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Premeltons In Dna
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Book Synopsis The Nonlinear Universe by : Alwyn C. Scott
Download or read book The Nonlinear Universe written by Alwyn C. Scott and published by Springer Science & Business Media. This book was released on 2007-10-02 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in Alwyn Scott’s inimitable style, one that readers will find both lucid and accessible, this masterwork elucidates the explosion of activity in nonlinear science in recent decades. The book explains the wide-ranging implications of nonlinear phenomena for future developments in many areas of modern science, including mathematics, physics, engineering, chemistry, biology, and neuroscience. Arguably as important as quantum theory, modern nonlinear science is essential for understanding the scientific developments of the twenty-first century.
Book Synopsis Proceedings of 9th International Conference on Genomics and Pharmacogenomics 2017 by : ConferenceSeries
Download or read book Proceedings of 9th International Conference on Genomics and Pharmacogenomics 2017 written by ConferenceSeries and published by ConferenceSeries. This book was released on with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: June 15-16, 2017 London, UK Key Topics : Cancer genomics, Functional Genomics, Next Generation Sequencing, Biomarkers, Pharmacogenomics, Clinical Genomics, Micro RNA, mRNA Analysis, Bioinformatics in Genomics, Comparative Genomics, Plant Genomics, Genome Engineering, Microbial Genomics, Future trends in Genomics, Genome Medicine, Genomics Market, Proteomics, Human Genomics,
Book Synopsis Encyclopedia of Nonlinear Science by : Alwyn Scott
Download or read book Encyclopedia of Nonlinear Science written by Alwyn Scott and published by Routledge. This book was released on 2006-05-17 with total page 1107 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 438 alphabetically-arranged essays, this work provides a useful overview of the core mathematical background for nonlinear science, as well as its applications to key problems in ecology and biological systems, chemical reaction-diffusion problems, geophysics, economics, electrical and mechanical oscillations in engineering systems, lasers and nonlinear optics, fluid mechanics and turbulence, and condensed matter physics, among others.
Book Synopsis Nucleic Acids: The Vectors of Life by : A. Pullman
Download or read book Nucleic Acids: The Vectors of Life written by A. Pullman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Sixteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry held in Jerusalem, Israel, May 2-5, 1983
Book Synopsis Nonlinear Electrodynamics in Biological Systems by : W. Adey
Download or read book Nonlinear Electrodynamics in Biological Systems written by W. Adey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past half century has seen an extraordinary growth in the fields of cellular and molecular biology. From simple morphologi cal concepts of cells as the essential units of living matter there has been an ever-sharper focus on functional organization of living systems, with emphasis on molecular dynamics. Thus, life forms have come to be defined increasingly in terms of metabolism, growth, reproduction and responses to environmental perturbations. Since these properties occur in varying degrees in systems below the level of cellular organization, there has been a blurring of older models that restricted the concepts of life to cellular systems. At the same time, a search has begun for elemental as pects of molecular and atomic behavior that might better define properties common to all life forms. This search has led to an examination of nonlinear behavior in biological macromolecules, whether in response to electrical or chemical stimulation, for example, or as a means of signaling along a molecular chain, or as a means of energy transfer. Experimental knowledge in this area has grown rapidly in the past decade, and in some respects has outstripped theoretical models adequate to ex plain these new observations. Nevertheless, it can be claimed that there is now an impressive body of experiments implicating non linear, nonequilibrium processes as fundamental steps in sequential operations of biological systems.
