Prion Diseases And Copper Metabolism

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Prion Diseases and Copper Metabolism

Author : D. Brown
Publisher : Elsevier
ISBN 13 : 0857099914
Total Pages : 265 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Prion Diseases and Copper Metabolism by : D. Brown

Download or read book Prion Diseases and Copper Metabolism written by D. Brown and published by Elsevier. This book was released on 2002-10-01 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: International authorities here investigate research into the prion diseases which include Scrapie of sheep, BSE the "Mad Cow" disease, and CJD one of the human diseases. The role of metals in these diseases has become of great importance, linking it with some of the changes in Alzheimer's disease. The book focuses on metabolism of copper and manganese which are found in these diseases. It stems from proceedings of the international workshop at Christ's College, Cambridge University in 2001. After an introduction on the history of research into the diseases, there are discussions on the effects of copper on biochemical properties and prion proteins of brain cells, and newer techniques for their study. There is also a section on the relationship of Alzheimers disease to prion diseases. Focuses on metabolism of copper and manganese, which are found in Scrapie of sheep; BSE, the "Mad Cow" disease; and CJD, one of the human prion diseases Discusses the effects of copper on biochemical properties, prion proteins of brain cells and new techniques for their study Stems from the proceedings of the international workshop at Christ’s College, Cambridge University in 2001

Handbook of Copper Pharmacology and Toxicology

Author : Edward J. Massaro
Publisher : Springer Science & Business Media
ISBN 13 : 1592592880
Total Pages : 600 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Handbook of Copper Pharmacology and Toxicology by : Edward J. Massaro

Download or read book Handbook of Copper Pharmacology and Toxicology written by Edward J. Massaro and published by Springer Science & Business Media. This book was released on 2002-07-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases, Menkes and Wilson's diseases and occipital horn syndrome, as well as the role of copper in Parkinson's disease, prion disease, familial amytrophic lateral sclerosis (ALS), and Alzheimer's disease.

Prion Protein

Author :
Publisher : Academic Press
ISBN 13 : 0128112271
Total Pages : 518 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Prion Protein by :

Download or read book Prion Protein written by and published by Academic Press. This book was released on 2017-08-22 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prion Protein, Volume 150, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on Prion Protein, a protein that is considered to be the archetype of intrinsically disordered proteins. This updated volume includes comprehensive sections on a variety of timely topics, including Functions of Prion Protein, Copper and Prion protein, Cell Biology of Prion Protein, Structural Studies of Prion Proteins, Molecular Simulations on Wild Type and Mutant Prion Proteins, Genetics of Prion Protein, The Prion Concept and Synthetic Prions, and Transgenic Mouse Models. As neurodegenerative diseases represent a health issue that is receiving increasing attention from the scientific community due to their social and economic impact, this series is an ideal resource for the latest research in molecular biology and translational science. Presents the latest volume in the Progress in Molecular Biology and Translational Science series Accessible to students and researcher alike Written by leading authorities in the field of prion protein

Copper Transport and Its Disorders

Author : Arturo Leone
Publisher : Springer Science & Business Media
ISBN 13 : 1461548594
Total Pages : 276 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Copper Transport and Its Disorders by : Arturo Leone

Download or read book Copper Transport and Its Disorders written by Arturo Leone and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of presentations at the first meeting devoted to the mo lecular and cellular biology of copper transport. When we first considered the possible program for the meeting, we felt that a forum to integrate the recent advances in molecular understanding of copper transport with the older knowledge of copper metabolism was needed. In addition we wished to have a strong emphasis on the diseases of copper includ ing the genetic diseases, Menkes and Wilson, and other possible health aspects of this met al seen from a molecular perspective. Overall we were very happy with the success of the meeting, and most participants were very enthusiastic. Unfortunately we were not able to obtain manuscripts from every contributor, but the selection in this book covers most of the topics discussed. The history of biological research into copper dates from the latter half of the last century when the presence of copper as a component of living systems was first noted, but it was not until the 1920s that the essential role of copper was first recognized. l. S. McHargue found that plants and animals needed copper for optimal growth and health and proposed that copper was needed for life (McHargue, 1925). Other groups soon confirmed these observations in plants. In animals the requirement of copper for hematopoiesis was discovered in 1928 (Hart et aI.

