Principles of Clinical Cancer Research

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Publisher : Springer Publishing Company
ISBN 13 : 1617052396
Total Pages : 576 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Principles of Clinical Cancer Research by : Loren K. Mell, MD

Download or read book Principles of Clinical Cancer Research written by Loren K. Mell, MD and published by Springer Publishing Company. This book was released on 2018-11-28 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Clinical Cancer Research provides comprehensive coverage of the fundamentals of clinical cancer research, including the full spectrum of methodologies used in the field. For those involved in research or considering research careers, this book offers a mix of practical advice and analytical tools for effective training in theoretical principles as well as specific, usable teaching examples. The clinical oncologist or trainee will find a high-yield, practical guide to the interpretation of the oncology literature and the application of data to real-world settings. Valuable for both researchers and clinicians who wish to sharpen their skills, this book contains all of the cornerstones and explanations needed to produce and recognize quality clinical science in oncology. Written from the physician-scientist’s perspective, the book lays a strong foundation in preclinical sciences that is highly relevant to careers in translational oncology research along with coverage of population and outcomes research and clinical trials. It brings together fundamental principles in oncology with the statistical concepts one needs to know to design and interpret studies successfully. With each chapter including perspectives of both clinicians and scientists or biostatisticians, Principles of Clinical Cancer Research provides balanced, instructive, and high-quality topic overviews and applications that are accessible and thorough for anyone in the field. KEY FEATURES: Gives real-world examples and rationales behind which research methods to use when and why Includes numerous tables featuring key statistical methods and programming commands used in everyday clinical research Contains illustrative practical examples and figures in each chapter to help the reader master concepts Provides tips and pointers for structuring a career, avoiding pitfalls, and achieving success in the field of clinical cancer research Access to fully downloadable eBook

Principles of Clinical Cancer Genetics

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Publisher : Springer Science & Business Media
ISBN 13 : 038793846X
Total Pages : 234 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Principles of Clinical Cancer Genetics by : Daniel C. Chung

Download or read book Principles of Clinical Cancer Genetics written by Daniel C. Chung and published by Springer Science & Business Media. This book was released on 2010-07-20 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed. In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.

Clinical Trials in Cancer

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Publisher : Oxford University Press, USA
ISBN 13 : 9780192629593
Total Pages : 367 pages
Book Rating : 4.6/5 (295 download)

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Book Synopsis Clinical Trials in Cancer by : David J. Girling

Download or read book Clinical Trials in Cancer written by David J. Girling and published by Oxford University Press, USA. This book was released on 2003 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Trials in Cancer provides concise, accessible and practical information on the practicalities of planning, designing, conducting, analysing, reporting, and interpreting phase III clinical trials predominantly, but also single-arm and randomized phase II trials. The book shows clearly how recent developments and current thinking can be implemented. Information on the need to decide and measure realistic target differences in trials, the conduct and interpretation of interim analyses, patient advocacy, good clinical practice, the study of quality of life, the role of meta-analyses, and informed consent and other ethical issues are also covered. DEGREESNL This book will prove invaluable for medical, statistical, and biological cancer researchers, health care professionals, and researchers in the pharmaceutical industry. Trial sponsors, principal investigators, members of data monitoring and trial supervisory committees, specialists invited to provide independent assessments, and many others involved in all aspects of research related to clinical trials should also find this book helpful.

Holland-Frei Cancer Medicine

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Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Cancer Immunotherapy Principles and Practice, Second Edition

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Publisher : Springer Publishing Company
ISBN 13 : 0826137431
Total Pages : 1339 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Cancer Immunotherapy Principles and Practice, Second Edition by : Lisa H. Butterfield, PhD

Download or read book Cancer Immunotherapy Principles and Practice, Second Edition written by Lisa H. Butterfield, PhD and published by Springer Publishing Company. This book was released on 2021-08-25 with total page 1339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs

The American Cancer Society's Principles of Oncology

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119468841
Total Pages : 472 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The American Cancer Society's Principles of Oncology by : The American Cancer Society

Download or read book The American Cancer Society's Principles of Oncology written by The American Cancer Society and published by John Wiley & Sons. This book was released on 2018-03-20 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed by the American Cancer Society this new textbook designed for a wide range of learners and practitioners is a comprehensive reference covering the diagnosis of cancer, and a range of related issues that are key to a multidisciplinary approach to cancer and critical to cancer control and may be used in conjunction with the book, The American Cancer Society's Oncology in Practice: Clinical Management. Edited by leading clinicians in the field and a stellar contributor list from the US and Europe, this book is written in an easy to understand style by multidisciplinary teams of medical oncologists, radiation oncologists and other specialists, reflecting day-to-day decision-making and clinical practice. Input from pathologists, surgeons, radiologists, and other specialists is included wherever relevant and comprehensive treatment guidelines are provided by expert contributors where there is no standard recognized treatment. This book is an ideal resource for anyone seeking a deeper understanding of cancer prevention, screening, and follow-up, which are central to the ACS's worldwide mission on cancer control.

