Enzyme Mechanism from Isotope Effects

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Author :
Publisher : CRC Press
ISBN 13 : 9780849353123
Total Pages : 656 pages
Book Rating : 4.3/5 (531 download)

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Book Synopsis Enzyme Mechanism from Isotope Effects by : Paul F. Cook

Download or read book Enzyme Mechanism from Isotope Effects written by Paul F. Cook and published by CRC Press. This book was released on 1991-09-20 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isotope effects have become one of the most powerful tools available to the enzymologist for probing enzymic mechanisms. Enzyme Mechanism from Isotope Effects presents the basic theory underlying isotope effects, including the latest findings on proton tunneling and coupled atomic notions. Specific theoretical applications are emphasized in regard to the types of information that can be obtained using isotope effects. The book also examines recent theoretical treatments of the product dependence of deuterium isotope effects, multiple isotope effects and isotope effects on intermediate partitioning. Other topics include a complete discussion of methods for measuring isotope effects, including a detailed description of the use of the isotope ratio mass spectrometer to obtain isotope effects, and a review of the literature regarding mechanistic information obtained from isotope effects for individual classes of enzyme-catalyzed reactions. Enzyme Mechanism from Isotope Effects is an excellent reference source for investigators using isotope effects in their research. The book is also valuable for reference libraries and instructors teaching courses in enzyme mechanism.

Quantum Tunnelling in Enzyme-catalysed Reactions

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 0854041222
Total Pages : 412 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Quantum Tunnelling in Enzyme-catalysed Reactions by : Rudolf K. Allemann

Download or read book Quantum Tunnelling in Enzyme-catalysed Reactions written by Rudolf K. Allemann and published by Royal Society of Chemistry. This book was released on 2009 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, there has been an explosion in knowledge and research associated with the field of enzyme catalysis and H-tunneling. Rich in its breath and depth, this introduction to modern theories and methods of study is suitable for experienced researchers those new to the subject. Edited by two leading experts, and bringing together the foremost practitioners in the field, this up-to-date account of a rapidly developing field sits at the interface between biology, chemistry and physics. It covers computational, kinetic and structural analysis of tunnelling and the synergy in combining these methods (with a major focus on H-tunneling reactions in enzyme systems). The book starts with a brief overview of proton and electron transfer history by Nobel Laureate, Rudolph A. Marcus. The reader is then guided through chapters covering almost every aspect of reactions in enzyme catalysis ranging from descriptions of the relevant quantum theory and quantum/classical theoretical methodology to the description of experimental results. The theoretical interpretation of these large systems includes both quantum mechanical and statistical mechanical computations, as well as simple more approximate models. Most of the chapters focus on enzymatic catalysis of hydride, proton and H" transfer, an example of the latter being proton coupled electron transfer. There is also a chapter on electron transfer in proteins. This is timely since the theoretical framework developed fifty years ago for treating electron transfers has now been adapted to H-transfers and electron transfers in proteins. Accessible in style, this book is suitable for a wide audience but will be particularly useful to advanced level undergraduates, postgraduates and early postdoctoral workers.

Nuclear Science Abstracts

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Publisher :
ISBN 13 :
Total Pages : 964 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Nuclear Science Abstracts by :

Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1976 with total page 964 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nuclear Science Abstracts

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Author :
Publisher :
ISBN 13 :
Total Pages : 918 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Nuclear Science Abstracts by :

Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1972 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dynamics in Enzyme Catalysis

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Author :
Publisher : Springer
ISBN 13 : 3642389627
Total Pages : 217 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Dynamics in Enzyme Catalysis by : Judith Klinman

Download or read book Dynamics in Enzyme Catalysis written by Judith Klinman and published by Springer. This book was released on 2013-09-14 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christopher M. Cheatum and Amnon Kohen, Relationship of Femtosecond–Picosecond Dynamics to Enzyme-Catalyzed H-Transfer. Cindy Schulenburg and Donald Hilvert, Protein Conformational Disorder and Enzyme Catalysis. A. Joshua Wand, Veronica R. Moorman and Kyle W. Harpole, A Surprising Role for Conformational Entropy in Protein Function. Travis P. Schrank, James O. Wrabl and Vincent J. Hilser, Conformational Heterogeneity Within the LID Domain Mediates Substrate Binding to Escherichia coli Adenylate Kinase: Function Follows Fluctuations. Buyong Ma and Ruth Nussinov, Structured Crowding and Its Effects on Enzyme Catalysis. Michael D. Daily, Haibo Yu, George N. Phillips Jr and Qiang Cui, Allosteric Activation Transitions in Enzymes and Biomolecular Motors: Insights from Atomistic and Coarse-Grained Simulations. Karunesh Arora and Charles L. Brooks III, Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase. Steven D. Schwartz, Protein Dynamics and the Enzymatic Reaction Coordinate.