Copper Coordination with Protein, Peptides, and Small Molecules

Author : Whitnee Leigh Nettles
Publisher :
ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.:/5 (968 download)

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Book Synopsis Copper Coordination with Protein, Peptides, and Small Molecules by : Whitnee Leigh Nettles

Download or read book Copper Coordination with Protein, Peptides, and Small Molecules written by Whitnee Leigh Nettles and published by . This book was released on 2016 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Copper is an essential element for all living organisms. However, due to its low redox potential it can be involved in the production of reactive oxygen species; where excess amounts of copper can be exceptionally toxic. In humans, malfunctions in copper metabolism are linked to diseases such as Menkes syndrome, Wilson’s disease, prion disease, and Alzheimer’s disease. Maintenance of copper homeostasis requires a number of proteins, such as copper transporters and chaperones to deliver copper to the correct protein while limiting free copper in the cell. Therefore, understanding the thermodynamics of copper(II) coordination in proteins is critical to our understanding of copper homeostasis. Herein we report human carbonic anhydrase II contains a novel copper binding site with picomolar affinity. A full characterization of the structure and thermodynamics associated with the coordination of both Cu atoms into their respective sites is discussed. Techniques including paramagnetic nuclear magnetic resonance spectroscopy (NMR), and x-ray absorption spectroscopy (XAS) techniques provide insight into the high affinity CuA̳ coordination environment. A detailed characterization of this high affinity binding site and related peptide-bound model complexes are included, with the results providing insights into the chemistry and physiological impact of copper binding in human carbonic anhydrase II.

Neuropathology of Neurodegenerative Diseases

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
ISBN 13 : 1316337650
Total Pages : 320 pages
Book Rating : 4.3/5 (163 download)

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Book Synopsis Neuropathology of Neurodegenerative Diseases by : Gabor G. Kovacs

Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.

Geriatric Gastroenterology

Author : C. S. Pitchumoni
Publisher : Springer Science & Business Media
ISBN 13 : 1441916237
Total Pages : 660 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Geriatric Gastroenterology by : C. S. Pitchumoni

Download or read book Geriatric Gastroenterology written by C. S. Pitchumoni and published by Springer Science & Business Media. This book was released on 2012-07-26 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.

Neurogenetics, Part II

Author :
Publisher : Elsevier
ISBN 13 : 0444640770
Total Pages : 480 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Neurogenetics, Part II by :

Download or read book Neurogenetics, Part II written by and published by Elsevier. This book was released on 2018-01-29 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurogenetics, Part II, Volume 148, the latest release in the Handbook of Clinical Neurology, provides the latest information on the genetic methodologies that are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is expected to dramatically grow in scope. Part II builds on the foundation of Part I, expanding the coverage to dementias, paroxysmal disorders, neuromuscular disorders, white matter and demyelination diseases, cerebrovascular diseases, adult psychiatric disorders and cancer and phacomatoses. Contains comprehensive coverage of neurogenetics Details the latest science and its impact on our understanding of neurological, psychiatric disorders Presents a focused reference for clinical practitioners and the neuroscience/neurogenetics research community

Protein Misfolding Diseases

Author : Marina Ramirez-Alvarado
Publisher : John Wiley & Sons
ISBN 13 : 1118031814
Total Pages : 1311 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Protein Misfolding Diseases by : Marina Ramirez-Alvarado

Download or read book Protein Misfolding Diseases written by Marina Ramirez-Alvarado and published by John Wiley & Sons. This book was released on 2010-12-01 with total page 1311 pages. Available in PDF, EPUB and Kindle. Book excerpt: An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.

Human Prion Diseases

Author :
Publisher : Elsevier
ISBN 13 : 0444639535
Total Pages : 512 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Human Prion Diseases by :

Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Clinical and Translational Perspectives on Wilson Disease

Author : Nanda Kerkar
Publisher : Academic Press
ISBN 13 : 9780128105320
Total Pages : 320 pages
Book Rating : 4.1/5 (53 download)

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Book Synopsis Clinical and Translational Perspectives on Wilson Disease by : Nanda Kerkar

Download or read book Clinical and Translational Perspectives on Wilson Disease written by Nanda Kerkar and published by Academic Press. This book was released on 2018-10-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Wilson Disease: A Worldwide Perspective and Translational Approach brings together the genetics & cell and structural biology of Wilson Disease into one contemporary, easy to navigate handbook. Aimed to meet the needs of the diverse clinical and research communities of Wilson Disease, this reference provides a worldwide approach that is concise and translational. Specifically, it provides a basis for clinicians to appreciate 'basic science' aspects of Wilson disease and similarly a basis for researchers to understand the clinical disorder on which their research is focused, fostering constructive dialogue and progress for this puzzling disorder. Offers a contemporary worldwide perspective with contributions from international experts in the field Delivers numerous succinct expert chapters with summaries designed for quick reference Includes a "How-to" appendix for diagnosis and management tips Contains access to a companion website with a self-help teaching module, links to key resources, and an extended reference list

Interrelations between Essential Metal Ions and Human Diseases

Author : Astrid Sigel
Publisher : Springer Science & Business Media
ISBN 13 : 9400775008
Total Pages : 603 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Interrelations between Essential Metal Ions and Human Diseases by : Astrid Sigel

Download or read book Interrelations between Essential Metal Ions and Human Diseases written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2014-01-27 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Elsevier's Dictionary of Acronyms, Initialisms, Abbreviations and Symbols

