Precision Medicine Approaches For Heterogeneous Conditions Such As Autism Spectrum Disorders The Need For A Biomarker Exploration Phase In Clinical Trials Phase 2m

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Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m)

Author : David Quentin Beversdorf
Publisher : Frontiers Media SA
ISBN 13 : 2832515681
Total Pages : 153 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m) by : David Quentin Beversdorf

Download or read book Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m) written by David Quentin Beversdorf and published by Frontiers Media SA. This book was released on 2023-04-17 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many therapeutic interventions for autism spectrum disorder fail when they are examined in a clinical trial. Frequently, there is a subset of patients that responds very well to the intervention, while others do not, and the overall result does not yield a positive result. As autism spectrum disorder is highly heterogeneous in its underlying genetics and other etiological risk factors, as well as its heterogeneous phenotypic manifestation, this variability in response to any specific treatment is not entirely surprising. However, it remains a challenge to meaningfully subtype this heterogeneity for targeted treatment. The purpose of this research topic is to solicit articles that address the heterogeneity in autism spectrum disorder in a manner that may meaningfully contribute to targeted treatment approaches. Studies that address the heterogeneity of autism that could theoretically lead to targeted treatment, and studies that more directly address the use of a marker in association with response to a treatment, are both aspects that will contribute to this purpose. It is hoped that this Research Topic will yield articles that can help advance the field towards precision medicine in autism spectrum disorders. Manuscripts that contribute to the specification of the heterogeneity of autism spectrum disorder in a manner that could theoretically lead to targeted treatment would be appropriate for this research topic. Additionally, articles that utilize subtyping in relation to response to treatment would be appropriate for this research topic.

Infancy

Author : J. Gavin Bremner
Publisher : Wiley-Blackwell
ISBN 13 : 9780631184669
Total Pages : 336 pages
Book Rating : 4.1/5 (846 download)

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Book Synopsis Infancy by : J. Gavin Bremner

Download or read book Infancy written by J. Gavin Bremner and published by Wiley-Blackwell. This book was released on 1994-12-05 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assuming little or no prior knowledge of the subject, Infancy presents a complete picture of our current understanding of the development of infants, their knowledge and understanding of the world from birth or before to their second birthday.

Perceptual Development

Author : Alan Slater
Publisher : Psychology Press
ISBN 13 : 9780863778513
Total Pages : 452 pages
Book Rating : 4.7/5 (785 download)

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Book Synopsis Perceptual Development by : Alan Slater

Download or read book Perceptual Development written by Alan Slater and published by Psychology Press. This book was released on 1998 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is both to reflect current knowledge of perceptual development and to point to some of the many questions that remain unanswered. The study of perceptual development is now a sophisticated science. The majority of the chapters tell a fascinating detective story: the way in which infants perceive and understand the world as they develop. Each of the major sections is prefaced by introductory comments, and the book will be useful for advanced undergraduates, postgraduates, researchers, and other professionals who have an interest in early perceptual development and in infancy in general.

Human Neural Stem Cells

Author : Leonora Buzanska
Publisher : Springer
ISBN 13 : 3319934856
Total Pages : 334 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Human Neural Stem Cells by : Leonora Buzanska

Download or read book Human Neural Stem Cells written by Leonora Buzanska and published by Springer. This book was released on 2018-09-12 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.

Genome Structure and Function

Author : C. Nicolini
Publisher : Springer Science & Business Media
ISBN 13 : 9780792345657
Total Pages : 358 pages
Book Rating : 4.3/5 (456 download)

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Book Synopsis Genome Structure and Function by : C. Nicolini

Download or read book Genome Structure and Function written by C. Nicolini and published by Springer Science & Business Media. This book was released on 1997-05-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Advanced Study Institute on Genome Structure and Function, held in Marciana Marina, Elba, Italy, 13-23 June 1996

The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it?

