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Frontotemporal Dementias

Author : Bernardino Ghetti
Publisher : Springer Nature
ISBN 13 : 3030511405
Total Pages : 320 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Frontotemporal Dementias by : Bernardino Ghetti

Download or read book Frontotemporal Dementias written by Bernardino Ghetti and published by Springer Nature. This book was released on 2021-01-12 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.

Progranulin and Central Nervous System Disorders

Author : Hideaki Hara
Publisher : Springer
ISBN 13 : 981136186X
Total Pages : 183 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Progranulin and Central Nervous System Disorders by : Hideaki Hara

Download or read book Progranulin and Central Nervous System Disorders written by Hideaki Hara and published by Springer. This book was released on 2019-03-25 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

Progranulin

Author : Andrew Bateman
Publisher : Humana Press
ISBN 13 : 9781493985579
Total Pages : 363 pages
Book Rating : 4.9/5 (855 download)

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Book Synopsis Progranulin by : Andrew Bateman

Download or read book Progranulin written by Andrew Bateman and published by Humana Press. This book was released on 2018-06-28 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biology; Part Three discusses the role of progranulin in cancer; and Part Four describes the process of using animal models to study progranulin in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Progranulin: Methods and Protocols is a valuable resource for experienced researchers who want to expand their studies of this field, and newcomers who want to begin including progranulin into their work.

Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches

Author : Claudia Duran-Aniotz
Publisher : Frontiers Media SA
ISBN 13 : 2889746070
Total Pages : 265 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches by : Claudia Duran-Aniotz

Download or read book Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches written by Claudia Duran-Aniotz and published by Frontiers Media SA. This book was released on 2022-10-05 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurobiology of Brain Disorders

Author : Michael J. Zigmond
Publisher : Academic Press
ISBN 13 : 0323898254
Total Pages : 1136 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Neurobiology of Brain Disorders by : Michael J. Zigmond

Download or read book Neurobiology of Brain Disorders written by Michael J. Zigmond and published by Academic Press. This book was released on 2022-05-20 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function. Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more. Links basic, translational and clinical research on disorders of the nervous system Covers a vast array of neurological and psychiatric disorders, including Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson's, Huntington's, Alzheimer's, OCD, PTSD, schizophrenia, depression and pain Features new chapters on the effects of aging and isolation on brain health Expands coverage on disorders, including new chapters on fibromyalgia, chronic fatigue, and restless legs syndrome Features in-text summary points, special feature boxes and research questions

Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias

Author : Michael J. Strong
Publisher : OUP Oxford
ISBN 13 : 0191637289
Total Pages : 426 pages
Book Rating : 4.1/5 (916 download)

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Book Synopsis Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias by : Michael J. Strong

Download or read book Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias written by Michael J. Strong and published by OUP Oxford. This book was released on 2012-10-11 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past ten years, there has been an increasing recognition that syndromes of frontotemporal dysfunction (FTD) are a common occurrence in patients with amyotrophic lateral sclerosis (ALS). Such syndromes may be present in as many as 60% of patients with ALS. Conversely, the occurrence of motor neuron dysfunction in patients with clinically pure frontotemporal dementia is increasingly recognized. This suggests that to some extent there are overlapping syndromes in which both ALS and FTD occur within the same individual. This volume summarizes the advances in our understanding of these two disorders, as well as the potential relationship between the two. Key topics include advances in our ability to clinically describe the frontotemporal syndromes, preclinical detection, neuroimaging, and genetics. The exploding field of new markers in neuropathology is examined, as is the role of new genetic mutations in DNA/RNA transport systems. This book is the essential reference text for this topic, and will be of interest to neurologists and neurological trainees with a clinical or research interest in the FTDs or ALS, neuropsychologists, neuropathologists, and researchers.

AACR 2017 Proceedings: Abstracts 1-3062

Author : American Association for Cancer Research
Publisher : CTI Meeting Technology
ISBN 13 :
Total Pages : 3186 pages
Book Rating : 4./5 ( download)

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Book Synopsis AACR 2017 Proceedings: Abstracts 1-3062 by : American Association for Cancer Research

Download or read book AACR 2017 Proceedings: Abstracts 1-3062 written by American Association for Cancer Research and published by CTI Meeting Technology. This book was released on 2017-03-13 with total page 3186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions outside their own areas of expertise, and learn how to apply exciting new concepts, tools, and techniques to their own research. Part A contains abstracts 1-3062 accepted for the 2017 meeting.

AACR 2016: Abstracts 1-2696

Author : American Association for Cancer Research (AACR)
Publisher : CTI Meeting Technology
ISBN 13 :
Total Pages : 1617 pages
Book Rating : 4./5 ( download)

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Book Synopsis AACR 2016: Abstracts 1-2696 by : American Association for Cancer Research (AACR)

Download or read book AACR 2016: Abstracts 1-2696 written by American Association for Cancer Research (AACR) and published by CTI Meeting Technology. This book was released on 2016-03-28 with total page 1617 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 1-2696 presented on April 17-18, 2016, at the AACR Annual Meeting.

