the disease’s relationship to media and representation. He shows how collective investments in different kinds of media have historically shaped how we understand, treat, and live with this disease. Selberg demonstrates how the cognitive abilities that Alzheimer’s threatens—memory, for example—are integrated into the operations of representational technologies, from Polaroid photographs to Post-its to digital artificial intelligence. Focusing on a wide variety of media technologies, such as neuroimaging, art therapy, virtual reality, and social media, he shows how these cognitively oriented media ultimately help define personhood for people with Alzheimer’s. Media have changed the practices of successful aging in the United States, and Selberg takes us deep into how technologies like digital brain-training and online care networks shape ideas of cognition and healthy aging. Packed with startlingly fresh insights, Mediating Alzheimer’s contributes to debates around bioethics, the labor of caregiving, and a national economy increasingly invested in communication and digital media. Probing the very technologies that promise to save and understand our brains, it gives us new ways of understanding Alzheimer’s disease and aging in America.

Alzheimer's In America

Author : Maria Shriver
Publisher : Free Press
ISBN 13 : 9781451639872
Total Pages : 0 pages
Book Rating : 4.6/5 (398 download)

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Book Synopsis Alzheimer's In America by : Maria Shriver

Download or read book Alzheimer's In America written by Maria Shriver and published by Free Press. This book was released on 2011-04-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Shriver Report: A Woman’s Nation Takes on Alzheimer’s will be the first comprehensive multi-disciplinary look at these questions at this transformational moment. The Report will digest the current trends in thinking about Alzheimer’s, examine cutting-edge medical research, look at societal impacts, and include a groundbreaking and comprehensive national poll. It will feature original photography and personal essays by men and women – some from the public arena with names you know, some from everyday America – sharing their personal struggles with the disease as patients, caregivers and family members.

Alzheimer's Disease Drug Development

Author : Jeffrey Cummings
Publisher : Cambridge University Press
ISBN 13 : 1108985157
Total Pages : 575 pages
Book Rating : 4.1/5 (89 download)

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Book Synopsis Alzheimer's Disease Drug Development by : Jeffrey Cummings

Download or read book Alzheimer's Disease Drug Development written by Jeffrey Cummings and published by Cambridge University Press. This book was released on 2022-03-31 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's Disease (AD) is a growing global public health challenge. The development of new therapies is urgently needed, and a complex ecosystem of organizations has grown to facilitate AD drug discovery and development. Masterfully collating information on the drug development ecosystem, this book emphasizes the contributions of each aspect in the pipeline with a uniform approach to chapters, enabling readers to access relevant information quickly. Topics covered include the use of non-clinical laboratory studies, biomarker development, artificial intelligence, design and management of clinical trials, and funding and financing models. Also discussed is the critical role of advocacy fundraising for drug development. With the approval of aducanumab, the function of the ecosystem has become apparent. This is a definitive overview of how the ecosystem works in transferring an AD drug from its discovery in the laboratory through clinical trial testing to regulatory review and eventual marketing.

Current Status of Natural Products Targeting Alzheimer’s Disease

Author : Syed Shams ul Hassan
Publisher : Frontiers Media SA
ISBN 13 : 2832540074
Total Pages : 162 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Current Status of Natural Products Targeting Alzheimer’s Disease by : Syed Shams ul Hassan

Download or read book Current Status of Natural Products Targeting Alzheimer’s Disease written by Syed Shams ul Hassan and published by Frontiers Media SA. This book was released on 2023-12-08 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite more than fifty years of intensive research on Alzheimer’s disease (AD) drug discovery, up till now only four medicines are approved by FDA for its treatment; among which three are acetylcholinesterase (AChE) inhibitors (donepezil, galantamine, and rivastigmine) and one is N-Methyl-D-aspartate (NMDA) antagonist memantine. These medications were launched during the initial research for AD but were not able to provide satisfactory results because of their limited efficacy and numerous side effects. The high-profile failure of late-stage clinical trials by prominent pharma firms for biomolecules that showed promising results in experimental models has added to the dissatisfaction of drug development research for AD in recent years. The global dementia patient population was expected to be 50 million in 2017, with projections of 82 million and 152 million in 2030 and 2045, respectively. There is a significant flaw in our understanding of AD pathology, as well as in the experimental models we use to depict human pathology and our therapeutic methods. In light of this, this Research Topic is created to highlight the critical significance of natural products in therapeutic development for human diseases. The therapeutic potential of several natural products, including crude extracts and purified compounds, has been demonstrated in numerous experimental models, with pharmacological efficacy comparable to that of known medicines. This includes effects via specific biological targets (enzymes, receptors, ion channels, and so on) or a variety of mechanisms extending from basic antioxidants and anti-inflammatory mechanisms to neuroprotection and neuroregeneration pathways. Insights into AD therapy using natural products in the form of original research articles or reviews in all areas of AD pathology, experimental designs, and therapeutic approaches are encouraged. The main goal of this collection is to put light on the current status of natural products in AD. As natural products including many polyphenols or other agents are given in combination with marketed available AD drugs to increase their efficacy. So, all those research areas that cover the current status of natural products in single or in combination with other agents to improve the efficacy of AD/dementia will be focused on. • Natural products targeting AD (In-vitro, in-vivo, and in-silico); • Drug discovery for AD by targeting pathways; • Combination therapy to improve the efficacy of Anti-AD agents; • Polytherapy vs single chemical entity; • Experimental models of dementia; • Novel bioassays for cognitive disorders.