Book Synopsis Proceedings of the National Academy of Sciences of the United States of America by :
Download or read book Proceedings of the National Academy of Sciences of the United States of America written by and published by . This book was released on 1985 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nucleic Acids and Interactive Proteins by : Frances A. Jurnak
Download or read book Nucleic Acids and Interactive Proteins written by Frances A. Jurnak and published by Wiley-Interscience. This book was released on 1985 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Premeltons in DNA written by Henry Sobell and published by . This book was released on 2023-01-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author is internationally renowned for his pioneering contributions to the understanding of how the anticancer agent, actinomycin D, binds to DNA and exerts its mechanism of action. Using the technique of X-ray crystallography, he and his research colleague, Shri C. Jain, solved the structure of a crystalline complex containing actinomycin and deoxyguanosine in the early 1970's, and this information led them to propose a model that is now widely accepted to understand the general features of how actinomycin binds to DNA. According to this model, the phenoxazone ring system on actinomycin intercalates between adjacent base pairs, while pentapeptide chains lie in the narrow groove of the B- helix, forming hydrogen bonds (in the case of d (pGpC) sequences) with guanine residues on opposite chains. Although X-ray crystallographic studies of actinomycin complexed to a number of different self-complementary oligonucleotides have now confirmed the overall features of this model, the precise nature of the DNA conformation remains unknown due to problems inherent in refining large structures with limited resolution data. Implicit in the original model was the assumption that actinomycin binds to B-DNA or to a distorted form of B-DNA. The possibility that actinomycin might bind to some other discretely different DNA conformational state was not envisioned at that time. Together with his research team, Dr. Sobell continued to extend his crystallographic studies to include other intercalators (these contain a diverse variety of heterocyclic ring systems) complexed to a number of different self-complementary DNA and RNA dinucleotides. The information obtained from these studies led him to propose the existence of beta-DNA, a metastable and hyperflexible DNA form, a form very different from the Watson-Crick B- and A- structures, which he believes, is intimately associated with the intercalation process. The existence of this beta-DNA structure required modification to the original actinomycin-DNA binding model. When combined with the realization that beta-DNA is an obligatory structural intermediate (i.e., transition-state intermediate) in the unwinding of duplex DNA leading to melting, this novel beta-DNA binding model leads to understanding the mechanism of action of actinomycin. This book calls attention to the wider repercussions this modified actinomycin-DNA binding model has had in understanding much of DNA physical chemistry and molecular biology. These stem from additional insights provided by another more recent area of inquiry known as Nonlinear Science.
Book Synopsis Partially Integrable Evolution Equations in Physics by : R. Conte
Download or read book Partially Integrable Evolution Equations in Physics written by R. Conte and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the many physical phenomena ruled by partial differential equations, two extreme fields are currently overcrowded due to recent considerable developments: 1) the field of completely integrable equations, whose recent advances are the inverse spectral transform, the recursion operator, underlying Hamiltonian structures, Lax pairs, etc 2) the field of dynamical systems, often built as models of observed physical phenomena: turbulence, intermittency, Poincare sections, transition to chaos, etc. In between there is a very large region where systems are neither integrable nor nonintegrable, but partially integrable, and people working in the latter domain often know methods from either 1) or 2). Due to the growing interest in partially integrable systems, we decided to organize a meeting for physicists active or about to undertake research in this field, and we thought that an appropriate form would be a school. Indeed, some of the above mentioned methods are often adaptable outside their original domain and therefore worth to be taught in an interdisciplinary school. One of the main concerns was to keep a correct balance between physics and mathematics, and this is reflected in the list of courses.
Book Synopsis Cambridge Scientific Biochemistry Abstracts by :
Download or read book Cambridge Scientific Biochemistry Abstracts written by and published by . This book was released on 1986 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Medicinal Chemistry of Anticancer Drugs by : Carmen Avendaño
Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature
Book Synopsis Peptide Nucleic Acids by : Peter E. Nielsen
Download or read book Peptide Nucleic Acids written by Peter E. Nielsen and published by Garland Science. This book was released on 2004 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Nucleic Acids, Second Edition has been extensively revised, updated, and enlarged to contain many new chapters covering the most recent topics and applications in this fast-moving field. The book contains state-of-the-art protocols and applications on all aspects of peptide nucleic acids. Concepts are clearly explained with each chapter containing concise background information. Written by leading experts in the field, the book is an invaluable and complete reference work on this novel and exciting area.
Download or read book Physical Review written by and published by . This book was released on 1993-09 with total page 1630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publishes papers that report results of research in statistical physics, plasmas, fluids, and related interdisciplinary topics. There are sections on (1) methods of statistical physics, (2) classical fluids, (3) liquid crystals, (4) diffusion-limited aggregation, and dendritic growth, (5) biological physics, (6) plasma physics, (7) physics of beams, (8) classical physics, including nonlinear media, and (9) computational physics.
