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Preparation Characterization And Intracellular Targeting Of Biomolecule Gold Nanoparticle Complexes
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Book Synopsis Preparation, Characterization and Intracellular Targeting of Biomolecule-gold Nanoparticle Complexes by : Huan Xie
Download or read book Preparation, Characterization and Intracellular Targeting of Biomolecule-gold Nanoparticle Complexes written by Huan Xie and published by . This book was released on 2004 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: gold nanoparticle, intracellular targeting, peptide, streptavidin, BSA, oligonucleotide.
Book Synopsis Preparation, Characterization and Intracellular Targeting of Biomolecule-Gold Nanoparticle Complexes by :
Download or read book Preparation, Characterization and Intracellular Targeting of Biomolecule-Gold Nanoparticle Complexes written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation described preparation, characterization and intracellular localization of peptide-modified gold nanoparticles as multifunctional nuclear targeting vectors. The vectors have the potential advantages for intracellular diagnostics and therapeutic delivery. Gold nanoparticles were used in this study as carriers to combine multiple-functional cell-translocating peptides and antisense oligonucleotides. Two proteins, bovine serum albumin (BSA) and streptavidin (SA), have been systematically studied for crosslinking peptides or oligonucleotides with gold nanoparticles. Protocols for modifying gold nanoparticles with BSA-peptide conjugates are described within. The resulting constructs were characterized using a number of techniques including UV-visible absorbance spectroscopy and fluorescence spectroscopy in order to quantify peptide-BSA binding isotherms, exchange rates, critical flocculation concentrations, and the composition of mixed peptide-BSA monolayers on gold nanoparticles. The abilities of BSA-peptide/gold complexes to target the nucleus of several cell lines (HeLa, 3T3-NIH and HepG2) were explored. Four peptide/nanoparticle complexes were investigated, particles modified with the adenovirus nuclear localization signal (NLS), the adenovirus receptor-mediated endocytosis (RME) peptide, the adenovirus fiber containing the RME and NLS and the NLS for SV 40. The translocation of the gold nanoparticles was identified by video-enhanced color differential interference contrast (VEC-DIC) microscopy. The strong affinity between SA and biotin was employed to conjugate SA with biotinylated peptide and oligonucleotide. Systematical studies have been done to characterize the complexes, including SA adsorption on nanoparticles, biotinylated DNA adsorption on SA-coated nanoparticles, stabilities in solution, exchange rate in cell growth media and the composition of mixed SA-biotin peptide and SA-biotin DNA monolayers on gold nanoparticles. VEC-DIC microscopy ch.
Book Synopsis Gold Nanoparticles by : Mohammed Muzibur Rahman
Download or read book Gold Nanoparticles written by Mohammed Muzibur Rahman and published by BoD – Books on Demand. This book was released on 2019-02-13 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold Nanoparticles - Reaching New Heights contains recent research on the preparation, characterization, fabrication, and potential of optical and biological applications of gold nanoparticles (AuNPs). It is promising novel research that has received a lot of interest over the last few decades. It covers advanced topics on optical, physical, medicinal, and biological applications of AuNPs. Development of green nanotechnology is generating the interest of researchers towards the synthesis of eco-friendly, safe, non-toxic applications, which can be used for manufacture at a large scale. These are simple, cost-effective, stable, enduring, and reproducible aqueous room temperature synthesis applications to obtain the self-assembly of AuNPs. This potentially unique work offers various approaches to R
Book Synopsis Gold Nanoparticles For Physics, Chemistry And Biology (Second Edition) by : Catherine Louis
Download or read book Gold Nanoparticles For Physics, Chemistry And Biology (Second Edition) written by Catherine Louis and published by World Scientific. This book was released on 2017-06-02 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold Nanoparticles for Physics, Chemistry and Biology offers an overview of recent research into gold nanoparticles, covering their discovery, usage and contemporary practical applications.This Second Edition begins with a history of over 2000 years of the use of gold nanoparticles, with a review of the specific properties which make gold unique. Updated chapters include gold nanoparticle preparation methods, their plasmon resonance and thermo-optical properties, their catalytic properties and their future technological applications. New chapters have been included, and reveal the growing impact of plasmonics in research, with an introduction to quantum plasmonics, plasmon assisted catalysis and electro-photon conversion. The growing field of nanoparticles for health is also addressed with a study of gold nanoparticles as radiosensibiliser for radiotherapy, and of gold nanoparticle functionalisation. This new edition also considers the relevance of bimetallic nanoparticles for specific applications.World-class scientists provide the most up-to-date findings for an introduction to gold nanoparticles within the related areas of chemistry, biology, material science, optics and physics. It is perfectly suited to advanced level students and researchers looking to enhance their knowledge in the study of gold nanoparticles.
