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Predicting The Outcomes Of Hiv Treatment Interruptions Using Computational Modelling
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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes
Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author :National Research Council and Institute of Medicine Publisher :National Academies Press ISBN 13 :0309176212 Total Pages :352 pages Book Rating :4.3/5 (91 download)
Book Synopsis Preventing HIV Transmission by : National Research Council and Institute of Medicine
Download or read book Preventing HIV Transmission written by National Research Council and Institute of Medicine and published by National Academies Press. This book was released on 1995-09-14 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses the interface of two major national problems: the epidemic of HIV-AIDS and the widespread use of illegal injection drugs. Should communities have the option of giving drug users sterile needles or bleach for cleaning needs in order to reduce the spread of HIV? Does needle distribution worsen the drug problem, as opponents of such programs argue? Do they reduce the spread of other serious diseases, such as hepatitis? Do they result in more used needles being carelessly discarded in the community? The panel takes a critical look at the available data on needle exchange and bleach distribution programs, reaches conclusions about their efficacy, and offers concrete recommendations for public policy to reduce the spread of HIV/AIDS. The book includes current knowledge about the epidemiologies of HIV/AIDS and injection drug use; characteristics of needle exchange and bleach distribution programs and views on those programs from diverse community groups; and a discussion of laws designed to control possession of needles, their impact on needle sharing among injection drug users, and their implications for needle exchange programs.
Book Synopsis Immune System Modelling and Simulation by : Filippo Castiglione
Download or read book Immune System Modelling and Simulation written by Filippo Castiglione and published by CRC Press. This book was released on 2015-04-07 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book describes a computational model of the immune system reaction, C-ImmSim, built along the lines of the computer model known as the Celada-Seiden model (CS-model). The computational counterpart of the CS-model is called IMMSIM which stands for IMMune system SIMulator. IMMSIM was written in 1992 by the physicist Phil E. Seiden and the immunol
Book Synopsis Integrative Computational Systems Biology Approaches in Immunology and Medicine by : Lars Kaderali
Download or read book Integrative Computational Systems Biology Approaches in Immunology and Medicine written by Lars Kaderali and published by Frontiers Media SA. This book was released on 2019-04-09 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modeling and Control of Infectious Diseases in the Host by : Esteban A. Hernandez-Vargas
Download or read book Modeling and Control of Infectious Diseases in the Host written by Esteban A. Hernandez-Vargas and published by Academic Press. This book was released on 2019-02-19 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R.
Book Synopsis Mathematical Methods and Models in Biomedicine by : Urszula Ledzewicz
Download or read book Mathematical Methods and Models in Biomedicine written by Urszula Ledzewicz and published by Springer Science & Business Media. This book was released on 2012-10-20 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical biomedicine is a rapidly developing interdisciplinary field of research that connects the natural and exact sciences in an attempt to respond to the modeling and simulation challenges raised by biology and medicine. There exist a large number of mathematical methods and procedures that can be brought in to meet these challenges and this book presents a palette of such tools ranging from discrete cellular automata to cell population based models described by ordinary differential equations to nonlinear partial differential equations representing complex time- and space-dependent continuous processes. Both stochastic and deterministic methods are employed to analyze biological phenomena in various temporal and spatial settings. This book illustrates the breadth and depth of research opportunities that exist in the general field of mathematical biomedicine by highlighting some of the fascinating interactions that continue to develop between the mathematical and biomedical sciences. It consists of five parts that can be read independently, but are arranged to give the reader a broader picture of specific research topics and the mathematical tools that are being applied in its modeling and analysis. The main areas covered include immune system modeling, blood vessel dynamics, cancer modeling and treatment, and epidemiology. The chapters address topics that are at the forefront of current biomedical research such as cancer stem cells, immunodominance and viral epitopes, aggressive forms of brain cancer, or gene therapy. The presentations highlight how mathematical modeling can enhance biomedical understanding and will be of interest to both the mathematical and the biomedical communities including researchers already working in the field as well as those who might consider entering it. Much of the material is presented in a way that gives graduate students and young researchers a starting point for their own work.