Reaction Rates of Isotopic Molecules

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Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Reaction Rates of Isotopic Molecules by : Lars C. S. Melander

Download or read book Reaction Rates of Isotopic Molecules written by Lars C. S. Melander and published by . This book was released on 1987 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Isotope Effects In Chemistry and Biology

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Publisher : CRC Press
ISBN 13 : 1420028022
Total Pages : 1092 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Isotope Effects In Chemistry and Biology by : Amnon Kohen

Download or read book Isotope Effects In Chemistry and Biology written by Amnon Kohen and published by CRC Press. This book was released on 2005-11-01 with total page 1092 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biolo

Bibliography of Mass Spectroscopy Literature for 1971

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Author :
Publisher :
ISBN 13 :
Total Pages : 626 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Bibliography of Mass Spectroscopy Literature for 1971 by :

Download or read book Bibliography of Mass Spectroscopy Literature for 1971 written by and published by . This book was released on 1973 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Physical Organic Chemistry

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Publisher : Elsevier
ISBN 13 : 0080471862
Total Pages : 325 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Advances in Physical Organic Chemistry by :

Download or read book Advances in Physical Organic Chemistry written by and published by Elsevier. This book was released on 2004-10-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.

Chemical Kinetics

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Publisher : Elsevier
ISBN 13 : 0080469345
Total Pages : 563 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Chemical Kinetics by : Luis Arnaut

Download or read book Chemical Kinetics written by Luis Arnaut and published by Elsevier. This book was released on 2006-12-21 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Kinetics bridges the gap between beginner and specialist with a path that leads the reader from the phenomenological approach to the rates of chemical reactions to the state-of-the-art calculation of the rate constants of the most prevalent reactions: atom transfers, catalysis, proton transfers, substitution reactions, energy transfers and electron transfers. For the beginner provides the basics: the simplest concepts, the fundamental experiments, and the underlying theories. For the specialist shows where sophisticated experimental and theoretical methods combine to offer a panorama of time-dependent molecular phenomena connected by a new rational. Chemical Kinetics goes far beyond the qualitative description: with the guidance of theory, the path becomes a reaction path that can actually be inspected and calculated. But Chemical Kinetics is more about structure and reactivity than numbers and calculations. A great emphasis in the clarity of the concepts is achieved by illustrating all the theories and mechanisms with recent examples, some of them described with sufficient detail and simplicity to be used in general chemistry and lab courses.* Looking at atoms and molecules, and how molecular structures change with time. * Providing practical examples and detailed theoretical calculations* Of special interest to Industrial Chemistry and Biochemistry

Compound-specific Stable Isotope Analysis

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Publisher : Royal Society of Chemistry
ISBN 13 : 1782626107
Total Pages : 306 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Compound-specific Stable Isotope Analysis by : Maik A Jochmann

Download or read book Compound-specific Stable Isotope Analysis written by Maik A Jochmann and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of Compound-specific Stable Isotope Analysis (CSIA) is increasing in many areas of science and technology for source allocation, authentication, and characterization of transformation reactions. Until now, there have been no textbooks available for students with an analytical chemical background or basic introductory books emphasising the instrumentation and theory. This book is the first to focus solely on stable isotope analysis of individual compounds in sometimes complex mixtures. It acts as both a lecture companion for students and a consultant for advanced scientists in fields including forensic and environmental science. The book starts with a brief history of the field before going on to explain stable isotopes from scratch. The different ways to express isotope abundances are introduced together with isotope effects and isotopic fractionation. A detailed account of the required technical equipment and general procedures for CSIA is provided. This includes sections on derivatization and the use of microextraction techniques in GC-IRMS. The very important topic of referencing and calibration in CSIA is clearly described. This differs from approaches used in quantitative analysis and is often difficult for the newcomer to comprehend. Examples of successful applications of CSIA in food authenticity, forensics, archaeology, doping control, environmental science, and extraterrestrial materials are included. Applications in isotope data treatment and presentation are also discussed and emphasis is placed on the general conclusions that can be drawn from the uses of CSIA. Further instrumental developments in the field are highlighted and selected experiments are introduced that may act as a basis for a short practical course at graduate level.