Author : Enrico Cherubini
Publisher : Frontiers Media SA
ISBN 13 : 2889196313
Total Pages : 167 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it? by : Enrico Cherubini

Download or read book The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it? written by Enrico Cherubini and published by Frontiers Media SA. This book was released on 2015-08-19 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low probability of release and pronounced frequency-dependent facilitation. In addition MF terminals are endowed with mGluRs that regulate their own release. We will describe the intrinsic membrane properties of pyramidal cells, which can sometimes fire in bursts, together with the geometry of their dendritic arborization. The single layer of pyramidal cells is quite distinct from the six-layered neocortical arrangement. The resulting aligned dendrites provides the substrate for laminated excitatory inputs. They also underlie a precise, diversity of inhibitory control which we will also describe in detail. The CA3 region has an especially rich internal connectivity, with recurrent excitatory and inhibitory loops. In recent years both in vivo and in vitro studies have allowed to better understand functional properties of the CA3 auto-associative network and its role in information processing. This circuit is implicated in encoding spatial representations and episodic memories. It generates physiological population synchronies, including gamma, theta and sharp-waves that are presumed to associate firing in selected assemblies of cells in different behavioral conditions. The CA3 region is susceptible to neurodegeneration during aging and after stresses such as infection or injury. Loss of some CA3 neurones has striking effects on mossy fiber inputs and can facilitate the generation of pathologic synchrony within the CA3 micro-circuit. The aim of this special topic is to bring together experts on the cellular and molecular mechanisms regulating the wiring properties of the CA3 hippocampal microcircuit in both physiological and pathological conditions, synaptic plasticity, behavior and cognition.We will particularly emphasize the dual glutamatergic and GABAergic phenotype of MF-CA3 synapses at early developmental stages and the steps that regulate the integration of newly generated neurons into the adult dentate gyrus-CA3 circuit.

The Science of Health Disparities Research

Author : Irene Dankwa-Mullan
Publisher : John Wiley & Sons
ISBN 13 : 1119374812
Total Pages : 548 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis The Science of Health Disparities Research by : Irene Dankwa-Mullan

Download or read book The Science of Health Disparities Research written by Irene Dankwa-Mullan and published by John Wiley & Sons. This book was released on 2021-03-16 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrates the various disciplines of the science of health disparities in one comprehensive volume The Science of Health Disparities Research is an indispensable source of up-to-date information on clinical and translational health disparities science. Building upon the advances in health disparities research over the past decade, this authoritative volume informs policies and practices addressing the diseases, disorders, and gaps in health outcomes that are more prevalent in minority populations and socially disadvantaged communities. Contributions by recognized scholars and leaders in the field—featuring contemporary research, conceptual models, and a broad range of scientific perspectives—provide an interdisciplinary approach to reducing inequalities in population health, encouraging community engagement in the research process, and promoting social justice. In-depth chapters help readers better understand the specifics of minority health and health disparities while demonstrating the importance of advancing theory, refining measurement, improving investigative methods, and diversifying scientific research. In 26 chapters, the book examines topics including the etiology of health disparities research, the determinants of population health, research ethics, and research in African American, Asians, Latino, American Indian, and other vulnerable populations. Providing a unified framework on the principles and applications of the science of health disparities research, this important volume: Defines the field of health disparities science and suggests new directions in scholarship and research Explains basic definitions, principles, and concepts for identifying, understanding and addressing health disparities Provides guidance on both conducting health disparities research and translating the results Examines how social, historical and contemporary injustices may influence the health of racial and ethnic minorities Illustrates the increasing national and global importance of addressing health disparities Discusses population health training, capacity-building, and the transdisciplinary tools needed to advance health equity A significant contribution to the field, The Science of Health Disparities Research is an essential resource for students and basic and clinical researchers in genetics, population genetics, and public health, health care policymakers, and epidemiologists, medical students, and clinicians, particularly those working with minority, vulnerable, or underserved populations.

Digital Personalized Health and Medicine

Author : L.B. Pape-Haugaard
Publisher : IOS Press
ISBN 13 : 1643680838
Total Pages : 1498 pages
Book Rating : 4.6/5 (436 download)

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Book Synopsis Digital Personalized Health and Medicine by : L.B. Pape-Haugaard

Download or read book Digital Personalized Health and Medicine written by L.B. Pape-Haugaard and published by IOS Press. This book was released on 2020-06-17 with total page 1498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Digital health and medical informatics have grown in importance in recent years, and have now become central to the provision of effective healthcare around the world. This book presents the proceedings of the 30th Medical Informatics Europe conference (MIE). This edition of the conference, hosted by the European Federation for Medical Informatics (EFMI) since the 1970s, was due to be held in Geneva, Switzerland in April 2020, but as a result of measures to prevent the spread of the Covid19 pandemic, the conference itself had to be cancelled. Nevertheless, because this collection of papers offers a wealth of knowledge and experience across the full spectrum of digital health and medicine, it was decided to publish the submissions accepted in the review process and confirmed by the Scientific Program Committee for publication, and these are published here as planned. The 232 papers are themed under 6 section headings: biomedical data, tools and methods; supporting care delivery; health and prevention; precision medicine and public health; human factors and citizen centered digital health; and ethics, legal and societal aspects. A 7th section deals with the Swiss personalized health network, and section 8 includes the 125 posters accepted for the conference. Offering an overview of current trends and developments in digital health and medical informatics, the book provides a valuable information resource for researchers and health practitioners alike.

