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Prognostic And Predictive Factors In Primary Breast Cancer
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Book Synopsis Prognostic and Predictive Factors in Primary Breast Cancer by : Pierre Stefanus Gerardus Johannes Hupperets
Download or read book Prognostic and Predictive Factors in Primary Breast Cancer written by Pierre Stefanus Gerardus Johannes Hupperets and published by . This book was released on 1995 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prognostic variables in node-negative and node-positive breast cancer by : Giampietro Gasparini
Download or read book Prognostic variables in node-negative and node-positive breast cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prognostic and Predictive Factors in Breast Cancer by : Rosemary A. Walker
Download or read book Prognostic and Predictive Factors in Breast Cancer written by Rosemary A. Walker and published by CRC Press. This book was released on 2008-09-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title reviews the key prognostic factors in breast cancer, discussing the methodologies involved in measuring and reporting. It also examines the roles of major predictive markers such as the steroid receptors, p53 and HER-2. Given the wealth of information in the medical literature on breast cancer, this volume is useful in that it focuses strictly on these factors. That focus makes this text extremely useful for oncologists and researchers who want to learn more about best practices in prognoses.
Book Synopsis Prognostic and Predictive Factors in Breast Cancer, Second Edition by : Rosemary A. Walker
Download or read book Prognostic and Predictive Factors in Breast Cancer, Second Edition written by Rosemary A. Walker and published by CRC Press. This book was released on 2003-06-12 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title reviews the key prognostic factors in breast cancer, discussing the methodologies involved in measuring and reporting. It also examines the roles of major predictive markers such as the steroid receptors, p53 and HER-2. Given the wealth of information in the medical literature on breast cancer, this volume is useful in that it focuses strictly on these factors. That focus makes this text extremely useful for oncologists and researchers who want to learn more about best practices in prognoses.
Book Synopsis Prognostic and Predictive Factors in Primary High-risk Post-menopausal Breast Cancer by : Ann Knoop
Download or read book Prognostic and Predictive Factors in Primary High-risk Post-menopausal Breast Cancer written by Ann Knoop and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomarkers in Breast Cancer by : Giampietro Gasparini
Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
Book Synopsis Diagnostic, Prognostic and Predictive Factors of Response in the Era of Precision Oncology in Breast Cancer by : Francesco Schettini
Download or read book Diagnostic, Prognostic and Predictive Factors of Response in the Era of Precision Oncology in Breast Cancer written by Francesco Schettini and published by Frontiers Media SA. This book was released on 2023-12-12 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last couple of decades, the study of the cancer genome and the progressive implementation of next-generation sequencing platforms have provided the Scientific and Oncology communities with a multitude of data, technologies, diagnostic, prognostic, and predictive tools that have been revolutionizing the way we can study, diagnose and treat cancer, including breast tumors. For example, genomic tests can now refine the prognosis of early-stage breast cancer patients beyond standard clinicopathological features and help guide escalated or de-escalated treatment choices. The identification of the molecular intrinsic subtypes might also be helpful in guiding treatment choices in advanced hormone receptor-positive disease. The identification of germline mutations in BRCA1 or BRCA2 has led to the development and introduction of PARP inhibitors for the treatment of advanced and early-stage breast cancer, along with personalized follow-up and prophylactic surgical procedures for patients with or without cancer, carrying such mutations.
Book Synopsis Prognostic Factors in Cancer by : Paul Hermanek
Download or read book Prognostic Factors in Cancer written by Paul Hermanek and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. K. Gospodarowicz, P. Hermanek, and D. E. Henson Attention to innovations in cancer treatment has tended to eclipse the importance of prognostic assessment. However, the recognition that prognostic factors often have a greater impact on outcome than available therapies and the proliferation of biochemical, molecular, and genetic markers have resulted in renewed interest in this field. The outcome in patients with cancer is determined by a combination of numerous factors. Presently, the most widely recognized are the extent of disease, histologic type of tumor, and treatment. It has been known for some time that additional factors also influence outcome. These include histologic grade, lymphatic or vascular invasion, mitotic index, performance status, symptoms, and most recently genetic and biochemical markers. It is the aim of this volume to compile those prognostic factors that have emerged as important determinants of outcome for tumors at various sites. This compilation represents the first phase of a more extensive process to integrate all prognostic factors in cancer to further enhance the prediction of outcome following treatment. Certain issues surround ing the assessment and reporting of prognostic factors are also considered. Importance of Prognostic Factors Prognostic factors in cancer often have an immense influence on outcome, while treatment often has a much weaker effect. For example, the influence of the presence of lymph node involvement on survival of patients with metastatic breast cancer is much greater than the effect of adjuvant treatment with tamoxifen in the same group of patients [5].
