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Author : Danyu Lin
Publisher :
ISBN 13 : 9781441990778
Total Pages : 340 pages
Book Rating : 4.9/5 (97 download)
Download or read book Proceedings of the Second Seattle Symposium in Biostatistics written by Danyu Lin and published by . This book was released on 2005-01-20 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Danyu Lin
Publisher : Springer Science & Business Media
ISBN 13 : 1441990763
Total Pages : 332 pages
Book Rating : 4.4/5 (419 download)
Download or read book Proceedings of the Second Seattle Symposium in Biostatistics written by Danyu Lin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a selection of papers presented at the Second Seattle Symposium in Biostatistics: Analysis of Correlated Data. The symposium was held in 2000 to celebrate the 30th anniversary of the University of Washington School of Public Health and Community Medicine. It featured keynote lectures by Norman Breslow, David Cox and Ross Prentice and 16 invited presentations by other prominent researchers. The papers contained in this volume encompass recent methodological advances in several important areas, such as longitudinal data, multivariate failure time data and genetic data, as well as innovative applications of the existing theory and methods. This volume is a valuable reference for researchers and practitioners in the field of correlated data analysis.
Author : Danyu Lin
Publisher : Springer Science & Business Media
ISBN 13 : 1468463160
Total Pages : 314 pages
Book Rating : 4.4/5 (684 download)
Download or read book Proceedings of the First Seattle Symposium in Biostatistics: Survival Analysis written by Danyu Lin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this volume discuss important methodological advances in several important areas, including multivariate failure time data and interval censored data. The book will be an indispensable reference for researchers and practitioners in biostatistics, medical research, and the health sciences.
Author : Thomas R. Fleming
Publisher : Springer Science & Business Media
ISBN 13 : 1461452457
Total Pages : 245 pages
Book Rating : 4.4/5 (614 download)
Download or read book Proceedings of the Fourth Seattle Symposium in Biostatistics: Clinical Trials written by Thomas R. Fleming and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a selection of chapters base on papers presented at the Fourth Seattle Symposium in Biostatistics: Clinical Trials. The symposium was held in 2010 to celebrate the 40th anniversary of the University of Washington School of Public Health and Community Medicine. It featured keynote lectures by David DeMets and Susan Ellenberg and 16 invited presentations by other prominent researchers. The papers contained in this volume encompass recent methodological advances in several important clinical trials research, such as biomarkers, meta-analyses, sequential and adaptive clinical trials, and various genetic bioinformatic techniques. This volume will be a valuable reference for researchers and practitioners in the field of clinical trials.
Author : Karl E. Peace
Publisher : Springer
ISBN 13 : 9811078203
Total Pages : 426 pages
Book Rating : 4.8/5 (11 download)
Download or read book Biopharmaceutical Applied Statistics Symposium written by Karl E. Peace and published by Springer. This book was released on 2018-09-03 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials. The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter. The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications. This book is the third of the 3-volume book series. The topics covered include: Targeted Learning of Optimal Individualized Treatment Rules under Cost Constraints, Uses of Mixture Normal Distribution in Genomics and Otherwise, Personalized Medicine – Design Considerations, Adaptive Biomarker Subpopulation and Tumor Type Selection in Phase III Oncology Trials, High Dimensional Data in Genomics; Synergy or Additivity - The Importance of Defining the Primary Endpoint, Full Bayesian Adaptive Dose Finding Using Toxicity Probability Interval (TPI), Alpha-recycling for the Analyses of Primary and Secondary Endpoints of Clinical Trials, Expanded Interpretations of Results of Carcinogenicity Studies of Pharmaceuticals, Randomized Clinical Trials for Orphan Drug Development, Mediation Modeling in Randomized Trials with Non-normal Outcome Variables, Statistical Considerations in Using Images in Clinical Trials, Interesting Applications over 30 Years of Consulting, Uncovering Fraud, Misconduct and Other Data Quality Issues in Clinical Trials, Development and Evaluation of High Dimensional Prognostic Models, and Design and Analysis of Biosimilar Studies.
Author : Carlo Berzuini
Publisher : John Wiley & Sons
ISBN 13 : 1119941733
Total Pages : 387 pages
Book Rating : 4.1/5 (199 download)
Download or read book Causality written by Carlo Berzuini and published by John Wiley & Sons. This book was released on 2012-06-04 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state of the art volume on statistical causality Causality: Statistical Perspectives and Applications presents a wide-ranging collection of seminal contributions by renowned experts in the field, providing a thorough treatment of all aspects of statistical causality. It covers the various formalisms in current use, methods for applying them to specific problems, and the special requirements of a range of examples from medicine, biology and economics to political science. This book: Provides a clear account and comparison of formal languages, concepts and models for statistical causality. Addresses examples from medicine, biology, economics and political science to aid the reader's understanding. Is authored by leading experts in their field. Is written in an accessible style. Postgraduates, professional statisticians and researchers in academia and industry will benefit from this book.