NMR-based Metabolomics

Author : Hector C Keun
Publisher : Royal Society of Chemistry
ISBN 13 : 184973643X
Total Pages : 384 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis NMR-based Metabolomics by : Hector C Keun

Download or read book NMR-based Metabolomics written by Hector C Keun and published by Royal Society of Chemistry. This book was released on 2018-01-17 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.

Developmental Psychopathology

Author : Thomas M. Achenbach
Publisher :
ISBN 13 : 9780471891826
Total Pages : 770 pages
Book Rating : 4.8/5 (918 download)

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Book Synopsis Developmental Psychopathology by : Thomas M. Achenbach

Download or read book Developmental Psychopathology written by Thomas M. Achenbach and published by . This book was released on 1982 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt: A completely updated edition of the standard survey of the field. Demonstrates how psychopathology is best understood in the context of biological, cognitive, social, and emotional development.

Laryngopharyngeal and Gastroesophageal Reflux

Author : Craig H. Zalvan
Publisher : Springer Nature
ISBN 13 : 303048890X
Total Pages : 487 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Laryngopharyngeal and Gastroesophageal Reflux by : Craig H. Zalvan

Download or read book Laryngopharyngeal and Gastroesophageal Reflux written by Craig H. Zalvan and published by Springer Nature. This book was released on 2020-09-29 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text comprehensively reviews the current state of the art in Laryngopharyngeal Reflux (LPR) together with a comprehensive explanation and description of the known gastroesophageal reflux (GERD) literature. With chapters written by experts from around the world, this text aims to deliver what is current in reflux recognition, diagnosis, reflux related complications, and the various treatment modalities. This is the first textbook to combine the most up to date knowledge of both LPR and GERD meant for both specialties and the general medicine population. Completely unique to the reflux literature is a section detailing the substantial benefits of a mostly plant based, Mediterranean style diet in the treatment of reflux disease. Encouraging patients to read and learn about diet and health is likely the most important step in improving their disease. The text provides direction to the caregiver on how to transition to a mostly plant-based diet. Review of myths, effects of diet in the setting of other disease states, and dietary consequences are explained. Guidelines on how to transition diet, dining out while maintaining a plant-based diet, and how to wean off medication, such as PPI, are also provided. Laryngopharyngeal and Gastroesophageal Reflux: A Comprehensive Guide to Diagnosis Treatment, and Diet-Based Approaches will provide the medical community with a resource to understand, teach, and provide the latest in LPR and GERD information to the caregiver and subsequently the patient.

Epitranscriptomics

Author : Stefan Jurga
Publisher : Springer Nature
ISBN 13 : 3030716120
Total Pages : 632 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Epitranscriptomics by : Stefan Jurga

Download or read book Epitranscriptomics written by Stefan Jurga and published by Springer Nature. This book was released on 2021-07-28 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.

Hospital-Based Health Technology Assessment

Author : Laura Sampietro-Colom
Publisher : Springer
ISBN 13 : 3319392050
Total Pages : 384 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Hospital-Based Health Technology Assessment by : Laura Sampietro-Colom

