Prevention of CLA-induced Insulin Resistance and Nonalcoholic Fatty Liver Disease by Docosahexaenoic Acid in Mice

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ISBN 13 : 9781303442483
Total Pages : pages
Book Rating : 4.4/5 (424 download)

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Book Synopsis Prevention of CLA-induced Insulin Resistance and Nonalcoholic Fatty Liver Disease by Docosahexaenoic Acid in Mice by : Dawn Fedor

Download or read book Prevention of CLA-induced Insulin Resistance and Nonalcoholic Fatty Liver Disease by Docosahexaenoic Acid in Mice written by Dawn Fedor and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin resistance (IR) is a condition in which normal amounts of insulin fail to maintain normal blood glucose because of decreased responsiveness of muscle (glucose uptake), liver (inhibition of gluconeogenesis) and adipocytes (inhibition of lipolysis). IR is often associated with nonalcoholic fatty liver disease (NAFLD), the most common liver disease in adults and children in the Western world. Results from human epidemiological studies indicate that n-3 PUFA reduce the development of IR and NAFLD although the mechanisms involved are poorly understood. Our lab previously showed that concomitant supplementation of 1.5% docosahexaenoic acid (22:6 n-3; DHA) with 0.5% t10, c12- conjugated linoleic acid (18:2 n-6; CLA) prevented the CLA-induced NAFLD and IR. The effective dose of DHA, the mechanisms involved and the effect of CLA on fatty acid compositions of adipose tissue and muscle, and whether DHA can prevent those CLA-induced changes in fatty acid composition is not known. In the first study, we examined the ability of DHA (0.5 and 1.5%) to prevent increases in NAFLD and homeostatic model assessment of insulin resistance (HOMA-IR) induced by CLA (0.5%) when fed concomitantly for 4 weeks to C57BL/6N female mice. We also examined changes in expression of hepatic genes involved in fatty acid synthesis and oxidation. CLA supplementation increased liver triglycerides (TG) and HOMA-IR by 221 and 547%, respectively, and decreased mass of adipose depots by 65-90%. When fed concomitantly, 0.5% and 1.5% DHA prevented CLA-induced increases in liver TG and circulating insulin with varying efficiency, but neither dose of DHA prevented the loss in adipose tissue mass. In CLA + DHA 0.5 % group the liver TG did not differ from those in the control group, but circulating insulin and HOMA-IR were 285 and 264 %, respectively, greater than those in the control group. In the CLA + DHA 1.5% group liver TG were 54% lower than those in the control group, but circulating insulin concentration and HOMA-IR did not differ between these two groups. CLA increased the expression of hepatic genes involved in fatty acid synthesis and decreased the expression of genes involved in fatty acid oxidation. 1.5% DHA prevented changes in the expression of hepatic genes caused by CLA, which may be a possible mechanism contributing to the prevention of TG accumulating in the liver. Based on these results, we further studied the 1.5% DHA diet. We investigated the effects of 1.5% DHA concomitantly fed with CLA on fatty acid compositions of liver, adipose, and muscle lipids in the same mice, as well as expression of genes involved in adipose fatty acid metabolism. CLA supplementation decreased total hepatic n-3 PUFA concentration. DHA not only prevented the CLA-induced changes in liver fat, but also increased n-3 PUFA by >350% as compared with the control group. CLA decreased adipose weight and the expression of genes involved in fatty acid synthesis, oxidation, and uptake, and increased that of UCP2 in the adipose. Supplementing DHA along with CLA increased adipose n-3 PUFA by >1000% compared with control group, but did not prevent the CLA-induced changes in mass or gene expression. Both CLA and DHA were incorporated into muscle lipids, but had minor effects on FA composition. In conclusion, liver, adipose tissue, and muscle responded differently to CLA and DHA supplementation. CLA was more potent than DHA in altering depot fat and insulin concentration. DHA prevented CLA-induced increase in liver fat but not loss of adipose mass. CLA and DHA were preferentially incorporated into adipose tissue lipids, but they had only modest effects on the overall fatty acid composition of the adipose tissue. The largest changes in fatty acid composition were seen in the liver and smallest in muscle lipids.

Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity

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ISBN 13 : 9780549000204
Total Pages : 216 pages
Book Rating : 4.0/5 (2 download)

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Book Synopsis Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity by : Angela Ann Wendel

Download or read book Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity written by Angela Ann Wendel and published by . This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The significant depletion of adipose in mice by CLA may contribute to the lipodystrophic-like effects that accompany. The final objective of this research was to determine mechanisms by which CLA reduces adipose mass. Six-week old, male ob/ob mice were fed either a control diet (CON) or a diet supplemented with 1.5% mixed isomer CLA (CLA) for 4 weeks. A third group of mice (LEPTIN) were fed the control diet and received daily, intraperitoneal injections of 1 mg/kg BW recombinant leptin as a positive control for adipose depletion in ob/ob mice. The depletion of adipose tissue by CLA was accompanied by the acquirement of brown adipose-like characteristics, such as increased CPT-1b, PGC-1alpha, and UCP-1, in the white adipose of CLA-fed mice. This alteration may facilitate the reduction of adipose mass by increasing mitochondrial oxidation and energy dissipation. However, it appears that CLA does not increase UCP-1 through beta3AR signaling.

Agricultural Research

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Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Agricultural Research by :

Download or read book Agricultural Research written by and published by . This book was released on 2010 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism

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Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (184 download)

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Book Synopsis Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism by : Amy Dianne Noto

Download or read book Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism written by Amy Dianne Noto and published by . This book was released on 2005 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA)

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ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (919 download)

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Book Synopsis Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA) by : Wan Shen

Download or read book Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA) written by Wan Shen and published by . This book was released on 2015 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Overweight and obesity are the most widespread nutritional diseases in the U.S., which greatly increase chronic disease risks and mortality. Therefore, it is urgent to develop a relatively efficacious and safe strategy for the weight management. Consumption of conjugated linoleic acid (CLA) supplements or one of its isomers, trans-10, cis-12 (10,12) CLA, has consistently demonstrated reductions in body weight or body fat in human and animal studies. Our lab has demonstrated that 10,12 CLA triggered calcium release from endoplasmic reticulum in human primary adipocytes, which activated downstream inflammatory signaling, resulting in impaired uptake of glucose and fatty acid, and delipidation. However, the upstream signals responsible for these actions are unknown. Therefore, my Aim 1 investigated the upstream mechanism by which 10,12 CLA increases intracellular calcium and inflammatory signaling in human primary adipocytes. The results indicated that phospholipase C plays an important role in 10,12 CLA-mediated activation of intracellular calcium accumulation, inflammatory signaling, delipidation, and insulin resistance in human primary adipocytes. It has been demonstrated that 10,12 CLA increased mRNA levels and protein levels of cyclooxygenase-2 (COX-2) and pro-inflammatory prostaglandins, which have been linked to increased energy expenditure associated with white adipose tissue (WAT) browning and uncoupling of ATP synthesis. It also has been shown that relatively high doses of 10,12 CLA lead to more significant reductions in body fat, but cause a greater level of inflammation, insulin resistance, and steatosis in animals. Therefore, Aims 2 and Aim 3 determined the extent to which a relative low dose of 10,12 CLA or a CLA isomer mixture increases markers of browning in mice and its dependence in inflammatory signaling. In Aim 2, a low threshold dose of 10,12 CLA was found that prevented body fat accumulation with minimum metabolic side-effects in non-obese mice. It was also found that 10,12 CLA-induced browning in WAT was accompanied by increases in mRNA levels of COX-2 and other markers of inflammation. In Aim 3, a relatively low dose of 10,12 CLA reduced body fat and increased browning of WAT in overweight mice, which were independent of inflammatory signaling. Collectively, these findings provide critical insights for the development of reliable dietary strategies for people who take CLA as method to lose weight. However, we still do not know (i) if 10,12 CLA supplementation would effectively reduce body fat in overweight mice when they are continuously fed an American-type, high-fat diet; (ii) potential risks of impaired regulation of body temperature, inflammation, and steatosis due to 10,12 CLA consumption in high fat-fed mice; and (iii) potential mechanisms by which 10,12 CLA reduces body fat in high fat-fed mice."--Abstract from author supplied metadata.

