Predictive Methods In Percutaneous Absorption

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Predictive Methods in Percutaneous Absorption

Author : Gary P. Moss
Publisher : Springer
ISBN 13 : 3662473712
Total Pages : 206 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Predictive Methods in Percutaneous Absorption by : Gary P. Moss

Download or read book Predictive Methods in Percutaneous Absorption written by Gary P. Moss and published by Springer. This book was released on 2015-07-01 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Prediction of Percutaneous Penetration

Author : R. C. Scott
Publisher : Hyperion Books
ISBN 13 :
Total Pages : 460 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prediction of Percutaneous Penetration by : R. C. Scott

Download or read book Prediction of Percutaneous Penetration written by R. C. Scott and published by Hyperion Books. This book was released on 1990 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Percutaneous Absorption

Author : Robert L. Bronaugh
Publisher : CRC Press
ISBN 13 : 9781420000948
Total Pages : 992 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Percutaneous Absorption by : Robert L. Bronaugh

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by CRC Press. This book was released on 1999-05-28 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Percutaneous Absorption

Author : Nina Dragićević
Publisher : CRC Press
ISBN 13 : 0429511566
Total Pages : 1008 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Percutaneous Absorption by : Nina Dragićević

Download or read book Percutaneous Absorption written by Nina Dragićević and published by CRC Press. This book was released on 2021-07-30 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption

Dermal Absorption and Toxicity Assessment

Author : Michael S. Roberts
Publisher : CRC Press
ISBN 13 : 0849375924
Total Pages : 706 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Dermal Absorption and Toxicity Assessment by : Michael S. Roberts

Download or read book Dermal Absorption and Toxicity Assessment written by Michael S. Roberts and published by CRC Press. This book was released on 2007-12-14 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab

Dermal Absorption Models in Toxicology and Pharmacology

Author : Jim E. Riviere
Publisher : CRC Press
ISBN 13 : 9780203020821
Total Pages : 392 pages
Book Rating : 4.0/5 (28 download)

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Book Synopsis Dermal Absorption Models in Toxicology and Pharmacology by : Jim E. Riviere

Download or read book Dermal Absorption Models in Toxicology and Pharmacology written by Jim E. Riviere and published by CRC Press. This book was released on 2005-08-24 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.

Artificial Neural Networks and Machine Learning -- ICANN 2012

Author : Alessandro Villa
Publisher : Springer
ISBN 13 : 3642332668
Total Pages : 612 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Artificial Neural Networks and Machine Learning -- ICANN 2012 by : Alessandro Villa

Download or read book Artificial Neural Networks and Machine Learning -- ICANN 2012 written by Alessandro Villa and published by Springer. This book was released on 2012-09-19 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two-volume set LNCS 7552 + 7553 constitutes the proceedings of the 22nd International Conference on Artificial Neural Networks, ICANN 2012, held in Lausanne, Switzerland, in September 2012. The 162 papers included in the proceedings were carefully reviewed and selected from 247 submissions. They are organized in topical sections named: theoretical neural computation; information and optimization; from neurons to neuromorphism; spiking dynamics; from single neurons to networks; complex firing patterns; movement and motion; from sensation to perception; object and face recognition; reinforcement learning; bayesian and echo state networks; recurrent neural networks and reservoir computing; coding architectures; interacting with the brain; swarm intelligence and decision-making; mulitlayer perceptrons and kernel networks; training and learning; inference and recognition; support vector machines; self-organizing maps and clustering; clustering, mining and exploratory analysis; bioinformatics; and time weries and forecasting.

Topical and Transdermal Drug Delivery

Author : Heather A. E. Benson
Publisher : John Wiley & Sons
ISBN 13 : 1118140494
Total Pages : 393 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Topical and Transdermal Drug Delivery by : Heather A. E. Benson

Download or read book Topical and Transdermal Drug Delivery written by Heather A. E. Benson and published by John Wiley & Sons. This book was released on 2012-02-03 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Author : Nina Dragicevic
Publisher : Springer
ISBN 13 : 3662450135
Total Pages : 340 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement by : Nina Dragicevic

Download or read book Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement written by Nina Dragicevic and published by Springer. This book was released on 2015-04-04 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This truly comprehensive reference, in a mini-series format with five volumes, offers a detailed description of both well-known and recently introduced methods for percutaneous penetration enhancement. The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many others. The fourth volume discusses the diverse physical methods used in penetration enhancement, such as sonophoresis, iontophoresis, electroporation, microporation, laser ablation, and microneedles. Determination of drug penetration is covered in the final volume, with a focus especially on mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. This edition of Percutaneous Penetration Enhancers will be an invaluable resource for researchers, pharmaceutical scientists, practitioners, and also students.