Book Synopsis Quantum Aspects of Life by : Derek Abbott
Download or read book Quantum Aspects of Life written by Derek Abbott and published by World Scientific. This book was released on 2008 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: A quantum origin of life? -- Quantum mechanics and emergence -- Quantum coherence and the search for the first replicator -- Ultrafast quantum dynamics in photosynthesis -- Modelling quantum decoherence in biomolecules -- Molecular evolution -- Memory depends on the cytoskeleton, but is it quantum? -- Quantum metabolism and allometric scaling relations in biology -- Spectroscopy of the genetic code -- Towards understanding the origin of genetic languages -- Can arbitrary quantum systems undergo self-replication? -- A semi-quantum version of the game of life -- Evolutionary stability in quantum games -- Quantum transmemetic intelligence -- Dreams versus reality : plenary debate session on quantum computing -- Plenary debate: quantum effects in biology : trivial or not? -- Nontrivial quantum effects in biology : a skeptical physicists' view -- That's life! : the geometry of p electron clouds.
Book Synopsis The Emerging Physics of Consciousness by : Jack A. Tuszynski
Download or read book The Emerging Physics of Consciousness written by Jack A. Tuszynski and published by Springer Science & Business Media. This book was released on 2006-09-05 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seeks answers to these questions using the underlying assumption that consciousness can be understood using the intellectual potential of modern physics and other sciences. There are a number of theories of consciousness, some based on classical physics while others require the use of quantum concepts. The latter ones have drawn criticism from the parts of the scientific establishment while simultaneously claiming that classical approaches are doomed to failure. The contributing authors presents a spectrum of opinions from both sides of this on-going scientific debate, allowing readers to decide for themselves which of the approaches are most likely to succeed.
Book Synopsis The Physical Basis of The Direction of Time by : H. Dieter Zeh
Download or read book The Physical Basis of The Direction of Time written by H. Dieter Zeh and published by Springer Science & Business Media. This book was released on 2007-08-13 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised 5th edition of Zeh's classic text investigates irreversible phenomena and their foundation in classical, quantum and cosmological settings. It includes new sections on the meaning of probabilities in a cosmological context, irreversible aspects of quantum computers, and various consequences of the expansion of the Universe. In particular, the book offers an analysis of the physical concept of time.
Book Synopsis Organization of DNA in Chromatin by : Henry Sobell
Download or read book Organization of DNA in Chromatin written by Henry Sobell and published by . This book was released on 2023-01-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the DNA in our genome comprises about three billion base-pairs, with each base-pair separated by a third of a nanometer - its total length is about a meter - of all which residing within a compact form knows as chromatin. At first guess, one might think the DNA to be a wound up like a ball of yarn, but chromatin turns out to be a more complex structure, DNA being organized into hierarchical series of superhelices. Counting the right-handed double-helix as the first stage in the hierarchical ordering, the second consists of 147 base-pairs wound around the outside of nucleosomes as a left-handed toroidal-superhelix containing one and three-quarter turns. Each nucleosome contains two pairs each of four different histones, small positively charged basic proteins called H2A, H2B, H3 and H4 spatially related by two-fold symmetry. Adjacent nucleosomes remain connected together by linker DNA, additional DNA (variable in length, but generally between 5- to 60 base-pairs) that exists between nucleosomes, resulting in the formation of an extended 100 Angstrom fiber. In the presence of an additional histone (H1), DNA is known to undergo a still higher level of compaction, organizing itself into a solenoidal super helical structure having a diameter of about 300 Angstroms. This 300 Angstrom fiber can readily be seen by electron microscopy and, almost certainly, the unraveling of its structure foreshadows still further complex structural features of chromatin to be discovered in future years. In order for DNA to be organized into this hierarchical series of superhelices, there must be a source of flexibility in DNA structure that allows this to happen. Earlier, the author put forward a kinked model to understand how DNA is organized within the nucleosome. The model assumed nucleosome DNA to be in its B- form, separated by 'mixed-puckered kinks' every 10 base-pairs. Ink this book, he presents a modification to this model; this being necessary to explain important additional experimental information uncovered several years after the model was proposed. The modified model proposed that if there were an equal probability of both 10 base-pars of B- DNA or 11 base-pairs of A- DNA existing within any given segment of the left-handed toroidal super helical structure - these being connected together by 'mixed-puckered kinks' - then a population of such aperiodic structures can be expected to give rise to the periodic cutting-patterns observed experimentally. This would be true for naked DNA molecules immobilized on a calcium-phosphate crystalline surface as well, provided they also formed left-handed toroidal superhelices under these conditions. In both cases, probability considerations predict cutting patters to be symmetrically distributed around integral multiples of 10.5 base-pairs along DNA, the relative magnitudes of the surroundings peaks in these patterns being governed by the binomial distribution - the proof of which is presented in this book.
