Prion Diseases

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Prion Diseases

Author : John Collinge (MD.)
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prion Diseases by : John Collinge (MD.)

Download or read book Prion Diseases written by John Collinge (MD.) and published by . This book was released on 1997 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of neurological conditions associated with the mutant "prion" protein continues to grow. The list includes BSE and scrapie, which affect cattle and sheep respectively, and Creutzfeldt-Jacob Disease, which affects humans. This is an area of intense interest to neuroscientists,veterinary scientists, and clinicians. It has also attracted significant media attention because of the potential risks to humans. This book brings together leading researchers in the field to provide the most up-to-date and authoritative summary available of the field. Contents include human and animal prion diseases; pathology and cell biology of prion diseases; and prion protein structure.

Human Prion Diseases

Author :
Publisher : Elsevier
ISBN 13 : 0444639535
Total Pages : 520 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Human Prion Diseases by :

Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. - Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms - Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans - Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Madness and Memory

Author : Stanley B. Prusiner
Publisher : Yale University Press
ISBN 13 : 0300191146
Total Pages : 344 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Madness and Memory by : Stanley B. Prusiner

Download or read book Madness and Memory written by Stanley B. Prusiner and published by Yale University Press. This book was released on 2014-04-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.

Advancing Prion Science

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309168597
Total Pages : 125 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Advancing Prion Science by : Institute of Medicine

Download or read book Advancing Prion Science written by Institute of Medicine and published by National Academies Press. This book was released on 2003-03-20 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.

Neurodegeneration and Prion Disease

Author : David R. Brown
Publisher : Springer Science & Business Media
ISBN 13 : 9780387239224
Total Pages : 498 pages
Book Rating : 4.2/5 (392 download)

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Book Synopsis Neurodegeneration and Prion Disease by : David R. Brown

Download or read book Neurodegeneration and Prion Disease written by David R. Brown and published by Springer Science & Business Media. This book was released on 2005-05-06 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first and only book on the subject of prions to cover the cause of cell death in the disease. It covers the full range of competing theories on the subject, from broad description and basic points up to the final details of the basic science.

Prions and Diseases

Author : Wen-Quan Zou
Publisher : Springer Science & Business Media
ISBN 13 : 1461453380
Total Pages : 322 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Prions and Diseases by : Wen-Quan Zou

Download or read book Prions and Diseases written by Wen-Quan Zou and published by Springer Science & Business Media. This book was released on 2012-11-08 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

Prions and Diseases

Author : Wen-Quan Zou
Publisher : Springer Nature
ISBN 13 : 3031205650
Total Pages : 773 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Prions and Diseases by : Wen-Quan Zou

Download or read book Prions and Diseases written by Wen-Quan Zou and published by Springer Nature. This book was released on 2023-01-01 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.

The Pathological Protein

Author : Philip Yam
Publisher : Springer Science & Business Media
ISBN 13 : 038721755X
Total Pages : 290 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis The Pathological Protein by : Philip Yam

Download or read book The Pathological Protein written by Philip Yam and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prions are an entirely new class of pathogens, and scientists are just beginning to understand them. Although they have plagued humans and animals for 3 centuries, only in the last 2 decades have researchers linked them to diseases like Mad Cow. This book tells the strange story of their discovery, and the medical controversies that swirl around them. The author, Philip Yam, is a well-respected and connected journalist who is now an editor at Scientific American.

Neuropathology of Neurodegenerative Diseases

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
ISBN 13 : 1316337650
Total Pages : 320 pages
Book Rating : 4.3/5 (163 download)

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Book Synopsis Neuropathology of Neurodegenerative Diseases by : Gabor G. Kovacs

Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.

Prion Diseases

Author : Martin H. Groschup
Publisher : Springer Science & Business Media
ISBN 13 : 3709163080
Total Pages : 284 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Prion Diseases by : Martin H. Groschup

Download or read book Prion Diseases written by Martin H. Groschup and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this book twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.

Prions

Author : Claudio Soto
Publisher : CRC Press
ISBN 13 : 142004012X
Total Pages : 191 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Prions by : Claudio Soto

Download or read book Prions written by Claudio Soto and published by CRC Press. This book was released on 2005-12-20 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy

Prion Biology

Author : Stanley B. Prusiner
Publisher :
ISBN 13 : 9781621820932
Total Pages : 0 pages
Book Rating : 4.8/5 (29 download)

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Book Synopsis Prion Biology by : Stanley B. Prusiner

Download or read book Prion Biology written by Stanley B. Prusiner and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book examines our under-standing of their structure, biochemistry, and pathophysiology.