Hepatic Insulin Resistance and Nonalcoholic Fatty Liver Disease

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ISBN 13 : 9781536111712
Total Pages : 85 pages
Book Rating : 4.1/5 (117 download)

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Book Synopsis Hepatic Insulin Resistance and Nonalcoholic Fatty Liver Disease by :

Download or read book Hepatic Insulin Resistance and Nonalcoholic Fatty Liver Disease written by and published by . This book was released on 2011 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Modern Dietary Fat Intakes in Disease Promotion

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Publisher : Springer Science & Business Media
ISBN 13 : 1603275711
Total Pages : 475 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Modern Dietary Fat Intakes in Disease Promotion by : Fabien De Meester

Download or read book Modern Dietary Fat Intakes in Disease Promotion written by Fabien De Meester and published by Springer Science & Business Media. This book was released on 2010-06-07 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nutrition and Health series of books have had great success because each volume has the consistent overriding mission of providing health professionals with texts that are essential because each includes (1) a synthesis of the state of the science, (2) timely, in-depth reviews by the leading researchers in their respective ?elds, (3) extensive, up-to-date fully annotated ref- ence lists, (4) a detailed index, (5) relevant tables and ?gures, (6) identi?cation of paradigm shifts and the consequences, (7) virtually no overlap of information between chapters, but targeted, inter-chapter referrals, (8) suggestions of areas for future research, and (9) balanced, data-driven answers to patient as well as health professionals questions which are based upon the totality of evidence rather than the ?ndings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter and in the choice of chapter authors. The editor(s), whose training(s) is (are) both research and practice oriented, has(ve) the opportunity to develop a primary objective for their book, de?ne the scope and focus, and then invite the leading authorities to be part of their initiative. The authors are encouraged to provide an overview of the ?eld, discuss their own research, and relate the research ?ndings to potential human health consequences.

Effects of Imidacloprid in the Development of Non-Alcoholic Fatty Liver Disease and the Effects of Exercise Training

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Effects of Imidacloprid in the Development of Non-Alcoholic Fatty Liver Disease and the Effects of Exercise Training by : Gabriel Jolin-Rodrigue

Download or read book Effects of Imidacloprid in the Development of Non-Alcoholic Fatty Liver Disease and the Effects of Exercise Training written by Gabriel Jolin-Rodrigue and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in developed countries with an estimated prevalence of 20 to 30% in the American population. A typically benign and asymptomatic pathology, NAFLD is characterized by hepatic steatosis and abnormal levels of hepatic enzymes stemming from an increase in circulating free fatty acids originating from white adipose tissue lipolysis, an increased de novo lipogenesis, reduced fatty acid oxidation and decreased hepatic triglycerides secretion, all within an insulin resistance context. NAFLD has the potential to progress to the non-alcoholic steatohepatitis (NASH), a condition marked by inflammation, advanced oxidative stress and fibrosis. NASH is expected to be the leading cause of liver transplant by 2020 due to its complications (i.e.: cirrhosis, hepatocellular carcinoma and liver failure). Various xenobiotics such as pesticides have been shown to promote the apparition and development of NAFLD. Of interest to this study is the neonicotinoid imidacloprid, more contemporarily known for its suspected role in the colony collapse disorder of various anthophilae species. Imidacloprid has been shown to induce hepatic oxidative stress in rats, a significant factor in the development of NAFLD and its progression to NASH. Lifestyle modifications, namely physical exercise, is a current treatment which has been proven beneficial to prevent and treat NAFLD by reducing hepatic steatosis, oxidative stress and improving insulin sensitivity. The role of any neonicotinoid on the development of NAFLD has yet to be examine and few have looked at the role of exercise in the treatment of NAFLD brought about by pesticide contamination.

Nutrition in the Prevention and Treatment of Abdominal Obesity

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Publisher : Elsevier
ISBN 13 : 0124079342
Total Pages : 559 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Nutrition in the Prevention and Treatment of Abdominal Obesity by : Ronald Ross Watson

Download or read book Nutrition in the Prevention and Treatment of Abdominal Obesity written by Ronald Ross Watson and published by Elsevier. This book was released on 2014-02-26 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition in the Prevention and Treatment of Abdominal Obesity focuses on the important roles that exercise, dietary changes, and foods play in promoting as well as reducing visceral fat. Nutritionists, dieticians, and healthcare providers seeking to address the abdominal obesity epidemic will use this comprehensive resource as a tool in their long-term goal of preventing chronic diseases, especially heart, vascular, and diabetic diseases. Experts from a broad range of disciplines are involved in dealing with the consequences of excessive abdominal fat: cardiology, diabetes research, studies of lipids, endocrinology and metabolism, nutrition, obesity, and exercise physiology. They have contributed chapters that define a range of dietary approaches to reducing risk and associated chronic diseases. They begin by defining visceral obesity and its major outcomes; they also discuss the importance and the challenges of dietary approaches to reduce abdominal obesity, as compared to clinical approaches, with major costs and risks. Offers detailed, well-documented reviews outlining the various dietary approaches to visceral obesity with their benefits and failures Includes chapters on types of foods, exercise, and supplements in reducing obesity and its chronic clinical companions, especially diabetes and cardiovascular disease Helps nutritionists, dieticians, and healthcare providers approach patients in making decision about nutritional therapies and clinical treatments for abdominal obesity, from an evidence-based perspective