Book Synopsis Multimodal Scene Understanding by : Michael Ying Yang
Download or read book Multimodal Scene Understanding written by Michael Ying Yang and published by Academic Press. This book was released on 2019-07-16 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multimodal Scene Understanding: Algorithms, Applications and Deep Learning presents recent advances in multi-modal computing, with a focus on computer vision and photogrammetry. It provides the latest algorithms and applications that involve combining multiple sources of information and describes the role and approaches of multi-sensory data and multi-modal deep learning. The book is ideal for researchers from the fields of computer vision, remote sensing, robotics, and photogrammetry, thus helping foster interdisciplinary interaction and collaboration between these realms. Researchers collecting and analyzing multi-sensory data collections – for example, KITTI benchmark (stereo+laser) - from different platforms, such as autonomous vehicles, surveillance cameras, UAVs, planes and satellites will find this book to be very useful. - Contains state-of-the-art developments on multi-modal computing - Shines a focus on algorithms and applications - Presents novel deep learning topics on multi-sensor fusion and multi-modal deep learning
Book Synopsis Intelligent Systems and Sustainable Computational Models by : Rajganesh Nagarajan
Download or read book Intelligent Systems and Sustainable Computational Models written by Rajganesh Nagarajan and published by CRC Press. This book was released on 2024-06-03 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fields of intelligent systems and sustainability have been gaining momentum in the research community. They have drawn interest in such research fields as computer science, information technology, electrical engineering, and other associated engineering disciples. The promise of intelligent systems applied to sustainability is becoming a reality due to the recent advancements in the Internet of Things (IoT), Artificial Intelligence, Big Data, blockchain, deep learning, and machine learning. The emergence of intelligent systems has given rise to a wide range of techniques and algorithms using an ensemble approach to implement novel solutions for complex problems associated with sustainability. Intelligent Systems and Sustainable Computational Models: Concepts, Architecture, and Practical Applications explores this ensemble approach towards building a sustainable future. It explores novel solutions for such pressing problems as smart healthcare ecosystems, energy efficient distributed computing, affordable renewable resources, mitigating financial risks, monitoring environmental degradation, and balancing climate conditions. The book helps researchers to apply intelligent systems to computational sustainability models to propose efficient methods, techniques, and tools. The book covers such areas as: Intelligent and adaptive computing for sustainable energy, water, and transportation networks Blockchain for decentralized systems for sustainable applications, systems, and infrastructure IoT for sustainable critical infrastructure Explainable AI (XAI) and decision-making models for computational sustainability Sustainable development using edge computing, fog computing and cloud computing Cognitive intelligent systems for e-learning Artificial Intelligence and machine learning for large scale data Green computing and cyber physical systems Real-time applications in healthcare, agriculture, smart cities, and smart governance. By examining how intelligent systems can build a sustainable society, the book presents systems solutions that can benefit researchers and professionals in such fields as information technology, health, energy, agricultural, manufacturing, and environmental protection.
Book Synopsis Biomedical Index to PHS-supported Research by :
Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1991 with total page 1104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Virus Dynamics : Mathematical Principles of Immunology and Virology by : Martin Nowak
Download or read book Virus Dynamics : Mathematical Principles of Immunology and Virology written by Martin Nowak and published by Oxford University Press, UK. This book was released on 2000-11-23 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature
Book Synopsis Biomedical Index to PHS-supported Research: pt. A. Subject access A-H by :
Download or read book Biomedical Index to PHS-supported Research: pt. A. Subject access A-H written by and published by . This book was released on 1992 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Innovations in Multivariate Statistical Modeling by : Andriëtte Bekker
Download or read book Innovations in Multivariate Statistical Modeling written by Andriëtte Bekker and published by Springer Nature. This book was released on 2022-12-15 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multivariate statistical analysis has undergone a rich and varied evolution during the latter half of the 20th century. Academics and practitioners have produced much literature with diverse interests and with varying multidisciplinary knowledge on different topics within the multivariate domain. Due to multivariate algebra being of sustained interest and being a continuously developing field, its appeal breaches laterally across multiple disciplines to act as a catalyst for contemporary advances, with its core inferential genesis remaining in that of statistics. It is exactly this varied evolution caused by an influx in data production, diffusion, and understanding in scientific fields that has blurred many lines between disciplines. The cross-pollination between statistics and biology, engineering, medical science, computer science, and even art, has accelerated the vast amount of questions that statistical methodology has to answer and report on. These questions are often multivariate in nature, hoping to elucidate uncertainty on more than one aspect at the same time, and it is here where statistical thinking merges mathematical design with real life interpretation for understanding this uncertainty. Statistical advances benefit from these algebraic inventions and expansions in the multivariate paradigm. This contributed volume aims to usher novel research emanating from a multivariate statistical foundation into the spotlight, with particular significance in multidisciplinary settings. The overarching spirit of this volume is to highlight current trends, stimulate a focus on, and connect multidisciplinary dots from and within multivariate statistical analysis. Guided by these thoughts, a collection of research at the forefront of multivariate statistical thinking is presented here which has been authored by globally recognized subject matter experts.