Understanding Organometallic Reaction Mechanisms and Catalysis

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Publisher : John Wiley & Sons
ISBN 13 : 3527678220
Total Pages : 483 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Understanding Organometallic Reaction Mechanisms and Catalysis by : Valentin P. Ananikov

Download or read book Understanding Organometallic Reaction Mechanisms and Catalysis written by Valentin P. Ananikov and published by John Wiley & Sons. This book was released on 2014-08-29 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring and highlighting the new horizons in the studies of reaction mechanisms that open joint application of experimental studies and theoretical calculations is the goal of this book. The latest insights and developments in the mechanistic studies of organometallic reactions and catalytic processes are presented and reviewed. The book adopts a unique approach, exemplifying how to use experiments, spectroscopy measurements, and computational methods to reveal reaction pathways and molecular structures of catalysts, rather than concentrating solely on one discipline. The result is a deeper understanding of the underlying reaction mechanism and correlation between molecular structure and reactivity. The contributions represent a wealth of first-hand information from renowned experts working in these disciplines, covering such topics as activation of small molecules, C-C and C-Heteroatom bonds formation, cross-coupling reactions, carbon dioxide converison, homogeneous and heterogeneous transition metal catalysis and metal-graphene systems. With the knowledge gained, the reader will be able to improve existing reaction protocols and rationally design more efficient catalysts or selective reactions. An indispensable source of information for synthetic, analytical, and theoretical chemists in academia and industry.

Oxidation Mechanisms

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Publisher : New York : W.A. Benjamin
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.:/5 (43 download)

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Book Synopsis Oxidation Mechanisms by : Ross Stewart

Download or read book Oxidation Mechanisms written by Ross Stewart and published by New York : W.A. Benjamin. This book was released on 1964 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Organic Reaction Mechanisms 1990

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Publisher : John Wiley & Sons
ISBN 13 : 0470066857
Total Pages : 674 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Organic Reaction Mechanisms 1990 by : A. C. Knipe

Download or read book Organic Reaction Mechanisms 1990 written by A. C. Knipe and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only book series to summarize the latest progress on organic reaction mechanisms, Organic Reaction Mechanisms, 1990 surveys the development in understanding of the main classes of organic reaction mechanisms reported in the primary scientific literature in 1990. The 26th annual volume in this highly successful series highlights mechanisms of stereo-specific reactions. Reviews are compiled by a team of experienced editors and authors, allowing advanced undergraduates, graduate students, postdocs, and chemists to rely on the volume's continuing quality of selection and presentation.

Isotope Effects

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Publisher : Springer Science & Business Media
ISBN 13 : 9048122651
Total Pages : 477 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Isotope Effects by : Max Wolfsberg

Download or read book Isotope Effects written by Max Wolfsberg and published by Springer Science & Business Media. This book was released on 2009-12-15 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the title suggests, Isotope Effects in the Chemical, Geological and Bio Sciences deals with differences in the properties of isotopically substituted molecules, such as differences in the chemical and physical properties of water and the heavy waters. Since the various fields in which isotope effects are applied do not only share fundamental principles but also experimental techniques, this book includes a discussion of experimental apparatus and experimental techniques. Isotope Effects in the Chemical, Geological and Bio Sciences is an educational monograph addressed to graduate students and others undertaking isotope effect research. The fundamental principles needed to understand isotope effects are presented in appropriate detail. While it is true that these principles are more familiar to students of physical chemistry and some background in physical chemistry is recommended, the text provides enough detail to make the book an asset to students in organic and biochemistry, and geochemistry.

Measurement and Analysis of Kinetic Isotope Effects

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Author :
Publisher : Academic Press
ISBN 13 : 0128122749
Total Pages : 634 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Measurement and Analysis of Kinetic Isotope Effects by :

Download or read book Measurement and Analysis of Kinetic Isotope Effects written by and published by Academic Press. This book was released on 2017-09-12 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions. Written by pioneers of modern isotope effect research Is the only collection of modern kinetic isotope effect methods currently available

Chemical Thermodynamics of Zirconium

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Author :
Publisher : Elsevier
ISBN 13 : 0080457533
Total Pages : 545 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Chemical Thermodynamics of Zirconium by :

Download or read book Chemical Thermodynamics of Zirconium written by and published by Elsevier. This book was released on 2005-12-06 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is part of the series on "Chemical Thermodynamics", published under the aegis of the OECD Nuclear Energy Agency. It contains a critical review of the literature on thermodynamic data for inorganic compounds of zirconium. A review team, composed of five internationally recognized experts, has critically reviewed all the scientific literature containing chemical thermodynamic information for the above mentioned systems. The results of this critical review carried out following the Guidelines of the OECD NEA Thermochemical Database Project have been documented in the present volume, which contains tables of selected values for formation and reaction thermodynamical properties and an extensive bibliography.* Critical review of all literature on chemical thermodynamics for compounds and complexes of Zr.* Tables of recommended Selected Values for thermochemical properties* Documented review procedure* Exhaustive bibliography* Intended to meet requirements of radioactive waste management community* Valuable reference source for the physical, analytical and environmental chemist.