Effects of Vagotomy and Fenugreek on Hyperlipidemia and Insulin Resistance

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ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis Effects of Vagotomy and Fenugreek on Hyperlipidemia and Insulin Resistance by : Rituraj Khound

Download or read book Effects of Vagotomy and Fenugreek on Hyperlipidemia and Insulin Resistance written by Rituraj Khound and published by . This book was released on 2017 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyperlipidemia is the impairment of lipid metabolism marked by abnormally high levels of lipid in circulation. This has been implicated in a number of metabolic diseases including diabetes, cardiovascular diseases, and nonalcoholic fatty liver disease. Insulin resistance is the impairment of insulin action, which leads to several diseases such as obesity and type 2 diabetes. New clinical and therapeutic approaches are warranted for the prevention and treatment of hyperlipidemia and insulin resistance. In our study, we investigated the mechanism underlying the effect of complete disruption of the sub-diaphragmatic vagus nerve (vagotomy) on hyperlipidemia and insulin sensitivity. We observed that vagotomy significantly reduced the fasting and postprandial TG levels and VLDL synthesis. Vagotomy also resulted in elevated circulatory GLP-1 levels which possibly led to reductions in de novo fatty acid synthesis and VLDL production. This surgical procedure also found to ameliorate HFD-induced hyperlipidemia and hepatic steatosis. Significant improvement in insulin sensitivity was also observed in vagotomized mice. We also studied the effect of fenugreek seeds on hyperlipidemia using CREBH-null mouse model. We observed that consumption of fenugreek and treatment with trigonelline, a bioactive compound derived from fenugreek, ameliorated induced hyperlipidemia by upregulating transcription of Insig proteins, preventing VLDL synthesis and enhancing fatty acid oxidation. These findings rationalize the use of vagotomy as an effective clinical procedure to treat obesity and diabetes. The study also substantiates the prospect of using fenugreek as a potent nutraceutical in the treatment of metabolic diseases..

Bioactive Lipids

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Publisher : Academic Press
ISBN 13 : 0128241748
Total Pages : 434 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Bioactive Lipids by : Manuela Pintado

Download or read book Bioactive Lipids written by Manuela Pintado and published by Academic Press. This book was released on 2022-09-14 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Lipids presents the topic of bioactive lipids from a functional food development perspective. This book explores the potential of dietary lipids to understand how such bioactive compounds can be used in the development of functional foods and nutraceuticals. The book includes case studies to enable readers to understand the potential of several dietary lipids and the possibilities regarding their incorporation into several food matrices. Bioactive Lipids will be a welcome reference for researchers, lecturers and students from the food science and nutrition fields. Reviews the health benefits of several lipids and dietary sources, providing bioactive targets for therapeutic purposes Provides readers with tools for the development of new lines of research and for supporting ongoing investigations Includes case studies to present solutions for bioactive lipids incorporation into food matrices, and consequently to functional foods and nutraceuticals development

Nutrition Abstracts and Reviews

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ISBN 13 :
Total Pages : 744 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Nutrition Abstracts and Reviews by :

Download or read book Nutrition Abstracts and Reviews written by and published by . This book was released on 2006 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Free Fatty Acid Receptors

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Publisher : Springer
ISBN 13 : 3319506935
Total Pages : 258 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Free Fatty Acid Receptors by : Graeme Milligan

Download or read book Free Fatty Acid Receptors written by Graeme Milligan and published by Springer. This book was released on 2017-02-08 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

Pathophysiology of Obesity-Induced Health Complications

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Publisher : Springer Nature
ISBN 13 : 3030353583
Total Pages : 348 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Pathophysiology of Obesity-Induced Health Complications by : Paramjit S. Tappia