Book Synopsis AIDS Pathogenesis by : H. Schuitemaker
Download or read book AIDS Pathogenesis written by H. Schuitemaker and published by Springer Science & Business Media. This book was released on 2000-03-31 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.
Book Synopsis HIV/AIDS in South Africa 25 Years On by : Poul Rohleder
Download or read book HIV/AIDS in South Africa 25 Years On written by Poul Rohleder and published by Springer Science & Business Media. This book was released on 2009-09-01 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much has happened since the first appearance of AIDS in 1981: it has been identified, studied, and occasionally denied. The virus has shifted host populations and spread globally. Medicine, the social sciences, and world governments have joined forces to combat and prevent the disease. And South Africa has emerged as ground zero for the pandemic. The editors of HIV/AIDS in South Africa 25 Years On present the South African crisis as a template for addressing the myriad issues surrounding the epidemic worldwide, as the book brings together a widely scattered body of literature, analyzes psychosocial and sexual aspects contributing to HIV transmission and prevention, and delves into complex intersections of race, gender, class, and politics. Including largely overlooked populations and issues (e.g., prisoners, persons with disabilities, stigma), as well as challenges shaping future research and policy, the contributors approach their topics with rare depth, meticulous research, carefully drawn conclusions, and profound compassion. Among the topics covered: The relationship between HIV and poverty, starting from the question, "Which is the determinant and which is the consequence?" Epidemiology of HIV among women and men: concepts of femininity and masculinity, and gender inequities as they affect HIV risk; gender-specific prevention and intervention strategies. The impact of AIDS on infants and young children: risk and protective factors; care of children by HIV-positive mothers; HIV-infected children. Current prevention and treatment projects, including local-level responses, community-based work, and VCT (voluntary counseling and testing) programs. New directions: promoting circumcision, vaccine trials, "positive prevention." South Africa’s history of AIDS denialism. The urgent lessons in this book apply both globally and locally, making HIV/AIDS in South Africa 25 Years On uniquely instructive and useful for professionals working in HIV/AIDS and global public health.
Book Synopsis Handbook of Model Predictive Control by : Saša V. Raković
Download or read book Handbook of Model Predictive Control written by Saša V. Raković and published by Springer. This book was released on 2018-09-01 with total page 693 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments in model-predictive control promise remarkable opportunities for designing multi-input, multi-output control systems and improving the control of single-input, single-output systems. This volume provides a definitive survey of the latest model-predictive control methods available to engineers and scientists today. The initial set of chapters present various methods for managing uncertainty in systems, including stochastic model-predictive control. With the advent of affordable and fast computation, control engineers now need to think about using “computationally intensive controls,” so the second part of this book addresses the solution of optimization problems in “real” time for model-predictive control. The theory and applications of control theory often influence each other, so the last section of Handbook of Model Predictive Control rounds out the book with representative applications to automobiles, healthcare, robotics, and finance. The chapters in this volume will be useful to working engineers, scientists, and mathematicians, as well as students and faculty interested in the progression of control theory. Future developments in MPC will no doubt build from concepts demonstrated in this book and anyone with an interest in MPC will find fruitful information and suggestions for additional reading.
Book Synopsis Advances in Computational Intelligence by : Ildar Batyrshin
Download or read book Advances in Computational Intelligence written by Ildar Batyrshin and published by Springer. This book was released on 2013-03-21 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two-volume set LNAI 7629 and LNAI 7630 constitutes the refereed proceedings of the 11th Mexican International Conference on Artificial Intelligence, MICAI 2012, held in San Luis Potosí, Mexico, in October/November 2012. The 80 revised papers presented were carefully reviewed and selected from 224 submissions. The second volume includes 40 papers focusing on soft computing. The papers are organized in the following topical sections: natural language processing; evolutionary and nature-inspired metaheuristic algorithms; neural networks and hybrid intelligent systems; fuzzy systems and probabilistic models in decision making.
Download or read book Predictive ADMET written by Jianling Wang and published by John Wiley & Sons. This book was released on 2014-02-28 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.