Book Synopsis Prognostic Factors in Primary Breast Cancer by : R. L. H. Jansen
Download or read book Prognostic Factors in Primary Breast Cancer written by R. L. H. Jansen and published by . This book was released on 1998 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis On Prognostic and Treatment Predictive Factors in Early Stage Breast Cancer by : Ann-Marie Billgren
Download or read book On Prognostic and Treatment Predictive Factors in Early Stage Breast Cancer written by Ann-Marie Billgren and published by . This book was released on 2002 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prognostic Factors in Cancer by : Mary K. Gospodarowicz
Download or read book Prognostic Factors in Cancer written by Mary K. Gospodarowicz and published by Wiley-Liss. This book was released on 2001-04-16 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prognostic Factors in Cancer, Second Edition updates the first authoritative monograph on prognostic factors and their use in planning treatment for cancer patients. The text is an extension of the work of the International Union Against Cancer (UICC) on the TNM Classification of Malignant Tumours and their current focus on prognostic factors in cancer. The TNM classification is the most widely used system for staging the progression of cancer. The anatomic extent of disease represented by the TNM system is the single most important predictor for outcomes of most tumors. Prognostic Factors in Cancer, Second Edition is divided into two parts. The first section examines prognosis in general and more specifically prognosis in cancer patients, including issues surrounding accuracy of measurement of prognosis, the methodology of studying and classifying prognostic factors, and the application of prognostic factors in clinical decision-making in the treatment of cancer. The second section provides chapters on site-specific or tumor-specific neoplasms and the prognostic factors associated with them. These chapters contain an overview of the relevant literature and include summaries that classify prognostic factors according to subject and relevance. Prognostic Factors in Cancer, Second Edition illustrates the scope of the field as it stands today, and will provide perspective on likely outcomes of neoplastic disease for all physicians and others responsible for the care of patients with cancer.
Book Synopsis Long-term Prognostic and Predictive Factors in Hormone Receptor Positive Breast Cancer by : Helena Fohlin
Download or read book Long-term Prognostic and Predictive Factors in Hormone Receptor Positive Breast Cancer written by Helena Fohlin and published by . This book was released on 2018 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: The breast cancer survival in Sweden is good (almost 90 % 5-year relative survival) and has increased over time. For women with hormone receptor negative tumors, most relapses occur within the first 5 years after diagnosis. Thereafter the recurrence risk decreases rapidly. For women with estrogen receptor positive (ER+) tumors the annual risk for late recurrences is 1 – 2 %, even after 5 years of endocrine therapy. This risk accumulates so that approximately 25 % of the patients that are recurrence-free after five years from diagnosis may experience a relapse within further 15 years of follow-up. The relatively high long-term risk calls for identification of prognostic and predictive markers with long-term effect. Though, the number of such markers with proven significance is limited. Of the clinical characteristics, only nodal status and to some extent tumor size and tumor grade have been shown to have long-term prognostic value. In this thesis, we propose long-term prognostic and predictive markers for breast cancer. In paper I , we suggest the protein v-akt murine thymoma viral oncogene homologue 2 (AKT2) as a long-term prognostic marker among patients with ER+ tumors. In our study, besides nodal status, AKT2 was the only factor with long-term prognostic value. This is in accordance with some other studies, though we also showed that the significance of AKT2 was limited to ER+ tumors and that the impact increased with higher ER expression. Approximately 75 – 85 % of the ER+ tumors are also progesterone receptor positive (PR+). ER+/progesterone receptor negative (PR-) tumors are considered to be more aggressive and patients with such tumors are often treated with chemotherapy. In this group, more specific subgroups for targeted therapy are needed. Whereas ER has long been established as a predictive factor regarding tamoxifen benefit, the role of PR has not been clarified to date. In paper II , we showed that PR status adds predictive value to ER considering the long-term benefit from tamoxifen. In paper III , we aimed to identify new prognostic markers among patients with ER+ tumors. Systemically untreated patients with ER+/PR- tumors and high expression of the Ras-related protein RAB6C (RAB6C) had reduced distant recurrence rate. Therefore, we suggest RAB6C as a candidate marker for subgroup division among patients with ER+/PR- tumors. According to the results from paper II, there might be subgroups of patients with ER+/PRtumors that do benefit from tamoxifen. The aim of paper IV was to identify such subgroups. Here, we suggest that patients with ER+/PR- tumors and low RAB6C expression do benefit from tamoxifen. The results from this thesis may encourage further studies for more specific subgroup divisions. Such studies may lead to changes in the management program, where some patients with ER+ tumors should receive prolonged or more intense treatment and others reduced treatment based on the pathological markers AKT2, PR and RAB6C.