Bridging the Family Care Gap

Author : Joseph E. Gaugler
Publisher : Academic Press
ISBN 13 : 0128138998
Total Pages : 498 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Bridging the Family Care Gap by : Joseph E. Gaugler

Download or read book Bridging the Family Care Gap written by Joseph E. Gaugler and published by Academic Press. This book was released on 2021-01-09 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the Family Care Gap explores expected future shortages of family caregivers of older persons and identifies potential solutions. The book examines the sustainability and availability of care management models and whether they can be effectively scaled up to meet community needs. It identifies newly emerging policy initiatives at local, state, and federal levels. The book addresses the state of family caregiving science, dissemination and implementation of promising programs and supports, technological innovations, and other strategies to offset the family care gap. This edited volume also explores lay healthcare workers as guides, interpreters, and advocates in healthcare systems that provide continuity of contact for family caregivers. Details threats to family caregiving-sociodemographic, chronic disease, and socioeconomic challenges Presents solutions to the caregiving gap in a systematic, synthesized manner Addresses the intersection of family caregiving and technology Discusses chronic disease management to offset and reduce the need for family caregiving Describes models of caregiver support in work settings Reimagines the delivery of long-term services and supports with novel initiatives

Alzheimer's Disease Drug Development

Author : Jeffrey Cummings
Publisher : Cambridge University Press
ISBN 13 : 1108838669
Total Pages : 575 pages
Book Rating : 4.1/5 (88 download)

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Book Synopsis Alzheimer's Disease Drug Development by : Jeffrey Cummings

Download or read book Alzheimer's Disease Drug Development written by Jeffrey Cummings and published by Cambridge University Press. This book was released on 2022-03-31 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Neurological Disorders

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241563362
Total Pages : 233 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Neurological Disorders by : World Health Organization

Download or read book Neurological Disorders written by World Health Organization and published by World Health Organization. This book was released on 2006 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.

Cognitive Aging

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309368650
Total Pages : 330 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Cognitive Aging by : Institute of Medicine

Download or read book Cognitive Aging written by Institute of Medicine and published by National Academies Press. This book was released on 2015-07-21 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors.

Acetylcholinesterase: Old Questions and New Developments

Author : Karl Tsim
Publisher : Frontiers E-books
ISBN 13 : 2889190986
Total Pages : 120 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Acetylcholinesterase: Old Questions and New Developments by : Karl Tsim

Download or read book Acetylcholinesterase: Old Questions and New Developments written by Karl Tsim and published by Frontiers E-books. This book was released on with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acetylcholinesterase (AChE) is a primary regulator of cholinergic signaling within and out of the central nervous system. It has been studied extensively for several decades, yet many basic questions about its regulation, composition and functions remain open. Thus, neither the full impact of AChE’s activities on neuronal development, maintenance and functioning nor the reasons for why and how different AChE molecular forms are being synthesized and degraded are fully known yet, although recent evidence suggests the involvement of micro-RNA regulators in both of these aspects. The identification of the anchoring proteins, PRiMA and ColQ, stimulates studies on AChE’s assembly and its specific localization in the brain and muscle. Additionally, non-cholinergic function(s) of AChE has been proposed as relevant both for neuronal differentiation and cognitive functioning, whereas transgenic engineering, recombinant production and structure-function analyses of this enzyme’s variants with various inhibitors paved new avenues for the development of novel Alzheimer’s disease therapeutics, agricultural pesticides and prophylactics in anticipation of warfare agent exposure. The aims of this Research Topic is to provide a forum for experts in the field to critically discuss recent developments in AChE studies, initiate global critiques of the current views for resolving the fundamental questions in AChE research and promote the development of novel versions and uses of AChE-targeted agents. Topics of interest include but are not limited to: (i) post-transcriptional regulation of AChE; (ii) the non-cholinergic functions of AChE; and (iii) anti-AChE inhibitors and diseases.

Reducing the Impact of Dementia in America

Author : National Academies of Sciences Engineering and Medicine
Publisher :
ISBN 13 : 9780309495035
Total Pages : pages
Book Rating : 4.4/5 (95 download)

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Book Synopsis Reducing the Impact of Dementia in America by : National Academies of Sciences Engineering and Medicine

Download or read book Reducing the Impact of Dementia in America written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2022-04-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: As the largest generation in U.S. history - the population born in the two decades immediately following World War II - enters the age of risk for cognitive impairment, growing numbers of people will experience dementia (including Alzheimer's disease and related dementias). By one estimate, nearly 14 million people in the United States will be living with dementia by 2060. Like other hardships, the experience of living with dementia can bring unexpected moments of intimacy, growth, and compassion, but these diseases also affect people's capacity to work and carry out other activities and alter their relationships with loved ones, friends, and coworkers. Those who live with and care for individuals experiencing these diseases face challenges that include physical and emotional stress, difficult changes and losses in their relationships with life partners, loss of income, and interrupted connections to other activities and friends. From a societal perspective, these diseases place substantial demands on communities and on the institutions and government entities that support people living with dementia and their families, including the health care system, the providers of direct care, and others. Nevertheless, research in the social and behavioral sciences points to possibilities for preventing or slowing the development of dementia and for substantially reducing its social and economic impacts. At the request of the National Institute on Aging of the U.S. Department of Health and Human Services, Reducing the Impact of Dementia in America assesses the contributions of research in the social and behavioral sciences and identifies a research agenda for the coming decade. This report offers a blueprint for the next decade of behavioral and social science research to reduce the negative impact of dementia for America's diverse population. Reducing the Impact of Dementia in America calls for research that addresses the causes and solutions for disparities in both developing dementia and receiving adequate treatment and support. It calls for research that sets goals meaningful not just for scientists but for people living with dementia and those who support them as well. By 2030, an estimated 8.5 million Americans will have Alzheimer's disease and many more will have other forms of dementia. Through identifying priorities social and behavioral science research and recommending ways in which they can be pursued in a coordinated fashion, Reducing the Impact of Dementia in America will help produce research that improves the lives of all those affected by dementia.