Principles Of Toxicology Testing Second Edition

Download Principles Of Toxicology Testing Second Edition full books in PDF, epub, and Kindle. Read online Principles Of Toxicology Testing Second Edition ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Principles of Toxicology Testing, Second Edition

Author : Frank A Barile
Publisher : CRC Press
ISBN 13 : 1842145282
Total Pages : 368 pages
Book Rating : 4.8/5 (421 download)

DOWNLOAD NOW!

Book Synopsis Principles of Toxicology Testing, Second Edition by : Frank A Barile

Download or read book Principles of Toxicology Testing, Second Edition written by Frank A Barile and published by CRC Press. This book was released on 2013-04-02 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.

Principles of Toxicology, Second Edition

Author : Stine Karen
Publisher : CRC Press
ISBN 13 : 084932856X
Total Pages : 392 pages
Book Rating : 4.8/5 (493 download)

DOWNLOAD NOW!

Book Synopsis Principles of Toxicology, Second Edition by : Stine Karen

Download or read book Principles of Toxicology, Second Edition written by Stine Karen and published by CRC Press. This book was released on 2006-01-24 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by two experienced toxicology lecturers, Principles of Toxicology provides a broad-based yet in-depth introduction to this diverse subject. Comprehensive and easy-to-read, the book covers this broad and interdisciplinary field from the viewpoint of three different functional levels: molecular and cellular; physiological; and ecological and environmental. This revised second edition expands the coverage of the book while keeping the organizational format that made the first edition a bestseller. It also includes a series of brief case studies illustrating the application of toxicological principles to current issues of interest. Each and every chapter has been revised, several have been significantly rewritten, and three are entirely new. This new edition retains the extensive cross-referencing system that links all sections and enhances the integration of material. It also includes an appendix of selected toxicants that describes chemical structure and category of use. These features combine to make finding specific information quick and easy. The highly readable format and uniform, consistent presentation of information will make this the most used reference on your shelf. See what's new in the second edition:

Principles of Forensic Toxicology

Author : Barry Levine
Publisher : Amer. Assoc. for Clinical Chemistry
ISBN 13 : 9781890883874
Total Pages : 406 pages
Book Rating : 4.8/5 (838 download)

DOWNLOAD NOW!

Book Synopsis Principles of Forensic Toxicology by : Barry Levine

Download or read book Principles of Forensic Toxicology written by Barry Levine and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2003 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicological Testing Handbook

Author : David Jacobson-Kram
Publisher : CRC Press
ISBN 13 : 9780849338588
Total Pages : 499 pages
Book Rating : 4.3/5 (385 download)

DOWNLOAD NOW!

Book Synopsis Toxicological Testing Handbook by : David Jacobson-Kram

Download or read book Toxicological Testing Handbook written by David Jacobson-Kram and published by CRC Press. This book was released on 2006-07-11 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Furnishing essential data on all areas of toxicity testing, this Second Edition provides guidance on the design and evaluation of product safety studies to help ensure regulatory acceptance. Every chapter highlights regulatory requirements specific to the United States, Europe, and Japan, and in addition to expanded information on data interpretation, hazard assessment, carcinogenicity studies, and Good Laboratory Practices, new chapters regarding safety pharmacology, juvenile studies, the health safety assessment of pharmaceuticals, and health assessment strategies in the food and cosmetic industry have been added to reflect changes to regulatory requirements. Toxicological Testing Handbook, Second Edition is a must-have reference for individuals responsible for assuring the safety of new pharmaceutical, biotechnical, and chemical products and materials.

Clinical Toxicology

Author : Frank A. Barile
Publisher : CRC Press
ISBN 13 : 142009226X
Total Pages : 484 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!

Book Synopsis Clinical Toxicology by : Frank A. Barile

Download or read book Clinical Toxicology written by Frank A. Barile and published by CRC Press. This book was released on 2010-02-15 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining the complex interactions associated with clinical toxicological events and chemical exposure of drug administration, this updated and revised Second Edition functions as a stand-alone text or reference of clinical toxicology for professionals, students of toxicology and pharmacy, as well as forensic toxicologists, occupational healthcare

Principles of Food Toxicology

Author : Tõnu Püssa
Publisher : CRC Press
ISBN 13 : 1466504110
Total Pages : 408 pages
Book Rating : 4.4/5 (665 download)

DOWNLOAD NOW!