Skin Decontamination

Author : Hanjiang Zhu
Publisher : Springer Nature
ISBN 13 : 3030240096
Total Pages : 284 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Skin Decontamination by : Hanjiang Zhu

Download or read book Skin Decontamination written by Hanjiang Zhu and published by Springer Nature. This book was released on 2019-09-26 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. However, some chemicals act directly on the skin including vesicants sulfur mustard and corrosive compounds such as strong acids or bases, and do not have to gain access to systemic circulation to cause extensive skin damage. Early and rapid skin decontamination is extremely important following exposure to chemical warfare agents and toxic industrial chemicals because it decreases serious skin damage to the patient and, potentially, their doctor. This multi-authored international text pulls together a century of decontamination research and helps the reader expedite solutions that will decrease morbidity and mortality. Complete with dozens of hiqh quality photographs and illustrations, Skin Decontamination aids industrial hygiene, dermatology, occupational physicians and those involved in the public health arena.

Physical Chemical Properties and Percutaneous Absorption of Dehydroepiandrosterone (DHEA).

Author : Pengjin Xu
Publisher :
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Physical Chemical Properties and Percutaneous Absorption of Dehydroepiandrosterone (DHEA). by : Pengjin Xu

Download or read book Physical Chemical Properties and Percutaneous Absorption of Dehydroepiandrosterone (DHEA). written by Pengjin Xu and published by . This book was released on 1998 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Cosmetic Science and Technology

Author : André O. Barel
Publisher : CRC Press
ISBN 13 : 1420069683
Total Pages : 890 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Cosmetic Science and Technology by : André O. Barel

Download or read book Handbook of Cosmetic Science and Technology written by André O. Barel and published by CRC Press. This book was released on 2009-03-03 with total page 890 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a team of experienced and internationally renowned contributors, the updated Third Edition is the standard reference for cosmetic chemists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for skin, hair, and nails.New features in the Third Editi

Topical Drug Bioavailability, Bioequivalence, and Penetration

Author : Vinod P. Shah
Publisher : Springer
ISBN 13 : 1493912895
Total Pages : 393 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Topical Drug Bioavailability, Bioequivalence, and Penetration by : Vinod P. Shah

Download or read book Topical Drug Bioavailability, Bioequivalence, and Penetration written by Vinod P. Shah and published by Springer. This book was released on 2015-01-30 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

New Technologies for Toxicity Testing

Author : Michael Balls
Publisher : Springer Science & Business Media
ISBN 13 : 1461430550
Total Pages : 282 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis New Technologies for Toxicity Testing by : Michael Balls

Download or read book New Technologies for Toxicity Testing written by Michael Balls and published by Springer Science & Business Media. This book was released on 2012-03-22 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.

Exposure to Contaminants in Drinking Water

Author : Stephen S Olin
Publisher : CRC Press
ISBN 13 : 1000102645
Total Pages : 247 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Exposure to Contaminants in Drinking Water by : Stephen S Olin

Download or read book Exposure to Contaminants in Drinking Water written by Stephen S Olin and published by CRC Press. This book was released on 2020-08-18 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exposure to Contaminants in Drinking Water: Estimating Uptake through the Skin and by Inhalation examines the current state of science in this field by identifying and reviewing the available information resources; evaluating various models and approaches; and demonstrating the feasibility of developing estimates of the distribution of absorbed doses of contaminants in drinking water through contact with the skin and by inhalation. This book, the product of a fifteen-member expert working group convened by the Risk Science Institute of the International Life Sciences Institute under a cooperative agreement with the U.S. Environmental Protection Agency's Office of Water, includes contributions from experts in exposure modeling and measurement; water chemistry; time-activity patterns; dermal and respiratory uptake; and the use of probability distributions in characterizing exposures.

Acute Toxicology Testing

Author : Shayne C. Gad
Publisher : Academic Press
ISBN 13 : 008052592X
Total Pages : 561 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Acute Toxicology Testing by : Shayne C. Gad

Download or read book Acute Toxicology Testing written by Shayne C. Gad and published by Academic Press. This book was released on 1997-10-27 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health.Key Features* Over 100 tables summarizing and interpreting results* Complete coverage of all major test designs and their limitations and advantages* Current status of alternative test designs and models

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264071083
Total Pages : 8 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...