Probing The Molecular Mechanisms Underlying Familial Amyotrophic Lateral Sclerosis

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Machiavelli and Empire

Author : Mikael Hörnqvist
Publisher : Cambridge University Press
ISBN 13 : 1139456342
Total Pages : 323 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Machiavelli and Empire by : Mikael Hörnqvist

Download or read book Machiavelli and Empire written by Mikael Hörnqvist and published by Cambridge University Press. This book was released on 2004-11-25 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mikael Hörnqvist challenges us to rethink the overall meaning and importance of Machiavelli's political thinking. Machiavelli and Empire combines close textual analysis of The Prince and The Discourses with a broad historical approach, to establish the importance of empire-building and imperial strategy in Machiavelli's thought. The primary context of Machiavelli's work, Hörnqvist argues, is not the mirror-for-princes genre or medieval and Renaissance republicanism in general, but a tradition of Florentine imperialist republicanism dating back to the late thirteenth-century, based on the twin notions of liberty at home and empire abroad. Weaving together themes and topics drawn from contemporary Florentine political debate, Medicean ritual and Renaissance triumphalism, this study explores how Machiavelli in his chancery writings and theoretical works promoted the long standing aspirations of Florence to become a great and expanding empire, modelled on the example of the ancient Roman republic. This is a distinctive and important work.

Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia

Author : Henry Houlden
Publisher : Frontiers Media SA
ISBN 13 : 2889669041
Total Pages : 141 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia by : Henry Houlden

Download or read book Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia written by Henry Houlden and published by Frontiers Media SA. This book was released on 2021-06-28 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Biology of Alzheimer Disease

Author : Dennis J. Selkoe
Publisher : Cold Spring Harbor Perspective
ISBN 13 : 9781936113446
Total Pages : 0 pages
Book Rating : 4.1/5 (134 download)

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Book Synopsis The Biology of Alzheimer Disease by : Dennis J. Selkoe

Download or read book The Biology of Alzheimer Disease written by Dennis J. Selkoe and published by Cold Spring Harbor Perspective. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progressesincluding the accumulation of amyloid plaques and neurofibrillary tanglesis critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid -protein precursor (APP), tau, presenilin, -secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.

Probing Intracellular Regulation

Author : Christian Neri
Publisher : Bentham Science Publishers
ISBN 13 : 1608057569
Total Pages : 342 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Probing Intracellular Regulation by : Christian Neri

Download or read book Probing Intracellular Regulation written by Christian Neri and published by Bentham Science Publishers. This book was released on 2013-11-04 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome science or genomics is essential to advancing knowledge in the fields of biology and medicine. Specifically, researchers learn about the molecular biology behind genetic expression in living organisms and related methods of treating human genetic diseases (including gene therapy). Advances in Genome Science is an e-book series which provides a multi-disciplinary view of some of the latest developments in genome research, allowing readers to capture the essentiality and diversity of genomics in contemporary science. The second volume of this ebook series contains a selection of articles on intracellular gene regulation and expression in human disease such as arthritis, Alzheimer’s disease, Nijmegen Breakage Syndrome, Tumors and Malaria among other diseases. The volume also features some chapters on plant genetics

Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464974276
Total Pages : 65 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2012 Edition by :

Download or read book Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative Diseases: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Neurodegenerative Diseases in a concise format. The editors have built Neurodegenerative Diseases: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neurodegenerative Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neurodegenerative Diseases: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Assessing Genetic Risks

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309047986
Total Pages : 353 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Assessing Genetic Risks by : Institute of Medicine

Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis

Author : Koji Abe
Publisher : Elsevier
ISBN 13 :
Total Pages : 404 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis by : Koji Abe

Download or read book Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis written by Koji Abe and published by Elsevier. This book was released on 2001 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the latest findings on the molecular mechanism and therapeutics of amyotrophic lateral sclerosis (ALS), including important research on 1) pathological characteristics and epidemiology of ALS, 2) selective vulnerability of spinal motor neurons, 3) genetic abnormality of ALS and neurotrophin, 4) mechanism of motor neuron death and glutamate toxicity, 5) motor axon, axonal transport, neurofilament, and glycation, 6) basic therapeutic approach, and 7) clinical therapeutic approach. The surprising discovery of Cu/Zn superoxide dismutase (SOD1) gene mutations in a part of familial ALS in 1993 has had a strong impact on all neuroscientists and clinicians dealing with this disease. This volume aims to help them to progress their future basic and clinical investigations, and to enhance strong scientific collaboration in elucidating the molecular mechanism and discovering the essential therapeutics of the disease.