Book Synopsis Advanced Synthesis of Gold and Zirconia Nanoparticles and Their Characterization by : Stephan Dankesreiter
Download or read book Advanced Synthesis of Gold and Zirconia Nanoparticles and Their Characterization written by Stephan Dankesreiter and published by Diplomica Verlag. This book was released on 2011 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of small and smallest particle is one of today's key features in modern science. The goal is to form materials with improved properties than their "classical" ancestors with just a fractional amount of raw material. However, the characterization of these particles is as important as their way of preparation. Different techniques with their origins in physics, inorganic, organic and physical chemistry have to be combined to reveal the secrets of this important field of science. This book gives a short overview of theoretical basics and synthesis methods to form and characterize gold and zirconia nanoparticles. Phenomenon like plasmon resonance self-assembly of surfactants and the different structures of ZnO2 are explained. Furthermore, analytical tools, like small angle X-ray scattering, X-ray powder diffraction and scanning electron microscopy are introduced. In addition, details on the synthesis of gold and zirconia nanoparticles are presented and are examined by the mentioned analytical and calorimetric methods.
Book Synopsis Gold Nanoparticles for Biomedical Applications by : Kattesh V. Katti
Download or read book Gold Nanoparticles for Biomedical Applications written by Kattesh V. Katti and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocompatible gold nanoparticles have gained considerable attention in recent years for potential applications in nanomedicine due to their interesting size dependent chemical, electronic and optical properties. In particular, the prospective use of gold nanoparticles as contrast enhancement agents in X-ray Computed Tomography (CT) and Photo Acoustic Tomography for early diagnosis of specific tumors is being extensively researched. Additionally, gold nanoparticles show promise in enhancing the effectiveness of various targeted cancer treatments such as radiotherapy and photothermal therapy. For these applications, biocompatible gold nanoparticles labeled with specific tumor targeting biomolecules are needed for site specific delivery. In the present project, gold nanoparticles stabilized and labeled with carbohydrate (starch) and glycoprotein (gum arabic) have been generated, characterized and tested for in vitro and in vivo stability. They are found to localize in specific tissues in the animal models. Additionally, gold nanoparticles labeled with a cancer seeking peptide, bombesin, exhibited excellent binding affinity towards prostate and breast cancer cells. The degree of contrast enhancement in cancer imaging or effectiveness of cancer treatments is limited by the number of nanoparticles that can be localized at the target tumor/cancer site. One way to augment the localization of nanoparticles at the target tissue is to utilize gold nanochains that hold more number of nanoparticles. Therefore, we developed biocompatible gold nanochains formed by self assembly of nanoparticles on gum arabic and they were shown to be in vitro stable. The change of optical properties of gold nanoparticles upon slight modification of the surrounding environment is the basis for the development of biosensors. Therefore, Surface Enhanced Raman Scattering (SERS), a spectroscopic method where the Raman scattering signal, which is sensitive to the molecular structure, is enhanced in the presence of gold nanoparticles has emerged as a powerful tool for the detection of specific molecules. Consequently, there is need for nanostructures that give maximum SERS signal. In the present project, gold nanoparticles set in agarose gel have been demonstrated to be excellent SERS substrates compared to commercially available gold nanoparticles for DNA nucleosides.