Download or read book Pathophysiology of Obesity-Induced Health Complications written by Paramjit S. Tappia and published by Springer Nature. This book was released on 2020-01-17 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​According to the World Health Organization, the epidemic of global obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults were overweight, over 650 million of which were obese. Being overweight and obese has been linked to a number of non-communicable, chronic diseases. Pathophysiology of Obesity-Induced Health Complications is a compilation of review articles dedicated to describe co-morbidities associated with obesity. The wide range that is covered is of significant interest to basic research scientists, clinicians and graduate students who are engaged in studying obesity-induced health complications. Furthermore, this book highlights the potential of novel approaches for the prevention and treatment of obesity and its related illnesses. Nineteen articles in this book are organized in four sections that are designed to provide an overview of obesity-induced health complications. The first section serves as an introductory section on the prevalence, causes, consequences, treatments and preventive approaches for obesity. Section two covers the metabolic disturbances and inflammation due to obesity. The third section is focused on neurological and visceral complications as a consequence of obesity. The final section covers strategies for the prevention of obesity-induced complications. The book illustrates that obesity can result in a diverse range of pathophysiological conditions that adversely affect health.

Nutrients in Dairy and Their Implications for Health and Disease

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Publisher : Academic Press
ISBN 13 : 0128097639
Total Pages : 492 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Nutrients in Dairy and Their Implications for Health and Disease by : Ronald Ross Watson

Download or read book Nutrients in Dairy and Their Implications for Health and Disease written by Ronald Ross Watson and published by Academic Press. This book was released on 2017-06-19 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrients in Dairy and Their Implications for Health and Disease addresses various dairy products and their impact on health. This comprehensive book is divided into three sections and presents a balanced overview of the health benefits of milk and milk products. Summaries capture the most salient points of each chapter, and the importance of milk and its products as functional foods is addressed throughout. Presents various dairy products and their impact on health Provides information on dairy milk as an important source of micro-and macronutrients that impact body functions Addresses dietary supplements and their incorporation into dairy products

Nordic Nutrition Recommendations 2012

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Publisher : Nordic Council of Ministers
ISBN 13 : 9289326719
Total Pages : 544 pages
Book Rating : 4.2/5 (893 download)

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Book Synopsis Nordic Nutrition Recommendations 2012 by : Nordic Council of Ministers

Download or read book Nordic Nutrition Recommendations 2012 written by Nordic Council of Ministers and published by Nordic Council of Ministers. This book was released on 2014-03-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nordic countries have collaborated in setting guidelines for dietary composition and recommended intakes of nutrients for several decades through the joint publication of the Nordic Nutrition Recommendations (NNR). This 5th edition, the NNR 2012, gives Dietary Reference Values (DRVs) for nutrients, and compared with earlier editions more emphasis has been put on evaluating the scientific evidence for the role of food and food patterns contributing to the prevention of the major diet-related chronic diseases. Recommendations on physical activity are included and interaction with physical activity has been taken into account for the individual nutrient recommendations wherever appropriate. A chapter on sustainable food consumption has been added. A Nordic perspective has been accounted for in setting the reference values.The NNR 2012 has used an evidence-based and transparent approach in assessing associations between nutrients and foods and certain health outcomes. Systematic reviews form the basis for the recommendations of several nutrients and topics, while a less stringent update has been done for others. The systematic reviews and individual chapters have been peer reviewed and the systematic reviews are published in the Food & Nutrition Research journal. The draft chapters were subject to an open public consultation. Recommendations have been changed only when sufficient scientific evidence has evolved since the 4th edition. The primary aim of the NNR 2012 is to present the scientific background of the recommendations and their application. A secondary aim is for the NNR 2012 to function as a basis for the national recommendations that are adopted by the individual

Functional Foods and Nutraceuticals

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Publisher : Springer Science & Business Media
ISBN 13 : 1461434807
Total Pages : 163 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Functional Foods and Nutraceuticals by : Rotimi E. Aluko

Download or read book Functional Foods and Nutraceuticals written by Rotimi E. Aluko and published by Springer Science & Business Media. This book was released on 2012-06-05 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Functional food or medicinal food is any fresh or processed food claimed to have a health-promoting and/or disease-preventing property beyond the basic nutritional function of supplying nutrients, although there is no consensus on an exact definition of the term. This is an emerging field in food science, in which such foods are usually accompanied by health claims for marketing purposes, such as a company's ‘cereal is a significant source of fiber. Studies have shown that an increased amount of fiber in one's diet can decrease the risk of certain types of cancer in individuals.’ Functional foods are sometimes called nutraceuticals, a portmanteau of nutrition and pharmaceutical, and can include food that has been genetically modified. The general category includes processed food made from functional food ingredients, or fortified with health-promoting additives, like "vitamin-enriched" products, and also fresh foods (e.g., vegetables) that have specific claims attached. Fermented foods with live cultures are often also considered to be functional foods with probiotic benefits."