Author : Garrett Fitzmaurice
Publisher : CRC Press
ISBN 13 : 142001157X
Total Pages : 633 pages
Book Rating : 4.4/5 (2 download)
Download or read book Longitudinal Data Analysis written by Garrett Fitzmaurice and published by CRC Press. This book was released on 2008-08-11 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many books currently available describe statistical models and methods for analyzing longitudinal data, they do not highlight connections between various research threads in the statistical literature. Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory
Author : Christian Esposito
Publisher : Springer Nature
ISBN 13 : 3030301435
Total Pages : 398 pages
Book Rating : 4.0/5 (33 download)
Download or read book Pervasive Systems, Algorithms and Networks written by Christian Esposito and published by Springer Nature. This book was released on 2019-11-26 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 16th International Symposium on Pervasive Systems, Algorithms and Networks, I-SPAN 2019, held in Naples, Italy, in September 2019. The 32 full papers and 8 short papers were carefully reviewed and selected from 89 submissions. The papers focus on all aspects of: big data analytics & machine learning; cyber security; cloud fog & edge computing; communication solutions; high performance computing and applications; consumer cyber security; and vehicular technology.
Author : Constantine Gatsonis
Publisher : CRC Press
ISBN 13 : 1351659456
Total Pages : 547 pages
Book Rating : 4.3/5 (516 download)
Download or read book Methods in Comparative Effectiveness Research written by Constantine Gatsonis and published by CRC Press. This book was released on 2017-02-24 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comparative effectiveness research (CER) is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care (IOM 2009). CER is conducted to develop evidence that will aid patients, clinicians, purchasers, and health policy makers in making informed decisions at both the individual and population levels. CER encompasses a very broad range of types of studies—experimental, observational, prospective, retrospective, and research synthesis. This volume covers the main areas of quantitative methodology for the design and analysis of CER studies. The volume has four major sections—causal inference; clinical trials; research synthesis; and specialized topics. The audience includes CER methodologists, quantitative-trained researchers interested in CER, and graduate students in statistics, epidemiology, and health services and outcomes research. The book assumes a masters-level course in regression analysis and familiarity with clinical research.
Author : Yichuan Zhao
Publisher : Springer Nature
ISBN 13 : 3031506901
Total Pages : 545 pages
Book Rating : 4.0/5 (315 download)
Download or read book Statistics in Precision Health written by Yichuan Zhao and published by Springer Nature. This book was released on with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stuart A. Karabenick
Publisher : IAP
ISBN 13 : 1623963362
Total Pages : 291 pages
Book Rating : 4.6/5 (239 download)
Download or read book Advances in Help-Seeking Research and Applications written by Stuart A. Karabenick and published by IAP. This book was released on 2013-06-01 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on help seeking has primarily focused on classrooms interactions that consist primarily of students asking teachers and peers for help. The rapid emergence of information and communications technologies and interactive learning environments, however, requires expanding the help-seeking landscape and rethinking such critical theoretical issues as the distinction between help seeking and information search, and whether help seeking is inevitably a social self-regulated learning strategy. There is also the need to focus attention on help seeking in the broader learning enterprise, which includes its role in the collaboration process, how to support adaptive rather than the over- or under-reliance on help seeking, as well as to scaffold help-seeking skills that render the process more efficient and useful. To examine these and other issues, the present volume assembled contributions from internationally recognized scholars and researchers to capture the state of the art and to anticipate future developments in this expanding field. Its relevance extends to anyone attempting to understand the role of technology in education, including educational researchers and teachers who do now or who expect to use technology to support instruction, and the rapidly expanding numbers of those developing new technological applications.
Author : Susan Halabi
Publisher : CRC Press
ISBN 13 : 1351620967
Total Pages : 701 pages
Book Rating : 4.3/5 (516 download)
Download or read book Textbook of Clinical Trials in Oncology written by Susan Halabi and published by CRC Press. This book was released on 2019-04-24 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others
Author : Bibhas Chakraborty
Publisher : Springer Science & Business Media
ISBN 13 : 1461474280
Total Pages : 220 pages
Book Rating : 4.4/5 (614 download)
Download or read book Statistical Methods for Dynamic Treatment Regimes written by Bibhas Chakraborty and published by Springer Science & Business Media. This book was released on 2013-07-23 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Methods for Dynamic Treatment Regimes shares state of the art of statistical methods developed to address questions of estimation and inference for dynamic treatment regimes, a branch of personalized medicine. This volume demonstrates these methods with their conceptual underpinnings and illustration through analysis of real and simulated data. These methods are immediately applicable to the practice of personalized medicine, which is a medical paradigm that emphasizes the systematic use of individual patient information to optimize patient health care. This is the first single source to provide an overview of methodology and results gathered from journals, proceedings, and technical reports with the goal of orienting researchers to the field. The first chapter establishes context for the statistical reader in the landscape of personalized medicine. Readers need only have familiarity with elementary calculus, linear algebra, and basic large-sample theory to use this text. Throughout the text, authors direct readers to available code or packages in different statistical languages to facilitate implementation. In cases where code does not already exist, the authors provide analytic approaches in sufficient detail that any researcher with knowledge of statistical programming could implement the methods from scratch. This will be an important volume for a wide range of researchers, including statisticians, epidemiologists, medical researchers, and machine learning researchers interested in medical applications. Advanced graduate students in statistics and biostatistics will also find material in Statistical Methods for Dynamic Treatment Regimes to be a critical part of their studies.