Download or read book Cat's Away written by and published by . This book was released on 1850* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nanoparticles in Biology and Medicine by : Mikhail Soloviev
Download or read book Nanoparticles in Biology and Medicine written by Mikhail Soloviev and published by Methods in Molecular Biology. This book was released on 2012-07-13 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern fascination with micro- and nano-sized materials can actually be traced back further to the 1960s and ‘70s when the first few reported attempts were made to use nanoparticles for controlled drug delivery. In Nanoparticles in Biology and Medicine: Methods and Protocols, experts in the field present a wide range of methods for synthesis, surface modification, characterization, and application of nano-sized materials (nanoparticles) in life science and medical fields, mostly for drug delivery. The methods presented cover all stages of nanoparticle manufacturing, modification, analysis, and applications. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Nanoparticles in Biology and Medicine: Methods and Protocols will help the beginner become familiar with this fascinating field and will provide scientists at all levels of expertise with easy-to-follow practical advice needed to make, modify, and analyze nanoparticles of their choice and to use them in a wide range of biomedical and pharmaceutical applications, including functional protein studies, drug delivery, immunochemistry, imaging, and many others.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2007 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bioconjugate Techniques by : Greg T. Hermanson
Download or read book Bioconjugate Techniques written by Greg T. Hermanson and published by Academic Press. This book was released on 2010-07-26 with total page 1233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions
Book Synopsis Gold Nanoparticles in Analytical Chemistry by :
Download or read book Gold Nanoparticles in Analytical Chemistry written by and published by Elsevier. This book was released on 2014-10-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical nanoscience and nanotechnology is a growing topic that is expected to have a great impact in the field of analytical chemistry. Many of the exceptional properties of gold nanoparticles make them suitable for different analytical applications and these applications allow extrapolations for their use in other fields as well. In analytical chemistry gold nanoparticles play two main roles, namely: i) As target analytes in the realm of the analysis of the nanoworld; and ii) As tools to improve analytical processes, such as the use of gold nanoparticles as components of electrodes, in spectroscopic techniques and (bio)chemical sensors and lateral flow sensors. This book is a comprehensive review of the role of gold nanoparticles in analytical nanoscience and nanotechnology, with chapters devoted to their synthesis, physico-chemical characteristics, derivatization and potential toxicity. The main microscopic, spectroscopic and separation techniques for the characterization are reviewed as well as the developments for their determination in environmental, biological and agrifood samples.
Download or read book Gold Nanoparticles written by P. E. Chow and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to their attractive electronic, optical, and thermal properties; gold nanoparticles (AuNPs) have emerged with great interest, as well as catalytic properties, in the fields of physics, chemistry, biology, medicine, material science and some interdisciplinary fields. This book examines a broad range of applications of gold nanoparticles such as: gold nanoparticles as an antigen carrier and as an adjuvant; laser synthesis of gold nanoparticles and the control over their properties; gold on carbon catalysts; gold nanoparticles as a delivery vehicle in biomedical applications; solution and solid-state methods to prepare Au nanoparticles; gold nanoparticles and their in-vitro property, the usefulness of gold nanoparticles in emerging infectious disease situations and a host of others.
Book Synopsis Gold Nanoparticles by : Abagail Jarnagin
Download or read book Gold Nanoparticles written by Abagail Jarnagin and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the authors present current research in the study of the synthesis, optical properties and applications for cancer treatment of gold nanoparticles. Topics discussed include the use of gold nanoparticles in cancer treatment and biomedical applications to target tumors and provide detection, drug carriers, gene silencing and radiotherapy; gold nanoparticle fabrication by laser ablation technique and their optical and morphological study; gold nanoparticles for metabolite imaging; formation of gold nanoparticles inside the corona of amphiphilic triblock copolymer micelles; and the intracellular delivery of gold nanoparticles and their application in nanomedicine.