Download or read book Hospital-Based Health Technology Assessment written by Laura Sampietro-Colom and published by Springer. This book was released on 2017-01-23 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely work describing how localized hospital-based health technology assessment (HB-HTA) complements general, ‘arms-length’ HTA agency efforts, and what has been the collective global impact of HB-HTA across the globe. While HB-HTA has gained significant momentum over the past few years, expertise in the field, and information on the operation and organization of HB-HTA, has been scattered. This book serves to bring this information together to inform those who are currently working in the field of HTA at the hospital, regional, national or global level. In addition, this book is intended for decision-makers and policy-makers with a stake in determining the uptake and decommissioning of new and established technologies in the hospital setting. HTA has traditionally been performed at the National/Regional level by HTA Agencies, typically linked to governments. Yet hospitals are the main entry door for most health technologies (HTs). Hospital decision-makers must undertake multiple high stakes investment and disinvestment decisions annually for innovative HTs, usually without adequate information. Despite the existence of arms-length HTA Agencies, inadequate information is available to hospital decision-makers either because relevant HTA reports are not yet released at the time of entry of new technologies to the field, or because even when the report exists, the information contained is insufficient to clarify the contextualized informational needs of hospital decision makers. Therefore, there has recently been a rising trend toward hospital-based HTA units and programs. These units/programs complement the work of National/Regional HTA Agencies by providing the key and relevant evidence needed by hospital decision makers in their specific hospital context, and within required decision-making timelines. The emergence of HB-HTA is creating a comprehensive HTA ecosystem across health care levels, which creates better bridges for knowledge translation through relevance and timeliness.

Computer Methods in Biomechanics and Biomedical Engineering

Author : J. Middleton
Publisher : CRC Press
ISBN 13 : 9782919875009
Total Pages : 582 pages
Book Rating : 4.8/5 (75 download)

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Book Synopsis Computer Methods in Biomechanics and Biomedical Engineering by : J. Middleton

Download or read book Computer Methods in Biomechanics and Biomedical Engineering written by J. Middleton and published by CRC Press. This book was released on 1996-03-18 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: These papers are concerned with new advances and novel solutions in the areas of biofluids, image-guided surgery, tissue engineering and cardovascular mechanics, implant analysis, soft tissue mechanics, bone remodeling and motion analysis. The contents also feature a special section on dental materials, dental adhesives and orthodontic mechanics. This edition contains many examples, tables and figures, and together with the many references, provides the reader with invaluable information on the latest theoretical developments and applications.

Cognitive Decline

Author : H. M. Fillit
Publisher : Cambridge University Press
ISBN 13 : 9780521026703
Total Pages : 156 pages
Book Rating : 4.0/5 (267 download)

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Book Synopsis Cognitive Decline by : H. M. Fillit

Download or read book Cognitive Decline written by H. M. Fillit and published by Cambridge University Press. This book was released on 2006-06 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cognitive Decline - Strategies for Prevention examines the problems associated with our understanding of the ageing brain, whether or not such decline is inevitable and if there are practical steps which can be taken to prevent or minimise cognitive decline in late life. Preventive medical strategies have primarily targeted the top three causes of death in the developed world: heart disease, cancer and stroke. Less attention to date has been paid to cognitive decline and dementia, possible because the generally held view has been that little of nothing could be done to help them. Our knowledge has grown rapidly and it is becoming clear that preventative strategies are now viable. Cognitive Decline - Strategies for Prevention brings together a group of leading researchers to assess and make practical recommendations about the strategies currently available. The chapters assess how 'normal' cognitive ageing should be defined and what the genetic, medical, psychological and environmental factors are which can adversely affect optimal cognitive function in late life. It then examines how 'healthy living' strategies can be employed throughout life to prevent cognitive decline in later years and what are the research strategies which promise new approaches to prevention in the future.

World Congress on Medical Physics and Biomedical Engineering 2018

Author : Lenka Lhotská
Publisher :
ISBN 13 : 9789811090363
Total Pages : pages
Book Rating : 4.0/5 (93 download)

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Book Synopsis World Congress on Medical Physics and Biomedical Engineering 2018 by : Lenka Lhotská

Download or read book World Congress on Medical Physics and Biomedical Engineering 2018 written by Lenka Lhotská and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the proceedings of the IUPESM World Congress on Biomedical Engineering and Medical Physics, a tri-annual high-level policy meeting dedicated exclusively to furthering the role of biomedical engineering and medical physics in medicine. The book offers papers about emerging issues related to the development and sustainability of the role and impact of medical physicists and biomedical engineers in medicine and healthcare. It provides a unique and important forum to secure a coordinated, multileveled global response to the need, demand, and importance of creating and supporting strong academic and clinical teams of biomedical engineers and medical physicists for the benefit of human health.

Genetic Epidemiology

Author : Evangelos Evangelou
Publisher : Humana Press
ISBN 13 : 9781493978670
Total Pages : 299 pages
Book Rating : 4.9/5 (786 download)

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Book Synopsis Genetic Epidemiology by : Evangelos Evangelou

Download or read book Genetic Epidemiology written by Evangelos Evangelou and published by Humana Press. This book was released on 2018-06-07 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.