Book Synopsis Local and Systemic Management of Primary Breast Cancers by : Masakazu Toi
Download or read book Local and Systemic Management of Primary Breast Cancers written by Masakazu Toi and published by Trans Pacific Press. This book was released on 2010 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preoperative therapy is used increasingly in the treatment of patients with Stages II and III breast cancer. Randomized trials have demonstrated the equivalence of preoperative therapy to standard adjuvant therapy with respect to disease-free and overall survival, with a higher proportion of women undergoing conservative surgery instead of a mastectomy. There are multiple questions about the optimal integration of preoperative system therapy into breast cancer management. This comprehensive handbook on preoperative therapy provides guidance to the clinician for patient management, and it outlines important areas of controversy that require further research.
Book Synopsis Practical Atlas of Breast Pathology by : Simona Stolnicu
Download or read book Practical Atlas of Breast Pathology written by Simona Stolnicu and published by Springer. This book was released on 2018-08-12 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the basic concepts for understanding and practicing breast pathology in routine practice. It explains how to tackle the diagnosis, emphasizing diagnostic clues for each entity as well as pitfalls and mimickers. Each chapter has concise, relevant text illustrated by numerous high-quality pictures highlighting the pearls and challenges in the diagnosis of breast lesions. Experts from around the world describe common and rarer conditions affecting the breast. Histology, immunohistochemistry, cytology, radiology and key morphologic criteria are covered. The book includes a chapter dedicated to breast normal histology, which is very important for understanding breast pathology, and a separate chapter for breast radiology, which is essential in understanding and diagnosing the breast lesions especially in a multidisciplinary team. Also, there is a chapter with the latest TNM staging system as well as the recently revised World Health Organization classification of breast tumors. Since in many breast units the cytology is still used to diagnose breast lesions there is a chapter dedicated to this technique. This book is aimed at trainees and practicing pathologists in surgical pathology, particularly those with an interest in breast pathology and those tackling the daily sign-out.
Book Synopsis Prognosis and Predictive Factors in Human Breast Cancer During Tumor Progression by :
Download or read book Prognosis and Predictive Factors in Human Breast Cancer During Tumor Progression written by and published by . This book was released on 2014 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cancer Among Blacks and Other Minorities by : National Cancer Institute (U.S.)
Download or read book Cancer Among Blacks and Other Minorities written by National Cancer Institute (U.S.) and published by . This book was released on 1986 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prognosis Research in Healthcare by : Richard D. Riley
Download or read book Prognosis Research in Healthcare written by Richard D. Riley and published by Oxford University Press. This book was released on 2019-01-17 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: "What is going to happen to me?" Most patients ask this question during a clinical encounter with a health professional. As well as learning what problem they have (diagnosis) and what needs to be done about it (treatment), patients want to know about their future health and wellbeing (prognosis). Prognosis research can provide answers to this question and satisfy the need for individuals to understand the possible outcomes of their condition, with and without treatment. Central to modern medical practise, the topic of prognosis is the basis of decision making in healthcare and policy development. It translates basic and clinical science into practical care for patients and populations. Prognosis Research in Healthcare: Concepts, Methods and Impact provides a comprehensive overview of the field of prognosis and prognosis research and gives a global perspective on how prognosis research and prognostic information can improve the outcomes of healthcare. It details how to design, carry out, analyse and report prognosis studies, and how prognostic information can be the basis for tailored, personalised healthcare. In particular, the book discusses how information about the characteristics of people, their health, and environment can be used to predict an individual's future health. Prognosis Research in Healthcare: Concepts, Methods and Impact, addresses all types of prognosis research and provides a practical step-by-step guide to undertaking and interpreting prognosis research studies, ideal for medical students, health researchers, healthcare professionals and methodologists, as well as for guideline and policy makers in healthcare wishing to learn more about the field of prognosis.