Neurobiology of Disease

Author : Michael V Johnston
Publisher : Oxford University Press
ISBN 13 : 0190219084
Total Pages : 1435 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Neurobiology of Disease by : Michael V Johnston

Download or read book Neurobiology of Disease written by Michael V Johnston and published by Oxford University Press. This book was released on 2016-08-18 with total page 1435 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Neurobiology of Disease includes nearly 200 articles surveying all major disorders of the nervous system in both adults and children, focusing on relevant diagnosis and treatments from the perspective of cutting edge clinical and basic neurobiological research. Akin to an encyclopedia of every neurologic disorder, this comprehensive work is ideal for graduate and medical school students, residents, and candidates preparing for their board certification examinations. Each chapter is illustrated with detailed figures, supplemented with descriptive and diagnostic tables, and thoroughly referenced for further investigations. The book's editors, Michael V. Johnston, Harold P. Adams Jr., and Ali Fatemi bring their unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this new edition, the following Section Editors provided oversight of their respective sections: · Movement Disorders-Joel Perlmutter, Washington University · Dementias-David Knopman, Mayo Clinic · Motorneuron Diseases-Merit Cudkowicz, Massachusetts General Hospital · Paroxysmal Disorders-Solomon Moshe, Albert Einstein College of Medicine · Pediatric Neurology and Developmental Disorders-Tanjala Gipson and Deepa Menon, Kennedy Krieger Institute and Johns Hopkins University · Neuroimmunological Diseases-Carlos Pardo-Villamizar, Johns Hopkins University · Cerebrovascular Diseases-Harold P. Adams Jr., University of Iowa · Peripheral and Autonomic Nervous System Disorders and Pain-Nicholas Maragakis, Johns Hopkins University · Neoplastic and Paraneoplastic Diseases-Lisa DeAngelis, Memorial Sloan-Kettering Cancer Center · Infectious Diseases of the Nervous System-Karen L. Roos, Indiana University · Sleep Disturbances-Mark Dyken, University of Iowa · Substance Abuse and Toxicology Disorders-Barry E. Kosofsky, Weill-Cornell University Medical Center · Neurologic Manifestations of Medical Disorders-John C. Probasco, Johns Hopkins University

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 107 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Molecular Diagnostics in the Detection of Neurodegenerative Disorders

Author : Megha Agrawal
Publisher : Frontiers Media SA
ISBN 13 : 2889451941
Total Pages : 92 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Molecular Diagnostics in the Detection of Neurodegenerative Disorders by : Megha Agrawal

Download or read book Molecular Diagnostics in the Detection of Neurodegenerative Disorders written by Megha Agrawal and published by Frontiers Media SA. This book was released on 2017-07-04 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegeneration is characterized by the progressive loss of neural tissue that result in various neurodegeneration-initiated cerebral failures and complex diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. All these medical conditions are accompanied by the disruption of blood-brain barrier (BBB). The BBB is an interface, separating the brain from the circulatory system and protecting the central nervous system from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. Owing to the inability of the neurons to regenerate on their own after neurodegeneration or severe damage to the neural tissue, neurodegenerative disorders do not have natural cures on their own. Neuroregeneration is a viable way to curb neurodegeneration. One of the current approaches is stem cell-based therapy that has been shown to be potentially helpful for the application of neuronal cell replacement for neuroregeneration. It is vital that the neurodegenerative disorder being detected at an early stage as it can provide a chance for treatment that may be helpful to prevent further progression of the fatal disease. Thus, research has focused on developing effective non-invasive diagnostic methods for early detection of these disorders. Molecular diagnostics can provide a powerful method to detect and diagnose various neurological disorders. Such diagnosis can enhance early detection, provide subsequent medical counsel based on medical pathway, as well as to gain better insight of neurogenesis and hopefully eventual cure of the neurodegenerative diseases. With research reports, reviews, mini-reviews and commentary, this research topic covers a wide range of areas in neurodegeneration research, including diagnosis and prognosis; regulating central nervous system; biomarkers and brain injury induced neurobehavioral outcomes among other timely reports on neurodegeneration.

Molecular Mechanisms of Cilia Related Diseases

Author : Joao Goncalves
Publisher : Frontiers Media SA
ISBN 13 : 2832549829
Total Pages : 175 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Molecular Mechanisms of Cilia Related Diseases by : Joao Goncalves