Book Synopsis Superparamagnetic Au-Fe3O4 Nanoparticles: One-pot Synthesis, Biofunctionalization and Toxicity Evaluation by : Akshay Pariti
Download or read book Superparamagnetic Au-Fe3O4 Nanoparticles: One-pot Synthesis, Biofunctionalization and Toxicity Evaluation written by Akshay Pariti and published by . This book was released on 2014 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This thesis study focuses on synthesizing and characterizing gold-magnetite optically active magnetic nanoparticle and its conjugation with biomolecules for biomedical applications, especially magnetic fluid hyperthermia treatment for cancerous tissue. Gold nanoparticles have already displayed their potential in the biomedical field. They exhibit excellent optical properties and possess strong surface chemistry which renders them suitable for various biomolecule attachments. Studies have showed gold nanoparticles to be a perfect biocompatible vector. However, clinical trials for gold mediated drug delivery and treatment studied in rat models identified some problems. Of these problems, the low retention time in bloodstream and inability to maneuver externally has been the consequential. To further enhance their potential applications and overcome the problems faced in using gold nanoparticles alone, many researchers have synthesized multifunctional magnetic materials with gold at one terminal. Magnetite, among the investigated magnetic materials is a promising and reliable candidate because of its high magnetic saturation moment and low toxicity. This thesis showcases a simple and facile one pot synthesis of gold-magnetite nanoparticles with an average particle size of 80 nm through hot injection method. The as-synthesized nanoparticles were characterized by XRD, TEM, Mössbauer spectroscopy, SQUID and MTS toxicity studies. The superparamagnetism of the as-synthesized nanoparticles has an interestingly high saturation magnetization moment and low toxicity than the literature values reported earlier. L-cysteine and ( - )-EGCG (epigallacatechin-3-gallate) were attached to this multifunctional nanoparticles through the gold terminal and characterized to show the particles applicability through Raman, FTIR and UV-Vis spectroscopy."--Abstract, page iv.
Book Synopsis Characterization of the Conjugation of Gold Nanoparticles with Biomolecules for Use as Bioanalytical Probe by : Nuri Tchah
Download or read book Characterization of the Conjugation of Gold Nanoparticles with Biomolecules for Use as Bioanalytical Probe written by Nuri Tchah and published by . This book was released on 2012 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis, Characterization, and Biological Evaluation of DNA-targeted Gold(I) Complexes by : Lauren Christine Eiter
Download or read book Synthesis, Characterization, and Biological Evaluation of DNA-targeted Gold(I) Complexes written by Lauren Christine Eiter and published by . This book was released on 2007 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gold Nanoparticles written by Xiong Liu and published by . This book was released on 2009 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation presents a systematic study on gold nanoparticles: from their chemical synthesis, modification of surface functionalities, optical properties studies with emphasis on the absorption and scattering properties, to applications of gold nanoparticles in biomolecular detection, imaging and photothermal therapy. In chapter 2, we studied the kinetics of gold nanoparticle growth under Brust-Shiffrin reaction conditions. In chapter 3, we further examined the reaction mechanism and growth kinetics of gold nanoparticles using oleylamine as both a reducing reagent and particle growth passivation ligand. From these two projects, important understanding was revealed on gold nanoparticle formation and growth mechanism. Chapter 4 describes the synthesis of a monofunctional gold nanoparticle through a solid phase place exchange reaction. From Chapter 5, we moved to the optical property study of gold nanoparticles, particularly the absorption and scattering phenomenon. In this work a systematic analysis on the extinction coefficient of gold nanoparticles was performed, providing meaningful references for applications based on optical absorption properties of gold nanoparticles. In Chapter 6 and Chapter 7, we developed a one-step homogeneous immunoassay for protein detection and analysis based on the strong light scattering of gold nanoparticles and dynamic light scattering detection technique. In Chapter 8, we further improved the stability of gold nanoparticle bioconjugates using a poly(ethylene glycol)-coated gold nanoparticles and further tested this nanoparticle in the one-step homogeneous immunoassay. Finally in Chapter 9, we demonstrated the application of gold nanoparticles for in vitro bioimaging and photothermal therapy of a lung cancer cell. In summary, this dissertation presents a comprehensive study on the synthesis, surface modification, property study of gold nanoparticles and their applications in biomolecular imaging and analysis.