Book Synopsis Principles of Food Toxicology by : Tõnu Püssa

Download or read book Principles of Food Toxicology written by Tõnu Püssa and published by CRC Press. This book was released on 2013-08-20 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following in the tradition of the popular first edition, Principles of Food Toxicology, Second Edition integrates the general principles of toxicology with a systematic characterization of the most important food-borne toxicants. Ideal as a textbook in a food toxicology course, and also as a monograph dealing with principles of food toxicology as t

Toxicology and Risk Assessment

Author : Helmut Greim
Publisher : John Wiley & Sons
ISBN 13 : 1119135923
Total Pages : 842 pages
Book Rating : 4.1/5 (191 download)

DOWNLOAD NOW!

Book Synopsis Toxicology and Risk Assessment by : Helmut Greim

Download or read book Toxicology and Risk Assessment written by Helmut Greim and published by John Wiley & Sons. This book was released on 2018-08-10 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.

Fundamentals of Toxicologic Pathology

Author : Matthew A. Wallig
Publisher : Academic Press
ISBN 13 : 0080919324
Total Pages : 714 pages
Book Rating : 4.0/5 (89 download)

DOWNLOAD NOW!

Book Synopsis Fundamentals of Toxicologic Pathology by : Matthew A. Wallig

Download or read book Fundamentals of Toxicologic Pathology written by Matthew A. Wallig and published by Academic Press. This book was released on 2009-11-23 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. - 25% brand new information, fully revised throughout - New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology - New color photomicrographs detailing specific toxicant-induced diseases in animals - Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels

Fundamentals of Analytical Toxicology

Author : Robert J. Flanagan
Publisher : John Wiley & Sons
ISBN 13 : 0470319348
Total Pages : 605 pages
Book Rating : 4.4/5 (73 download)

DOWNLOAD NOW!

Book Synopsis Fundamentals of Analytical Toxicology by : Robert J. Flanagan

Download or read book Fundamentals of Analytical Toxicology written by Robert J. Flanagan and published by John Wiley & Sons. This book was released on 2008-03-03 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electrophoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: “This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.” Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists “Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background “Boxes”. The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.” GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German) “Many toxicologists will add this important reference to their libraries because it competently fills a need ...” International Journal of Toxicology “The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.” International Journal of Environmental Analytical Chemistry

Basic Principles of Drug Discovery and Development

Author : Benjamin E. Blass
Publisher : Academic Press
ISBN 13 : 0128172150
Total Pages : 738 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Basic Principles of Drug Discovery and Development by : Benjamin E. Blass

Download or read book Basic Principles of Drug Discovery and Development written by Benjamin E. Blass and published by Academic Press. This book was released on 2021-03-30 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. - Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property - Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape - Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery - Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

Barile’s Clinical Toxicology

Author : Frank A. Barile
Publisher : CRC Press
ISBN 13 : 1498765386
Total Pages : 623 pages
Book Rating : 4.4/5 (987 download)

DOWNLOAD NOW!

Book Synopsis Barile’s Clinical Toxicology by : Frank A. Barile

Download or read book Barile’s Clinical Toxicology written by Frank A. Barile and published by CRC Press. This book was released on 2019-04-24 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: As with the two previous editions, Barile’s Clinical Toxicology: Principles and Mechanisms, Third edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. With special emphasis placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs, the new edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. The new edition presents the latest, up-to-date protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology. In addition, the effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered. KEY FEATURES • Discusses source of the drug or chemical, pharmacological and toxicological mechanisms of action, detection, identification, and treatment • Examines the complex interactions associated with clinical toxicological events • Emphasizes the signs and symptoms of diseases and pathology caused by toxins and clinical drugs • Covers effect of toxins on body systems and drug-induced adverse reactions • Offers a unique perspective for toxicology, pharmacology, pharmacy and health professions students The target audience for this book is undergraduate and graduate toxicology students, clinical pharmacy (Pharm.D.) students, emergency medical personnel, regulatory agencies, and other related health science professionals. It satisfies an essential need for a concise yet detailed authoritative, fundamental text addressing the current principles of clinical toxicology.

Principles of Genetic Toxicology

Author : D. Brusick
Publisher : Springer Science & Business Media
ISBN 13 : 1489919805
Total Pages : 292 pages
Book Rating : 4.4/5 (899 download)

DOWNLOAD NOW!

Book Synopsis Principles of Genetic Toxicology by : D. Brusick

Download or read book Principles of Genetic Toxicology written by D. Brusick and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and expanded as a result of increased effort, testing, and the sharing of data. This expansion has occurred not only in the industrialized countries, but also in countries that are comparatively less advanced in scientific implementation. These developing countries have taken advan tage of the basic practical methods that were so well described in the first edition of this work. It is significant to note how many centers have been established throughout the world and are now studying the basic concepts and applying them to practical problems such as the detection of genetic effects caused by exposure to chemicals. In fact, there are now toxicology training centers in twelve countries. Genetic toxicology, in addition to being investigated as a science unto itself, has been taught to people in the applied fields so that these techniques may be put to use in solving other biological problems. For these reasons, it is most useful to have an update of the basic methods and their development. Dr. Brusick should be congratulated for doing such an excellent job of assembling a text that will be worthwhile to any researcher who is interested in the principles of genetic toxicology. Alexander Hollaender Council for Research Planning in Biological Sciences, Inc. Washington, D. C.