Author : Wan Tang
Publisher : Springer Science & Business Media
ISBN 13 : 1461443229
Total Pages : 256 pages
Book Rating : 4.4/5 (614 download)
Download or read book Modern Clinical Trial Analysis written by Wan Tang and published by Springer Science & Business Media. This book was released on 2012-09-05 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. The intent of the book is to provide an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out analyses. While classic topics such as survival data analysis, analysis of diagnostic test data and assessment of measurement reliability are well known and covered in depth by available topic-specific texts, this volume serves a different purpose: it provides a quick introduction to each topic for self-learning, particularly for those who have not done any formal coursework on a given topic but must learn it due to its relevance to their multidisciplinary research. In addition, the chapters on these classic topics will reflect issues particularly relevant to modern clinical trials such as longitudinal designs and new methods for analyzing data from such study designs. The coverage of these topics provides a quick introduction to these important statistical issues and methods for addressing them. As with the classic topics, this part of the volume on modern topics will enable researchers to grasp the statistical methods for addressing these emerging issues underlying modern clinical trials and to apply them to their research studies.
Author : Weili He
Publisher : Springer Nature
ISBN 13 : 3031263286
Total Pages : 431 pages
Book Rating : 4.0/5 (312 download)
Download or read book Real-World Evidence in Medical Product Development written by Weili He and published by Springer Nature. This book was released on 2023-05-11 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides state-of-art statistical methodologies, practical considerations from regulators and sponsors, logistics, and real use cases for practitioners for the uptake of RWE/D. Randomized clinical trials have been the gold standard for the evaluation of efficacy and safety of medical products. However, the cost, duration, practicality, and limited generalizability have incentivized many to look for alternative ways to optimize drug development. This book provides a comprehensive list of topics together to include all aspects with the uptake of RWE/D, including, but not limited to, applications in regulatory and non-regulatory settings, causal inference methodologies, organization and infrastructure considerations, logistic challenges, and practical use cases.
Author : Michael R. Kosorok
Publisher : SIAM
ISBN 13 : 1611974178
Total Pages : 354 pages
Book Rating : 4.6/5 (119 download)
Download or read book Adaptive TreatmentStrategies in Practice: Planning Trials and Analyzing Data for Personalized Medicine written by Michael R. Kosorok and published by SIAM. This book was released on 2015-12-08 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized medicine is a medical paradigm that emphasizes systematic use of individual patient information to optimize that patient's health care, particularly in managing chronic conditions and treating cancer. In the statistical literature, sequential decision making is known as an adaptive treatment strategy (ATS) or a dynamic treatment regime (DTR). The field of DTRs emerges at the interface of statistics, machine learning, and biomedical science to provide a data-driven framework for precision medicine.? The authors provide a learning-by-seeing approach to the development of ATSs, aimed at a broad audience of health researchers. All estimation procedures used are described in sufficient heuristic and technical detail so that less quantitative readers can understand the broad principles underlying the approaches. At the same time, more quantitative readers can implement these practices. This book provides the most up-to-date summary of the current state of the statistical research in personalized medicine; contains chapters by leaders in the area from both the statistics and computer sciences fields; and also contains a range of practical advice, introductory and expository materials, and case studies.?
Author : John E. Kolassa
Publisher : Springer Science & Business Media
ISBN 13 : 0387322272
Total Pages : 228 pages
Book Rating : 4.3/5 (873 download)
Download or read book Series Approximation Methods in Statistics written by John E. Kolassa and published by Springer Science & Business Media. This book was released on 2006-09-23 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised book presents theoretical results relevant to Edgeworth and saddlepoint expansions to densities and distribution functions. It provides examples of their application in some simple and a few complicated settings, along with numerical, as well as asymptotic, assessments of their accuracy. Variants on these expansions, including much of modern likelihood theory, are discussed and applications to lattice distributions are extensively treated.