Cancer Immunotherapy Principles and Practice

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Author :
Publisher : Springer Publishing Company
ISBN 13 : 1617052736
Total Pages : 920 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Cancer Immunotherapy Principles and Practice by : Lisa H. Butterfield, PhD

Download or read book Cancer Immunotherapy Principles and Practice written by Lisa H. Butterfield, PhD and published by Springer Publishing Company. This book was released on 2017-06-28 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Immunotherapy Principles and Practice, from the Society of Immunotherapy of Cancer (SITC), is the authoritative reference on cancer immunobiology and the immunotherapy treatments that harness the immune system to combat malignant disease. Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy and propelled it to its current place at the forefront of cancer treatment innovation. This volume is a comprehensive resource for oncologists and fellows, immunologists, cancer researchers, and related practitioners seeking understanding of the basic science and clinical applications of cancer immunotherapy. As well as presenting the evidence for immune-based cancer treatment, it positions immunotherapy in the context of other available cancer treatments and provides data on response rates, risks, and toxicities across a variety of diseases. Filled with detailed tables, and instructive illustrations, as well as key points for quick reference, Cancer Immunotherapy Principles and Practice simplifies a challenging and dynamic subject. Key Features: Clearly summarizes the basic principles and research supporting cancer immunotherapy clinical translation Contains expert guidance and treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, and treatment combinations Includes expert perspectives from leading authorities in the field Provides information on all FDA-approved immunotherapies, including clinical management and outcome data Discusses clinical aspects of immunotherapy for individual cancer types, including melanoma and other skin cancers, lung cancers, gynecologic cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain and other CNS cancers, breast cancer, and pediatric malignancies. Explains regulatory aspects behind the development and approval of immunotherapy drugs Includes Online Access to the Digital Book

Cancer Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics

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Author :
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469833883
Total Pages : 348 pages
Book Rating : 4.4/5 (698 download)

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Book Synopsis Cancer Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics by : Ellen Matloff

Download or read book Cancer Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics written by Ellen Matloff and published by Lippincott Williams & Wilkins. This book was released on 2013-03-25 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical, user-friendly guidebook will allow the clinician to search under disease site for the hereditary cancer syndromes relevant for his/her patient's cancer. For example, a gynecologist oncologist whose patient has ovarian cancer can turn to the Ovary chapter and quickly read a summary of all of the hereditary cancer syndromes that include ovarian cancer. She can learn the questions she should be asking when expanding that patient's personal and family history, which genes are most relevant, whether to refer that patient on for genetic counseling and testing, and how to manage that patient long-term if the patient is mutation positive or negative. The same holds true for the practicing oncologist, surgeon, urologist, endocrinologist, gynecologist, primary care physician, physician's assistant, advanced practice nurse and any other clinician seeing a patient who has had cancer. This guidebook also contains an overview article on genetic counseling and testing and several in depth articles on issues that are up and coming in the field of hereditary cancer.

Principles and Practice of Clinical Research

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Publisher : Academic Press
ISBN 13 : 0123821673
Total Pages : 798 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Principles and Practice of Clinical Research by : John I. Gallin

Download or read book Principles and Practice of Clinical Research written by John I. Gallin and published by Academic Press. This book was released on 2012-05-31 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: This expanded third edition provides an introduction to the conduct of clinical research as well as more comprehensive and expansive content about the infrastructure necessary for a successful clinical research organization or enterprise. With authors who are experts in clinical research in both the public and private sectors, this publication provides essential information to clinical investigators who wish to develop and conduct well designed patient-based research protocols that comply with rigorous study design, ethical, and regulatory requirements.

Cancer Research and Clinical Trials in Developing Countries

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Publisher : Springer
ISBN 13 : 3319184431
Total Pages : 218 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Cancer Research and Clinical Trials in Developing Countries by : Daniela Cristina Stefan

Download or read book Cancer Research and Clinical Trials in Developing Countries written by Daniela Cristina Stefan and published by Springer. This book was released on 2015-12-16 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the principles around which cancer research and clinical trials can be developed. Additionally, by describing the particularities of planning and implementing cancer research in developing countries, this book provides valuable practical information for researchers in resource-rich countries who contemplate cooperating with scientists from limited-resource countries in performing research.Written and edited by leaders in the field who work in these developing countries, Cancer Research and Clinical Trials in Developing Countries: A Practical Guide will appeal to a wide range of researchers, students, and physicians who are engaging in cancer research and clinical trials. It focuses on methodology and statistics while structured around the needs of cancer research. It provides valuable information regarding international collaboration, funding mechanisms as well as publishing and dissemination of research findings.