Principles of Toxicology

Author : Phillip L. Williams
Publisher : John Wiley & Sons
ISBN 13 : 0471459232
Total Pages : 625 pages
Book Rating : 4.4/5 (714 download)

DOWNLOAD NOW!

Book Synopsis Principles of Toxicology by : Phillip L. Williams

Download or read book Principles of Toxicology written by Phillip L. Williams and published by John Wiley & Sons. This book was released on 2003-10-10 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully updated and expanded edition of the bestselling guide on toxicology and its practical application The field of toxicology has grown enormously since Industrial Toxicology: Safety and Health Applications in the Workplace was first published in 1985. And while the original edition was hugely popular among occupational health professionals, the time is ripe to address toxic agents not only in the industrial setting but also in the environment at large. Renamed Principles of Toxicology: Environmental and Industrial Applications, this new edition provides health protection professionals as well as environmental scientists with precise, up-to-date, practical information on how to apply the science of toxicology in both the occupational and environmental setting. Through contributions from leading experts in diverse fields, Principles of Toxicology, Second Edition features: Clear explanations of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems Coverage of occupational medicine and epidemiological issues The manifestation of toxic agents such as metals, pesticides, organic solvents, and natural toxins Special emphasis on the evaluation and control of toxic hazards Specific case histories on applying risk assessment methods in the modern workplace Ample figures, references, and a comprehensive glossary of toxicological terms

Principles of Environmental Toxicology

Author : I. Shaw
Publisher : CRC Press
ISBN 13 : 1482284766
Total Pages : 222 pages
Book Rating : 4.4/5 (822 download)

DOWNLOAD NOW!

Book Synopsis Principles of Environmental Toxicology by : I. Shaw

Download or read book Principles of Environmental Toxicology written by I. Shaw and published by CRC Press. This book was released on 2018-10-08 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental toxicology is the study of the action of chemicals upon ecosystems. Understanding the effects of exogenous chemicals upon the inhabitants of an ecosystem may enable us to predict and possibly prevent their deleterious effects. This textbook provides a good general introduction to all the major areas of environmental toxicology, including the fate of chemicals in the environment, environmental toxicity testing, risk assessment, radioactivity in the environment, legislation, environmental monitoring and the future impact of industrial development on the environment. It is written in an informal, accessible style with many examples of environmental issues taken from the author's personal experience and will provide students and other interested individuals with a broad overview of the science of environmental toxicology.

Toxicology

Author : Raymond Niesink
Publisher : CRC Press
ISBN 13 : 9780849392320
Total Pages : 1312 pages
Book Rating : 4.3/5 (923 download)

DOWNLOAD NOW!

Book Synopsis Toxicology by : Raymond Niesink

Download or read book Toxicology written by Raymond Niesink and published by CRC Press. This book was released on 1996-03-29 with total page 1312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing primarily on basic principles and concepts, Toxicology also provides 200 tables worth of toxicological data. Each heavily illustrated chapter is a complete study unit containing a table of contents, an introduction, a learning core, a self-test, and feedback. The main text for the unit is followed by a self-test, which reveals whether the learning objectives have been met. The feedback section answers frequently asked questions, while a summary enables the student to review the main concepts before moving on to the next unit.

The Clinical Toxicology Laboratory

Author : Leslie M. Shaw
Publisher : Amer. Assoc. for Clinical Chemistry
ISBN 13 : 9781890883539
Total Pages : 564 pages
Book Rating : 4.8/5 (835 download)

DOWNLOAD NOW!

Book Synopsis The Clinical Toxicology Laboratory by : Leslie M. Shaw

Download or read book The Clinical Toxicology Laboratory written by Leslie M. Shaw and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2001 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Validation of Alternative Methods for Toxicity Testing

Author : Chantra Eskes
Publisher : Springer
ISBN 13 : 3319338269
Total Pages : 418 pages
Book Rating : 4.3/5 (193 download)

DOWNLOAD NOW!

Book Synopsis Validation of Alternative Methods for Toxicity Testing by : Chantra Eskes

Download or read book Validation of Alternative Methods for Toxicity Testing written by Chantra Eskes and published by Springer. This book was released on 2016-09-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.