Download or read book Molecular Mechanisms of Cilia Related Diseases written by Joao Goncalves and published by Frontiers Media SA. This book was released on 2024-05-29 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eukaryotic cilia are evolutionarily conserved microtubule-based structures that protrude from the cell surface. In vertebrates, multiple motile and primary (immotile) cilia fulfill sensory and motility functions that are critical for embryonic development and the homeostasis of adult tissues. Cilia malfunction has been shown to cause a growing number of diseases presenting phenotypes such as brain and skeletal developmental problems, intellectual disability, blindness, infertility, obesity, and kidney cysts. Despite their clinical relevance, we are still far from fully understanding the basic biology of these multiple cilia types. For example, we do not know the molecular compositions of all types of cilia nor how cilia structural and functional diversity is generated. Also, we are still identifying the genetic causes of ciliopathies and the impact of mutations on ciliary protein function, cilia biogenesis/maintenance, ciliary functions, and disease development. Understanding all these aspects concerning vertebrate cilia will greatly contribute to the design of innovative therapeutic approaches for cilia-related disorders. Understanding the basic biology of vertebrate cilia is critical for the understanding of cilia-related disorders. However, there are still many open questions about these organelles. For example, we do not know the proteomes and protein-protein interaction networks specific of each cilium type. Also, the function of ciliary proteins is often studied mostly in vitro and in the context of primary cilia. This limits our possibility to answer questions like “why does a certain disease mutation affect only certain types of cilia in specific tissues?”. Therefore, this Research Topic aims to address these issues and focus on the latest findings on the basic biology of vertebrate cilia such as their molecular composition and biogenesis pathways, and also on advances on our understanding of the molecular mechanisms of ciliopathies. The goal of this Research Topic is to cover novel research focused on furthering our understanding on the molecular mechanisms underlying the development of cilia-associated diseases. Areas to be covered in this Research Topic may include, but are not limited to: - Identification of novel cilia-related diseases - Genetic causes of ciliopathies - Molecular mechanisms of disease and development of therapeutic approaches - Molecular composition of vertebrate cilia - Molecular mechanisms of vertebrate cilia biogenesis and multiple functions Original research articles as well as review articles are welcomed.

Neuroscience: From the Molecular to the Cognitive

Author : Floyd E. Bloom
Publisher : Elsevier
ISBN 13 : 044481678X
Total Pages : 303 pages
Book Rating : 4.4/5 (448 download)

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Book Synopsis Neuroscience: From the Molecular to the Cognitive by : Floyd E. Bloom

Download or read book Neuroscience: From the Molecular to the Cognitive written by Floyd E. Bloom and published by Elsevier. This book was released on 1994-07-19 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This hundredth volume is a commemorative milestone in the prestigeous Progress in Brain Research series. Accordingly, authors were invited to write on any topic, given that their choice represented the topic most near and dear to their own efforts over a significant period of the recent past, and to which they would likely continue to be devoted in the future. In that sense, this volume does not represent a scientific meeting, but rather an overview sample of problems and methodologies that epitomize brain research broadly at this special moment in the maturation of the field. The chapters comprising this volume assort themselves readily into five or six established categories of topics: developmental brain research, molecular brain research, integrative brain research, neuroplasticity, and neuro-psychiatric conditions. This volume reports through a sample of recognized leaders in the neuroscientific community at a significant instant in the history and evolution of the field.

Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis

Author : Ricardo Tapia
Publisher : Frontiers Media SA
ISBN 13 : 2889193764
Total Pages : 191 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis by : Ricardo Tapia

Download or read book Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis written by Ricardo Tapia and published by Frontiers Media SA. This book was released on 2015-02-11 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. The cognitive process is not affected and is not merely the result of aging because may occur at young ages. The only known cause of the disease is associated with genetic mutations, mainly in the gene encoding superoxide dismutase 1 (familial ALS), whereas there is no known cause of the sporadic form of ALS (SALS), which comprises >90% of cases. Both ALS types develop similar histopathological and clinical characteristics, and there is no treatment or prevention of the disease. Because effective treatments for ALS, as for other neurodegenerative diseases, can only result from the knowledge of their cellular and molecular pathophysiological mechanisms, research on such mechanisms is essential. Although progress in neurochemical, physiological and clinical investigations in the last decades has identified several mechanisms that seem to be involved in the cell death process, such as glutamate-mediated excitotoxicity, alterations of inhibitory circuits, inflammatory events, axonal transport deficits, oxidative stress, mitochondrial dysfunction and energy failure, the understanding of the origin and temporal progress of the disease is still incomplete and insufficient. Clearly, there is a need of further experimental models and approaches to discern the importance of such mechanisms and to discover the factors that determine the selective death of motor neurons characteristic of ALS, in contrast to other neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Whereas studies in vitro in cell cultures, tissue slices or organotypic preparations can give useful information regarding cellular and molecular mechanisms, the experiments in living animal models obviously reflect more closely the situation in the human disease, provided that the symptoms and their development during time mimics as close as possible those of the human disease. It is necessary to correlate the experimental findings in vitro with those in vivo, as well as those obtained in genetic models with those in non-genetic models, aiming at designing and testing therapeutic strategies based on the results obtained.

Protein Homeostasis Diseases

Author : Angel L. Pey
Publisher : Academic Press
ISBN 13 : 0128191333
Total Pages : 452 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Protein Homeostasis Diseases by : Angel L. Pey

Download or read book Protein Homeostasis Diseases written by Angel L. Pey and published by Academic Press. This book was released on 2020-02-13 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. - Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands - Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease - Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 2036 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 2036 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1876 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Leucine-Rich Repeat Kinase 2 (LRRK2)

Author : Hardy J. Rideout
Publisher : Springer
ISBN 13 : 3319499696
Total Pages : 280 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Leucine-Rich Repeat Kinase 2 (LRRK2) by : Hardy J. Rideout

Download or read book Leucine-Rich Repeat Kinase 2 (LRRK2) written by Hardy J. Rideout and published by Springer. This book was released on 2017-03-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.