Handbook of Research on Advancements in Cancer Therapeutics

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Publisher : IGI Global
ISBN 13 : 1799865312
Total Pages : 913 pages
Book Rating : 4.7/5 (998 download)

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Book Synopsis Handbook of Research on Advancements in Cancer Therapeutics by : Kumar, Sumit

Download or read book Handbook of Research on Advancements in Cancer Therapeutics written by Kumar, Sumit and published by IGI Global. This book was released on 2020-11-27 with total page 913 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.

Oncology Clinical Trials

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Publisher : Demos Medical Publishing
ISBN 13 : 9781935281764
Total Pages : 168 pages
Book Rating : 4.2/5 (817 download)

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Book Synopsis Oncology Clinical Trials by : Susan Halabi, PhD

Download or read book Oncology Clinical Trials written by Susan Halabi, PhD and published by Demos Medical Publishing. This book was released on 2009-12-22 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well conceived, carefully designed and efficiently conducted clinical trial can produce results that change clinical practice overnight, deliver new oncology drugs and diagnostics to the marketplace, and expand the horizon of contemporary thinking about cancer biology. A poorly done trial does little to advance the field or guide clinical practice, consumes precious clinical and financial resources and challenges the validity of the ethical contract between investigators and the volunteers who willingly give their time and effort to benefit future patients. With chapters written by oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives, Oncology Clinical Trials, provides a comprehensive guide for both early-career and senior oncology investigators into the successful design, conduct and analysis of an oncology clinical trial. Oncology Clinical Trials covers how to formulate a study question, selecting a study population, study design of Phase I, II, and III trials, toxicity monitoring, data analysis and reporting, use of genomics, cost-effectiveness analysis, systemic review and meta-analysis, and many other issues. Many examples of real-life flaws in clinical trials that have been reported in the literature are included throughout. The book discusses clinical trials from start to finish focusing on real-life examples in the development, design and analysis of clinical trials. Oncology Clinical Trials features: A systematic guide to all aspects of the design, conduct, analysis, and reporting of clinical trials in oncology Contributions from oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives Hot topics in oncology trials including multi-arm trials, meta-analysis and adaptive design, use of genomics, and cost-effectiveness analysis Real-life examples from reported clinical trials included throughout

Principles and Practice of Pediatric Oncology

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496318765
Total Pages : 5113 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Principles and Practice of Pediatric Oncology by : Philip A. Pizzo

Download or read book Principles and Practice of Pediatric Oncology written by Philip A. Pizzo and published by Lippincott Williams & Wilkins. This book was released on 2015-06-24 with total page 5113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now thoroughly updated to include new advances in the field,and with regular content updates to the eBook, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer and the diagnosis, multimodal treatment, and long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families. Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.” Reference your eBook version for key updates in the field during the life of the edition! Chapters included on palliative care and education. Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition. The most updated and authoritative information is provided by the leading experts in the field. Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy. Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families. Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.

Clinical Oncology

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Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (124 download)

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Book Synopsis Clinical Oncology by : Anthony J. Neal

Download or read book Clinical Oncology written by Anthony J. Neal and published by . This book was released on 1997 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Principles of Molecular Oncology

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Publisher : Springer Science & Business Media
ISBN 13 : 9781597454704
Total Pages : 420 pages
Book Rating : 4.4/5 (547 download)

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Book Synopsis Principles of Molecular Oncology by : Miguel H. Bronchud

Download or read book Principles of Molecular Oncology written by Miguel H. Bronchud and published by Springer Science & Business Media. This book was released on 2008-03-16 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on years of significant advances and developments, the editors of this third edition have thoroughly updated the highly praised first and second editions and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, pharmacogenomics, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular-weight molecules.

Principles of Cancer Biotherapy

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Publisher : Springer Science & Business Media
ISBN 13 : 9048122899
Total Pages : 743 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Principles of Cancer Biotherapy by : Robert K. Oldham

Download or read book Principles of Cancer Biotherapy written by Robert K. Oldham and published by Springer Science & Business Media. This book was released on 2009-08-29 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.

Principles and Practice of Clinical Research

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Author :
Publisher : Elsevier
ISBN 13 : 9780080489568
Total Pages : 448 pages
Book Rating : 4.4/5 (895 download)

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Book Synopsis Principles and Practice of Clinical Research by : John I. Gallin

Download or read book Principles and Practice of Clinical Research written by John I. Gallin and published by Elsevier. This book was released on 2011-04-28 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers. *Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research *Delves into data management and addresses how to collect data and use it for discovery *Contains valuable, up-to-date information on how to obtain funding from the federal government