Tumor Microenvironment

Author : Alexander Birbrair
Publisher : Springer Nature
ISBN 13 : 3030731197
Total Pages : 548 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Tumor Microenvironment by : Alexander Birbrair

Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2021-10-18 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Frontiers in Clinical Drug Research - Alzheimer Disorders

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1681080680
Total Pages : 305 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Frontiers in Clinical Drug Research - Alzheimer Disorders by : Atta-ur-Rahman

Download or read book Frontiers in Clinical Drug Research - Alzheimer Disorders written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2015-06-04 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research - Alzheimer Disorders is an e-Book series concerned with Alzheimer's disease (AD) that causes dementia, or loss of brain function. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on (Alzheimer Disorders) drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in field of Alzheimers Disease research. The third volume of this series features research on -perfusional modifications in prodromal Alzheimer's disease, -BACE inhibition treatment, -frontotemporal dementia caused by progranulin mutations -evidence-based treatment for psychological symptoms of Alzheimer’s Diseas.

The Encyclopedia of Alzheimer's Disease

Author : Carol Turkington
Publisher : Infobase Publishing
ISBN 13 : 1438128584
Total Pages : 321 pages
Book Rating : 4.4/5 (381 download)

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Book Synopsis The Encyclopedia of Alzheimer's Disease by : Carol Turkington

Download or read book The Encyclopedia of Alzheimer's Disease written by Carol Turkington and published by Infobase Publishing. This book was released on 2010 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: In more than 500 entries, The Encyclopedia of Alzheimer's Disease, Second Edition presents a wealth of information on the physical, emotional, and intellectual conditions that affect Alzheimer's sufferers. It also examines the current research on prevention, causes, and treatments, as well as the social issues surrounding the disease. Appendixes include major resources, organizations, helpful books and publications, an extensive bibliography, and a glossary.

Neurodegeneration

Author : Dennis Dickson
Publisher : John Wiley & Sons
ISBN 13 : 1444341235
Total Pages : 497 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Neurodegeneration by : Dennis Dickson

Download or read book Neurodegeneration written by Dennis Dickson and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

AACR 2022 Proceedings: Part A Online-Only and April 10

Author : American Association for Cancer Research
Publisher : CTI Meeting Technology
ISBN 13 : 1005372799
Total Pages : 2287 pages
Book Rating : 4.0/5 (53 download)

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Book Synopsis AACR 2022 Proceedings: Part A Online-Only and April 10 by : American Association for Cancer Research

Download or read book AACR 2022 Proceedings: Part A Online-Only and April 10 written by American Association for Cancer Research and published by CTI Meeting Technology. This book was released on 2022-05-09 with total page 2287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.

Deciphering the biomarkers of Alzheimer’s disease

Author : Yu Chen
Publisher : Frontiers Media SA
ISBN 13 : 2889743837
Total Pages : 241 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Deciphering the biomarkers of Alzheimer’s disease by : Yu Chen

Download or read book Deciphering the biomarkers of Alzheimer’s disease written by Yu Chen and published by Frontiers Media SA. This book was released on 2022-02-11 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Progranulin

Author : Andrew Bateman
Publisher : Humana
ISBN 13 : 9781493993253
Total Pages : 363 pages
Book Rating : 4.9/5 (932 download)

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Book Synopsis Progranulin by : Andrew Bateman

Download or read book Progranulin written by Andrew Bateman and published by Humana. This book was released on 2019-07-12 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biology; Part Three discusses the role of progranulin in cancer; and Part Four describes the process of using animal models to study progranulin in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Progranulin: Methods and Protocols is a valuable resource for experienced researchers who want to expand their studies of this field, and newcomers who want to begin including progranulin into their work.

The Behavioral Neurology of Dementia

Author : Bruce L. Miller
Publisher : Cambridge University Press
ISBN 13 : 1107077206
Total Pages : 491 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis The Behavioral Neurology of Dementia by : Bruce L. Miller

Download or read book The Behavioral Neurology of Dementia written by Bruce L. Miller and published by Cambridge University Press. This book was released on 2016-11-17 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Distils the most valuable discoveries in dementia research into clear, insightful chapters written by international experts.

Neurodegenerative Diseases

Author : Daniela Galimberti
Publisher : Springer
ISBN 13 : 3319729381
Total Pages : 412 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Neurodegenerative Diseases by : Daniela Galimberti

Download or read book Neurodegenerative Diseases written by Daniela Galimberti and published by Springer. This book was released on 2018-03-15 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.