Prions and Prion Diseases

Author : Glenn C. Telling
Publisher : Taylor & Francis
ISBN 13 : 9780954523268
Total Pages : 307 pages
Book Rating : 4.5/5 (232 download)

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Book Synopsis Prions and Prion Diseases by : Glenn C. Telling

Download or read book Prions and Prion Diseases written by Glenn C. Telling and published by Taylor & Francis. This book was released on 2004 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research into prions and prion diseases has progressed at a rapid pace in recent years, and has shed new light on areas such as transmissible spongiform encephalopathies. Telling (Center on Aging, University of Kentucky) provides an overview of the pathogenesis, molecular biology, biochemistry, cellular biology, animal models, and immunology of prions, for researchers working in microbiology, molecular biology, and biochemistry, and for those in pharmaceutical and biotechnology companies. Specific topics include the prion protein in cell culture, binding and conversion reactions between prion protein isoforms, PrP deletion mutants, and targeting the murine PrP gene. Other subjects are transgenic mouse models of prion diseases, peripheral pathogenesis, and immunological advances in prion diseases.

Prion Diseases of Humans and Animals

Author : Stanley B. Prusiner
Publisher : Prentice Hall
ISBN 13 :
Total Pages : 628 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prion Diseases of Humans and Animals by : Stanley B. Prusiner

Download or read book Prion Diseases of Humans and Animals written by Stanley B. Prusiner and published by Prentice Hall. This book was released on 1992 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prion Diseases

Author : Stanley B. Prusiner
Publisher :
ISBN 13 : 9781621820109
Total Pages : 0 pages
Book Rating : 4.8/5 (21 download)

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Book Synopsis Prion Diseases by : Stanley B. Prusiner

Download or read book Prion Diseases written by Stanley B. Prusiner and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Infectious proteins called prions are responsible for the devastating transmissible spongioform encephalopathy Creutzfeldt-Jakob disease. Prions are misfolded versions of proteins that replicate by converting their normal cellular counterparts into new prions and may play an important role in numerous other conditions, including Alzheimer and Parkinson's disease. Highlights include: Structural biology of PrP prions - Genetics of APP in Alzheimer's disease - Challenges of therapeutics for prion diseases and blood-brain barrier "--

Prion Proteins

Author : Jörg Tatzelt
Publisher : Springer
ISBN 13 : 3642240674
Total Pages : 308 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Prion Proteins by : Jörg Tatzelt

Download or read book Prion Proteins written by Jörg Tatzelt and published by Springer. This book was released on 2011-09-15 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Prion Disease, by S. Lloyd, S. Mead and J. Collinge. Atypical Prion Diseases in Humans and Animals, by M. A. Tranulis, S. L. Benestad, T. Baron and H. Kretzschmar. Chronic Wasting Disease, by S. Gilch, N. Chitoor, Y. Taguchi, M. Stuart, J. E. Jewell and H. M. Schätzl. Transgenic Mouse Models and Prion Strains, by G. C. Telling. Neuroprotective and Neurotoxic Signaling by the Prion Protein, by U. K. Resenberger, K. F. Winklhofer and J. Tatzelt. Prion Seeded Conversion and Amplification Assays, by C. D. Orrú and B. Caughey. Prion Protein and Its Conformational Conversion: A Structural Perspective, by W. K. Surewicz and M. I. Apostol. Molecular Dynamics as an Approach to Study Prion Protein Misfolding and the Effect of Pathogenic Mutations, by M.W. van der Kamp and V. Daggett. Chemical Biology of Prion Protein: Tools to Bridge the In Vitro/Vivo Interface, by R. Seidel and M. Engelhard. The PrP-Like Proteins Shadoo and Doppel, by D. Westaway, N. Daude, S. Wohlgemuth and P. Harrison. Fungal Prions: Structure, Function and Propagation, by M. F. Tuite, R. Marchante and V. Kushnirov.

Fatal Protein

Author : Rosalind M. Ridley
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Fatal Protein by : Rosalind M. Ridley

Download or read book Fatal Protein written by Rosalind M. Ridley and published by . This book was released on 1998 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a clear and authoritative account of the prion diseases for the non-specialist. It deals with the history of scrapie in sheep, the spread of kuru through cannibalism in Papua New Guinea, BSE, which has killed 170,000 cattle in the UK, and the question of whether the newvariant form of Creutzfeld-Jakob disease (CJD) results from eating BSE-infected meat. All aspects of the diseases are covered, including genetics, clinical aspects, laboratory research, epidemiology, and field studies. Accessibly written by authors who are leading researchers in the field, it is thefirst book to provide a scientifically accurate yet readable account of these topical diseases.