Author : Fioretta. Benedetto Mattia
Publisher : Elsevier
ISBN 13 : 0080544134
Total Pages : 742 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Elsevier's Dictionary of Acronyms, Initialisms, Abbreviations and Symbols by : Fioretta. Benedetto Mattia

Download or read book Elsevier's Dictionary of Acronyms, Initialisms, Abbreviations and Symbols written by Fioretta. Benedetto Mattia and published by Elsevier. This book was released on 2003-09-30 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dictionary contains an alphabetical listing of approximately 30,000 (thirty thousand) acronyms, initialisms, abbreviations and symbols covering approximately 2,000 fields and subfields ranging from Pelagic Ecology to Anthrax Disease, Artificial Organs to Alternative Cancer Therapies, Age-related Disorders to Auditory Brainstem Implants, Educational Web Sites to Biodefense, Biomedical Gerontology to Brain Development, Cochlear Implants to Cellular Phones, Constructed Viruses to Copper Metabolism, Drug Discovery Programs to Drug-resistant Strains, Eugenics to Epigenetics, Epilepsy Drugs to Fertility Research, Genetically Modified Foods/Crops to Futuristic Cars, Genetic Therapies to Glycobiology, Herbicide-tolerant Crops to Heritable Disorders, Human Chronobiology to Human gene Therapies, Immunization Programs to Lunar Research, Liver Transplantation to Microchip Technology, Mitochondrial Aging to Molecular Gerontology, Neurodegenerative Diseases to Neuropsychology of Aging, Neurosurgery to Next Generation Programs, Obesity Research to Prion Diseases, Quantum Cryptography to Reemerging Diseases, Retinal Degeneration to Rice Genome Research, Social Anthropology to Software Development, Synchrotron Research to Vaccine Developments, Remote Ultrasound Diagnostics to Water Protection, Entomology to Chemical Terrorism and hundreds of others, as well as abbreviations/acronyms/initialisms relating to European Community and U.S., Japanese and International Programs/Projects/Initiatives from year 2000 up to 2010 as well as World Bank Programs.

The Prion Protein

Author : Jorg Tatzelt
Publisher :
ISBN 13 : 9780954333522
Total Pages : 80 pages
Book Rating : 4.3/5 (335 download)

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Book Synopsis The Prion Protein by : Jorg Tatzelt

Download or read book The Prion Protein written by Jorg Tatzelt and published by . This book was released on 2010 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected. In this timely book, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrPC and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrPC for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrPSc. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.

Prion Biology and Diseases

Author : Stanley B. Prusiner
Publisher : CSHL Press
ISBN 13 : 9780879696931
Total Pages : 1130 pages
Book Rating : 4.6/5 (969 download)

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Book Synopsis Prion Biology and Diseases by : Stanley B. Prusiner

Download or read book Prion Biology and Diseases written by Stanley B. Prusiner and published by CSHL Press. This book was released on 2004 with total page 1130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize-winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

Principles of Bioinorganic Chemistry

Author : Stephen J. Lippard
Publisher : University Science Books
ISBN 13 : 9780935702729
Total Pages : 444 pages
Book Rating : 4.7/5 (27 download)

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Book Synopsis Principles of Bioinorganic Chemistry by : Stephen J. Lippard

Download or read book Principles of Bioinorganic Chemistry written by Stephen J. Lippard and published by University Science Books. This book was released on 1994 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of unnatural metals - which have been introduced into human biology as diagnostic probes and drugs - is another active area of tremendous medical significance.

Biochemistry of Copper

Author : Maria C. Linder
Publisher : Springer Science & Business Media
ISBN 13 : 1475794320
Total Pages : 534 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Biochemistry of Copper by : Maria C. Linder

Download or read book Biochemistry of Copper written by Maria C. Linder and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Copper has long been known as essential to living systems, in part through its fundamental role in electron transport and respiration. Over the years into the present, its involvement in an ever increasing number of processes in all kinds of organisms has become apparent, and new and exciting vistas of its roles in such areas as the central nervous system, and in humoral functions, are appearing on the horizon. Although the biochemistry of this element has not been studied nearly as much as that of many others, a for midable amount of work has been carried out. It has thus been a challenge to produce a summary of what has been found that provides both breadth and depth. My goal has been to try to be as comprehensive as possible, within some limitations. I have tried to provide basic information and basic data that should continue to be useful for a long time. The goal has also been to interpret where we currently stand in our knowledge of the structure, function, regulation, and metabolism of Cu-dependent processes and sub stances, especially proteins. Thus, I have tried to make this a source book for historic as well as current information on all aspects of copper bio chemistry, and a summary of our current knowledge of copper-dependent proteins and processes. Most of the research on copper has been carried out on vertebrates, especially mammals. This has played a role in the organization of the book.